Could a Pre-Surgery drug shrink kidney tumors?
NCT ID NCT04022343
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether the drug cabozantinib can shrink tumors in 22 people with advanced kidney cancer before they have surgery. The goal is to see if the drug reduces tumor size enough to improve surgical outcomes and delay cancer return. Participants take cabozantinib by mouth before their scheduled operation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cabozantinib (a drug that blocks enzymes needed for tumor growth)
What this could lead to
If successful, this could show that taking cabozantinib before surgery helps shrink kidney tumors and delays cancer recurrence.
What could go wrong
This is a small, early-phase trial with only 22 participants, so results may not apply to everyone. Cabozantinib can cause side effects like fatigue, diarrhea, and high blood pressure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States