CANCER

This program offers a personalized cancer vaccine to patients with solid tumors that have spread or are locally advanced. It is for people who have run out of standard treatment options or cannot take them, and who have a less than 50% chance of surviving 5 years. The vaccine is …

This early-phase study tests a new mRNA vaccine, designed by artificial intelligence, in 9 people with advanced solid tumors that have not responded to standard treatments. The vaccine is injected directly into tumors to teach the immune system to attack cancer cells. The main go…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study collects and freezes ovarian tissue from females aged 0-45 who are at risk of early menopause due to cancer treatment or ovary removal. The goal is to develop methods to thaw and mature eggs from the tissue, so they might have a genetically related child later. It is a…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (including breast and endometrial cancers) have a specific AKT1 E17K gene mutation. The main goals are to check the drug's safety and find the right dose. Participant…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This study tests whether a once-daily dose of the blood thinner apixaban can safely prevent dangerous blood clots in cancer patients at moderate risk. About 996 adults with solid tumors or lymphoma will be randomly assigned to take apixaban twice daily, once daily, or no blood th…

This study tests a 6-month program of supervised exercise, heart risk management, and online support for young cancer survivors (ages 18-45) who have mild heart dysfunction. The goal is to see if this approach improves fitness and heart health better than standard advice. 336 par…

This early-phase study tests a new drug called INV-1120, either by itself or combined with pembrolizumab (Keytruda), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses and check for side effects. About 7…

This early-phase study tests a new drug called DXP-106 in 54 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose, either alone or combined with chemotherapy. Researchers will also loo…

This early-phase study tests CPO301, a drug that delivers chemotherapy directly to cancer cells, in adults with advanced solid tumors (e.g., lung, breast, colorectal) that have stopped responding to standard treatments. The main goals are to find a safe dose and check for early s…

This study tests whether adding a special type of radiation, called Adaptive Pulse Radiotherapy, to standard immunotherapy can help people with advanced solid tumors. About 35 participants will receive their usual immunotherapy plus 2-3 high-dose radiation sessions. Researchers w…

This study looks at whether removing a brain tumor and the nearby area where seizures start can reduce or stop seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery impr…

This study tests whether lower doses of three drugs (isatuximab, lenalidomide, and dexamethasone) can safely and effectively treat newly diagnosed multiple myeloma in patients who are very likely to have severe side effects from standard treatment. The goal is to reduce side effe…

This early-stage study tests whether combining a focused ultrasound treatment (histotripsy) with standard immunotherapy drugs (ipilimumab and nivolumab) is safe and tolerable for people with advanced cancer that has not responded to other treatments. About 24 adults with metastat…

This early-phase trial tests an experimental drug called IMA402 in about 145 adults with solid tumors that have returned or not responded to standard treatments. The drug is designed to help the immune system find and attack cancer cells that carry a protein called PRAME. The mai…

This study tests a combination of two drugs, sarilumab and capecitabine, in people with aggressive breast cancer (triple negative or hormone-resistant). The goal is to eliminate tiny amounts of cancer that remain after standard treatment, which can lead to deadly spread. About 65…

This study tests an experimental drug called MBRC-101 in people with advanced solid tumors that no longer respond to standard therapies. The drug works like a guided missile, delivering a chemotherapy agent directly to cancer cells that carry a specific marker (EphA5). The trial …

This study tests a new way to help men who became infertile after childhood cancer treatment. Doctors will take testicular tissue that was frozen before treatment and transplant it back into the man's testicles. The goal is to see if the tissue can start making sperm again. Only …

This study tests whether adding the drug azeliragon to targeted radiation therapy can safely shrink brain tumors and keep them under control longer. About 46 adults with cancer that has spread to the brain will receive the combination. The goal is to improve tumor response and de…

This study looks at whether people with multiple myeloma who are in a very deep remission (called MRD-negative) can safely stop their maintenance therapy. About 70 adults who have been on maintenance for at least 2 years will stop treatment and be monitored for 12-24 months. The …

This early-phase study tests a new drug, IMC-P115C, designed to help the immune system find and attack cancer cells that have a protein called PRAME. It is for people with advanced solid tumors who have a specific genetic marker (HLA-A*02:01) and have tried other treatments. The …

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay, and improve their quality of life. One hundred cancer survivors who finished treatment at least 6 months ago will either get the telehealth program or usual …

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This early-phase study tests a new drug, IMC-R117C, in people with advanced colorectal, esophageal, stomach, or ovarian cancers that have a specific protein (PIWIL1) and a certain immune type (HLA-A*02:01). The goal is to see if the drug is safe and can shrink tumors. About 600 a…

This study tests a drug called entrectinib, already approved for certain lung and solid tumors, in people with rare cancers that have a specific genetic change called ROS1 fusion. About 30 adults, teens, and children with these rare cancers will receive the drug. Researchers will…

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This study tests a new treatment for adults with solid tumors that have come back or not responded to standard therapies. The treatment uses a patient's own immune cells that are genetically modified to recognize and attack cancer cells. Some participants will also receive the dr…

This study tests alectinib, a drug already approved for some lung cancers, in patients with rare cancers that have an ALK gene change. About 30 adults and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops them from growing. The goal is…

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This study tests whether a mobile app that sends personalized messages and lets smokers with cancer choose their own quit schedule can help them stop smoking more effectively than standard advice. About 1,448 smokers with cancer in Hong Kong will take part. The goal is to see if …

This expanded access study offers balstilimab alone or combined with zalifrelimab to cancer patients who previously received these drugs in a clinical trial and saw benefit. The goal is to allow continued treatment for those who qualify. Participants must have completed the earli…

This study tests a pill called abemaciclib in people with advanced solid tumors that have certain genetic changes in cyclin or CDK genes. The goal is to see if the drug can stop or slow cancer growth. About 38 participants will receive the treatment, and researchers will track ho…

This study tests whether a mobile health program can help young adults (ages 18-39) who have survived cancer and are now overweight or obese lose weight. Participants will be randomly assigned to either a full mobile weight management program or a self-guided version with digital…

This early-phase study is testing an experimental drug called WTX212A, given alone or with radiation therapy, in 12 people with advanced solid tumors. The goal is to see if the drug is safe and can shrink or control tumors. Participants must be 18-75 years old and have a confirme…

This study tests a new way to treat large solid tumors that have come back or not responded to standard treatments. It combines a special type of radiation therapy with two immunotherapy drugs to help the immune system fight the cancer. The goal is to see if this approach is safe…

This study tests a new way to treat liver metastases by combining a drug called bevacizumab with a procedure called TACE, which delivers chemotherapy directly to the liver. The goal is to see if this combination helps patients live longer and shrinks tumors better than TACE alone…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study looks at whether adding a breathing muscle training device to standard pre-surgery exercise can help people with lung cancer recover better after surgery. About 100 adults who are scheduled for lung cancer surgery will take part. One group will do standard pre-surgery …

This study is for women with a common type of early-stage breast cancer (ER+/HER2-) who have already had radiation and now need a second lumpectomy. Researchers want to see if giving another round of radiation after surgery is safe and helps prevent the cancer from coming back. A…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This early-stage study tests a single injection of umbilical cord blood cells (XJ-MK-002) in 16 adults aged 18-75 who have low platelets from cancer therapy. The main goal is to check safety and find the best dose. Researchers will monitor side effects and platelet counts for 28 …

This study tests a new treatment that uses a patient's own immune cells, specially engineered to recognize and attack cancer. The goal is to see if it is safe and works against different types of cancer. About 100 adults with advanced cancer will take part.

This study looks at whether giving people healthy prepared meals and education helps them eat better compared to just getting physical activity coaching. About 120 adults in Anson County who have or are at risk for chronic diseases like obesity, diabetes, or heart disease will ta…

This study tests whether a new version of the drug olaparib (DWZ2501) works the same as the current version (DWC202510) in women with advanced BRCA-mutated ovarian cancer. About 40 participants will take both versions at different times to compare drug levels and side effects. Th…

This study is for people with certain advanced cancers that have spread in the belly or pelvis. It combines a special type of radiation called PULSAR with drugs that boost the immune system. The goal is to see if this combination is safe and helps control the cancer longer. About…

This study tests if abatacept, a drug used for arthritis, can prevent serious heart problems in cancer patients who develop heart inflammation from immunotherapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo. The goal is to see if t…

This early-stage study tests a new drug called TTX-080, which blocks a protein that helps cancers hide from the immune system. It is given alone or with other cancer drugs to people with advanced solid tumors (like colorectal cancer) that have not responded to standard therapies.…

This program provides oral sevabertinib to adults with advanced non-small cell lung cancer that has a specific HER2 gene mutation and has stopped responding to other treatments. Participants must have a life expectancy of at least 12 weeks and be well enough to perform daily acti…

This study offers continued access to an investigational cancer drug for patients who were already benefiting from it in a previous study. The main goal is to monitor long-term safety. Participants must have completed an earlier Lilly study and still be getting benefit from the d…

This early-phase study tests a new drug called ALTA3263 in adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS gene mutation. The main goals are to check safety and find the right dose. About 188 people who have tried other tr…

This early-phase study tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink tumors. It is a first-in-human trial, so the main focus is on …

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This trial tests a drug called atezolizumab, already approved for some cancers, in people with rare cancers that have high numbers of genetic mutations or specific DNA repair problems. About 30 adults and children with these rare tumor types will receive the drug. The main goal i…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The main goals are to find a safe dose, understand side effects, and see if the drug can slow tumor…

This study looks at whether starting nutrition support early can help cancer patients on palliative chemotherapy keep their weight, muscle mass, and quality of life. About 200 adults with lung, colorectal, ovarian, or pancreatic cancer will receive nutritional guidance and be com…

This study looks at whether cancer survivors who had heart damage from their cancer treatment, but whose heart function has since recovered, can safely stop taking heart failure medications. About 335 adults who finished cancer therapy at least 6 months ago and are currently on h…

This study is for cancer patients who have already taken part in earlier trials of nivolumab or other BMS cancer treatments. The main goal is to check the long-term safety of continuing these therapies. About 1,500 participants with various tumor types will be enrolled. The study…

This study tests a new treatment for gastrointestinal cancers using a patient's own immune cells, which are engineered in a lab to better recognize and attack cancer. About 100 adults with certain cancer markers will receive these cells to see if they are safe and can shrink tumo…

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This study tests an experimental drug called zotiraciclib for people whose brain tumors (a type of glioma with IDH1 or IDH2 mutations) have returned after previous treatment. About 96 participants aged 15 and older will take the drug by mouth on a specific schedule over 28-day cy…

This study tests a new way to help men who lost fertility due to cancer treatment. Doctors will take frozen testicular tissue stored before treatment and transplant it back into the patient. The goal is to see if this is safe and can restart sperm production. Ten men who are heal…

This study tests whether inhaling a drug called tranexamic acid can help cancer patients who have severe lung bleeding and are on a breathing machine. The goal is to see if it lowers the chance of death within 28 days compared to standard care. About 60 adults with blood cancers …

This study provides ongoing access to experimental cancer treatments for people who were already in a Roche-sponsored trial and still need the drug. It includes about 100 participants and focuses on safety and continued therapy. The goal is to keep treating patients who have no o…

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs. The goal is to see if taking larotrectinib before standard radioactive iodine treatment helps shrink …

This is the first study in people testing a new antibody drug called NTX-1088, which targets a protein found on many cancer cells. The trial will test the safety of NTX-1088 given alone and in combination with an existing immunotherapy drug (pembrolizumab) in 90 patients with adv…

This is the first study in people to test a new drug called JMT108 for advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose, see how the body processes the drug, and look for early signs that it can shrink tumors. About 270 …

This study looks at whether checking DNA and proteins in urine can find bladder and kidney cancers without needing a scope or surgery. Researchers will collect urine samples from 500 adults, including those with known or suspected cancer and healthy volunteers. The goal is to see…

This study is testing two new blood tests designed to help doctors detect cancer in people who have symptoms that might be cancer. The study will involve 1,650 adults aged 45 and older who are already undergoing medical tests for possible cancer. The goal is to see how well these…

This study tests an injectable dye called NC527-X that makes tumors glow during surgery, helping surgeons see and remove them more precisely. About 400 adults with solid tumors who are scheduled for surgery will take part. The goal is to find the best dose and timing for the dye …

This early-phase study tests a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 participant…

This study aims to develop and test an artificial intelligence (AI) model that can automatically detect whether cancer has spread to lymph nodes by analyzing digital images of tissue samples. Researchers will compare the AI's accuracy to that of standard pathology reports from 10…

This study tests a health workshop for Latino parents with children ages 6 to 12 living in rural Florida. The workshop teaches healthy eating, physical activity, and sun safety to reduce cancer risk. Researchers will see if families find the program useful and if it helps them ma…

This study tests whether a supportive digital avatar can help reduce anxiety and improve quality of life for cancer patients receiving a stem cell transplant as outpatients. About 90 adults will be randomly assigned to use the avatar program or receive usual care. The goal is to …

This study tests a mobile app (Mio-App) designed to help children and teens aged 8-16 who have or had cancer. The app combines thinking exercises and physical tasks to boost metacognitive awareness and reduce long-term cognitive and physical problems. About 40 participants will u…

This study looks at whether guided play sessions can help children aged 10 to 18 with leukemia feel less pain and manage their emotions better while getting chemotherapy. Over 4 weeks, kids will take part in therapeutic play during treatment. Researchers will measure changes in p…

This study is testing whether a Maitake mushroom supplement can improve immune function in people receiving chemotherapy or CDK4/6 inhibitors for cancer. Researchers will measure changes in blood neutrophil counts and other immune markers. The trial involves 40 adults with solid …

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This study is creating and testing a nurse-led program to help women who go through early menopause after cancer treatment. The program offers personalized education, decision support, and skills to manage symptoms. About 117 women will take part in video sessions and fill out qu…

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. Over 6,500 participants will use either the guide (with videos and activities) or a control app with resource links. The goal is to see if the program reduces depressiv…

This study tests whether an herbal formula called MZRW can help cancer survivors who have constipation. About 70 adults who have finished cancer treatment at least a month ago will take either MZRW or a placebo pill for 2 weeks. Researchers will check if bowel movements improve a…

This study tests a therapy called EMDR Toolbox to see if it can improve the emotional well-being of people with cancer. The therapy helps process difficult life experiences that may add to stress. About 46 adults with early-stage cancer will receive either standard EMDR or the EM…

This study tests a new type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this treatme…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in people with advanced cancer. About 188 participants will be randomly assigned to recei…

This study tests a program to help cancer survivors and their caregivers in low-income areas eat healthier and be more active. About 100 adults aged 18-89 who have had cancer or are close to a survivor can join. The program adapts proven health tips to fit each person's life and …

This study tests whether MDMA-assisted therapy can help cancer patients and their close loved ones cope with adjustment disorder—a condition causing severe emotional distress after a cancer diagnosis. Twenty participants (10 patient-loved one pairs) will receive two doses of MDMA…

This study looks at whether a supervised, stationary cycling program can help reduce nerve pain and improve daily function in people who have chemotherapy-induced peripheral neuropathy (CIPN). Thirty adults with cancer who have mild CIPN will cycle twice a week for 12 weeks. The …

This study tests whether testosterone replacement can ease fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. About 230 participants will receive either testosterone or a placebo for several months. The goal is to see if this treatm…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely reduce depression in people with cancer. About 86 adults with cancer-related depression will receive either electroacupuncture or a control treatment. The goal is to see if…

This study tests whether a smartphone app called Resilience PRO can improve quality of life for cancer patients receiving treatment. About 1,458 adults with any stage of cancer will either use the app plus usual care or just usual care. The app asks about symptoms and alerts the …

This study tests whether ustekinumab can safely control diarrhea and colitis caused by immune checkpoint inhibitors in cancer patients. About 10 adults with solid tumors who have moderate to severe symptoms will receive the drug. The goal is to ease these side effects without int…

This study explores whether virtual reality (VR) can help people with cancer manage chronic pain and possibly reduce their need for opioid painkillers. Researchers will work with 25 adults who have active cancer and moderate-to-severe pain to develop and test a VR program designe…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study tests a new text-message program designed to help cancer survivors who feel depressed connect with mental health care. Researchers will enroll 60 cancer survivors who have signs of depression and own a cellphone. The program sends tailored texts and a referral link to …

This study is testing whether a personalized exercise and rehabilitation program given before cancer treatment (called prehabilitation) can improve how well patients function and their overall quality of life. Researchers will enroll 60 adults with cancer who are starting care at…

This study tests whether a program that lets cancer patients report symptoms from home using a phone or computer can improve their quality of life and reduce emergency room visits. About 1,055 adults with cancer will use an online questionnaire weekly or monthly and get advice fr…

This study tests whether two different digital programs can improve the health, well-being, and daily functioning of people recently diagnosed with cancer. About 440 participants will complete online questionnaires, access courses from Stanford experts, and provide blood samples …

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. About 126 participants will either use the tool or receive usual care. The goal is to see if the tool boosts their confidence and ability to hand…

This study tests a program called enCompass Humana, designed to support family caregivers of people with both cancer and diabetes. The program offers coaching and help finding resources to reduce stress and improve coping skills. About 162 caregivers will take part to see if the …

This study looks at whether it is safe and helpful to stop taking statins (cholesterol-lowering drugs) in people with advanced cancer who are receiving palliative care. Statins are often continued even when they may no longer be needed, causing side effects like muscle weakness a…

This study is testing a yoga program designed to fit different cultures for cancer patients who are in the hospital for a stem cell transplant. The goal is to see if the yoga program can help reduce symptoms of depression. About 60 adults from India, Tanzania, and the United Stat…

This study looks at whether adding chaplain-led spiritual care or psychotherapy/meditation to usual palliative care can help people with advanced, incurable cancer live longer and have a better quality of life. About 854 adults with metastatic cancer and a life expectancy of one …

This study tests a mobile health app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. Researchers will enroll 35 English- or Spanish-speaking adults with cancer who are starting or recently started a new oral therapy…

This study tests three common pain management methods used during minimally invasive cancer surgery. About 48 adults having surgery for cancers like liver, stomach, or colorectal cancer will be randomly assigned to one of three groups: a nerve block with numbing medicine, the ner…

This study looks at whether a food farmacy (free healthy food) plus online cooking classes can help cancer survivors who struggle to afford food. About 80 survivors will take part, and researchers will check if the program is safe and easy to use. The goal is to improve their hea…

This study tests whether a 30-minute supervised cycling session right before chemotherapy or immunotherapy can help cancer patients maintain their fitness. Researchers will enroll 80 adults with breast, ovarian, or colorectal cancer. Participants in the exercise group will bike w…

This study tests whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep quality, anxiety, depression, fatigue, and inflammation in 276 participants over 20 weeks. The goal is to see if a si…

This study tests whether a combined mobile exercise and cognitive training program can help older cancer survivors (age 60+) who have memory or thinking concerns after treatment. About 40 participants will use a smartphone app for exercise tracking and attend group workshops. The…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. Researchers wa…

This study tests whether watching a virtual reality experience before or during radiotherapy can lower anxiety and improve satisfaction for cancer patients. About 150 adults receiving radiation at the University of Miami will be randomly assigned to different VR techniques or a s…

This study looks at whether a computer-assisted vacuum device can safely remove blood clots from the lungs of cancer patients who have a moderate-risk pulmonary embolism. About 25 adults with current or past cancer will be enrolled. The goal is to see if the procedure improves qu…

This study looks at whether giving cancer patients healthy groceries and nutrition advice can improve their diet, reduce symptoms, and boost quality of life. One hundred adults with any type of cancer living in four Maine counties will be split into three groups: some get groceri…

This study looks at whether massage therapy can improve sleep for children and teens (ages 12-21) who are in the hospital for cancer treatment or a stem cell transplant. Researchers will compare sleep minutes and quality between those who get standard care and those who also rece…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests a smartphone app called Moodivate designed to help with depression in adults who have incurable cancer and feel down. About 279 participants will be randomly assigned to use the app or not for 12 weeks. Researchers will track changes in mood, anxiety, and quality…

This study looks at whether resistance training and a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while undergoing chemotherapy. About 30 women will be randomly assigned to exercise and protein or standard care. The goal is t…

This study tests a program called Dyadic Life Review (DLR) for people aged 65+ with advanced cancer and their caregivers. The program helps them talk about their lives together to improve emotional well-being and closeness. Researchers want to see if it's practical to run a large…

This study looks at whether a one-year, home-based exercise program can help older adults (60+) undergoing cancer treatment improve their strength, balance, and quality of life. About 180 participants will be split into two groups: one doing guided exercises at home and the other…

This study tests a video-based program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six sessions, they learn strategies to manage daily challenges. The goal is to see if this approach reduces distress and improves quality o…

This study looks at whether a relaxing therapy called Reiki can help adults with cancer who feel very tired from immunotherapy. Twelve people will either get six weekly Reiki sessions right away or wait six weeks before starting. Researchers will track changes in fatigue, pain, a…

This study tests if a special type of acupuncture (on the tongue area) can help cancer patients who have a bad or lost sense of taste from chemotherapy. 75 patients will either get real acupuncture, fake acupuncture, or standard dietary advice. The goal is to see if acupuncture c…

This study tests whether creating and sharing personal digital stories can reduce depressive symptoms and improve self-esteem and quality of life in Chinese childhood cancer survivors aged 13 to 18. Participants attend four 2.5-hour workshops in small groups to craft their storie…

This study looks at whether adding motivational counseling to a virtual exercise program helps cancer survivors become more active. About 236 adults who finished cancer treatment within the last 5 years will take part. They will do supervised physical activity from home and recei…

This study tests whether a smartphone app that guides users through art therapy can help young adults (ages 18-25) who survived childhood cancer feel better emotionally. Participants use the app for 6 weeks, completing weekly art prompts and surveys about their mood and quality o…

This study tests ways to help Black women who have had cancer keep up physical activity over the long term. Participants will wear a motion sensor for a week and report on fatigue, health, and quality of life. The goal is to make healthy habits stick and improve well-being after …

This small pilot study tests whether using a hand-held vibrating device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Researchers will enroll 16 adults who completed certain types of chemotherapy at least 60 days ago. T…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study is testing a values assessment tool for women with metastatic breast cancer and their caregivers. The goal is to see if the tool helps them feel less conflicted about treatment decisions and improves communication with their doctors. About 40 participants will use the …

This study looks at whether nerve transfer surgery can improve facial movement and quality of life in cancer patients who have facial paralysis. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure changes in how patie…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests whether acupuncture can help young women with cancer regain their periods after chemotherapy. Researchers will enroll 60 women aged 15–40 who have lost their periods due to chemo. The goal is to see if acupuncture is practical and whether it helps restore menstru…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help cancer survivors who struggle with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain tumors will receive the drug in a contro…

This study tests a therapy program (Parent-FORT) for parents of childhood cancer survivors who have high fear of cancer returning. About 36 parents in Canada will be randomly assigned to get the therapy right away or wait three months. The goal is to see if the program is accepta…

This study tests whether a smartphone app called iCANSleep can help cancer survivors with insomnia sleep better. The app uses a proven therapy called Cognitive Behavioural Therapy for Insomnia (CBT-I). Researchers will compare the app to a waitlist in 146 Canadian cancer survivor…

This study looks at whether giving cancer patients personalized dietary advice and palliative care counseling can improve their quality of life, daily function, and nutrition. About 215 cancer patients in Bangladesh will be split into two groups: one gets the extra support, the o…

This study looks at whether hearing aids can improve the quality of life for cancer patients who develop hearing problems from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing loss will be offered a hearing aid. Researche…

This early-stage study tests a new inhaled form of fentanyl, a strong painkiller, for cancer patients. About 100 adults with tumors will receive both the inhaled spray and an IV injection to compare how the drug moves through the body and its safety. The goal is to see if the inh…

This study looks at whether combining aromatherapy (smelling essential oils) with hypnosis can help cancer patients feel less anxious and more comfortable during uncomfortable procedures like blood draws or dressing changes. About 66 adults with cancer who are also receiving pall…

This study compares two approaches to supportive care for adults with cancer: one using technology and one using a redesigned team-based model. The goal is to see which approach better improves quality of life. About 3,000 newly diagnosed or recurring cancer patients will partici…

This study tests a 4-week smartphone app that teaches mindfulness to cancer survivors who have finished their main treatments. The goal is to see if using the app helps lower stress. About 345 adults who have had any type of cancer will take part, with some getting the app right …

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests a new 5-session phone therapy called CARE for older adults (70+) with cancer who feel depressed or distressed. It compares CARE to standard supportive counseling to see which works better. The goal is to improve emotional well-being, not to treat the cancer itsel…

This study tests whether a drug called NPX-5 (psilocybin) combined with talk therapy can reduce severe anxiety in people who have been diagnosed with cancer. About 87 adults aged 18 to 80 will receive one of three doses (25 mg, 10 mg, or 1 mg) during an 8-hour therapy session. Th…

This study tests how well naldemedine works for constipation caused by opioid painkillers in 100 adults with cancer. Participants take the medicine while researchers track symptom changes and personal experiences. The goal is to see if this gut-specific opioid blocker improves bo…

This study tests a brief motivational program to help 84 cancer survivors who are part of the World Trade Center Health Program become more physically active. Participants will wear a Fitbit to track their activity, and the goal is to increase moderate-to-vigorous exercise by 25%…

This study is testing a virtual reality (VR) device that uses cognitive behavioral therapy to help people with chronic cancer pain. The goal is to see if the VR headset is easy to use, safe, and can reduce pain and distress. About 40 adults with cancer who have had pain for at le…

This study looks at whether doing resistance exercises at home with digital guidance works as well as doing them in a supervised studio for people who have finished cancer treatment. The goal is to see if the home option helps more people stick with exercise and improves their st…

This study tests a short therapy program for young adults (ages 25-39) with cancer and their partners. The goal is to see if it helps them cope with stress and stay connected as a couple. About 20 couples will take part in 8 sessions. The study focuses on whether people find it h…

This study tests an 8 to 12-week exercise program for people with or past cancer. The program includes supervised exercise classes, either online or in person. The goal is to help participants become more active and reduce cancer-related symptoms like fatigue. About 740 adults ac…

This study looks at two different programs designed to support the emotional and spiritual wellbeing of people with advanced cancer and their family caregivers. Researchers want to see which program better reduces depression and improves quality of life. About 400 patient-caregiv…

This study tests a short program designed to improve the emotional wellbeing and quality of life of people who care for someone with advanced cancer. About 150 adult caregivers will take part. The program focuses on building positive feelings and coping skills through phone or in…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. Researchers will enroll 192 adults who have finished their main cancer treatment within the last 5 years. Participants will write about their experiences,…

This study looks at whether live, online group exercise classes help cancer survivors become more physically active compared to watching recorded workout videos. Researchers will track changes in exercise, fitness, quality of life, and loneliness over 9 months. About 300 adults w…

This study tests a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for chronic nerve pain caused by cancer or its treatment. 60 adults will receive both real and fake (placebo) stimulation in random order to see if the real treatment provides bet…

This study is testing a 4-month coaching program called SONATA for people aged 60 and older with advanced cancer. The program helps patients build a support network of family and friends to improve treatment adherence and quality of life. Up to 330 participants will receive 6 coa…

This study looks at two different exercise programs—flexi band resistance training and whole-body electrical muscle stimulation—for people with cancer. The goal is to see which one better improves muscle strength, body composition, and quality of life. About 100 participants will…

This study tests whether immersive virtual reality exercises can improve thinking skills in people with cancer who have memory and attention problems after chemotherapy. About 60 participants will either do virtual reality activities or continue usual care. The goal is to see if …

This study tests a program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. Participants join weekly online group sessions and do short daily activities on an app to help with anxiety and depression. The goal is to see if the program is pra…

This study tests a nature-based healing meditation for adults who recently lost a loved one to cancer and served as their caregiver. The goal is to see if the meditation is practical and helpful for reducing grief and improving focus. About 70 participants will try the meditation…

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to improve …

This study tests whether a virtual reality (VR) program can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. Thirty adults who finished cancer treatment at least 3 months ago will use either VR or an audio program at home for 4 weeks. Res…

This study tests whether expressive writing can improve emotional well-being in Chinese American cancer survivors. About 108 participants who finished cancer treatment within the last 5 years will write about their experiences. The goal is to see if this simple activity reduces d…

This study tests whether a mobile app that tracks symptoms and sensor data can help people receiving chemotherapy feel better and stay connected with their care team. About 50 adults with solid tumors will use the app and a Fitbit for 90 days. The goal is to see if the app is eas…

This study explores whether a type of writing called 'compassionate expressive writing' can help people living with or after cancer feel better emotionally and physically. About 50 adults who have experienced body changes from cancer or its treatment will be asked to write for 20…

This study compares three types of support for parents who lost a child to cancer at least six months ago and still have high grief levels. The programs are Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care. Researchers will measure changes in grief a…

This study tests a program that gives cancer patients free help with legal problems like health insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will receive legal navigation and be followed for 6 months. Researchers want to see if t…

This study tests whether an artificial intelligence (AI) app can improve quality of life and reduce anxiety or depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the app plus usual therapy or jus…

This study looks at whether a low dose of the steroid prednisolone can effectively treat liver inflammation (hepatitis) that sometimes occurs as a side effect of cancer immunotherapy. About 63 cancer patients who develop moderate to severe liver inflammation from their treatment …

This study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss. 26 adults recently diagnosed with cancer will either receive usual care or extra support from a physiotherapist navigator for 12-18 weeks. The navigat…

This study tests whether using a small ultrasound scanner helps nurses place an IV drip on the first try more often than the traditional touch-and-feel method. About 98 cancer patients receiving treatment will be randomly assigned to one of the two methods. The goal is to reduce …

This study is testing an online educational program called On-Trac for adult cancer survivors who have significant anxiety. The program teaches coping strategies based on cognitive-behavioral therapy and acceptance commitment therapy. About 80 participants will use the program at…

This study tests a tele-exercise program called RISE-YA to reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past curative treatment and currently get little exercise. The program is delivered remote…

This study tests a mobile health exercise program (GO-EXCAP) in 100 older adults (60+) with myeloid neoplasms who are receiving chemotherapy. Participants will either follow the exercise program or receive standard education. The goal is to see if the exercise program improves ph…

This study explores whether a virtual group-based expressive writing program can help improve quality of life for survivors of adolescent and young adult cancer. Researchers will enroll 30 participants aged 18-39 who were diagnosed with cancer between 1 and 5 years ago. Participa…

This study looks at how different supervised group exercise programs affect fitness and body composition in women who have completed breast cancer treatment. About 15 women aged 20-89 will try one of four resistance training regimens to see which best improves heart-lung fitness …

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study tests whether a structured, personalized care plan based on patient-reported symptoms can improve quality of life for adults with advanced cancer. About 120 participants will either receive standard palliative care or a tailored pathway that triggers specific support b…

This study tests a support program for Chinese cancer patients and survivors. It combines education sessions, counseling, and peer support groups to see which mix works best. The goal is to improve quality of life. About 64 people from New York and New Jersey who speak Mandarin w…

This study is testing whether a yoga program led by trainers who share the same racial background as participants can improve quality of life and reduce symptoms for Black and African American cancer survivors. The research focuses on 50 adults in California who have had cancer t…

This study is testing whether an online pain coping skills program helps cancer survivors manage persistent pain better than standard care alone. Researchers will enroll 456 adult cancer survivors who have pain that started or worsened after cancer diagnosis or treatment. Partici…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study is testing a computer program that uses interactive stories and artificial intelligence to help teenagers aged 15-17 who already drink alcohol make healthier choices. About 200 teens will use the program during their regular clinic visits. The goal is to see if the pro…

This study looks for new genetic causes of cancer in people diagnosed at a young age (under 40, or under 30 for breast cancer). Standard genetic tests often miss the cause, so researchers will use a more detailed method called exome sequencing to search for hidden risk factors. T…

This study is testing a virtual reality (VR) education tool called Life at 100.4 for teenagers and young adults newly diagnosed with cancer, along with their caregivers. The goal is to see if using VR to learn about treatment is helpful and easy to use. About 45 participants will…

This study is testing whether a short video can help people with early-stage cancer living in rural Vermont better understand their treatment and speak up for themselves. About 40 adults with breast, lung, or colon cancer will be split into two groups: one gets the video right aw…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study tests a new, high-resolution PET-CT scanner that takes detailed pictures of a tumor right after it is removed during surgery. The goal is to help surgeons see if any cancer cells are left behind, so they can remove more tissue if needed. About 50 adults with solid tumo…

This study is for 500 adults with cancer who are willing to give extra blood samples over time. Researchers will use these samples to track DNA changes and look for clues that may help predict how cancer behaves. The goal is to gather information, not to test a new treatment.

This study looks at 380 cancer patients getting chemotherapy to find out who is most likely to develop a dangerous blood clot. Researchers will measure clotting-related substances in the blood at four points during treatment. The goal is to create a blood test that can predict cl…

This study tests whether group educational sessions help veterans with newly diagnosed cancer plan their future medical care better than usual care alone. About 50 veterans will take part, and researchers will check if goals-of-care discussions happen more often and if patients f…

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 adults with cancer will have their tumor genes analyzed, and the board will suggest …

This study surveys 200 adult cancer patients who have received CAR-T cell therapy to understand its impact on fertility. The goal is to gather patient experiences to help doctors improve future treatment plans and fertility preservation options. No new treatments are tested; this…

This study asks 50 people — including cancer patients, doctors, and industry workers — whether a 1939 UK law that bans advertising cancer treatments is still useful. The goal is to understand how people use online and social media for cancer information and whether the law should…

This study aims to collect and store blood, tissue, urine, and stool samples from up to 10,000 cancer patients across Texas. Researchers will use these samples to study how the immune system responds to cancer treatments and find markers that predict which therapies work best. Th…

This study looks at whether blood tests can help predict side effects in cancer patients receiving immunotherapy (immune checkpoint inhibitors). Researchers will collect blood samples and health data from 200 adults with various cancers during routine visits. The goal is to find …

This study looks at how satisfied cancer patients are after a team-based check-up in a day hospital. About 309 adults will fill out a questionnaire after meeting with doctors, dietitians, and social workers. The goal is to find what works well and what can be improved to make car…

This study tests a program called 'My Care My Voice' that helps people with cancer start conversations about palliative care with their doctors. The goal is to make sure patients get the support they need earlier, improving quality of life. About 271 participants will use a quest…

This study is testing a new way to help teenagers and young adults with hard-to-treat cancer, along with their parents and doctors, have better conversations about what the future may hold. The goal is to see if this personalized approach is practical and helpful for everyone inv…

This study looks at how tumors and nearby healthy organs change in size and shape during and after radiation therapy. By analyzing scans from 500 people who have already completed radiation, researchers hope to learn more about these changes. The goal is to use this information t…

This study looks at the immune cells and genetic makeup of thymic epithelial tumors (a rare type of chest cancer). Researchers will analyze tumor samples from 50 patients who have not yet been treated. The goal is to better understand the disease and identify potential new target…

This study follows 100 cancer patients aged 0-50 who chose fertility preservation before treatments that could harm their ability to have children. Researchers will review medical records to see which factors affect the success of these fertility-saving methods. The goal is to be…

This study is checking whether new molecular markers (biological clues from tumors) can be used in everyday care for people with rare adrenal cancers. Researchers want to see if these markers can be reported quickly after surgery and if they help doctors make better treatment dec…

This study is testing whether a program of eating walnuts and doing moderate exercise before cancer treatment is practical and acceptable for American Indian patients. Researchers will also measure markers of inflammation in blood and tumor tissue to see if the program has an eff…

This study collects blood samples from up to 700 people receiving stem-cell transplants for blood cancers and their donors. Researchers will analyze the samples to learn how the immune system rebuilds after transplant and what affects graft-versus-host disease. Participants provi…

This study is testing a blood test called Galleri that can find many types of cancer early, before symptoms appear. Researchers will compare 50,000 Medicare members who get the test with those who don't, to see if it lowers the number of late-stage cancers. The goal is to learn h…

This study tests whether a digital visual communication tool can help newly diagnosed cancer patients, their caregivers, and doctors better understand treatment options. About 86 adults with breast or head and neck cancer will use the tool and then rate their satisfaction. The go…

This study tests a program called CTNow that helps cancer patients and doctors in rural areas learn more about clinical trials. The program uses education and teleconference tools to make it easier for patients to find and join trials. About 50 adults with cancer from Hawaii, Kau…

This study is a registry that gathers information from adult cancer patients receiving routine care at participating clinics. Researchers will collect data on treatments, side effects, and outcomes, along with patient surveys. The goal is to create a rich dataset that helps more …

This study is testing a new tool called CANoPy that predicts the risk of developing nerve pain in cancer patients before they begin treatment. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer to see if the tool can accurately identify thos…

This study looks at how weight loss changes the way people with advanced cancer feel about their bodies. Researchers want to understand if these feelings differ between men and women and across countries. The goal is to create better, fairer nutrition advice for cancer patients. …

This study is testing a new imaging agent called 68Ga-NYM096, which is used with PET/CT scans to see how it collects in various cancers, including both primary tumors and those that have spread. Researchers will measure how bright the tracer appears in tumors compared to normal t…

This study looks at whether adding routine physical health checkups to mental health care helps find hidden diseases like diabetes, heart problems, and lung disease in people with serious mental illness. About 2,800 adults in Denmark will get these screenings, and their results w…

This study creates a registry of 500 children, teens, and young adults (up to age 39) diagnosed with cancer. Participants fill out surveys, do physical and thinking tests, and give blood or other samples at diagnosis, during treatment, and yearly after. The goal is to learn how c…

This study is creating a large databank of blood, imaging, and tissue samples from 5,000 cancer patients and healthy volunteers. The goal is to find links between biological markers and how well treatments work, including tumor control, side effects, and quality of life. Particip…

This study interviews 20 cancer patients, caregivers, and healthcare providers to learn what they think about receiving hospital-level care at home. The goal is to understand their knowledge, attitudes, and beliefs to help design better home care programs for people with cancer. …

This study looks at what motivates people aged 70 and older with cancer to be physically active and eat well. Researchers will group participants based on their motivation patterns, then use that information to design a personalized program to help them stay active and improve th…

This study looks at whether digital rehabilitation (like online exercise or therapy) is practical and helpful for cancer patients during and after treatment. About 300 people from Denmark, Sweden, Germany, Poland, and Lithuania will take part. The goal is to learn what helps or h…

This study looks at adults aged 65 and older who are starting chemotherapy. Researchers will measure their resilience and create personalized care plans to better support them. The goal is to learn what these patients need and improve their experience during treatment.

This study collects genetic and health information from 3,000 people to help doctors choose safer and more effective medications. Participants have conditions like diabetes, high blood pressure, heart disease, or cancer, and take multiple medications. The goal is to learn how gen…

This study tests a 4-session virtual coaching program to help young adult cancer survivors (ages 26-39) better understand their health insurance, lower financial stress, and stay on top of follow-up cancer checks. About 300 survivors of certain cancers will take part. The goal is…

This study follows 1,538 cancer patients in China to see how their nutritional status affects their response to chemotherapy and radiation. Researchers will track changes in diet, weight, and quality of life over time. The goal is to find ways to use nutrition to improve treatmen…

This study looks at whether cancer patients do better when they go to the emergency department at their own cancer hospital versus another hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hos…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for image-guided treatments. The device is placed through a needle into the tumor and shows up clearly on scans. The study uses organs removed during surgery, not live patients, …

This study aims to find more accurate ways to measure metabolism (how your body uses food for energy) by looking at body size and shape. Researchers will study 2000 healthy people and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital …

This study is a disease registry that collects information from about 700 people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. Researchers will track which treatments patients receive, how well they work, and any side effects…

This study looks at whether changing people's hidden feelings about exercise can help them be more active. Researchers will work with 120 overweight or obese adults who currently exercise less than 60 minutes per week. Participants will use a smartphone app and wear a Fitbit to t…

This study tests a method called bioelectrical impedance to monitor fluid retention (edema) in cancer patients. It includes 46 people: breast cancer patients with arm swelling after radiotherapy and hospitalized patients with leg swelling after chemotherapy. Participants will hav…

This study aims to learn how tumors and healthy tissues change during radiotherapy by taking detailed MRI scans at each treatment session. About 250 cancer patients and 10 healthy volunteers will participate. Researchers will also collect blood and urine samples to find biologica…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device that tracks heart rate, activity, and other health signs for 4 weeks. Researchers will use this da…

This study looks at how interested people are in using telehealth and digital tools for genetic counseling and testing for cancer. About 360 adults who meet guidelines for genetic testing or are interested based on family history will take part. Participants can choose to use dig…

This study follows 540 adults with solid cancers to see how anxiety and depression change over time. Researchers will look at factors like age, cancer type, and coping style to predict who might need extra support. No new treatment is given—the goal is to learn how to better help…

This study looks at whether sending a text message to check for depression is a good way to screen cancer survivors. About 60 people who have had cancer and own a cellphone will take part. The goal is to see if this method is easy to use and works better than the usual way of scr…

This study looks at why certain cancer patients—especially those from minority backgrounds, lower-income areas, or with decision-making challenges—are less likely to take part in research. By surveying 300 patients and mapping where they live versus available trials, researchers …

This study asks teenagers and young adults with cancer to write freely about their thoughts and feelings in logbooks. Researchers will analyze these writings to find common themes, emotions, and concerns. The goal is to help doctors and hospitals better understand what young pati…

This study looks at how cancer patients use a mobile app called EveryDose to track their oral chemotherapy pills. Researchers want to see if the app helps patients take their medicine as prescribed and if they find it easy to use. About 25 adults with cancer who are starting a ne…

This study looks at whether a simple ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. About 55 adults aged 18-74 with certain cancers will have an ultrasound and a standard body scan (DEXA) to compare results. The go…

This study aims to understand how chronic breathlessness differs in people with cancer, COPD, or heart failure by using brain scans (fMRI) and virtual reality. Sixteen adults with persistent breathlessness will undergo an fMRI while experiencing virtual reality, and report their …

This study is for adults who want to understand their personal risk of developing cancer. Researchers will look at lifestyle, family history, and exposures, and provide education on healthy habits and screening. No treatment is given; high-risk participants are referred to a doct…

This study tests a program to help young women who have had cancer and live in rural areas get reproductive health care that matches their personal goals. About 64 participants will receive screening, counseling, and telehealth consultations. The goal is to see if this approach i…

This study follows people who have received gene transfer therapy to monitor long-term safety and any effects over 15 years. It involves 130 participants from MD Anderson Cancer Center. No new treatment is given; the goal is to collect information and build a database for researc…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study aims to learn how inherited genes and environmental factors contribute to rare tumors and cancer in individuals and families. Up to 500 people of any age with unusual tumors, a family history of cancer, or certain exposures can join. Participants provide medical histor…

This study tests whether a more detailed analysis of a person's tumor DNA (complex exome analysis) helps doctors choose better treatments compared to a standard analysis. About 8,000 adults with advanced solid tumors will have their tumor genes read both ways. The goal is to see …

This study looks at whether adding patient navigators and easy-to-understand educational materials can increase the number of Black and Latino cancer patients who are referred to and enroll in cancer clinical trials. About 500 patients from community oncology clinics will take pa…

This study is a registry that collects medical information and patient feedback from 2,000 adults with metastatic cancer who are receiving radiation therapy as part of their standard care. The goal is to build a large dataset to help researchers understand how radiation affects o…

This study aims to help preserve fertility in females under 40 who face infertility due to treatments like chemotherapy or radiation. Participants will have an ovary surgically removed and frozen for future use. Researchers will also study how to improve the freezing and maturati…

This study looks at how cancer patients in palliative care feel about stopping medications that are not for their cancer. Researchers will give patients a brochure and video explaining their medicines and then ask them questions to see if their views change. The goal is to learn …

This study looks at whether cancer survivors can use a smartwatch and a phone app to regularly report their symptoms and activity levels. About 50 adults who have finished active cancer treatment and have controlled disease will wear a smartwatch for 4 months and fill out weekly …

This study aims to understand the different types of fatigue people experience, especially those with conditions like cancer, lupus, and chronic fatigue syndrome. Researchers will compare fatigued and non-fatigued adults using interviews, questionnaires, physical tests, and optio…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study is building a registry of 10,000 adults interested in inherited cancer research. Participants fill out a consent form and questionnaires every two years. No treatment or medication is given—the goal is to collect data for future studies on cancer genetics. Anyone 18 or…

This study tests whether data from a smartphone and smartwatch can help identify teens and young adults with cancer who are at risk for depression and other mental health issues. About 25 participants aged 10-25 will use an app and wearable device for two months. The goal is to s…

This study is collecting information from 500 adults with solid tumors who are receiving proton therapy, a type of radiation that may cause fewer side effects than standard radiation. The goal is to gather real-world data on how well proton therapy controls cancer and its side ef…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…

This study is testing whether a special blood test (thrombin generation assay) can help predict which cancer patients with blood clots are at higher risk of bleeding while taking blood thinners. Researchers will follow 212 patients for 6 months to see if the test results match bl…

This study tests a Clinical Trials Navigator program that helps cancer patients, families, and doctors find and enroll in clinical trials outside their local cancer center. The program will be rolled out to 20 centers across Canada over 12 months. Researchers will measure if it i…

This study looks at whether getting genetic counseling for cancer risk online works as well as meeting with a counselor in person. About 1000 adults who are at risk for hereditary cancer will take part. They will either use a self-guided website or have traditional counseling to …

This study looks at cancer patients who have a blood clot in a vein just under the skin (superficial venous thrombosis). About 1,500 adults with active cancer and a recent clot will be watched for 3 months to see how different blood thinners affect the risk of another clot or a m…

This study tests whether community outreach, navigation help, and digital tools can increase the number of Black and Hispanic patients enrolling in cancer treatment trials at Moffitt Cancer Center. About 7,600 community members, doctors, and staff will take part. The goal is to m…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a camera in a pill) to screen for early growths or cancer. The goal is to see how well this test finds precancerous or cancerous lesions in the small bowel. Results …

This study collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national data to better understand the benefits and risks of radi…

This study looks at whether a comprehensive genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in people with cancer. Researchers will enroll 120 adults with gastrointestinal cancer who are about to receive chemotherapy. The goal…

This study looks at whether advanced imaging (HyperSight) and adaptive planning (Ethos) can help doctors adjust radiation treatment as a child's body changes during therapy. Twenty children aged 18 or under with non-cranial tumors will receive standard radiation plus extra scans …

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers will track their physical and emotional distress, financial burden, care needs, and quality of life over one year. The goal is to develop a tool that can predict who is at high risk fo…

This study looks at whether a tool called TrialTalk™ helps improve conversations between cancer patients and their doctors. About 30 patients and their providers will fill out questionnaires before and after a regular clinic visit. The goal is to see if the tool makes communicati…

This study tests a telehealth program designed to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. Researchers will track whether the program increases the number of patients who receive fertility counseling or preservation services. Th…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep problems. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand when and why sleep issues start and what factors—like treatment type or emotion…

This study explores the link between gut bacteria, fatigue, and thinking problems in people with cancer. Researchers will collect stool samples and measure cognitive function in 250 adults receiving standard cancer treatment. The goal is to better understand these connections, no…

This study tests a new way to help cancer survivors manage long-term side effects from treatment. Doctors will use a patient questionnaire to guide conversations and create personalized care plans. The goal is to see if this approach improves referrals to support services and ove…

This study aims to understand how skin conditions related to cancer or cancer treatments affect the well-being of patients and survivors. Over 1,000 participants will fill out questionnaires about their skin condition. The goal is to improve how doctors treat these skin issues an…

This study is testing whether a new lab platform can quickly suggest personalized cancer treatments for 210 patients in Florida whose cancer has come back or not responded to standard therapy. The platform combines drug sensitivity testing and genetic profiling to recommend optio…

This study aims to understand how COVID-19 impacts patients with cancer by asking them to fill out surveys and participate in phone interviews. Researchers will track how many people take part over 12 months. The goal is to gather information, not to test a treatment.

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immune checkpoint inhibitors. The goal is to understand why some patients develop inflammatory side effects (immune-related adverse events) and find ways to …

This study tests whether a special clinic that checks your genes and all your medications can lower the risk of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple drugs will get a consultation. The goal is to help doctors presc…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive general health information. Th…

This study looks at whether improving the clarity of instructions for first-time radiotherapy patients helps them attend all their treatment sessions and feel more at ease. Researchers will compare updated, easy-to-understand materials with standard ones in 650 adults starting ra…

This early-stage study tests the safety of a new drug called LY4066708 in 104 healthy volunteers. Researchers will measure how much drug enters the blood and brain, and how fast the body clears it. The study lasts up to 24 weeks and does not aim to treat any disease, but will hel…

This study is testing a new PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match what the lab finds under a microscope. About 850 people with prostate, breast, head and neck, or other …

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out surveys about what they were taught regarding exercise, sexual health, fertility, finances, and other key topics. The goal is to find gaps in education so hospitals can better support…

This study tests whether a special website with a virtual health educator can help more Black and Hispanic cancer patients in Florida find and sign up for cancer clinical trials. About 350 patients will be split into two groups: one gets standard online information, the other get…

This study aims to understand why some cancer patients develop autoimmune problems after receiving a type of immunotherapy called checkpoint inhibitors. Researchers will analyze blood samples and health records from 600 adults with cancer who are prescribed these drugs. The goal …

This study looks at how the bacteria in your gut might influence how well immunotherapy works for solid cancers. Researchers will collect stool samples from 16 adults aged 35-75 who are already receiving standard immunotherapy. The goal is to understand the connection, not to pro…

This study looks at why cancer patients feel very tired during chemotherapy and radiation. Researchers will collect blood and stool samples from 125 adults with different cancers before, during, and after treatment. They aim to find links between fatigue and changes in genes and …

This study tests a communication program called COACH-Cog for older adults who have both Alzheimer's or related dementia and cancer. The goal is to help patients, their care partners, and doctors talk together more clearly about cancer treatment choices. About 300 people will tak…

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers, then develop and test strategies to overcome them with a…

This study is an online survey for people who have been diagnosed with cancer or who have cared for someone with cancer. It asks about your feelings, physical health, finances, and decisions during your experience. The goal is to learn from real experiences to improve support and…

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers aim to build a biobank to improve cancer prevention, early detection, and treatment. Participants must have a con…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving a common type of cancer immunotherapy (PD-1/PD-L1 inhibitors). Researchers will measure vitamin D and thyroid function before and during standard c…

This study compares two procedures—thoracentesis (draining fluid) and pleuroscopy (taking a tissue sample)—to see which one helps diagnose cancer in the chest faster. About 98 adults with suspected cancer-related fluid buildup will be randomly assigned to one procedure first. The…

This study follows up to 700 people who have already received radiation therapy for cancer. Researchers will collect information from routine check-ups to learn about long-term side effects and how the disease progresses over time. No new treatments or procedures are given—the go…

This study is gathering information from up to 10,000 cancer patients to see if choosing treatments based on the unique genetic makeup of each person's tumor leads to better results and fewer side effects. Researchers will look at medical records and may test leftover tissue or b…

This study is testing whether whole-body MRI, ultrasound, and a new blood test can detect cancer early in firefighters. Firefighters have a higher risk of certain cancers due to job exposures. The study will enroll 800 active firefighters aged 35 and older with at least 10 years …

This study follows 5,500 Canadian cancer patients whose tumors have rare genetic changes. Researchers will collect data on how these cancers behave and how well different treatments work, including newer targeted drugs. The goal is to learn more about these uncommon mutations to …

This study is creating a registry of 1000 adults with cancer who use cannabis. Participants use a secure app to track their symptoms, cannabis use, and how they feel after using it. The goal is to collect real-world data to help patients and doctors make informed decisions about …

This study surveys 100 young adults (ages 18-39) receiving cancer treatment at North Carolina Basnight Cancer Hospital to compare their satisfaction with two different infusion spaces. Participants fill out surveys and may join interviews about the environment and mental health s…

This study tests whether digital messages (texts, emails, or apps) can encourage teens and young adults who survived childhood cancer to schedule and attend their long-term follow-up appointments. About 530 survivors aged 15-29 who are overdue for care will receive different sequ…

This study looks at why some cancer patients who have needs like help with food, housing, or transportation choose not to accept support services. Researchers will survey 500 adults with cancer who previously said they had a need but declined assistance. The goal is to learn what…

This study trains high school students to encourage their adult family members to get screened for cancer. Researchers want to see if this youth-led approach increases screening rates in people who are overdue. About 84 teens and adults from New Jersey are taking part.

This study is testing whether wearable devices that track heart rate and other vital signs can help doctors spot infections earlier and better predict how long a person with advanced cancer has to live. About 120 hospice patients will wear a small ECG patch while receiving standa…

This study aims to learn more about what causes cancer and how to prevent it. Researchers will follow 200,000 adults aged 30–70 who have never had cancer, collecting health surveys, blood, urine, and saliva samples over many years. By studying lifestyle, genetics, and medical his…

This study looks at whether exercise helps prevent cancer from coming back in adults who have already been treated for cancer. Researchers will review data from 1,000 cancer survivors to see if those who exercise have better outcomes. The goal is to understand the link between ph…

This study tracks 5,000 cancer patients receiving chemotherapy or targeted drugs to detect heart-related side effects early. Researchers use regular heart tests and blood markers to build a system that predicts serious heart problems. The goal is to improve patient safety and qua…

This study aims to learn how the bacteria living in our bodies (the microbiome) are linked to major diseases like cancer and heart disease. Researchers will collect samples and health information from 16,000 adults over age 40. No treatments or medications are given; the goal is …

This study looks at how cancer patients feel and how long they live when given treatments that have some early promise but unclear overall benefit. Researchers will track 100 people with cancer to collect real-world information on quality of life and survival. The goal is to help…

This study is testing a new screening tool called SOCS-OTS to see if it correctly identifies cancer survivors who need occupational therapy. Researchers will compare it to a standard screening method already used at MD Anderson Cancer Center. About 80 adults who are being seen in…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to learn how cancer treatments like radiation, chemotherapy, and surgery affect health years later. Participants com…

This study tests a new way to help people with cancer, especially those from African American, Hispanic, or underserved areas. The program provides extra support and resources to reduce distress and improve quality of life. About 375 adults with suspicious cancer findings or a ca…

This study looks at the genes of people with advanced pancreatic cancer to find patterns that might help choose better treatments in the future. Researchers will take a small sample of the tumor and analyze its DNA. They want to see if they can get the results back to doctors wit…

This study from Mayo Clinic is watching how a blood test that can detect many types of cancer is used in everyday doctor visits. About 500 adults who have already had or are scheduled for this test will take surveys about their feelings, satisfaction, and the costs that follow. T…

This study is for people with advanced cancer. Researchers will use a special genetic test (high-throughput sequencing) on tumor samples to find specific gene changes. The goal is to see if this information can help doctors choose a more personalized treatment. Up to 1,000 partic…

This study is collecting short video and sound recordings of 200 adults with cancer to create a secure database. The goal is to help researchers develop an artificial intelligence tool that can automatically detect and measure pain by analyzing facial expressions and voice. Parti…

This study looks at whether having a radiopharmacist review a patient's full medication list before they receive targeted radionuclide therapy (TRT) can improve safety. TRT is a type of radiation treatment that targets cancer cells while sparing healthy tissue. Researchers will c…

This study looks at whether cancer patients are willing to answer questions about their social and economic circumstances, such as income, education, and housing. Researchers want to understand how these factors affect access to healthcare and participation in clinical trials. Ab…

This study tests whether a nurse-led program using online questionnaires can help cancer patients transition safely from hospital to home. About 50 adults with cancer who own a smartphone or tablet will use an app to report their health after discharge. The goal is to see if this…

This study aims to find new inherited gene changes that make people more likely to develop cancer. Researchers will analyze genetic information from 1,500 adults and children who have or may have a hereditary cancer syndrome. The goal is to better understand these genes so doctor…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study explores whether cancer patients undergoing chemotherapy can monitor their own blood counts at home instead of traveling to the hospital for every test. About 265 adults with cancer from Denmark, Poland, and Germany will participate, with some using home monitoring and…

This study tests a digital platform called the Genetics Navigator that helps patients and parents of children get genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults referred for genetic testing at two h…

This study is not testing a new drug or treatment. Instead, it will collect information from 3000 adults taking oral anticancer drugs at home to understand how well the prescribed doses match what patients actually take, what side effects occur, and how care coordination between …

This study looks at how cannabis affects symptoms like pain, sleep, and anxiety in 450 adults with cancer who are receiving immunotherapy. Participants will complete surveys and daily check-ins over a year. The goal is to understand if cannabis helps or causes harm, so doctors ca…

This study looks at whether using video calls for geriatric check-ups before cancer treatment can reduce unplanned hospital stays for patients aged 75 and older who live far from specialized care. About 500 participants will be randomly assigned to either standard care or a telem…

This study aims to understand what helps or blocks a good hospital experience for Asian cancer patients at MD Anderson. Researchers will survey 520 former patients and their healthcare providers. The goal is to find ways to improve care for this group.

This study is building a large registry and sample bank to understand why some groups face more barriers to cancer screening and early detection. Researchers will follow 100,000 adults aged 35 and older for up to 10 years, collecting health records, questionnaires, and blood, sal…

This study looks at whether adding a special helper called an oncology research navigator (ORN) to standard cancer care helps patients access support services and join clinical trials. About 686 adults with new cancer appointments at UNC Medical Center will take part. The goal is…

This study is for adults with rare cancers or rare genetic changes in their tumors who are already taking a targeted therapy approved by Health Canada but not yet publicly funded. The goal is to collect real-world information on how long patients live, their quality of life, and …

This study looks at why some childhood cancer survivors continue to have symptoms like fatigue, pain, and trouble sleeping. Researchers will ask 600 survivors aged 8-18 about their symptoms and collect stool samples to study gut bacteria. The goal is to find links between gut hea…

This study follows 600 Black and White adults with solid tumor cancer to see how they use cannabis, opioids, and tobacco, and how that affects their pain, sleep, and quality of life. Participants use a smartphone app to report symptoms daily for 84 days and complete surveys for a…

This study looks at muscle loss (sarcopenia) and cognitive problems (chemobrain) in people who have finished cancer treatment. Researchers will collect data from 100 adults aged 18-74 with certain cancers to understand how common these issues are. The goal is to improve support a…

This study is for people with cancer who are about to start or have already received FDA-approved immunotherapy. Researchers want to see if special blood tests (immune-methylation and cytokine profiling) can predict whether the treatment will work. The goal is to better understan…

This study listens to cancer survivors to understand how they experience and talk about fatigue. Researchers will interview 80 survivors and their doctors to create a visual poster that helps patients describe their fatigue better. The goal is to improve communication and help pe…

This study aims to uncover the molecular mechanisms behind kidney disease, immune disorders, and complications in organ transplant patients. Researchers will analyze blood and urine samples from 5,000 participants to find genetic and protein markers that predict disease progressi…

This study follows 10,000 childhood cancer survivors treated at St. Jude Children's Research Hospital over their entire lives. The goal is to learn about long-term health problems that may appear years after cancer treatment. Researchers will track health outcomes, identify risk …

This study is creating a large collection of blood and tissue samples from 100,000 adults with cancer. The goal is to store these samples and health data for future research to improve cancer detection and treatment. Participants provide consent and samples, but do not receive an…

This study collects and freezes testicular tissue from boys who are not yet producing sperm and are at risk of infertility due to cancer or autoimmune disease treatments. The tissue is stored in a lab for possible future use to help them have biological children once experimental…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…

This study is testing new blood and urine tests to find cancer early in firefighters, who are at higher risk for certain cancers. Researchers will enroll 2,000 firefighters to see how well these tests work. The goal is to improve early detection and save lives.

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors, called biomarkers, in the blood. The goal is to see how often these markers can be found. Participants will give blood samples over time, but their regular cancer care will n…

This study collects and stores tumor, tissue, and blood samples from people with cancer. The samples are kept in a secure database and used by researchers to learn more about cancer. Anyone being treated for cancer at the Arizona Cancer Center or University Medical Center can joi…

This study looks at how the bacteria in your gut (the microbiome) might be linked to diarrhea caused by cancer treatments. Researchers will follow 150 adults starting cancer therapy and collect stool and blood samples to see if certain gut bacteria or markers in the body predict …

This study is building a large collection of human biological samples and health data to help scientists understand diseases better. It will collect samples from up to 10,000 people, including both healthy individuals and those with conditions like cancer, heart disease, and diab…

This study is testing different outreach methods to see which ones work best for enrolling more African American patients in early-phase cancer treatment trials. Researchers will work with both patients and their doctors to test various recruitment approaches. The goal is to unde…