Promising combo offers hope for kids with relapsed tumors

NCT ID NCT02574728

First seen Mar 26, 2026 · Last updated May 15, 2026 · Updated 8 times

Summary

This study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have returned or not responded to standard treatment. The goal is to see if this approach can shrink or stabilize the tumors. Researchers also track side effects to understand the safety of this treatment plan.

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Contacts and locations

Locations

  • Children's Healthcare of Atlanta, Scottish Rite

    Atlanta, Georgia, 30342, United States

  • Children's Healthcare of Atlanta-Egleston

    Atlanta, Georgia, 30322, United States

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • Nemours/Alfred I. duPont Hospital for Children

    Wilmington, Delaware, 19803, United States

  • Phoenix Children's Hospital

    Phoenix, Arizona, 85016, United States

  • University of Virginia Health System

    Charlottesville, Virginia, 22908, United States

Conditions

Explore the condition pages connected to this study.