CANCER

This program offers a personalized cancer vaccine to people with solid tumors that have spread or are locally advanced. It is for patients who have run out of standard treatment options and have a low chance of long-term survival. The vaccine is made from unique markers on each p…

This early-phase study tests a new drug, IMC-P115C, in people with advanced cancers that have a specific marker called PRAME and a certain immune type (HLA-A*02:01). The drug is designed to help the immune system attack cancer cells. Researchers will check safety and whether the …

This early-phase trial tests a new drug called IMA402 in adults with solid tumors that have returned or not responded to standard treatments. The drug is designed to help the immune system attack cancer cells by targeting a protein called PRAME. The study aims to find a safe dose…

This early-phase study tests whether adding a special ultrasound treatment (histotripsy) to standard immunotherapy can be safe and tolerable for people with advanced cancer that has stopped responding to other treatments. About 24 adults will receive one session of focused sound …

This early-stage study tests a new drug called TTX-080, which blocks a protein that helps cancers hide from the immune system. It is given alone or with other cancer drugs to people with advanced solid tumors (like colorectal cancer) that have not responded to standard therapies.…

This program gives people with certain solid tumors or blood cancers access to an experimental drug called AVM0703. It is for patients in the US whose doctor requests it. So far, 37 patients have received the drug, and side effects have been mostly mild, like itching during infus…

This program provides oral sevabertinib to adults with advanced non-small cell lung cancer that has a specific HER2 gene mutation and has stopped responding to other treatments. Participants must have a life expectancy of at least 12 weeks and be well enough to perform daily acti…

This study tests a new drug, MBRC-101, in people with advanced solid tumors that have not responded to standard therapies. The drug works like a guided missile, delivering a chemotherapy agent directly to cancer cells that have a specific marker (EphA5). The trial has three parts…

This study looks at whether giving people healthy prepared meals and education helps them eat better compared to just getting physical activity coaching. It involves 120 adults in Anson County who have or are at risk for chronic diseases like obesity, diabetes, or heart disease. …

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay, and improve their quality of life. Researchers will enroll 100 cancer survivors who finished primary treatment at least 6 months ago. Participants will eithe…

This study tests whether the drug abatacept can reduce serious heart problems in cancer patients who develop heart inflammation (myocarditis) from immune checkpoint inhibitor therapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo, an…

This study tests a new drug, IMC-R117C, for people with advanced cancers (colorectal, esophageal, stomach, or ovarian) that have a specific protein (PIWIL1) and a certain immune type (HLA-A*02:01). The goal is to see if the drug is safe and works by helping the immune system atta…

This study offers continued access to an investigational cancer drug for patients who were already benefiting from it in a previous study. The main goal is to monitor long-term safety. Participants must have completed an earlier Lilly study and still be getting benefit from the d…

This study tests a pill called abemaciclib in people with advanced solid tumors that have certain genetic changes (in cyclin or CDK genes). The goal is to see if the drug can stop or slow cancer growth. About 38 participants will receive the treatment, and researchers will monito…

This study looks at whether a common blood thinner (apixaban) can safely prevent dangerous blood clots in cancer patients who are at moderate risk. About 996 adults with solid tumors or lymphoma will be randomly assigned to take apixaban twice a day, once a day, or no blood thinn…

This early-phase study tests a new drug called ALTA3263 in adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS gene mutation. The main goals are to check safety and find the right dose. About 188 people who have tried other tr…

This early-phase study tests a new drug called INV-1120, given alone or with pembrolizumab, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses and check for side effects. About 78 participants will take …

This early-phase study tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink tumors. It is a first-in-human trial, so the main focus is on …

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study tests a new way to help men who became infertile after childhood cancer treatment. Doctors will take testicular tissue that was frozen before cancer therapy and transplant it back into the man's testicles. The goal is to see if the tissue can start making sperm again. …

This trial tests a drug called atezolizumab, already approved for some cancers, in people with rare cancers that have high numbers of genetic mutations or specific DNA repair problems. About 30 adults and children with these rare tumor types will receive the drug. The main goal i…

This early-phase study is testing an experimental drug called WTX212A in 12 people with advanced solid tumors that have not responded to other treatments. The drug is given alone or with radiation therapy to see if it can shrink tumors and control the disease. The main goal is to…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This early-phase study tests CPO301, a drug that delivers chemotherapy directly to cancer cells, in adults with advanced solid tumors (like lung, breast, or colorectal cancer) that have stopped responding to other treatments. The main goals are to find a safe dose and check for s…

This early-phase trial tests an experimental drug called ALTA2618 in adults with advanced solid tumors (like breast or endometrial cancer) that have a specific AKT1 E17K gene mutation. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors.…

This study tests a new treatment that uses a patient's own immune cells, specially engineered to target cancer. The goal is to see if these cells are safe and can shrink tumors. The trial is for people with different types of cancer whose tumors have certain markers. It is still …

This study tests a three-drug combination (isatuximab, lenalidomide, dexamethasone) at lower-than-standard doses in 50 people newly diagnosed with multiple myeloma who are at high risk for side effects. The goal is to see if the lower doses can still shrink the cancer while reduc…

This trial tests alectinib, a drug already approved for certain lung cancers, in people with other rare cancers that have the same ALK genetic change. About 30 adults, children, and teens with ALK-positive cancers will receive the drug. The goal is to see if it can shrink tumors …

This early-stage trial tests a new drug called DXP-106 in 54 people with advanced solid tumors that have not responded to other treatments. The main goal is to check the drug's safety and find the best dose, either alone or with standard chemotherapy. The study is currently recru…

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The main goals are to find a safe dose, understand side effects, and see if the drug can slow tumor…

This study offers boys aged 0-17 a chance to preserve their fertility before undergoing treatments like chemotherapy or radiation that could cause infertility. Researchers will freeze a small sample of testicular tissue for potential future use. The goal is to see if this frozen …

This study looks at whether starting nutrition support early can help cancer patients on palliative chemotherapy keep their weight, muscle mass, and quality of life. About 200 adults with lung, colorectal, ovarian, or pancreatic cancer will receive nutritional guidance and be com…

This study looks at whether it is safe to give radiation therapy again to the breast after a second lumpectomy in women who have already had radiation before. The goal is to see what side effects occur and how well it controls cancer. The study includes 114 women with a specific …

This study looks at whether cancer survivors who had heart damage from their cancer treatment, but whose heart function has since recovered, can safely stop taking heart failure medications. About 335 adults who finished cancer therapy at least 6 months ago and are currently on h…

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through an IV and aims to attack cancer cells. The main goals are to find the safest dose and understand side effects. Abou…

This study is for people with advanced ovarian cancer that has a BRCA gene mutation. It compares two different forms of the drug olaparib to see if they work the same way in the body. About 40 participants will take both versions at different times, and researchers will measure d…

This study is for cancer patients who have already taken part in earlier trials of nivolumab or other BMS cancer treatments. The main goal is to check the long-term safety of continuing these therapies. About 1,500 participants with various tumor types will be enrolled. The study…

This study tests a new treatment for gastrointestinal cancers using a patient's own immune cells, which are engineered in a lab to better recognize and attack cancer. About 100 adults with certain cancer markers will receive these cells to see if they are safe and can shrink tumo…

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This study looks at whether people with multiple myeloma who have achieved a very deep remission (called MRD-negative) can safely stop their maintenance therapy without the cancer coming back. About 70 adults who have been on maintenance for at least two years will stop treatment…

This study tests an experimental drug called zotiraciclib for people whose brain tumors (a type of glioma with IDH1 or IDH2 mutations) have returned after previous treatment. About 96 participants aged 15 and older will take the drug by mouth on a specific schedule over 28-day cy…

This study tests a new treatment for people with solid tumors that have come back or not responded to standard therapies. The treatment uses a patient's own immune cells that are genetically modified to recognize and attack cancer cells. Some participants will also receive the dr…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive NK cells along with chemot…

This study tests a new treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen by analyzing a tumor sample or a blood test. The study includes adults aged 18-75 with advanced solid tumors that have not respond…

This study tests whether adding the drug bevacizumab to a procedure called TACE (which delivers chemotherapy directly to the liver) can help people with liver metastases live longer and shrink their tumors. About 40 adults with liver cancer that has spread from another part of th…

This study is for people with certain advanced cancers that have spread in the belly or pelvis, including liver, kidney, and bladder cancers. It combines a special type of radiation (PULSAR) with immunotherapy drugs that help the immune system fight cancer. The goal is to see if …

This study tests a new way to help men who lost fertility due to cancer treatment. Doctors will take frozen testicular tissue stored before treatment and transplant it back into the patient. The goal is to see if this is safe and can restart sperm production. Ten men who are heal…

This study tests whether adding the drug sarilumab to standard chemotherapy (capecitabine) can eliminate tiny amounts of cancer left behind after initial treatment in people with triple negative breast cancer. The goal is to prevent the cancer from coming back and improve surviva…

This study tests whether adding short, high-dose radiation pulses (adaptive pulse radiotherapy) to standard immunotherapy can help shrink advanced solid tumors or slow their growth. About 35 adults with various cancers who are already receiving immune checkpoint inhibitors will g…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The treatment uses the patient's own immune cells, modified to target cancer cells while sparing healthy ones. The s…

This study tests whether inhaling a drug called tranexamic acid can help cancer patients who have severe lung bleeding and are on a breathing machine. The goal is to see if it lowers the chance of death within 28 days compared to standard care. About 60 adults with blood cancers …

This study tests whether a mobile health program can help young adults who have survived cancer manage their weight. About 240 people aged 18-39 who are overweight and finished cancer treatment at least 6 months ago will join. One group gets a full mobile program with coaching, w…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with various cancer types will receive the drug to see if it shrinks tumors or stops the…

This study provides ongoing access to experimental cancer treatments for people who were already in a Roche-sponsored trial and still need the drug. It includes about 100 participants and focuses on safety and continued therapy. The goal is to keep treating patients who have no o…

This early-stage study tests a single injection of cells from umbilical cord blood (XJ-MK-002) in 16 adults aged 18-75 who have low platelets due to cancer therapy. The main goal is to check safety and find the right dose. Participants receive one of three dose levels and are mon…

This study looks at whether removing a brain tumor and the area causing seizures can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if surgery can gre…

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction. The goal is to see if this program improves fitness and heart health better than standard advice. 336 part…

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors that have spread from other cancers. About 46 adults with metastatic cancer will receive the combination. The goal is to see if the tumors shrink and stay controlled l…

This study compares giving radiation therapy before mastectomy with immediate breast reconstruction versus the standard approach of radiation after mastectomy with delayed reconstruction. The goal is to see if the new order leads to higher patient satisfaction and better quality …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, and breast cancers) that have not responded to standard therapies. The treatment uses specially designed immune cells to attack cancer cells while protecting healthy ones.…

This study tests capmatinib, a drug already approved for some lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will take capmatinib pills to see if the drug shrinks tumors or stops them from growing. The goal is to control…

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs. The goal is to see if taking larotrectinib before standard radioactive iodine treatment helps shrink …

This is the first study in people testing a new antibody drug called NTX-1088, which targets a protein found on many cancer cells. The trial will test the safety of NTX-1088 given alone and in combination with an existing immunotherapy drug (pembrolizumab) in 90 patients with adv…

This study is testing a new support program to help people with cancer quit smoking. It involves letting patients choose their own quit date and sending them encouraging text messages through a mobile app. Researchers will compare this approach to standard advice to see which one…

This study offers women at risk of early menopause—often due to cancer treatments or surgery—the option to freeze ovarian tissue for potential future use. The goal is to preserve fertility by developing methods to mature eggs from this tissue in the lab or transplant the tissue b…

This is the first study in people to test a new drug called JMT108 for advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose, see how the body processes the drug, and look for early signs that it can shrink tumors. About 270 …

This study aims to create and test an artificial intelligence (AI) model that can detect whether cancer has spread to lymph nodes by analyzing digital images of tissue samples. Researchers will compare the AI's accuracy to standard pathology reports from doctors. The goal is to s…

This study is testing an injectable imaging agent called NC527-X in 400 adults with solid tumors who are scheduled for surgery. The goal is to see if the dye makes tumors glow brighter than healthy tissue, helping surgeons remove cancer more precisely. Participants receive the in…

This study is testing two new blood tests designed to help doctors detect cancer in people who have symptoms that might be cancer. The study will enroll 1,650 adults aged 45 and older who are already undergoing standard testing for suspected cancer. The goal is to see how well th…

This study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a PET-MR scan. Researchers want to see if it can safely and accurately find clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 healthy volunteers …

This study is testing whether analyzing DNA and proteins in urine can help detect urothelial cancers of the bladder and kidney. Researchers will collect urine samples from 500 adults, including those with known or suspected cancer and healthy volunteers. The goal is to find a non…

This study tests whether a health workshop can help Latino families in rural Florida make healthier choices to reduce cancer risk. About 50 Spanish-speaking parents of children aged 6 to 12 will attend a one-hour workshop on diet, exercise, and sun protection. Some will later joi…

This study tests a nature-based healing meditation for adults who recently lost a loved one to cancer and served as their caregiver. The goal is to see if the meditation is practical and helpful for reducing grief and improving focus. About 70 participants will try the meditation…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it shrinks tumors better than standard radiation and helps patients feel better. About 37 adults with advanced solid tumors will receive this tre…

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to improve …

This study tests whether a virtual reality (VR) program can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. Thirty adults who finished cancer treatment at least 3 months ago will use either VR or an audio program at home for 4 weeks. Res…

This study tests if acupuncture on the tongue can reduce taste problems caused by chemotherapy in people with gynecologic cancers. Researchers will compare real acupuncture to a fake version and standard dietary advice. The goal is to see if this simple treatment can improve tast…

This study tests a new program that screens adults with cancer for disability and then offers them a tailored rehab plan before their main cancer treatment starts. The goal is to see if this approach helps patients maintain their physical function and improve their overall qualit…

This study tests a mobile app (Mio-App) designed to help children and teens with cancer reduce long-term thinking and physical problems. About 40 participants aged 8-16 will use the app to do cognitive and physical exercises and answer questions about their own thinking. The goal…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help cancer survivors who feel depressed or anxious. Twenty adults who have finished cancer treatment and have no brain tumors will receive the therapy. Researcher…

This study tests a 6-session therapy program called Acceptance & Commitment Therapy (ACT) to help cancer patients avoid misusing opioids. The program focuses on managing difficult thoughts and feelings that can lead to opioid overuse. Researchers will enroll 40 adults with cancer…

This study looks at whether giving cancer patients dietary advice and palliative care counseling can improve their quality of life, daily functioning, and nutrition. About 215 cancer patients in Bangladesh will be split into two groups: one gets the extra support, the other does …

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. Researchers will enroll 192 adults who have finished their main cancer treatment within the last 5 years. Participants will write about their experiences,…

This study tests whether a digital avatar program can help reduce anxiety and improve quality of life for cancer patients receiving a stem cell transplant as an outpatient. About 90 adults will be randomly assigned to either the avatar program or usual care. The goal is to make o…

This study looks at whether acupuncture can help young women with cancer regain their periods after chemotherapy. About 60 women aged 15 to 40 who have lost their periods due to chemo will receive acupuncture sessions. The goal is to see if this approach is practical and whether …

This study looks at whether live, online group exercise classes help cancer survivors become more physically active compared to watching recorded workout videos. Researchers will track changes in exercise, fitness, quality of life, and loneliness over 9 months. About 300 adults w…

This study tests a medicine called naldemedine for constipation caused by opioids (strong painkillers) in people with cancer. About 100 adults who are already using laxatives but still constipated will take naldemedine to see if it improves bowel function and quality of life. The…

This study tests a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for chronic nerve pain caused by cancer or its treatment. 60 adults will receive both real and fake (placebo) stimulation in random order to see if the real treatment provides bet…

This study tests whether a computer tool called C-SCAT helps adolescents and young adults with cancer feel more confident in managing their symptoms and take more steps to manage them. About 126 participants who are within 3 months of diagnosis and receiving regular treatment wil…

This study looks at whether stopping statins (cholesterol-lowering drugs) early in people with advanced cancer who are in palliative care is safe and helpful. Many patients take these preventive drugs even near the end of life, which can cause side effects like muscle weakness an…

This study tests a brief motivational program to help cancer survivors who were part of the World Trade Center Health Program become more physically active. About 84 participants will use a Fitbit to track their activity. The goal is to see if the program leads to a 25% increase …

This study is testing a 4-month coaching program called SONATA for people aged 60 and older with advanced cancer. The program helps patients build a support network of family and friends to improve treatment adherence and quality of life. Up to 330 participants will receive 6 coa…

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness caused by chemotherapy (CIPN). Sixteen adults who finished chemo at least 60 days ago will try the therapy at home. The main goals are to …

This study looks at whether adding a special breathing exercise device to standard pre-surgery rehab can help people with lung cancer recover better after surgery. About 100 adults with lung cancer who are scheduled for surgery will take part. Half will get standard rehab plus th…

This study looks at two different exercise programs—flexi band resistance training and whole-body electrical muscle stimulation—for people with cancer. The goal is to see which one better improves muscle strength, body composition, and quality of life. About 100 participants will…

This study tests whether immersive virtual reality exercises can improve thinking skills in people with cancer who have memory and attention problems after chemotherapy. About 60 participants will either do virtual reality activities or continue usual care. The goal is to see if …

This study looks at whether smelling essential oils (aromatherapy) combined with self-hypnosis can reduce discomfort for cancer patients during common procedures like blood draws, dressing changes, or bed baths. About 66 adults with cancer who are also under a palliative care tea…

This study is testing whether a mushroom called Maitake can help improve immune function in people receiving standard cancer treatments like chemotherapy. About 40 adults with solid tumors will take Maitake supplements alongside their regular therapy. Researchers will measure cha…

This study tests a program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. Participants join weekly online group sessions and do short daily activities on an app to help with anxiety and depression. The goal is to see if the program is pra…

This study tests if nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure changes in …

This study tests whether expressive writing can improve emotional well-being in Chinese American cancer survivors. About 108 participants who finished cancer treatment within the last 5 years will write about their experiences. The goal is to see if this simple activity reduces d…

This study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to help them cope with stress and keep their relationship strong. About 20 couples will take part in 8 therapy sessions to see if the program is practi…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. The goal is to see if art can improve communication about …

This study looks at whether adding motivational counseling to a virtual exercise program helps cancer survivors become more active. About 236 adults who finished cancer treatment within the last 5 years will take part. They will do supervised exercise from home and get either sta…

This study tests three common pain management methods used during minimally invasive cancer surgery. About 48 adults having surgery for cancers of the liver, stomach, pancreas, or other organs will be randomly assigned to one of three groups. The goal is to see which method provi…

This study tests a program called MyCarePulse and ASCENT to help cancer patients overcome barriers to healthy eating. About 100 adults recently diagnosed with cancers like breast, lung, or colorectal cancer will either get the program or standard care. Researchers will check if t…

This study tests whether a mobile app that tracks symptoms and sensor data can help people receiving chemotherapy feel better and stay connected with their care team. About 50 adults with solid tumors will use the app and a Fitbit for 90 days. The goal is to see if the app is eas…

This study looks at whether doing resistance exercises at home with digital guidance works as well as going to a gym with a trainer for people who have finished cancer treatment. About 120 adults who completed cancer therapy within the last year will be split into two groups: one…

This study explores whether a type of writing called 'compassionate expressive writing' can help people living with or after cancer feel better emotionally and physically. About 50 adults who have experienced body changes from cancer or its treatment will be asked to write for 20…

This study looks at whether a supervised stationary cycling program can reduce nerve pain and improve daily function in cancer patients who have mild nerve damage from chemotherapy. Thirty adults will cycle twice a week for 12 weeks. The main goal is to see if the program is acce…

This study tests whether a digital art therapy app is practical and acceptable for young adults (ages 18-25) who survived childhood cancer and have mood issues. Participants use the app for 6 weeks, completing weekly art prompts and surveys. The goal is to see if at least 10 out …

This study tests whether a single dose of NPX-5 (a psilocybin drug) combined with talk therapy can reduce severe anxiety in adults struggling after a cancer diagnosis. About 87 participants will be randomly assigned to receive 25 mg, 10 mg, or a low 1 mg dose during an 8-hour the…

This study looks at how two different supportive care programs affect the emotional health and quality of life of people with advanced cancer and their family caregivers. About 400 patient-caregiver pairs will take part. The goal is to find better ways to manage stress and improv…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. About 260 participants who h…

This study tests whether a one-year, home-based exercise program can help older adults (60+) undergoing cancer treatment improve their strength, balance, and quality of life. Participants are randomly assigned to either the exercise program or usual care. Researchers will measure…

This study explores whether virtual reality (VR) can help people with cancer manage chronic pain and reduce their need for opioid painkillers. Researchers will work with 25 adults who have active cancer and ongoing pain to develop and test a VR program. Participants will use a VR…

This study is testing a yoga program designed to fit different cultures for cancer patients who are getting a stem cell transplant. The goal is to see if the yoga can help reduce feelings of depression. About 60 adults from India, Tanzania, and the United States will take part.

This study tests whether ustekinumab can help control severe diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. Ten adults with solid tumors who experience these side effects will receive the drug. The goal is to improve quality of life by …

This study compares three types of support for parents who lost a child to cancer at least six months ago and still have high grief levels. The programs are Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care. Researchers will measure changes in grief a…

This study is testing an 8 to 12 week exercise program for people who have or had cancer. The program includes twice-weekly supervised exercise classes, either online or in person. The goal is to help participants become more physically active and reduce cancer-related symptoms l…

This study tests whether creating a short digital story about their cancer journey can reduce depressive symptoms and improve self-esteem and quality of life in Hong Kong Chinese teens who have finished cancer treatment. About 248 survivors aged 13-18 will either join four 2.5-ho…

This study explores whether a guided life review program, where older patients with advanced cancer and their caregivers share memories and reflect together, can improve emotional well-being and strengthen their relationship. The program is compared to standard care, which includ…

This study looks at whether massage therapy can improve sleep for children and teens aged 12 to 21 who are in the hospital for cancer treatment or a stem cell transplant. Researchers will measure sleep minutes and quality using a wrist-worn device. The goal is to see if adding ma…

This study tests a program that gives cancer patients free help with legal problems like health insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will receive legal navigation and be followed for 6 months. Researchers want to see if t…

This study tests a new text-message system designed to help cancer survivors who feel depressed connect with mental health care. Researchers will enroll 60 adults with cancer and signs of depression to see if the approach is easy to use and helpful. The goal is to make getting su…

This study tests a smartphone app called Moodivate designed to help treat depression in adults with incurable cancer. About 279 participants will be randomly assigned to use the app or not for 12 weeks. Researchers will track changes in depression, anxiety, and quality of life th…

This study tests a smartphone app called Resilience PRO that asks cancer patients about their symptoms regularly. If a symptom is serious, the app alerts their care team so they can adjust treatment sooner. The goal is to see if using the app improves quality of life compared to …

This study tests whether watching virtual reality (VR) experiences during radiotherapy can lower anxiety and improve treatment satisfaction for cancer patients. Researchers will compare different VR techniques and a standard informational video in 150 adults receiving radiation a…

This study tests whether an artificial intelligence (AI) app can improve quality of life and reduce anxiety or depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the app plus usual therapy or jus…

This study tests two digital programs designed to improve the health, wellbeing, and daily functioning of people recently diagnosed with cancer. About 440 participants will be randomly assigned to one of two online courses, complete questionnaires, and provide blood samples by ma…

This study looks at whether a low dose of the steroid prednisolone can effectively treat liver inflammation (hepatitis) that sometimes occurs as a side effect of cancer immunotherapy. About 63 cancer patients who develop moderate to severe liver inflammation from their treatment …

This study looks at whether hearing aids can improve quality of life for cancer patients who develop hearing loss or tinnitus from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing problems will be offered a hearing aid. T…

This study tests whether using virtual reality (VR) can safely help cancer patients feel less anxious and improve their mood during treatment. About 24 adults with cancer will use VR headsets to explore calming environments like forests or oceans. The goal is to see if this appro…

This study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss. 26 adults recently diagnosed with cancer will either receive usual care or extra support from a physiotherapist navigator for 12-18 weeks. The navigat…

This study tests whether using a small ultrasound scanner helps nurses place an IV drip on the first try more often than the traditional touch-and-feel method. About 98 cancer patients receiving treatment will be randomly assigned to one of the two methods. The goal is to reduce …

This study is testing an online educational program called On-Trac for adult cancer survivors who have significant anxiety. The program teaches coping strategies based on cognitive-behavioral therapy and acceptance commitment therapy. About 80 participants will use the program at…

This study tests whether using the Calm meditation app for 10 minutes a day can improve sleep, reduce fatigue, and ease anxiety or depression in people with blood cancer. Researchers will enroll 276 patients who have trouble sleeping but no diagnosed sleep disorder. Participants …

This study tests whether testosterone replacement therapy can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. About 230 participants will receive either testosterone or a placebo. The goal is to see if this treatment helps…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study looks at whether a community-based program can help cancer survivors and their loved ones in low-income areas eat healthier and be more active. About 100 adults from Birmingham will take part. The program adapts proven health tips to fit local needs, with the goal of i…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study compares two approaches to supportive cancer care: a technology-based model and a redesigned team-based model. About 3,000 adults with newly diagnosed or recurrent solid tumors will participate. The goal is to see which model better improves quality of life over 12 mon…

This study is for people caring for a loved one with advanced cancer. It tests a short program called Positive Affect Treatment (PAT) to improve caregivers' quality of life and emotional wellbeing. About 150 caregivers will take part, using phone or internet from home.

This study tests whether a smartphone app called iCANSleep can help cancer survivors with insomnia sleep better. The app uses a proven therapy called Cognitive Behavioural Therapy for Insomnia (CBT-I). Researchers will compare 146 cancer survivors who use the app to those on a wa…

This study is testing an online program called My Wellbeing Guide to help cancer patients who feel depressed or anxious. About 6,500 participants will use either the program (with videos and activities) or a control app with resource links for 7 weeks. The goal is to see if the p…

This study tests whether a specialized form of EMDR therapy, called the EMDR Toolbox Method, can improve psychological well-being in people diagnosed with cancer. The trial will include 46 adults with early-stage cancer who will receive either standard EMDR or the enhanced Toolbo…

This study tests a mobile health exercise program (GO-EXCAP) in 100 older adults (60+) with myeloid neoplasms who are receiving chemotherapy. Participants will either follow the exercise program or receive standard education. The goal is to see if the exercise program improves ph…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy (CBT) can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least …

This study looks at whether a food farmacy (free healthy food) plus online cooking classes can help cancer survivors who struggle to afford food. About 80 survivors will take part. The goal is to see if the program is safe and helpful for improving diet and well-being.

This study looks at whether providing healthy groceries and nutrition counseling can improve diet, reduce symptoms, and lower hospital visits for 100 adults with any type of cancer living in Maine. Participants are split into three groups: one gets groceries plus counseling, one …

This study explores whether a virtual group-based expressive writing program can help improve quality of life for survivors of adolescent and young adult cancer. Researchers will enroll 30 participants aged 18-39 who were diagnosed with cancer between 1 and 5 years ago. Participa…

This study tests a program for older adults (65+) with cancer and mild memory concerns, along with their spouse or caregiver. Over six video sessions, they learn strategies to cope better. The goal is to see if this approach reduces stress and improves quality of life for both th…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely reduce depression in people with cancer. About 86 adults with cancer-related depression will receive either electroacupuncture or a sham treatment. Researchers will measure mo…

This study tests whether the herbal formula Ma-Zi-Ren-Wan (MZRW) can help cancer survivors with constipation. About 70 participants will receive either MZRW or a placebo for two weeks. Researchers will track bowel movements and examine changes in gut bacteria. The goal is to see …

This study looks at whether a computer-assisted vacuum device can safely remove blood clots from the lungs of cancer patients who have a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will be treated. The goal is to see i…

This study tests whether a 4-week smartphone app teaching mindfulness can help reduce stress in cancer survivors who have finished their main treatments. About 345 adults with any cancer type will either use the app right away or wait 3 months. The goal is to see if this easy-to-…

This study tests whether cancer patients can use digital tools (like apps or video calls) for physical rehabilitation during or after chemotherapy. Researchers will enroll 300 people across five European countries to see if this approach is practical and helpful. The goal is to m…

This study tests a combined mobile exercise and cognitive rehabilitation program for older cancer survivors (age 60+) who have memory or thinking concerns after treatment. The goal is to see if the program is practical and helpful. About 40 participants will use a phone app for e…

This study tests whether a program of resistance training (weight lifting) combined with a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while undergoing chemotherapy before surgery. Researchers will enroll 30 women aged 20-89 …

This study adapts a proven therapy (FORT) for parents of childhood cancer survivors who struggle with intense fear that their child's cancer might return. About 36 parents across Canada will be randomly assigned to receive the therapy right away or after a 3-month wait. The goal …

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, skin melanoma, or bladder) who also smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit smoki…

This study tests an inhaled form of fentanyl, a strong painkiller, for cancer patients. It involves 100 Chinese adults with malignant tumors who will receive both the inhaled and intravenous versions to compare how the drug works and its safety. The goal is to find a more conveni…

This study looks at how different supervised group exercise programs affect fitness and body composition in women who have completed breast cancer treatment. About 15 women aged 20-89 will try one of four resistance training regimens to see which best improves heart-lung fitness …

This study tests ways to help African American women who have had cancer stay physically active over time. Participants will wear a motion sensor for a week and report on fatigue, health, and quality of life. The goal is to find what helps make healthy habits last.

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study tests whether a structured, personalized care plan based on patient-reported symptoms can improve quality of life for adults with advanced cancer. About 120 participants will either receive standard palliative care or a tailored pathway that triggers specific support b…

This study looks at whether adding chaplain-provided spiritual care or psychotherapy/meditation to standard palliative care can help people with advanced, non-curable cancer live longer and have a better quality of life. About 854 adults with metastatic cancer and a life expectan…

This study looks at whether therapeutic play can help children aged 10-18 with acute lymphoblastic leukemia better tolerate pain and control their emotions while receiving chemotherapy. Over 4 weeks, some children will take part in guided play sessions during their treatment. The…

This study tests a new phone-based therapy called CARE for older adults (70+) with cancer who feel depressed or distressed. The therapy involves five phone sessions designed to address aging and cancer-related worries. Researchers will compare CARE to standard supportive counseli…

This study tests a support program for Chinese cancer patients and survivors. It combines education sessions, counseling, and peer support groups to see which mix works best. The goal is to improve quality of life. About 64 people from New York and New Jersey who speak Mandarin w…

This study is testing a support program designed to help young women who have survived cancer in rural areas manage their reproductive health needs. The program includes screening, counseling, and telehealth consultations to help participants make informed decisions about fertili…

This study is testing a new virtual reality (VR) device designed to help people with chronic cancer pain. The device uses distraction and therapy techniques to help manage pain, offering a non-drug option. Researchers will compare the VR device to watching a regular video on a ta…

This study is testing a coaching and navigation program designed to support family members who care for loved ones with both cancer and diabetes. It aims to help caregivers cope better, reduce their stress and loneliness, and connect them with helpful resources. The program is be…

This study is testing whether a yoga program led by trainers who share the same racial background as participants can improve quality of life and reduce symptoms for Black and African American cancer survivors. The research focuses on 50 adults in California who have had cancer t…

This study is testing whether an online pain coping skills program helps cancer survivors manage persistent pain better than standard care alone. Researchers will enroll 456 adult cancer survivors who have pain that started or worsened after cancer diagnosis or treatment. Partici…

This study is collecting short video and sound recordings of 200 adults with cancer to create a secure database. The goal is to help researchers develop an artificial intelligence tool that can automatically detect and measure pain by analyzing facial expressions and voice. Parti…

This study follows 130 people who have received gene transfer therapy to track any long-term side effects, good or bad. Participants are checked yearly for the first 5 years, then by questionnaire for up to 15 years. No new treatment is given; the goal is to build a safety databa…

This study is testing a new approach called xDRIVE that combines lab tests on a patient's tumor with artificial intelligence to suggest personalized cancer treatments. It aims to see if these recommendations can be delivered quickly enough to help doctors make treatment decisions…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can improve safety. TRT is a type of radiation treatment that targets cancer cells while sparing healthy tissue. Researchers will c…

This study looks at whether cancer patients are willing to answer questions about their social and economic circumstances, such as income, education, and housing. Researchers want to understand how these factors affect access to healthcare and participation in clinical trials. Ab…

This study tests whether a nurse-led program using online questionnaires can help cancer patients transition safely from hospital to home. About 50 adults with cancer who own a smartphone or tablet will use an app to report their health after discharge. The goal is to see if this…

This study collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will compare outcomes with national data to better understand the benefits and risks of radiation. The goal is to improv…

This study aims to find new inherited gene changes that make people more likely to develop cancer. Researchers will analyze genetic information from 1,500 adults and children who have or may have a hereditary cancer syndrome. The goal is to better understand these genes so doctor…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study looks at whether group education sessions can help veterans with newly diagnosed cancer make better plans for their future medical care. About 50 veterans will take part, and researchers will check if this group approach works better than the usual one-on-one care plan…

This study explores whether cancer patients undergoing chemotherapy can monitor their own blood counts at home instead of traveling to the hospital for every test. About 265 adults with cancer from Denmark, Poland, and Germany will participate, with some using home monitoring and…

This study looks at how cancer patients feel and how long they live when given treatments that have some early promise but unclear overall benefit. Researchers will track 100 people with cancer to collect real-world information on quality of life and survival. The goal is to help…

This study is testing a new screening tool called SOCS-OTS to see if it correctly identifies cancer survivors who need occupational therapy. Researchers will compare it to a standard screening method already used at MD Anderson Cancer Center. About 80 adults who are being seen in…

This study looks at whether improving the clarity of instructions helps cancer patients better follow their first radiotherapy schedule. Researchers will compare updated, easy-to-understand materials with standard ones in 650 adults starting radiation. The goal is to see if bette…

This study tests whether sending depression screening questions by text message is a practical and acceptable way to check on the mental health of cancer survivors. Researchers will compare the text message approach to the usual in-clinic screening method. The goal is to see if t…

This study surveys 200 adult cancer patients who have received CAR-T cell therapy to learn how it affects their fertility. The goal is to gather information that can help doctors improve future treatment plans and fertility preservation options. No new treatment is being tested.

This study tests a telehealth program designed to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. Researchers will track whether the program increases the number of patients who receive fertility counseling, referrals, or preservation …

This study explores how chronic breathlessness affects the brain in people with advanced cancer, COPD, or heart failure. Researchers will use brain scans (fMRI) and virtual reality to see if different diseases have unique breathlessness patterns. The goal is to learn if current t…

This study collects genetic and health information from 3,000 people with conditions like diabetes, heart disease, or cancer to help doctors choose the safest and most effective medications. Participants must be taking five or more medications (or blood pressure or depression med…

This study looks at the immune cells and genetic makeup of thymic epithelial tumors (TETs). Researchers will analyze tumor tissue and blood from 50 adults who have not yet been treated. The goal is to better understand these rare tumors and identify potential targets for future t…

This study aims to collect and store samples like tissue, blood, urine, and stool from up to 10,000 cancer patients across Texas. Researchers will use these samples to study how the immune system responds to cancer treatments and find markers that predict which therapies work bes…

This study looks at whether a special nutrition and exercise program before cancer treatment is practical and helpful for American Indian patients. About 30 adults with any type of cancer will eat walnuts and do moderate exercise for several weeks before their first treatment. Re…

This study is a registry that collects information from 2,000 adults with metastatic cancer who are receiving radiation therapy as part of their standard care. The goal is to gather clinical data and patient-reported outcomes to help researchers better understand how radiation th…

This study looks at why cancer patients feel very tired during chemotherapy and radiation therapy. Researchers will collect blood and stool samples and track fatigue levels in 125 adults with different cancers. The goal is to find links between fatigue and changes in genes and im…

This study is building a registry of 1,000 adults with cancer who use cannabis. Participants use an app to track symptoms, cannabis use, and how they feel after using it. The goal is to collect real-world data to help patients and doctors decide together if cannabis can help mana…

This study uses surveys and interviews to learn how COVID-19 impacts the health and daily life of adults with cancer. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study asks 300 adolescents and young adults who have or had cancer to fill out surveys about what they were taught regarding exercise, sexual health, fertility, money issues, relationships, and clinical trials. The goal is to find gaps in education so hospitals can better su…

This study is testing a new, high-resolution PET-CT scanner that can image a tumor right after it is removed from the body. The goal is to help surgeons see if any cancer cells are left behind at the edges of the removed tissue, so they can decide during the same surgery if more …

This study looks at why people with both cancer and HIV in Zimbabwe sometimes struggle to keep up with their HIV care while they are being treated for cancer. The researchers will first watch a group of 150 patients to understand the barriers. Then they will work with hospital st…

This study tests whether a weekly electronic questionnaire can help catch cancer treatment delays early, especially among different racial groups. About 240 people with newly diagnosed breast or colorectal cancer will use the tool before starting treatment. The goal is to see if …

This study tests different digital messages and reminders to help teens and young adults (ages 15-29) who survived childhood cancer return to their long-term follow-up appointments. About 530 participants will receive various types of information and be tracked to see which appro…

This study is testing a blood test called Galleri that looks for many types of cancer at once. Researchers will follow 50,000 people aged 50 and older with Medicare to see if the test helps find cancer earlier and reduces the number of advanced cancers. The goal is to learn how w…

This study looks at people who got cancer at a young age (before 40, or before 30 for breast cancer) but whose standard genetic tests came back normal. Researchers will use a more detailed method called exome sequencing to search for new, rare gene changes that might explain why …

This study is for cancer patients who have developed blood clots and are taking blood thinners. These medications can cause serious bleeding in 10-15% of patients. Researchers want to see if a special blood test (thrombin generation assay) can help predict who is at higher risk o…

This study looks at whether adding regular physical health checkups to mental health care can help find and manage hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults with psychotic or mood disorders will be sc…

This study tests whether a special clinic that looks at your genes and all your medications can help reduce harmful drug interactions and side effects. Researchers will enroll 1,300 adults with cancer or mental health conditions who take multiple medications. Participants will ge…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make informed treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive standard information.…

This study is testing a new PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match the standard lab analysis and if they help doctors make better decisions. About 850 people with prostat…

This study is testing a virtual reality (VR) tool called Life at 100.4 to help teens and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment in an immersive way. About 45 participants will use the VR program, and researchers will measu…

This study looks at how willing people are to use telehealth and digital tools for genetic counseling and testing related to cancer. About 360 adults who meet guidelines for genetic testing or are interested based on family history will participate. They can choose to use optiona…

This study is testing whether an artificial intelligence tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to ma…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving a common type of cancer immunotherapy (PD-1/PD-L1 inhibitors). Researchers will measure vitamin D and thyroid function in 17 cancer patients before…

This study is collecting information from 500 adults with solid tumors who are receiving proton therapy, a type of radiation that may cause fewer side effects than standard radiation. Researchers want to see how well it controls cancer and track any side effects. The goal is to g…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study aims to identify markers and causes of cancer by analyzing DNA, RNA, and tissue samples from 500 participants. Researchers will use genetic testing to find changes in cancer cells and normal cells, which may help improve prevention, early diagnosis, and treatment. The …

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to learn how cancer treatments like radiation, chemotherapy, and surgery affect health years later. Participants com…

This study looks at how well a small, swallowed camera (capsule endoscopy) can find early signs of small bowel cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will review medical records from 400 patients who had this screening betwe…

This study looks at whether a simple ultrasound of the thigh muscle can detect muscle loss in people who have finished cancer treatment. About 55 adults aged 18-74 with certain cancers will have an ultrasound and a full-body scan to compare results. The goal is to find a cheaper,…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers will track their physical and emotional distress, financial struggles, care needs, and quality of life over one year. The goal is to develop a tool that can predict which patients are …

This study looks at whether cancer survivors can use a smartwatch and answer weekly symptom questionnaires from home. About 50 adults who have finished cancer treatment and have controlled disease will wear a smartwatch for 4 months and fill out surveys. The goal is to see if thi…

This study collects personal writings from teenagers and young adults being treated for cancer. Researchers will analyze these stories to better understand patients' emotions and experiences. The goal is to improve how doctors and hospitals care for young people with cancer. No n…

This study is a disease registry that collects information from people with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called METex14 skipping. Researchers will track treatments, side effects, and outcomes over time to understand how this cance…

This study tests a digital platform called the Genetics Navigator that helps patients and parents of children get genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults referred for genetic testing at two h…

This study tests a program called CTNow that helps cancer patients in rural Hawaii learn about clinical trials. It also trains their doctors to refer them to trials. The goal is to see if the program increases patients' knowledge and awareness of clinical trial options.

This early-stage study is testing a new drug called LY4066708 in 104 healthy volunteers to see if it is safe and what side effects it might cause. Researchers will also measure how much of the drug enters the blood and brain, and how quickly the body gets rid of it. The study las…

This study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand which cancers lose a specific marker (HLA) and to store participants' own T cells for possible future CAR T-cell ther…

This study looks at how cancer patients use a smartphone app called EveryDose to track their oral chemotherapy pills. Researchers want to see if the app helps patients take their medication as prescribed and if they find it easy to use. The goal is to gather feedback from 25 pati…

This study is not testing a new drug or treatment. Instead, it will collect information from 3000 adults taking oral anticancer drugs at home to understand how well the prescribed doses match what patients actually take, what side effects occur, and how care coordination between …

This study tests a device that uses a small, painless electrical current to measure fluid buildup (edema) in cancer patients. Researchers want to see if this method works better than current approaches. The study includes 46 adults with breast cancer who have arm swelling after r…

This study looks at how cannabis affects symptoms like pain, sleep, and anxiety in 450 adults with cancer who are receiving immunotherapy. Participants will complete surveys and daily check-ins over a year. The goal is to understand if cannabis helps or causes harm, so doctors ca…

This study is testing whether a more detailed genetic analysis (complex exome) helps doctors choose better cancer treatments compared to a standard genetic test (simple exome). About 8,000 adults with advanced solid tumors will have their DNA analyzed both ways. The goal is to se…

This study tests a 4-session virtual coaching program to help young adult cancer survivors (ages 26-39) better understand their health insurance, reduce financial stress, and keep up with recommended follow-up care. About 300 participants who have finished initial cancer treatmen…

This study is for adults 18 and older who want to learn about their personal risk of developing cancer. Researchers will track participants' lifestyle, family history, and health habits over time using questionnaires and body measurements. The goal is to identify high-risk indivi…

This study is testing a nutrition program for cancer survivors who are overweight or have obesity. The program includes one-on-one counseling with a dietitian, behavioral skills training, and group support. The goal is to see if the program is practical and well-liked by particip…

This study asks cancer patients how satisfied they are after a special team assessment at the hospital. During this visit, patients meet with a pharmacist, dietitian, psychologist, social worker, and other care providers. The goal is to find out what works well and what can be im…

This study trains high school students to encourage their adult family members to get screened for cancer. Researchers want to see if this youth-led approach increases screening rates and knowledge. About 84 teens and adults are taking part.

This study looks at whether using video calls for geriatric check-ups before cancer treatment can reduce unplanned hospital stays for patients aged 75 and older who live far from specialized care. About 500 participants will be randomly assigned to either standard care or a telem…

This study tests a new way to help patients, parents, and doctors have better conversations about how cancer may affect a person's future. It includes teens and young adults with hard-to-treat cancers and their caregivers. The goal is to see if this approach is practical and help…

This study tests whether a digital visual tool can help newly diagnosed cancer patients, their caregivers, and doctors better understand treatment options and feel more satisfied with the experience. About 86 adults with breast or head and neck cancer will use the tool and then r…

This study is building a registry of 10,000 adults interested in cancer genetics research. Participants fill out questionnaires every two years and may be invited to join other studies. There is no treatment involved—just observation and education. The goal is to learn more about…

This study collects blood samples from up to 700 people receiving stem-cell transplants for blood cancers, as well as their donors. Researchers want to understand how the immune system rebuilds itself after transplant and what affects graft-versus-host disease. Participants provi…

This study aims to understand why some cancer patients develop autoimmune side effects when treated with immune checkpoint inhibitors. Researchers will analyze blood samples and genetic data from 600 participants to identify immune system features linked to these reactions. The g…

This study looks at why some cancer patients choose not to accept help for things like transportation, food, or housing needs. Researchers will survey 500 adults who previously said they had a need but declined assistance. The goal is to learn what influences their decision so th…

This study tracks 5,000 cancer patients receiving chemotherapy or targeted drugs to detect heart-related side effects early. Researchers use regular heart tests and blood markers to build a system that predicts serious heart events. The goal is to improve patient safety and quali…

This study tests a program called 'My Care My Voice' that helps people with cancer start conversations about palliative care with their doctors. Palliative care focuses on quality of life and symptom relief, and can be given alongside cancer treatment. The goal is to see if the p…

This study aims to understand what helps or blocks a good hospital experience for Asian cancer patients at MD Anderson. Researchers will survey 520 former patients and their healthcare providers. The goal is to find ways to improve care for this group.

This study looks at adults aged 65 and older receiving chemotherapy for any type of cancer. Researchers will use a frailty index to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces…

This study looks at whether exercise helps prevent cancer from coming back in adult cancer survivors. Researchers will review data from 1,000 people who have completed cancer treatment. They want to see if those who exercise have better outcomes, like longer time without the canc…

This study aims to learn how genes and environmental factors cause rare tumors and cancer in individuals and families. Researchers will collect medical history, samples, and test results from up to 500 participants of any age who have unusual cancer patterns, family history, or r…

This study is building a large registry and sample bank to understand why some groups face more barriers to cancer screening and early detection. Researchers will follow 100,000 adults aged 35 and older for up to 10 years, collecting health records, questionnaires, and blood, sal…

This study looks at whether adding a special helper called an oncology research navigator (ORN) to standard cancer care helps patients access support services and join clinical trials. About 686 adults with new cancer appointments at UNC Medical Center will take part. The goal is…

This study is for adults with rare cancers or rare genetic changes in their tumors who are already taking a targeted therapy approved by Health Canada but not yet publicly funded. The goal is to collect real-world information on how long patients live, their quality of life, and …

This study tests whether a short video can help people with early-stage cancer living in rural Vermont feel more in control of their care. About 40 participants will be randomly assigned to watch the video right away or after four months. Researchers will measure changes in cance…

This study looks at whether getting genetic counseling online is as good as meeting with a counselor in person for people at risk of hereditary cancer. About 1,000 adults who qualify for genetic testing will be randomly assigned to either online or standard counseling. The goal i…

This study interviews cancer doctors, nurses, patients, and caregivers to learn what they think about receiving hospital-level care at home. The goal is to understand the benefits and challenges of home hospital care for cancer. About 20 people will share their opinions through i…

This study is a registry that collects information from adult cancer patients during their routine care. It aims to gather detailed data on treatments, side effects, and outcomes to help researchers better understand cancer care and make it easier for patients to join future clin…

This study looks at why some childhood cancer survivors continue to have symptoms like fatigue, pain, and trouble sleeping. Researchers will ask 600 survivors aged 8-18 about their symptoms and collect stool samples to study gut bacteria. The goal is to find links between gut hea…

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immune checkpoint inhibitors. The goal is to understand why some patients develop inflammatory side effects and to find ways to predict and manage them. Part…

This study follows over 1,500 cancer patients who have a superficial vein clot (a clot just under the skin). Doctors want to see how different blood thinner treatments affect the risk of the clot coming back or causing more serious problems. The goal is to gather real-world data …

This study tests whether adding patient navigators and easy-to-understand educational materials helps more Black and Latino cancer patients learn about and enroll in cancer clinical trials. About 500 patients from community oncology clinics will take part. The goal is to make tri…

This study is looking at the genes of people with advanced pancreatic cancer to see if certain gene changes can help doctors choose better treatments in the future. Researchers will take a small sample of the tumor and analyze its DNA. They want to see if they can get these resul…

This study is building a large database of information from 5,000 cancer patients, including blood samples, scans, and quality-of-life surveys. The goal is to find links between biological markers and how well treatments work, side effects, and patient well-being. Participants re…

This study follows 600 Black and White adults with solid tumor cancer to see how they use cannabis, opioids, and tobacco, and how that affects their pain, sleep, and quality of life. Participants use a smartphone app to report symptoms daily for 84 days and complete surveys for a…

This study is testing a new tool called CANoPy that predicts the risk of developing nerve pain in cancer patients. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer to see if the tool can identify who is most likely to suffer from chronic p…

This study looks at whether a new type of imaging (HyperSight) and adaptive radiation planning can better track changes in tumors and nearby organs during radiation therapy in children. Twenty children aged 18 or under with non-brain tumors will receive standard radiation plus ex…

This study looks at whether a special genetic test (microarray PGx) can find more useful information than the standard single-gene test for cancer patients. The goal is to help doctors choose the right drug and dose, especially for people with gastrointestinal cancers. About 120 …

This study looks at muscle loss (sarcopenia) and cognitive problems (chemobrain) in people who have finished cancer treatment. Researchers will collect data from 100 adults aged 18-74 with certain cancers to understand how common these issues are. The goal is to improve support a…

This study watches how a blood test that can find many types of cancer is used in regular medical care. About 500 adults who have had or will have this test will take part. Researchers will track costs, how people feel about their results, and if they are satisfied with the test.

This study looks at whether whole-body MRI, ultrasound, and a new blood test can find cancer early in firefighters. 800 firefighters aged 35 and older with at least 10 years of service will be screened. The goal is to see how well these tests detect early signs of cancer, not to …

This study is for people with cancer who are about to start or have already received FDA-approved immunotherapy. Researchers want to see if special blood tests (immune-methylation and cytokine profiling) can predict whether the treatment will work. The goal is to better understan…

This study looks at why certain cancer patients—especially those from minority backgrounds, lower-income areas, or with decision-making challenges—are less likely to join research studies. Researchers will survey 300 adults with cancer at The Clatterbridge Cancer Centre to identi…

This study aims to bring new molecular markers (biomarkers) into everyday care for patients with rare adrenal cancers. Researchers will check if these markers can be delivered within 3 months after surgery and if they give useful information. The goal is to see if these markers h…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…

This study follows 540 adults with solid cancers to see how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to find who needs extra support. The goal is to improve care, not to test a new treatment.

This study collects blood and tissue samples from 500 adults with cancer to track genetic changes over time. Researchers will analyze ctDNA (bits of tumor DNA in the blood) to see how it relates to treatment outcomes. No new treatments are tested—the goal is to gather data to imp…

This study is testing whether wearable devices (like smartwatches) can help spot early signs of infection in children receiving cancer treatment. About 150 children aged 5-18 will wear a device for 4 weeks, tracking heart rate, activity, and other health data. The goal is to use …

This study tests a Clinical Trials Navigator program that helps cancer patients, families, and doctors find and enroll in clinical trials outside their local cancer centre. The program was previously tested in Windsor, Ontario, and increased trial enrollment by 8%. Now researcher…

This study aims to uncover the molecular mechanisms behind kidney disease, immune disorders, and complications in organ transplant patients. Researchers will analyze blood and urine samples from 5,000 participants to find genetic and protein markers that predict disease progressi…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study follows up to 700 people who have already received radiation therapy for cancer. Researchers want to learn about the long-term side effects of radiation and how the disease progresses over time. Participants do not receive any new treatments—only standard follow-up car…

This study looks at how people's automatic, gut-level feelings about exercise influence whether they actually stay active. Researchers will use smartphone surveys to track these hidden attitudes in real time. The goal is to understand what makes it easier or harder for inactive a…

This study looks at how well different fertility preservation methods work for people with cancer or other conditions that may harm their ability to have children. Researchers will review medical records of 100 patients aged 0-50 who used fertility preservation services. The goal…

This study tests a tool called TrialTalk™ designed to improve how cancer doctors and patients talk to each other. About 30 patients and their doctors will fill out questionnaires before and after a regular clinic visit. The goal is to see if the tool helps patients better underst…

This study is testing a values assessment tool for 40 women with metastatic breast cancer and their caregivers. The goal is to see if using the tool helps patients and caregivers feel less conflicted about treatment decisions and improves communication with their cancer doctors. …

This study involves 120 advanced cancer patients in hospice care. Researchers will use wearable patches to remotely monitor heart rate and other vital signs. The goal is to see if this helps detect infections earlier and improve predictions of how long a person has to live.

This study collects live tumor samples from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants undergo a standard biopsy as part of their care, and the tissue is analyzed in the lab. The goal is to develop better ways …

This study tests whether data from smartphones and smartwatches can help identify teens and young adults with cancer who are at risk for depression and other mental health issues. About 25 participants aged 10-25 will use an app and wearable device for two months. The goal is to …

This study looks at how the bacteria in your gut might influence how well immunotherapy works for solid cancers. Researchers will collect stool samples from 16 people with advanced cancer who are already receiving standard immunotherapy. The goal is to understand the connection, …

This study is for people with advanced cancer. Researchers will use high-speed genetic testing on tumor samples to find specific gene changes. The goal is to see if these results can help doctors choose more effective, personalized treatments. About 1,000 participants will be enr…

This study looks at whether cancer patients do better when they go to an emergency room at their own cancer hospital versus a general hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital…

This study follows 10,000 childhood cancer survivors treated at St. Jude Children's Research Hospital over their entire lives. The goal is to learn about long-term health problems that may appear years after cancer treatment. Researchers will track health outcomes, identify risk …

This study aims to understand how the collection of bacteria living in your body (the microbiome) relates to health and diseases like cancer and heart disease. Researchers will collect health information and samples from 16,000 adults over age 40. The goal is to build a large res…

This study is testing a new imaging agent called 68Ga-NYM096 to see how well it highlights various cancers in PET/CT scans. Researchers will measure the tracer's uptake in both primary and metastatic tumors in 120 adult cancer patients. The goal is to identify which cancer types …

This study looks at a way to help people under 40 who might become infertile due to treatments like chemotherapy or radiation. Participants have an ovary removed and frozen to save their eggs for possible future use. The goal is to improve the freezing process and learn how to be…

This study asks 100 young adults (ages 18-39) with cancer about their satisfaction in two different infusion spaces at a hospital. Participants fill out surveys and may join interviews to share how the environment and staff affect their experience. The goal is to learn which spac…

This study is gathering information from up to 10,000 people with cancer to see if treatments chosen based on the genetic makeup of their tumors work better and cause fewer side effects. Researchers will look at medical records and may test leftover tissue or blood samples to cre…

This study is creating a large collection of blood and tissue samples from 100,000 adults with cancer. The goal is to store these samples and health data for future research to improve cancer detection and treatment. Participants provide consent and samples, but do not receive an…

This study follows 260 adults newly diagnosed with cancer who had no prior sleep issues. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand how sleep problems emerge and what factors—like treatments or emotional distress—m…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for treatments like radiation. The study uses donated human organ samples, not live patients, to see if the marker is easy to use, stays in place, and shows up clearly on scans. …

This study aims to understand how skin conditions related to cancer or cancer treatments affect the well-being of patients and survivors. Over 1,000 participants will fill out questionnaires about their skin condition. The goal is to improve how doctors treat these skin issues an…

This study collects and freezes testicular tissue from boys who are not yet producing sperm and are at risk of infertility due to cancer or autoimmune disease treatments. The tissue is stored in a lab for possible future use to help them have biological children once experimental…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…

This study is testing a new way to help people navigate cancer care, especially those from African American, Hispanic, or underserved communities. Researchers will see if this support reduces distress and improves quality of life. The goal is to make cancer care more fair and eff…

This study is testing a mobile health app designed to help cancer patients remember to take their oral anticancer pills and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers will enrol…

This study looks at whether recommendations from a Molecular Tumor Board (a team of cancer experts) help doctors make better treatment decisions for people with cancer. About 192 participants will have their tumor genes tested, and the board will suggest targeted therapies or imm…

This study looks at how people's bodies use energy (metabolism) and whether current measurement methods are accurate for everyone. Researchers will study up to 2,000 healthy volunteers and people with conditions like diabetes, obesity, or cancer. Participants stay in the hospital…

This study is testing new blood and urine tests to find cancer early in firefighters, who are at higher risk for certain cancers. Researchers will enroll 2,000 firefighters to see how well these tests work. The goal is to improve early detection and save lives.

This study explores the link between gut bacteria, fatigue, and thinking problems in people with cancer. Researchers will follow 250 adults for 6 months, analyzing stool samples and testing memory and attention. The goal is to better understand these connections, not to test a ne…

This study tests a new computer program that uses artificial intelligence to create personalized stories for teens who drink alcohol. The goal is to help them understand the risks and make healthier choices. About 200 teens aged 15-17 who already drink will use the program during…

This study is testing a new program to help cancer survivors manage long-term side effects from their treatment. About 30 doctors and their patients will use a questionnaire before visits to guide discussions and create personalized care plans. The goal is to see if this approach…

This study tests a communication program called COACH-Cog for older adults who have both dementia and cancer. The goal is to help patients, their care partners, and doctors talk more openly about memory concerns and treatment goals. About 300 people will take part to see if the p…

This study compares two ways to diagnose fluid buildup around the lungs in people with suspected cancer: a needle drainage (thoracentesis) or a scope biopsy (pleuroscopy). Researchers want to see which method provides a better tissue sample and leads to a faster cancer diagnosis …

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors, called biomarkers, in the blood. The goal is to see how often these markers can be found. Participants will give blood samples over time, but their regular cancer care will n…

This study aims to understand the different types of fatigue people experience, especially those with conditions like cancer, chronic fatigue syndrome, lupus, and Sjogren's. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, computer games…

This study looks at what motivates people aged 70 and older with cancer to be physically active and eat a healthy diet. Researchers will group participants based on their motivational factors, then use that information to design a personalized program to help them stay active and…

This study is for cancer patients receiving immune checkpoint inhibitors (a type of immunotherapy). Researchers want to see if blood tests can predict who will develop side effects from this treatment. About 200 adults will give blood samples during their regular check-ups. The g…

This study tests whether outreach, navigation, and digital tools can help more Black and Hispanic patients join cancer treatment trials. Researchers will compare enrollment rates in areas that receive the intervention versus those that do not. The goal is to make cancer research …

This study collects and stores tumor, tissue, and blood samples from people with cancer. The samples are kept in a secure database and used by researchers to learn more about cancer. Anyone being treated for cancer at the Arizona Cancer Center or University Medical Center can joi…

This study looks at how the bacteria in your gut (the microbiome) might be linked to diarrhea caused by cancer treatments. Researchers will follow 150 adults starting cancer therapy and collect stool and blood samples to see if certain gut bacteria or markers in the body predict …

This study collects information from Canadian cancer patients who have uncommon genetic changes in their tumors. Researchers will track how these patients respond to different treatments and what side effects they experience. The goal is to better understand how cancers with rare…

This large, long-term study aims to understand what causes cancer by tracking 200,000 healthy adults over many years. Participants will regularly answer surveys, share health records, and donate blood, urine, and saliva samples. Researchers will analyze this information to identi…

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…

This study is testing different outreach methods to see which ones work best for enrolling more African American patients in early-phase cancer treatment trials. Researchers will work with both patients and their doctors to test various recruitment approaches. The goal is to unde…

This study aims to understand how people with advanced cancer feel about weight loss and changes in their body image. Researchers will survey 800 men and women from eight different countries using a one-time anonymous questionnaire. The goal is to gather information that can help…

This study aims to understand how cancer patients receiving palliative care feel about safely reducing or stopping non-cancer medications (a process called deprescribing). Researchers will survey 120 Romanian patients about their attitudes and health knowledge, then provide an ed…