CANCER

This early-phase trial tests a new mRNA vaccine called PAN-NeoVax, designed by artificial intelligence to target multiple cancer types. The vaccine is injected directly into tumors in 9 patients with advanced solid cancers who have run out of standard options. The main goal is to…

This study explores how to best help cancer patients, survivors, and their caregivers quit tobacco. Participants can choose between group or one-on-one counseling sessions. The goal is to see if this program is practical and well-received, paving the way for better tobacco cessat…

This study tests a new drug called IMA402 in people with advanced solid tumors that have come back or not responded to treatment. IMA402 is designed to help the immune system attack cancer cells. The trial will check if the drug is safe and whether it can shrink tumors.

This study tests a drug called zotiraciclib in people with a certain type of brain tumor (glioma) that has come back after treatment. The tumor must have a specific gene mutation (IDH1 or IDH2). Participants take the drug by mouth in cycles. The goal is to see if the drug can slo…

This early-stage trial is testing whether specially engineered immune cells (called CAR-T and CTL cells) and a dendritic cell vaccine can safely treat people with neurofibromatosis or schwannomatosis, conditions that cause nerve tumors. The study will enroll 100 participants aged…

This study tests whether carefully managing body temperature during major cancer surgery can lower the risk of postoperative delirium (sudden confusion) and improve long-term survival in patients aged 65 and older. About 4,000 participants will be randomly assigned to either rout…

This study offers continued access to experimental oral cancer drugs for patients who are already benefiting from them in a previous Lilly study. The main goal is to monitor long-term safety. Participants must not be in any other conflicting research.

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This study tests a new treatment for gastrointestinal cancer using a patient's own immune cells, which are engineered in a lab to target cancer. About 100 participants will receive these cells to see if they are safe and can shrink tumors. The trial is currently recruiting and co…

This study tests whether specially engineered immune cells (EIE) can safely fight cancer. Researchers take a patient's own immune cells, modify them to target tumor-related markers, and infuse them back. The trial involves 100 people with various cancers whose tumors show specifi…

This study tests a program called Comprehensive Connected Cancer Care (C4) for people newly diagnosed with cancer who also have social needs (like trouble paying for medicine or getting to appointments). The program uses patient navigators, a digital needs assessment, and better …

This study has two parts. Part A tests whether cancer patients who stopped a type of immunotherapy (checkpoint inhibitors) due to side effects can safely restart treatment with durvalumab, given alongside the steroid prednisone to reduce the risk of side effects returning. Part B…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy to see if it increases helpful gut bacteria and improves tumor shrinkage. T…

This study gives people with cancer continued access to an experimental Roche treatment they were already receiving in a previous trial. It is for patients who still need the drug and cannot get it locally. The goal is to keep providing the treatment and monitor any side effects.

This study tests a new treatment using a patient's own immune cells, called CAR T cells, that are specially designed to target and kill solid tumor cells while leaving healthy cells unharmed. It is for adults with certain advanced cancers, including lung, colon, pancreatic, ovari…

This early-phase trial tests an oral drug called ALTA3263 in about 448 adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety, find the right dose, and see how the body processes the drug. Part…

This program offers oral sevabertinib to adults with advanced non-small cell lung cancer that has a specific HER2 gene change and has stopped responding to other treatments. Participants must have a life expectancy of at least 12 weeks and be in good enough health to take oral me…

This study tests whether adding the chemotherapy drug capecitabine to the standard temozolomide regimen can help people with newly diagnosed glioblastoma live longer without their tumor growing. About 67 adults who have completed initial radiation and chemo will take both pills a…

This study tests whether text-based support can help rural cancer survivors who smoke to quit. Participants will either receive text messages that gradually reduce cigarette use or a self-help manual. The goal is to see which approach works better for long-term smoking cessation.

This study offers long-term treatment with nivolumab and other cancer therapies to 1,500 patients who previously benefited from Bristol-Myers Squibb trials. The main goal is to monitor safety and side effects over time. Participants must have had a good response in their earlier …

This phase 2 study tests a combination of three drugs—isatuximab, lenalidomide, and dexamethasone—at lower doses than usual for people newly diagnosed with multiple myeloma who are at high risk for side effects. The goal is to see if the treatment can still control the cancer whi…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This study tests whether monitoring levels of a harmless virus called TTV can help doctors personalize immune-suppressing drugs for kidney transplant patients. The goal is to prevent long-term complications like infections, cancer, and organ rejection. About 600 adults who receiv…

This study is for people with advanced cancer who have run out of standard treatment options. Researchers will analyze the genetic makeup of each patient's tumor and recommend a targeted drug therapy based on those results. The goal is to see if this personalized approach can slo…

This study is testing whether giving cancer treatment based on a person's unique tumor genetic profile can help patients with aggressive, hard-to-treat cancers. Researchers will analyze each patient's tumor to find specific genetic changes and then recommend a targeted drug. The …

This study tests a new treatment for people with solid tumors that have come back or not responded to standard care. The treatment uses a patient's own immune cells (T-cells) that are genetically modified in a lab to recognize and attack a protein called PRAME found on cancer cel…

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

This study tests whether a new version of the drug olaparib (DWZ2501) works as well as the current version (DWC202510) in women with advanced BRCA-mutated ovarian cancer. About 40 participants will take both versions at different times to compare drug levels and safety. The goal …

This expanded access program offers balstilimab, alone or with zalifrelimab, to cancer patients who previously received these drugs in a clinical trial and saw benefit. The goal is to allow continued treatment for those who wish to stay on therapy. Only patients who completed the…

This phase 2 trial is testing a new approach for people with large, relapsed solid tumors that have not responded to standard treatments. It combines a special type of radiation (spatially fractionated radiation therapy) with two immunotherapy drugs (iparomlimab and tuvonralimab)…

This study tests a drug called abemaciclib in people with advanced solid tumors that have specific changes in cyclin or CDK genes. The drug works by blocking proteins that help cancer cells grow. Researchers want to see if it can stop or slow the cancer for at least 4 months. Abo…

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men to restore sperm production. Five men who had fertility-threatening treatments as children will receive their own preserved tissue. The goal is to see if sperm can be found in…

This study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant the patient's own frozen testicular tissue back into them. The goal is to see if it is safe and can restart sperm production.

This study tests whether giving the targeted drug selpercatinib for 6 months before standard radioactive iodine therapy can improve outcomes for children, adolescents, and young adults (ages 2-25) with a specific type of thyroid cancer linked to RET gene fusions. The goal is to s…

This early-stage trial tests a new drug called DXP-106 in 54 people with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and see if DXP-106 works better when given alone or with chemotherapy. Participants receive the drug by…

This early-phase trial is testing an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The study aims to find a safe dose and watch for side effects, while also looking for early si…

This study looks at whether cancer survivors who had heart problems from their cancer treatment can safely stop taking heart failure medications once their heart function is back to normal. About 335 adults who have finished cancer therapy and are on heart medications will be ran…

This study tests a mobile health program designed to help young adults (ages 18-39) who have survived cancer and are now overweight or obese. Participants will either get a full weight management program through their phone or receive basic digital tools and support. The goal is …

This early-phase trial tests CPO301, a drug designed to seek out and attack cancer cells that have a protein called EGFR on their surface. About 132 adults with advanced solid tumors (including lung, breast, and head & neck cancers) will receive the drug by IV every three weeks. …

This early-phase trial is testing an experimental drug called INV-1120, either by itself or combined with the immunotherapy pembrolizumab (Keytruda), in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find safe doses an…

This study tests whether adding the drug sarilumab to chemotherapy (capecitabine) can eliminate tiny amounts of cancer left behind after standard treatment in people with triple negative breast cancer, a very aggressive type. The goal is to prevent the cancer from coming back and…

This early-phase trial is testing MBRC-101, a drug that seeks out cancer cells and delivers a chemotherapy payload directly to them. It is for people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then check f…

This early-stage trial tests a new drug called IMC-P115C in people with advanced cancers that have a specific protein (PRAME) and a certain immune type (HLA-A*02:01). The drug is designed to help the immune system find and attack cancer cells. The study will check safety and whet…

This study tests a new approach using immune cells from healthy donors, engineered to recognize and attack cancer cells. The target is chosen based on each participant's tumor profile. The trial includes 85 adults with advanced solid tumors that have not responded to standard tre…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This early-stage trial tests whether combining high-intensity focused ultrasound (HIFU) with immune checkpoint inhibitors (ipilimumab and nivolumab) is safe and feasible for people with metastatic or unresectable cancer that has worsened after standard treatments. 24 adults will …

This early-phase trial is testing an experimental drug called TTX-080, which blocks a protein (HLA-G) that tumors use to hide from the immune system. The study will give TTX-080 alone or combined with other cancer drugs (pembrolizumab, cetuximab, or FOLFIRI plus cetuximab) to abo…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This study compares two different dosing schedules of the blood thinner apixaban (Eliquis) against no blood thinner in about 996 cancer patients at moderate risk for blood clots. Participants take either 2.5 mg twice daily, 5 mg once daily, or no anticoagulant for 6 months. The g…

This study combines a special type of radiation (PULSAR) with immunotherapy drugs to treat metastatic cancers in the abdomen and pelvis, including liver, kidney, and bladder cancers. About 103 participants will receive the treatment to see if it is safe and helps control the dise…

This study looks at how different group exercise programs affect fitness and body composition in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training regimens. The goal is to see which approach best improves heart-lun…

This phase 2 trial is testing whether adding a special type of radiation called adaptive pulse radiotherapy to standard immunotherapy can help treat advanced solid tumors. The study will enroll 35 people who are already receiving or planning to receive immune checkpoint inhibitor…

This study tests whether adding a hand-held breathing muscle trainer to standard pre-surgery exercise rehab can reduce complications and hospital stays for people with lung cancer. About 100 adults scheduled for lung cancer surgery will be split into two groups: one gets standard…

This study tests a new drug called IMC-R117C, alone or with other cancer drugs, in people with advanced colorectal, esophageal, stomach, or ovarian cancers that have a specific genetic marker (HLA-A*02:01) and produce a protein called PIWIL1. The trial aims to find safe doses and…

This phase 2 trial is testing whether a liquid extract from maitake mushrooms can improve immune function in 40 adults receiving chemotherapy or CDK4/6 inhibitors for cancer. Participants take the supplement alongside their standard treatment. The study measures changes in white …

This early-phase study tests JMT108, a bispecific antibody, in 270 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants receive JMT108 by …

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether inhaling a drug called tranexamic acid can help stop lung bleeding in cancer patients who are on breathing machines. The trial includes 60 adults with blood cancers and severe lung bleeding. Half will get the inhaled drug plus usual care, and half will ge…

This program offers a personalized vaccine made from each patient's unique cancer mutations (neoantigens) to help their immune system fight solid tumors. It is for patients aged 12 and older with local or metastatic cancer who have no other FDA-approved options and a low chance o…

This study offers young female cancer patients the option to freeze a piece of their ovarian tissue before starting cancer treatment, then have it transplanted back later to restore fertility. The goal is to help preserve the chance of having biological children after cancer. Res…

This study tests whether early, personalized nutritional support and a simple home exercise program can prevent weight loss and improve quality of life in 200 adults with lung, colorectal, ovarian, or pancreatic cancer starting palliative chemotherapy. Participants receive guidan…

This early study is testing a new drug called WTX212A, alone or with radiation, in 12 people with advanced solid tumors. The goal is to see if it shrinks tumors and is safe. It's a small first step to find out if this approach is worth studying further.

This study offers boys aged 0-17 the chance to freeze testicular tissue before undergoing treatments like chemotherapy or radiation that could cause permanent infertility. The tissue is stored for potential future use to achieve pregnancy. Researchers will track whether transplan…

This study tests a mobile app program to help smokers with cancer quit. Participants can choose their own quit schedule and receive supportive text messages. The goal is to see if this personalized approach leads to more people quitting compared to standard advice. The study invo…

This study tests whether a six-month program of supervised exercise, heart risk management, and online support can improve heart and lung fitness in young cancer survivors (ages 18-45) who have mild heart dysfunction. About 336 participants across Canada will be randomly assigned…

This early-phase trial is testing a new approach for people with liver metastases (cancer that has spread to the liver from elsewhere). Doctors are using a procedure called TACE to deliver the drug bevacizumab directly into the liver's blood vessels, aiming to concentrate the tre…

This trial tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if it can shrink tumors or stop them from growing for at least 24 weeks. The goal is …

This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and chi…

This trial tests atezolizumab, a drug already approved for several cancers, in people with rare cancers that have high tumor mutational burden (TMB) or microsatellite instability (MSI). The goal is to see if the drug can shrink tumors or stop them from growing for at least 24 wee…

This study tests a drug called alectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change called ALK. About 30 adults, teens, and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops…

This phase 2 trial tests whether giving larotrectinib for 6 months can make thyroid cancer cells more responsive to radioactive iodine therapy. It enrolls 13 children and young adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is t…

This study tests whether giving radiation again after a second lumpectomy is safe for women with a common type of breast cancer (ER+HER2-). About 114 women who had radiation before and whose cancer came back at least 18 months later will receive targeted radiation over 3 weeks. T…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in 29 people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or slows cancer growth. Participants take both…

This study tests whether providing healthy frozen meals, produce boxes, and nutrition counseling helps adults in Anson County eat better compared to those who only get physical activity coaching. About 120 participants with or at risk for chronic diseases like obesity, diabetes, …

This program provides early access to an experimental drug called AVM0703 for people with various solid tumors and blood cancers, including hard-to-treat types like glioblastoma and metastatic breast cancer. It is available to patients in the US whose doctor requests it. So far, …

This early-stage trial tests an experimental oral drug called CID-078 in 220 adults with advanced solid tumors that have not responded to standard treatments. The study is split into two parts: first, finding a safe dose, and then checking if the drug shrinks tumors. It is a firs…

This study looks at whether low-dose prednisolone (a steroid) can safely treat liver inflammation (hepatitis) caused by immune checkpoint inhibitors in cancer patients. Researchers will enroll 63 adults with grade 2 or 3 immune-related hepatitis and give them 0.5-1 mg/kg of predn…

This phase 3 trial tests whether abatacept (Orencia) can reduce major heart complications in cancer patients who develop myocarditis (heart inflammation) from immune checkpoint inhibitors. About 390 hospitalized adults will receive either abatacept or placebo plus standard care. …

This early-stage trial is testing a single infusion of cells from umbilical cord blood (called XJ-MK-002) in 16 cancer patients whose platelet counts have dropped due to chemotherapy or other cancer treatments. The main goal is to see if the treatment is safe and tolerable, and t…

This study tests A2B395, a donor-derived CAR T-cell therapy designed to target cancer cells while sparing healthy ones. It is for adults with advanced solid tumors like colorectal, lung, or breast cancer that have lost a specific immune marker. The trial has two phases: first to …

This early-stage study tests a new injection called [18F]LY4214835 to see if it is safe and how it spreads in the body. It includes healthy volunteers and people with cancer. The goal is to improve how doctors see tumors using imaging scans.

This study offers a Lung Health Check to 500 people aged 55-74 who smoke or used to smoke. It uses a low-dose CT scan along with blood tests, an ECG, and a breathing test to find lung cancer and other conditions like COPD and heart disease early. The goal is to see if this combin…

This study tests whether whole-body MRI, ultrasound, and a new blood test can find cancer early in firefighters. Firefighters have a higher risk of certain cancers due to job exposures. The study will enroll 800 active firefighters aged 35 and older with at least 10 years of serv…

This study tests a new imaging approach for people with advanced breast or prostate cancer. It uses two radioactive tracers to find tumors that have a specific protein (GRPR). The goal is to see if this method is safe and can help doctors see where the cancer is in the body. Abou…

This study tests whether an AI program can help emergency doctors find undiagnosed heart failure, COPD, and cancer by analyzing chest X-rays. Researchers will compare diagnosis rates when doctors have access to the AI's findings versus when they don't. The trial involves 17,000 a…

This study is testing a blood test called Galleri that looks for signals of many different cancers at once. Researchers will enroll 50,000 people aged 50 and older with Medicare coverage. Half will get the Galleri test plus usual care, and half will get usual care alone. The main…

This registry study is testing a blood test designed to detect multiple types of cancer early by looking for DNA and protein changes linked to cancer. Researchers will follow 25,000 people aged 50 to 80 who take the test and any follow-up imaging. The goal is to see how well the …

This study is testing a new blood test that looks for DNA from cancer cells. The goal is to see if an artificial intelligence program can accurately detect many different types of cancer at an early stage. The study will include 6,000 adults, some with cancer and some healthy vol…

This early-stage trial is testing an injectable dye called NC527-X that may make tumors glow during surgery, helping surgeons see exactly where the cancer is. The study will enroll 400 adults with solid tumors who are already scheduled for surgery. Participants receive one of fou…

This study is testing two new blood tests designed to help doctors detect cancer in people who have symptoms that might be cancer. The study will involve 1,650 adults aged 45 and older who are already undergoing medical tests for possible cancer. The goal is to see how well these…

This early-stage study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on a special PET-MR scan. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, COVID-19, or cancer. The study involves 165 pa…

This study is looking at whether analyzing DNA and proteins in urine can help detect cancers of the bladder and kidney without invasive procedures. Researchers will collect urine samples from 500 adults, including those with known or suspected cancer and healthy volunteers. The g…

This study is developing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes by analyzing digital images of tissue slides. Researchers will compare the AI's accuracy to that of pathologists using slides from 10,000 cancer patients. The goal is…

This early study tests a new type of MRI that uses a special substance called hyperpolarized pyruvate to see how tumors use energy. Cancer cells often change how they process energy, and this scan aims to detect that difference. The study will include 25 people with various cance…

This study is testing a new radioactive tracer called 68Ga-NYM096 in 120 adults with various cancers. Participants receive one injection of the tracer followed by a PET/CT scan to see how well it highlights both primary tumors and cancer that has spread. The goal is to identify w…

This study tests whether a dexamethasone mouthwash can prevent moderate to severe mouth sores caused by chemotherapy in adults with cancer. Participants use the mouthwash four times daily during chemo for up to 8 weeks. Researchers compare their outcomes to a historical group to …

This study tests a special cooling and compression sleeve (Paxman Limb Cryocompression System) worn during chemotherapy to prevent nerve damage, a common side effect. About 200 cancer patients receiving weekly paclitaxel will use the device for up to 4 hours per session. Research…

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study tests whether a smartphone app that teaches mindfulness can help reduce stress in people who have finished cancer treatment. About 345 cancer survivors will be randomly assigned to use the app right away or wait three months. The goal is to see if the app makes a real …

This study compares three support programs for parents who lost a child to cancer at least six months ago and still have high grief levels. The programs include Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care. Researchers will measure changes in gri…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults who have survived cancer. Participants will receive BA or supportive psychotherapy remotely via video or phone over 10 weeks. The goal is to see if BA reduc…

This study tests a support program for Chinese cancer patients and survivors that includes education sessions, counseling, and peer support. The program is delivered by phone or video call. Researchers want to see if the program is practical and whether it improves quality of lif…

This study tests whether a respiratory rehabilitation program—including exercise training, breathing exercises, and education—can improve quality of life for people with advanced non-small cell lung cancer who are on maintenance chemotherapy and immunotherapy. Researchers will co…

This trial investigates whether an online, nurse-guided version of cognitive behavioral therapy (CBT) can reduce severe fatigue in people with advanced cancer who are receiving palliative systemic treatment. Participants complete a 12-week online CBT program with support from the…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer reduce distress and improve mood and quality of life. About 50 adults who have had cancer will use the app at home for 8 weeks and fill out questionnaires about thei…

This Canadian study is testing whether cannabinoid oils (CBD and THC) can safely help manage symptoms like pain in children aged 4-17 with relapsed or refractory cancer. The trial will enroll 60 kids across three hospitals, giving them different ratios of CBD to THC oils to see w…

This study tests whether a six-week at-home light therapy program is practical and helpful for childhood cancer survivors who have nerve pain or numbness from chemotherapy. Twenty survivors aged 5 and older will use a light therapy device on their symptoms for 15 minutes, three d…

This study compares two ways to treat depression in cancer survivors: a mobile app called Moodivate that tracks activities and mood, and 8 sessions of telehealth therapy with a mental health provider. About 45 adults who have had cancer and currently feel depressed will take part…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study tests a mobile health tool to help women on hormone therapy for breast cancer track and manage side effects. About 60 women who recently started hormone therapy will use the app to report symptoms and get health tips. The goal is to see if the app is easy to use and he…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study tests a program to help cancer patients transition from hospital to home. It includes a meeting with a nurse before leaving, an app to report symptoms, and a follow-up phone call. The goal is to see if this approach is feasible and improves patient satisfaction and qua…

This study is testing a support program for teens and young adults (ages 16-30) who have just been diagnosed with cancer. The program includes a meeting with a special team and a structured course called PRISM that teaches skills like stress management and goal setting. About 130…

This study tests whether virtual reality (VR) can help children and young adults with cancer be more physically active while in the hospital. 40 participants aged 10-25 will try both VR-assisted physical therapy and traditional physical therapy to see which one gets them moving m…

This study tests a web-based program called OMGYES.com to see if it helps young adult female cancer survivors who have sexual problems. About 30 people will take part, using online modules at home and visiting the clinic every 5 weeks for questionnaires. The goal is to see if the…

This study is testing a program called FOCUS ON US, designed to help sexual and gender minority (LGBTQ+) cancer patients and their caregivers. The program includes five sessions covering topics like family involvement, coping skills, and symptom management. Researchers want to se…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study looks at whether two simple relaxation methods—progressive muscle relaxation and deep breathing exercises—can reduce shortness of breath and severe tiredness in people with advanced cancer receiving palliative care. About 90 participants will be assigned to one of the …

This study tests an online program called My Wellbeing Guide for cancer patients who feel depressed or anxious. The program uses videos, activities, and written tips based on cognitive behavioral therapy over 7 weeks. About 6,500 participants will be randomly assigned to the prog…

This study tests a physical activity program designed for cancer survivors and their caregivers. About 164 adults who have finished cancer treatment (except hormone therapy or maintenance chemo) will take part. The goal is to see if the program improves physical function and redu…

This small pilot study tests whether using a hand-held vibration device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Sixteen adults who finished chemotherapy at least 60 days ago will try the therapy at home. The main …

This study is testing a short group therapy program based on Dialectical Behavior Therapy (DBT) to help cancer patients reduce or stop smoking. The program focuses on building skills in emotion regulation, distress tolerance, and mindfulness. The trial will enroll 16 participants…

This study compares music therapy and cognitive behavioral therapy (CBT) for reducing anxiety in people who have had cancer. 368 cancer survivors with anxiety will receive seven weekly virtual sessions of either music therapy or CBT. Researchers will track anxiety levels over 26 …

This study tests a communication coaching program for adolescent and young adult cancer survivors (ages 18-35) who have finished treatment at least a year ago. Participants complete online sessions and AI coaching to improve how they talk with peers. The goal is to see if the pro…

This study tests a computer program called C-SCAT that helps adolescents and young adults with cancer track and manage their symptoms. Participants use the tool to rate symptoms, find patterns, and plan how to cope. The goal is to see if using C-SCAT boosts their confidence and a…

This study tests a mobile app called Moodivate that helps people with incurable cancer track their daily activities and mood, and suggests new activities to improve their mood. About 279 participants will be randomly assigned to use the app or receive usual care for 8 weeks, with…

This study tests whether a traditional herbal formula called MZRW can help cancer survivors who suffer from constipation. Researchers will give 70 participants either MZRW or a placebo for two weeks and track bowel movements and gut bacteria changes. The goal is to see if MZRW is…

This study looks at whether teaching cancer patients about taste changes caused by chemotherapy and giving them self-management tools can help reduce those symptoms and maintain healthy eating. About 400 adults starting chemotherapy will be split into two groups: one gets standar…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study tests a 9-week mindfulness program (MBRP-SA) designed to help cancer survivors quit smoking and reduce heavy drinking. Six hundred participants in Florida will either get the mindfulness program plus nicotine patches or standard quitline support. The goal is to see if …

This study is testing an online educational program called On-Trac to help adult cancer survivors cope with anxiety. The program teaches practical strategies based on well-known therapies like CBT and ACT. Researchers will measure changes in anxiety levels and emotional well-bein…

This study tests whether a walking program and cognitive rehabilitation exercises can improve memory and thinking in people aged 65 and older who have finished cancer treatment. Forty participants will be randomly assigned to one of four groups: exercise only, cognitive training …

This study tests whether an artificial intelligence (AI) app can improve quality of life, anxiety, and depression in people with cancer who are already receiving psychotherapy. About 60 participants will be randomly assigned to either get the AI app alongside their usual therapy …

This study is creating and testing a nurse-led program for women who experience early menopause after cancer. The program includes personalized education, decision support, and skills to manage menopause symptoms. About 117 women who have completed cancer treatment will take part…

This study looks at whether having access to a specialized palliative care clinic helps cancer patients feel more secure and reduces unnecessary hospital visits. Researchers will compare patients who use the clinic with those who do not, and also ask family members about their ex…

This study tests whether Reiki, a gentle hands-on relaxation therapy, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions right away or after a waiting period. Researchers will measure changes in fa…

This study tests whether a 12-week personalized exercise program, done at home with a trainer guiding via video, can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. About 350 adults who finished cancer treatment wi…

This study looks at whether a three-month stay focused on adapted physical activity can improve the physical fitness and quality of life of children with chronic illnesses, rare diseases, or disabilities who have become physically deconditioned. About 50 children aged 8 to 18 wit…

This study explores whether a simple writing exercise can help people living with or after cancer feel better emotionally. Participants will write about their cancer experience in four sessions, either with a compassionate prompt or a standard one. Researchers will measure change…

This study looks at whether a one-year, home-based exercise program can help people aged 60 and older who are undergoing cancer treatment. Participants will be split into two groups: one doing guided exercises at home, and the other receiving usual care. Researchers will measure …

This study tests whether MDMA (the drug in ecstasy) combined with talk therapy can help cancer patients and their partners who are struggling with adjustment disorder—a condition where they have trouble coping with the cancer diagnosis. Twenty participants (10 patient-partner pai…

This pilot study tests a behavioral program called Mindset Moments for young adults (ages 19-25) who have finished cancer treatment. The program includes weekly online group sessions and daily app activities focused on coping skills, mindfulness, and peer support. Researchers wan…

This study tests whether a tablet-based video program can help rural cancer patients better understand their care and feel more coordinated. About 40 adults with early-stage breast, lung, or colon cancer living in rural Vermont will be randomly assigned to receive the videos righ…

This study explores whether a virtual reality (VR) program can help reduce anxiety in adults preparing for cancer surgery. Researchers will recruit 20 participants to test if the VR approach is practical and well-liked. The goal is to see if this calming tool can make the day of …

This study is testing a new smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. About 50 adults who have been diagnosed with cancer and smoke at least one cigarette a day will try the app. The goal is to see if the app is easy to use and if peopl…

This study tests whether a 30-minute moderate cycling session just before chemotherapy or immunotherapy can help cancer patients maintain their fitness. 80 adults with breast, ovarian, or colorectal cancer will either receive standard advice or also exercise with a physiotherapis…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better than standard radiation and help people feel better. About 37 adults with advanced solid tumors will receive this tre…

This study tests whether playing a serious game on an iPad can help older adults (60+) better manage nausea and vomiting caused by chemotherapy. About 610 participants will be randomly assigned to play the game or receive usual care. Researchers will track symptom severity, quali…

This study tests whether an internet-based parent-child interaction therapy (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the…

This study compares two approaches to supportive cancer care for nearly 3,000 adults with cancer. One group gets information through email or their health record, while the other works one-on-one with a lay health worker over 12 months. The goal is to see which model better impro…

This study tests a program where cancer patients report symptoms from home using a digital questionnaire. A nurse monitors the results and provides advice between clinic visits. The goal is to see if this improves quality of life and reduces emergency room visits and hospital sta…

This study is testing whether adding acupuncture or touch therapies (like reflexology and shiatsu) to standard cancer care can reduce symptoms and improve quality of life. 750 adults currently undergoing cancer treatment will receive 8 weekly sessions of either acupuncture or tou…

This study tests whether a virtual reality (VR) program used at home can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. About 30 adults who finished cancer treatment at least 3 months ago will use either VR or an audio program daily for…

This study tests if using a small ultrasound scanner helps nurses place an IV drip on the first try more often than the traditional touch-and-feel method. About 98 cancer patients receiving treatment will be randomly assigned to one of the two methods. The goal is to reduce disco…

This study tests a 6-week online program called the Chronic Disease Self-Management Program (CDSMP) for people in Israel living with a kidney transplant or cancer. The program teaches practical skills like managing symptoms, setting health goals, and communicating with doctors. R…

This study tests a new phone-based therapy called CARE (Cancer and Aging: Reflections for Elders) to help older adults with cancer who feel depressed or distressed. About 459 participants aged 70 and older will receive either CARE or standard supportive counseling over the phone.…

This study tests whether immersive virtual reality (VR) exercises can improve memory, attention, and thinking speed in people with cancer who have mental fogginess after chemotherapy. Sixty participants will either use VR-based cognitive, physical, and mindfulness training or do …

This study tests if a special type of acupuncture (on the tongue area) can reduce taste problems caused by chemotherapy in people with gynecologic cancers. 75 participants will be randomly assigned to real acupuncture, fake acupuncture, or standard dietary advice. The goal is to …

This study tests whether regular massage therapy can improve sleep for children aged 12-21 who are hospitalized for cancer treatment or stem cell transplant. Seventy participants will either receive standard care or a 20-30 minute massage five days a week for three weeks. Sleep w…

This study looks at whether acupuncture can help young women (ages 15-40) with cancer get their periods back after chemotherapy caused them to stop. About 60 participants will receive acupuncture or usual care. Researchers will measure how many people join and finish the study, a…

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This study tests whether a mobile app called EnergyPoints can help cancer survivors reduce fatigue and improve sleep by guiding them through self-acupressure. About 180 adults who have or had cancer and feel at least moderately tired will use the app daily for six weeks while wea…

This study tests whether a mobile app exercise program can improve physical function and reduce fatigue in older adults (age 60+) with myeloid neoplasms, a type of blood cancer. Participants will either use the app for guided walking and resistance exercises or receive standard e…

This study tests a therapy called EMDR Toolbox to see if it can improve the psychological well-being of people with early-stage cancer. About 46 participants will receive either standard EMDR or the enhanced Toolbox method over 15 sessions. The goal is to reduce distress, anxiety…

This pilot study is testing a combined program of mobile health exercise and cognitive rehabilitation for older cancer survivors (age 60+) who have concerns about memory or thinking after treatment. The program uses a smartphone app for exercise tracking and group workshops for b…

This study tests whether a smartphone app called Resilience PRO can improve quality of life for cancer patients receiving chemotherapy or other systemic treatments. About 1,458 adults with any stage of cancer will either use the app to report symptoms (with alerts sent to their c…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study tests a 4-month coaching program called SONATA that helps older adults (age 60+) with advanced cancer build a support network of family and friends. The goal is to see if this social support makes it easier to stick with treatment and feel better. About 330 patients an…

This study tests whether live, group-based exercise classes held over Zoom can help cancer survivors increase their physical activity, improve fitness, and enhance quality of life. Researchers will randomly assign 300 cancer survivors to either live online classes or recorded exe…

This study is testing whether a daily testosterone gel can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. The trial involves 230 participants who will apply either the gel or a placebo for six months. Researchers will mea…

This study looks at whether a supervised exercise and health counseling program can help children and teens (ages 4–21) who have had a stem cell transplant for cancer. Many young patients survive but face long-term weakness, fatigue, and lower quality of life. The program aims to…

This study tests whether telepresence robots can help children aged 5-17 with cancer attend school remotely when they can't be there in person. The robots let kids see, hear, and talk in class from their hospital or home. Researchers will track school attendance, social well-bein…

This pilot study tests a 4-week personalized exercise program for people aged 70 and older who are about to have cancer surgery. Participants follow daily exercises at home using a smartphone app. The goal is to see if this approach improves their physical fitness before the oper…

This study tests a personalized physical activity program for cancer survivors who have finished an exercise class. About 105 adults who completed cancer treatment in the last five years will join. Researchers will see if the program helps them stay active and improve quality of …

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study tests if creating a short digital story about their cancer journey can reduce depressive symptoms and improve self-esteem and quality of life in Hong Kong Chinese teens who have finished cancer treatment. About 248 survivors aged 13-18 will either join four 2.5-hour wo…

This study tests whether combining aromatherapy (smelling essential oils) with hypnosis can help cancer patients feel more comfortable during uncomfortable procedures like blood draws or dressing changes. About 66 adults with cancer will be randomly assigned to receive hypnosis a…

This study is testing whether a 12-week supervised cycling program can reduce nerve pain and improve quality of life in 30 adults who have had chemotherapy for cancer. Participants will ride a stationary bike twice a week for up to an hour. The main goal is to see if people find …

This study tests whether a structured, symptom-driven care pathway improves symptom control and satisfaction for adults with advanced cancer receiving outpatient palliative care. 120 participants will be randomly assigned to either standard care or a tailored pathway that trigger…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests whether digital exercise programs can help cancer patients during or after treatment. Researchers in Denmark, Sweden, Germany, Poland, and Lithuania will enroll 300 people. The goal is to see if remote rehab is practical and acceptable, not yet to prove it works.

This study tests whether using a virtual reality helmet during painful medical procedures (like needle sticks or bone marrow tests) can reduce pain in children with cancer. About 74 children aged 6 to 18 will be split into two groups: one gets standard care plus the VR helmet, th…

This study tests a personalized program called SPOT-ON for cancer patients suffering from severe shortness of breath. Participants will receive a combination of breathing techniques, relaxation methods, posture adjustments, and oxygen-based therapies, either starting early or aft…

This study tests whether a 12-week tele-exercise program called RISE-YA can help reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants receive energy conservation counseling, behavior coaching, and exercise training via video calls…

This study tests a short program designed to improve the emotional wellbeing and quality of life of people caring for a loved one with advanced cancer. Researchers will enroll 150 adult caregivers who live with a patient with stage IV cancer. Participants will learn skills to inc…

This study tests if the drug ustekinumab can control diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. Ten adults with solid tumors who have moderate to severe symptoms will receive ustekinumab and be monitored for side effects and symptom…

This study tests two supportive care programs—meditation and discussion sessions—for people with advanced (stage IV) cancer and their family caregivers. Researchers want to see if these programs can reduce depressive symptoms and improve quality of life. About 400 patient-caregiv…

This study tests whether offering free legal navigation services to cancer patients and their caregivers can reduce financial stress and improve quality of life. About 60 adults who have or care for someone with cancer and face legal barriers to care will receive direct legal hel…

This study tests whether a friendly animated pet avatar on a tablet, guided by a human-AI team, can help reduce anxiety and improve quality of life for adults undergoing outpatient stem cell transplant for cancer. About 90 participants will be randomly assigned to receive the ava…

This study tests whether a single dose of NPX-5 (a psilocybin drug) combined with talk therapy can reduce severe anxiety in people who have trouble adjusting to a cancer diagnosis. About 87 adults aged 18–80 with moderate-to-severe anxiety will receive one of three doses (25 mg, …

This study is testing whether a yoga program designed to fit different cultures can help cancer patients who are getting a stem cell transplant. About 60 adults in India, Tanzania, and the United States will take part in up to 12 yoga sessions before and during their hospital sta…

This study tests whether a visual communication tool called MyCareGorithm helps newly diagnosed cancer patients understand their treatment options. About 86 patients with breast or head and neck cancer, along with their caregivers, will use the tool during consultations. The main…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This pilot study is testing whether intermittent fasting (calorie restriction on alternate days) combined with a plant-based protein diet can help cancer patients respond better to chemotherapy. The study will enroll 30 adults with various cancers who are scheduled for chemothera…

This study tests a smartphone app called iCANSleep, which provides a type of talk therapy (CBT-I) to help cancer survivors with insomnia. Researchers will enroll 146 Canadian cancer survivors who have trouble sleeping and compare those using the app to a waitlist group. The goal …

This study looks at whether giving cancer survivors free healthy food and online cooking lessons can improve their health and well-being. The program is for survivors who struggle to afford food and are treated at a safety-net hospital. Researchers will check if the program is sa…

This study looks at whether using the Calm meditation app for 10 minutes a day can help blood cancer patients who have trouble sleeping. Researchers will track sleep, mood, and inflammation in 276 participants over 20 weeks. The goal is to find a simple, drug-free way to improve …

This pilot study is testing whether a personalized exercise and rehabilitation program given before cancer treatment (called prehabilitation) can help adults with cancer maintain their function and quality of life. Sixty participants will be randomly assigned to either receive th…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests a program that helps cancer patients deal with legal problems like insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will get free legal navigation and be followed for 6 months. Researchers want to see if this support…

This study is testing whether a mobile app that combines daily symptom reports with Fitbit data can help cancer patients better manage side effects during chemotherapy. Fifty adults with solid tumors will use the app for 90 days, receiving tips for mild symptoms and alerts to con…

This study is testing whether resistance training combined with a post-workout protein drink can help women with breast cancer maintain muscle and reduce fat gain while they undergo chemotherapy. Thirty women will be randomly assigned to receive either 20 or 60 grams of whey prot…

Depression is common among cancer survivors, but many don't get help. This pilot study tests a text-based referral platform that sends tailored messages and a video to encourage survivors to take up a mental health referral. The study will enroll 60 cancer survivors with depressi…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests a program called TIPPI-R that teaches children with cancer and their families ways to manage pain and distress during treatment. About 100 children aged 0-18 will either receive the program or standard care. Researchers will compare how well they cope with pain a…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program uses video sessions and online materials to teach skills for managing symptoms like pain, fatigue, and emotional distress, and to encourage follow-up care. Rese…

This study tests whether an internet-based pain coping skills program can help cancer survivors manage ongoing pain. About 456 adults who have completed cancer treatment or are on maintenance therapy will take part. Participants will either get the online program plus enhanced us…

This study tests whether group education sessions can help veterans with newly diagnosed cancer discuss their goals of care and complete advance directives. Fifty veterans will attend two virtual or in-person sessions led by a trained health educator. Researchers will check if th…

This study tests whether a virtual group writing program can improve quality of life for young adults who survived cancer. Thirty survivors aged 18-39, diagnosed 1-5 years ago, will write about their cancer experiences in a group setting. The goal is to see if this simple, access…

This study looks at whether guided play sessions can help children aged 10 to 18 with leukemia handle pain and regulate emotions while receiving chemotherapy. Over 4 weeks, kids will take part in therapeutic play during their treatment. Researchers will measure changes in pain to…

This study looks at two different exercise programs—using flexi bands or whole-body electrical stimulation—for people with cancer. The goal is to see which one better helps maintain muscle strength, reduce inflammation, and improve quality of life during treatment. About 100 part…

This study looks at whether socio-aesthetic care (like skincare and makeup sessions) can lower anxiety in cancer patients who are starting chemotherapy. About 192 people who have never had chemo before will take part. Researchers will measure their anxiety levels before treatment…

This pilot study tests a brief psychotherapy program for young adults (ages 25-39) with cancer and their caregiving partners. The therapy uses cognitive-behavioral and couples therapy techniques to improve coping and maintain the relationship. The study will enroll 20 couples to …

This study tests whether a nerve block called the transversalis fascia plane block can reduce pain after inguinal lymph node removal in cancer patients. The goal is to lower the need for strong painkillers like opioids, which can cause nausea, dizziness, and breathing problems. 9…

This study tests a virtual reality (VR) program that uses cognitive behavioral therapy to help people with long-term cancer pain. Forty adults with cancer and pain lasting at least 3 months will use the VR headset at home for 10 minutes daily over two weeks. The goal is to see if…

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to reduce d…

This study tests a nurse-led program called Dreamcatchers to help children aged 6-12 with cancer sleep better. The program uses relaxation techniques like breathing exercises and muscle relaxation instead of sleep medications. About 68 children will take part to see if this appro…

This study tests a medicine called naldemedine for constipation caused by opioids (strong painkillers) in people with cancer. About 100 adults with cancer who take opioids and still have constipation despite laxatives will receive naldemedine. Researchers will measure how well it…

This study aims to help Asian American cancer patients and their caregivers feel better emotionally and reduce the sense of burden. Researchers will test a program of positive activities designed to boost feelings of independence, skill, and connection. About 186 patient-caregive…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment manage stress and build resilience. Participants will use the app to learn skills to cope with difficult situations. The goal is to see which version …

This study explores whether virtual reality (VR) can help people with cancer manage chronic pain and possibly reduce their need for opioid painkillers. Researchers will ask 25 adults with cancer-related pain to use a VR headset for at least 10 minutes daily for one week. The goal…

This study tests whether spending time with horses can improve quality of life and reduce anxiety in children and teenagers (ages 8-17) who are receiving radiotherapy for cancer. Participants will take part in 10 horse-assisted therapy sessions. The goal is to see if this approac…

This study tests whether electroacupuncture, a type of acupuncture with mild electrical pulses, can safely reduce depression in people with cancer. Researchers will enroll 86 adults with cancer-related depression and give them electroacupuncture sessions targeting specific points…

This study tests whether watching a virtual reality video about radiotherapy before treatment can lower anxiety in cancer patients. About 150 adults with cancer will be randomly assigned to see a standard 2D video, a first-person VR video, or a third-person VR video. Researchers …

This phase 3 trial is testing whether adding chaplain-provided spiritual care or psychotherapy/meditation to standard palliative care can improve survival and quality of life in people with advanced, non-curable cancer. About 854 participants with a life expectancy of one year or…

This study tests whether taking a fisetin supplement can lessen fatigue in older adults who have survived cancer. About 60 people who finished cancer treatment more than a year ago will take fisetin or a placebo. Researchers will measure changes in fatigue levels using a standard…

This study tests whether EMDR therapy can reduce nausea and vomiting that some cancer survivors continue to experience long after chemotherapy ends. About 20 adults who have finished cancer treatment and still have these symptoms will receive EMDR sessions. The goal is to see if …

This study tests a nurse-led program to help cancer patients be more physically active while receiving chemotherapy. About 50 adults with cancer will take part. The program includes activity plans, safety checks, and support tools. The goal is to see if this approach is practical…

This study tests whether cognitive behavioral therapy (CBT) can reduce fear, anxiety, and depression in cancer patients who are distressed about stopping immunotherapy. One hundred adults who have finished immunotherapy will receive CBT sessions. The goal is to see if this talkin…

This study tests whether a 12-week at-home taste and smell training program can improve taste function in cancer patients who experience taste changes from tyrosine kinase inhibitors. Ninety participants across 12 Dutch hospitals will be randomly assigned to the training or stand…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This study tests a mobile app called Mio-App designed to help children and teenagers with cancer improve their thinking, memory, and motor skills. The app includes cognitive and physical exercises along with questions to boost self-awareness. Researchers will enroll 40 participan…

This study tests an online, therapist-guided program to help cancer survivors who have anxiety, depression, or fear of cancer returning. About 400 adults in Sweden who finished cancer treatment at least 6 months ago will take part. The goal is to see which parts of the 10-week on…

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study is testing whether a 12-week high-intensity functional training program, like CrossFit, can improve movement, body composition, and quality of life in cancer survivors. Researchers will enroll 500 adult cancer survivors who have been cleared by their doctor. The goal i…

This study looks at whether combining a stepped-care mental health program with an exercise plan can improve mood and physical activity in Latina cancer survivors. Twenty women who are currently in or recently finished cancer treatment will take part. The goal is to see if this a…

This study tests a program called Mental Health CPR, designed to help Hispanic/Latino cancer survivors in Puerto Rico improve their emotional well-being and connect with mental health services. About 1,260 participants will attend community sessions led by trained workers, compar…

This study tests a brief motivational program to increase physical activity in 84 cancer survivors who are part of the World Trade Center Health Program. The program combines counseling, a Fitbit to track steps, and personalized activity planning. The goal is to see if participan…

This study tests whether adding olanzapine to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children will be randomly assigned to get either olanzapine or a placebo. The goal is to see if olanzapine helps more kids…

This study is testing a supervised exercise program for people with cancer. Participants will take part in group exercise classes twice a week for 8 to 12 weeks. The goal is to see if the program helps improve physical activity levels and manage cancer-related symptoms. The study…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests whether personalized text messages and support from a peer coach can help Black female cancer survivors keep up a regular exercise routine after treatment. Researchers will enroll 260 women and track their physical activity, fatigue, and quality of life. The goal…

This study tests whether adding motivational counselling to a supervised virtual exercise program helps cancer survivors stay physically active. 236 survivors who have finished primary cancer treatment will be split into two groups: one gets standard exercise advice, the other ge…

This early-stage study tests an inhaled form of fentanyl, a strong painkiller, in 100 Chinese adults with cancer. The goal is to see how safe it is and how the body processes it compared to fentanyl given through an IV. Participants will receive both forms in a random order to co…

Many parents of childhood cancer survivors struggle with intense fear that their child's cancer will come back. This study tests a 7-session group therapy program, adapted from one used for adult survivors, to see if it is acceptable and helpful for parents. Thirty-six parents in…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce chronic nerve pain in people with cancer. Sixty participants will receive both real and sham (placebo) stimulation in a crossover design, with an 8-week break in between. The goal is to see…

This study tests a program called CARES that provides cancer patients with integrated screening and stepped care for symptoms like pain and depression. About 1,750 adults with cancer will be randomly assigned to CARES or standard care. The goal is to see if CARES improves quality…

This study tests whether a digital art therapy app called ARTCan is practical and acceptable for young adults aged 18-25 who survived childhood cancer. Participants use the app for 6 weeks to create art and complete mood surveys. The goal is to see if at least 10 out of 15 partic…

This study compares three routine pain control methods used during minimally invasive cancer surgery: a nerve block plus local anesthetic, nerve block alone, or local anesthetic alone. About 48 adults having surgery for various cancers will be randomly assigned to one of the thre…

This study tests whether a nature-based healing meditation program can help friends and family caregivers who are grieving the loss of a loved one to cancer. The program includes six audio meditation modules available online. Researchers will measure how feasible and acceptable t…

This pilot study tests two surgical methods—targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI)—alone and together to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned …

This study is testing whether giving cancer patients in Maine free, medically tailored groceries plus nutrition counseling can improve their diet and well-being. One hundred adults with any stage or type of cancer will be split into three groups: one gets groceries and counseling…

This study tests whether giving cancer patients personalized advice on nutrition and palliative care can improve their quality of life, daily functioning, and nutritional health. About 215 adults receiving standard cancer treatment in Bangladesh will be randomly assigned to get t…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study follows 6,000 adults with solid tumors who are receiving immune checkpoint inhibitors as part of their routine cancer care. Researchers are tracking how long patients live and how long their disease stays under control. The goal is to learn how well these drugs work in…

This registry collects detailed information from cancer patients treated with proton radiation therapy. Researchers will track treatment plans, side effects, and quality of life over 15 years. The goal is to learn which patients benefit most from this precise form of radiation an…

This study tests a Clinical Trials Navigator program that helps cancer patients, families, and doctors find and enroll in clinical trials outside their local cancer centre. The program will be rolled out to 20 centres across Canada, starting with Thunder Bay and Winnipeg. Researc…

This study follows about 700 cancer patients who have already received radiation therapy to understand the long-term side effects and how their disease progresses over time. No new treatments are given—researchers simply collect data from routine follow-up visits. The goal is to …

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This observational study is looking at whether certain markers in the blood can predict immune-related side effects in cancer patients receiving immunotherapy. Researchers will collect blood samples and health data from 200 participants during routine visits. The goal is to bette…

This study is translating and testing an Italian version of a questionnaire that measures anxiety in cancer patients during whole-body MRI scans. Researchers will enroll 175 adult cancer patients at the European Institute of Oncology. The goal is to ensure the Italian version is …

This study enrolls 750 adults in Chicago to see if working with a trained health navigator (a non-clinical guide) helps people complete recommended cancer screenings. Participants are randomly assigned to standard navigation or navigation plus a health checklist. The study lasts …

SPECTA is a large research platform that collects tumor samples, genetic data, and patient information from nearly 5,000 people with all types of cancer. The goal is to help scientists better understand cancer biology and find new ways to match patients with the right clinical tr…

This study is a disease registry that will follow about 700 people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. Researchers will collect information on patient characteristics, treatments, and outcomes over time to better un…

This study tests an artificial intelligence (AI) tool designed to help doctors and physicists review radiation treatment plans for cancer patients before therapy begins. The AI highlights differences in how providers plan treatments and flags potential warning signs, aiming to re…

This study is testing whether people in early-phase cancer trials will consistently wear a smartwatch and complete weekly symptom surveys on a phone app. Thirty participants will use the devices for 4 weeks. The goal is to see if this approach is practical and acceptable, not to …

This study tests a digital app called the Genetics Adviser for Mainstream Care (GA-Mainstream) that educates cancer patients about genetic testing and delivers their results. Researchers want to see if using the app reduces distress and improves the patient experience compared to…

This study is testing a new PET-CT scanner that takes high-resolution images of tissue removed during cancer surgery. Researchers want to see if these images match lab results and help surgeons make better decisions. The study will include 850 people with prostate, breast, head a…

This study tests an online portal called SCP-PHR designed to help colon and rectal cancer survivors manage their survivorship care. Researchers will enroll 250 adults who have completed initial treatment within the past year. The goal is to see if the portal improves how often su…

This study is testing a digital platform called the Genetics Navigator to see if it can reduce distress for people undergoing genetic testing. The platform provides education, counseling, and management recommendations. Researchers will compare it to standard care in 170 adults a…

This study follows 334 cancer patients to see if switching between different-looking generic chemo pills affects their adherence and health outcomes. Researchers will track pill counts and patient surveys over six months. The goal is to understand if changes in pill color, shape,…

This study tests a program called SUPPORT that helps Black and Latino cancer patients learn about and join clinical trials. The program includes a website and a navigator who guides patients. Researchers will see if this increases the number of patients referred to and enrolled i…

This study follows 10,000 childhood cancer survivors treated at St. Jude Children's Research Hospital over their entire lives. Researchers will track health problems that may appear years after cancer treatment, such as heart issues or second cancers. The goal is to learn how to …

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21 between 1970 and 1999) and 10,000 of their siblings. Researchers want to understand how cancer treatments like radiation, chemotherapy, and surgery affect health years later. By comparin…

This study will follow 1 million Chinese adults with cancer to measure how common and severe cancer-related fatigue is. Researchers will look at what factors influence fatigue and how it affects treatment and survival. The goal is to better understand this common but often overlo…

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study is collecting blood and urine samples from 150 cancer patients who have had blood clots. The goal is to learn more about why clots happen in cancer and how to prevent them. Participants will be followed over time to track clot recurrence and bleeding risks.

This study looks at 100 people with advanced solid tumors whose cancer stopped responding to immunotherapy. Researchers will take a fresh tumor sample and blood tests to compare genetic and immune differences between those who never responded and those who initially improved but …

This study is testing a program to help Native American cancer patients get better coordinated care. It brings together a cancer center and tribal health systems to improve communication and support. About 187 adults newly diagnosed with cancer will take part. The goal is to see …

This long-term study aims to uncover the causes of cancer by following 200,000 adults aged 30–70 who have never had cancer. Participants complete online surveys, donate blood, urine, and saliva every few years, and share their electronic health records. The goal is to learn how l…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This pilot study explores whether eating high-fermented foods (like yogurt and kimchi) followed by high-fiber supplements can change the gut microbiome and improve immune response in people with melanoma or lung cancer who are receiving standard immunotherapy. Researchers will tr…

This study collects tumor tissue, blood, and cheek swabs from 50 adults with cancer to create personalized 3D models in the lab. Researchers will analyze the genetics and drug responses of these models to find new treatment targets. The goal is to improve understanding of aggress…

This study is checking how well lower lip reconstruction works after skin cancer removal. About 20 patients who had the surgery will fill out questionnaires about how their lip looks and works, and how it affects their daily life. Doctors will also review the results to help impr…

This study looks at whether cancer patients are willing to share information about their social and economic background, such as income, education, and housing. Researchers want to learn what barriers people face when joining clinical trials and getting healthcare. About 1,000 ad…

This study will follow 6,000 children, adolescents, and young adults with cancer in low- and middle-income countries. Researchers will collect data from medical records and questionnaires to understand why treatment failure and severe side effects are more common in these setting…

This study aims to learn how genes and the environment contribute to rare tumors and cancer risk in individuals and families. Researchers will collect medical histories, genetic samples, and health data from up to 500 participants of all ages. No treatment is given; the goal is t…

This study follows 600 childhood cancer survivors aged 8-18 to understand why symptoms like fatigue, pain, and depression often occur together. Researchers will use questionnaires and stool samples to see if gut bacteria and their byproducts play a role. The goal is to find bette…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This study collects tissue and fluid samples from up to 5,000 cancer patients to help researchers learn more about cancer and develop new tests and treatments. Samples are taken from routine procedures or from extra biopsies done just for research. The goal is to build a resource…

This study looks at 200 adults with moderate to severe cancer pain who are taking opioid painkillers like hydrocodone or oxycodone. Researchers will use smartwatches and questionnaires to track pain, sleep quality, and mood over three months. The goal is to understand how pain, i…

This study tests whether a digital chatbot can help more adolescents and young adults (AYA) with cancer get genetic counseling and testing compared to standard remote services. About 535 participants aged 18-39 will use either a chatbot or standard telehealth. The goal is to see …

This study enrolls adults with cancer or benign tumors who are already participating in other trials at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a patient's past, current, and future studies. The goal is to …

This study looks at how to help cancer patients from low-income and low-literacy backgrounds take their oral chemotherapy pills correctly. Researchers will test different support strategies to see which ones work best. The goal is to reduce missed doses and improve overall care f…

This study aims to build a large biobank of blood samples from 40,000 cancer patients to help identify biomarkers that can predict survival and response to treatment. Participants provide an extra 36ml of blood during routine blood draws. The samples will be used in future resear…

This study is testing a mobile app called EveryDose to see if it helps cancer patients take their oral chemotherapy medications on time. About 25 adults with cancer who are starting a new oral chemo drug will use the app for 12 weeks. The goal is to learn if the app is easy to us…

This study looks at how to better support adults aged 65 and older during chemotherapy. Researchers will use a frailty score to create personalized care plans and track how well participants handle treatment. The goal is to see if this approach improves resilience and reduces hos…

This study asks 300 adolescents and young adults (ages 15-39) who have or had cancer to fill out questionnaires. The goal is to find gaps in education about exercise, sexual health, fertility, finances, and more. No treatment is given—just a survey to help improve future care.

This study collects blood and tumor samples from 700 adults receiving approved CAR-T therapy for blood cancers. Researchers will analyze these samples to identify biological markers that predict whether the therapy will work or if the cancer will return. The goal is to improve fu…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is testing a new questionnaire called PRO-AYA, designed to measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers want to see if the survey is reliable and accurate, including a Spanish version. 120 participants will fill out the …

This study, led by Mayo Clinic, will take leftover tumor tissue from 250 cancer patients after surgery. Researchers will treat small fragments of the live tumor with different chemotherapy and immunotherapy drugs in the lab, monitoring responses over 72 hours. The goal is to see …

This study works with cancer survivors and their loved ones living in poor areas to improve their diet and physical activity. Researchers will adapt existing health programs to fit the community's needs. About 100 participants from the Birmingham area will track their eating, exe…

This study looks at the reasons parents consider when deciding whether to enroll their child in a cancer clinical trial. Researchers will survey and interview 400 parents of children newly diagnosed with cancer. The goal is to understand how social factors, personal preferences, …

This study is testing whether a new tool called xDRIVE, which combines artificial intelligence and tumor profiling, can quickly suggest personalized treatment options for cancer patients in Florida whose cancer has come back or not responded to standard treatments. The goal is to…

This study is testing a new safety tool for cancer patients on chemotherapy. Patients wear a wristband with a QR code. If they go to the emergency room, doctors can scan the code and quickly fill out a checklist about possible serious side effects. The goal is to see if this help…

This study uses anonymous surveys to ask cancer patients, healthcare professionals, and industry workers whether the UK's 1939 Cancer Act—which bans advertising cancer treatments to the public—still works in today's digital world. The goal is to understand how people use online a…

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study is developing and testing a program to help female adolescent and young adult cancer survivors make informed decisions about building a family after treatment. The program includes four video sessions that provide personalized education about fertility risks and coping…

This study follows 1,538 cancer patients in China to see how their nutritional status affects how well they handle chemotherapy and radiation, their quality of life, and how long they live. Researchers will track changes in diet, weight, and blood markers over time. The goal is t…

This study is building a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Participants will complete physical and mental function tests, surveys, and provide blood samples over time. The goal is to learn how cancer and its treatments affect agi…

This study is for people with advanced cancers who are taking long-term targeted treatments. Researchers want to learn about their experiences through interviews. The goal is to find better ways to support these patients. The study is currently recruiting 75 participants.

This study aims to learn how tumors and healthy tissues change during radiotherapy. Researchers will use a special MRI machine built into the radiation device to take detailed images during each treatment session. About 250 cancer patients and 10 healthy volunteers will participa…

This study is testing whether a website with a virtual community health educator can help Black and Hispanic cancer patients in Florida learn about and sign up for clinical trials. About 350 adults will be randomly assigned to either a standard information portal or one with a vi…

This study looks at two ways to place a thin, flexible tube (called a PICC) in cancer patients who need long-term IV treatments. One method uses magnetic tracking, and the other uses heart signals (ECG) to guide the tube to the right spot. Researchers want to see which method wor…

This study tests a high-resolution PET-CT scanner that images removed tumors right in the operating room. About 50 adults with solid cancers will get a standard PET tracer before surgery, then the removed tissue is scanned to see if all cancer was taken out. The goal is to see if…

This study looks at how tumors and nearby healthy organs change in size and shape during and after radiation therapy. Researchers will measure these changes in 500 people who have already completed radiation treatment. The goal is to learn more about these changes so doctors can …

This study looks at whether giving doctors genetic information about their patients can help them choose safer and more effective pain medications. Researchers will enroll 800 cancer patients who are expected to need opioid painkillers. Half will have their genes tested to guide …

This study tests a new approach called RIGHTimeCPV, designed to help children with poor-prognosis cancer and their families talk more openly with doctors about the future. Participants choose a communication companion and attend a special visit to share their preferences. The goa…

This registry is collecting information from 2,000 people with metastatic cancer who are receiving radiation therapy as part of their standard care. Researchers will gather clinical data and patient-reported outcomes to better understand how radiation affects cancer outcomes. The…

This study is collecting blood samples from 300 cancer patients to look for immune cells that target tumors. Researchers want to understand how the immune system responds to cancer and treatments. The study does not test a new drug or therapy, but aims to gather knowledge that co…

This study aims to understand what helps or hinders a positive experience for Asian patients being treated for cancer at MD Anderson. Researchers will survey former patients and healthcare providers to identify key factors. The goal is to use these insights to improve care and su…

This study looks at how satisfied cancer patients are after a special team assessment in a day hospital. About 309 adults with cancer will fill out a questionnaire after meeting with a pharmacist, dietitian, psychologist, social worker, and other care providers. The goal is to fi…

This study looks at how to help people with both HIV and cancer stay engaged in their HIV care while receiving cancer treatment. Researchers will first observe 150 patients to identify barriers, then develop and test strategies to improve care. A second group of 150 patients will…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers will track their physical and emotional distress, financial burden, care needs, and quality of life over one year. The goal is to develop a tool that can predict which patients are at …

This study is testing whether a 3-week program of eating walnuts, supervised exercise, and nutrition counseling is practical for American Indian adults recently diagnosed with cancer. The 30 participants will follow the program before starting their cancer treatment. Researchers …

This study is testing a new AI tool that creates patient-friendly summaries of radiology reports for people with cancer. The goal is to see if these easy-to-read summaries help patients better understand their scan results and reduce the number of questions doctors receive. About…

This study trains high school students (ages 15-18) to become health advocates and talk with adults in their community about cancer screening. The goal is to see if these youth-led conversations can increase screening rates among adults who are overdue. About 84 pairs of students…

This study explores whether a device that sends a tiny, safe electrical current through the body can better track fluid retention (edema) in cancer patients. Researchers will measure 46 people—breast cancer patients with arm swelling after radiation and others with leg swelling a…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. Researchers want to see if the program is practical and helpful for improving sleep quality, reducing stress, and boost…

This study uses surveys and phone interviews to learn how COVID-19 impacts people with cancer. Researchers want to understand the challenges these patients face during the pandemic. About 50 adults with cancer will take part. No treatments or medications are involved.

This study looks at how children with cancer (ages 12-25) and their families experience hope while taking part in early-phase clinical trials. Researchers will use photos and interviews to understand how hope changes over time. The goal is to find better ways to support families …

This study tests a 4-session virtual program called CHAT-S for young adult cancer survivors aged 26-39. The program aims to improve their understanding of health insurance, reduce financial burden, and help them get recommended follow-up cancer screenings. Researchers will track …

This study looks at whether exercise after finishing cancer treatment is linked to better outcomes, like longer survival without the cancer coming back. Researchers will analyze data from 1,000 adult cancer survivors at Memorial Sloan Kettering. The goal is to see if those who ex…

This study collects and freezes testicular tissue from boys and young men who are at risk of becoming infertile due to cancer, autoimmune disorders, or their treatments. The tissue is stored in a research bank, with the hope that future medical advances will allow it to be used t…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study looks at whether it is safe and beneficial for people with advanced cancer to stop taking statins, which are cholesterol-lowering drugs often used for prevention. Researchers will follow 80 patients in palliative care for 12 weeks, monitoring cholesterol levels, muscle…

This study is a large registry that collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national data to better understand the b…

This study tests a program called 'My Care My Voice' that gives cancer patients and their doctors tools like videos, brochures, and conversation cards to make it easier to talk about palliative care. The goal is to help patients bring up their care needs earlier, so they can get …

This study looks at why certain groups of cancer patients—such as those from minority backgrounds or lower-income areas—are less likely to take part in research. By surveying 300 patients and mapping where they live, the team hopes to identify barriers and improve access. The goa…

This study collects and analyzes personal writings from 500 teenage cancer patients to understand their emotions and experiences. The goal is to improve communication between patients and healthcare providers and make hospital care more supportive. No new drugs or treatments are …

This pilot study tests two new technologies—HyperSight CBCT imaging and Ethos adaptive planning—in children receiving radiation for non-brain tumors. Twenty patients aged 18 or under will get extra scans twice a week to see if the radiation plan needs adjusting. The goal is to se…

This study is testing a new questionnaire called SOCS-OTS to see if it can correctly identify cancer survivors who need occupational therapy. Researchers at MD Anderson will compare it to a standard screening tool in 80 adults. The goal is to make sure the new tool accurately fin…

This study looks at cancer patients who have a type of blood clot called superficial venous thrombosis (SVT). About 15-20% of SVTs happen in people with cancer, but there are no clear treatment guidelines for them. Researchers will observe 1,576 patients to see how different bloo…

This study is collecting blood samples from up to 2050 cancer patients to look for tiny pieces of tumors, called biomarkers, in the blood. The goal is to see how often these markers can be detected. Participation does not change standard cancer care or treatments.

This study tests whether special heart MRI scans can find early signs of heart damage in cancer patients getting anthracycline chemotherapy. Current tests often miss this damage until it's advanced. About 93 adults will get several MRI scans before, during, and after treatment. T…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for image-guided treatments. Researchers will use donated organ samples (not live patients) to see if the marker is easy to place, stays in place, and shows up clearly on scans. …

This study aims to validate a questionnaire that measures anxiety in cancer patients before surgery. Researchers will test the Italian version of the Surgical Anxiety Questionnaire (SAQ) with 180 adult patients. The goal is to better understand patients' fears and concerns so tha…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study is for people with advanced cancer. Researchers will use a special genetic test on tumor samples to look for DNA changes. The goal is to see if these test results can help doctors choose a more personalized treatment. Up to 1000 participants will be enrolled, and the s…

This observational study will enroll 100,000 adults aged 35 and older to build a registry and biorepository focused on cancer health disparities. Participants will provide health information, complete questionnaires, and donate blood, saliva, and stool samples over five years, wi…

This study is creating a repository of tumor, tissue, and blood samples from cancer patients. The goal is to store these biospecimens for future research that could improve our understanding of cancer. Up to 10,000 participants will provide samples during their routine care at th…

This study is testing whether wearable devices that monitor heart rate and other vital signs can help doctors and nurses spot infections and other problems earlier in hospice patients with advanced cancer. The researchers will also see if these measurements can help predict how l…

This Mayo Clinic study is observing 500 adults who have had or will have a multi-cancer detection (MCD) blood test. Researchers want to see how these tests affect medical decisions, patient emotions, and satisfaction in everyday practice. Participants will give blood samples and …

This study aims to find markers and causes of cancer by analyzing participants' DNA, RNA, and tissue samples. Researchers will use this information to improve cancer prevention, early detection, and treatment. The study will enroll 500 adults with cancer at Mayo Clinic.

This study tests a program called CTNow, which uses educational videos for patients and workshops for doctors to help rural cancer patients in Hawaii learn about and access clinical trials. About 50 patients and their providers will take part. The goal is to see if the program in…

This study looks at people who developed cancer at a young age (before 40, or before 30 for breast cancer) but had normal results on standard genetic tests. Researchers will use a more advanced technique called exome sequencing to search for new genetic changes that might raise c…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make informed treatment choices. About 1,020 participants will be randomly assigned to use the tool or receive standard information. T…

This study is testing a short set of questions to see if it can consistently capture the support needs and symptoms of cancer patients. Researchers will ask 900 patients and their healthcare providers about how easy and useful the questions are. The goal is to create a standard t…

This study explores whether cancer patients can drink a radioactive sugar solution instead of receiving it through an IV for PET scans. Researchers will compare image quality and find the best time to scan after drinking. About 27 adults who already had a standard PET scan will g…

This study is collecting information from up to 10,000 cancer patients to see if choosing treatments based on the genetic makeup of their tumors leads to better outcomes. Researchers will look at medical records and may test leftover tissue or blood samples to create a genetic pr…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study aims to see if community education, a digital referral portal, and newsletters can increase the number of Black and Hispanic patients enrolling in cancer clinical trials at Moffitt Cancer Center. Over 7,600 community members, doctors, and staff will take part. The goal…

This study aims to bring molecular markers into routine care for patients with rare adrenal cancers. Researchers will collect blood, urine, and tumor samples from 450 patients before and after surgery to see if these markers can guide treatment decisions. The goal is to make thes…

This study looks at whether the amount of vitamin D in your blood affects your chance of developing thyroid problems while receiving immunotherapy for cancer. Researchers will measure vitamin D and thyroid function before and during standard cancer treatment. The goal is to see i…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study tests a communication tool called TrialTalk™ in cancer clinics. The goal is to see if it helps doctors and patients talk more clearly about treatment options. About 30 patients and their doctors will fill out questionnaires before and after a regular visit. The study f…

This study tests a communication program called COACH-Cog for older adults with both dementia and cancer. It includes a training video for doctors and a coaching session for patients and their care partners. The goal is to see if this helps everyone work together better when maki…

This study follows 249 children and young adults with cancer who are receiving physical or neuropsychomotor therapy at hospitals across Italy. Researchers will measure changes in their ability to move and perform daily tasks over time. The goal is to understand which rehabilitati…

This study is collecting genetic and health information from 120,000 people aged 65 and older who have a personal or family history of cancer. The goal is to see if genetic testing can help doctors find cancer risks earlier and guide prevention efforts. Participants will provide …

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study is building a large collection of blood, tissue, urine, and stool samples from 10,000 cancer patients across Texas. Researchers will match these samples with detailed medical records to study why some patients respond to cancer treatments while others do not. The goal …

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …

This study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…

This study looks at what motivates people aged 70 and older with cancer to be physically active and eat healthy. Researchers will group participants based on their motivation patterns, then test a personalized program to help them improve their activity and diet. The goal is to d…

This study is collecting short video and voice recordings from 200 cancer patients—some in pain, some not—to create a secure database. The goal is to provide raw material for future artificial intelligence tools that could automatically assess pain from facial expressions and spe…

This study looks at whether people are interested in using telehealth and digital tools for genetic counseling and testing for hereditary cancer. 360 adults who meet guidelines for genetic testing will receive counseling at home and may use optional digital tools. The goal is to …

This study aims to preserve fertility for up to 500 female patients under 40 who are at risk of infertility due to cancer, autoimmune diseases, or their treatments. Participants will have an ovary surgically removed and frozen for potential future use. Researchers will also study…

This study looks at whether people with multiple myeloma who have achieved a very deep remission (called MRD-negative) can stop their maintenance therapy without the cancer coming back quickly. It involves 70 adults who have been on maintenance therapy for at least two years. Res…

This study is creating a large registry and collection of blood, urine, and tumor samples from people with cancer or benign tumors who are receiving radiation therapy. The goal is to gather health information and biological samples for future research. Anyone 18 or older with a c…

This study tests whether a Personalized Therapeutics Clinic (PTC) can lower the risk of harmful drug interactions in cancer patients. Participants get genetic testing to see how their medications interact with each other and with their genes. The goal is to help doctors prescribe…

This study looks at whether improving the clarity of patient instructions helps people stick to their daily radiation therapy schedule and feel more at ease. Researchers will give 650 first-time radiation patients updated, easy-to-understand materials and track missed treatments,…

This study interviews cancer care providers, patients, and caregivers to learn their thoughts and feelings about receiving hospital-level care at home. The goal is to understand what people know and believe about home hospital care, so that future programs can be designed to bett…

This early-stage study tests the safety of a new drug called LY4066708 in 104 healthy people. Researchers will measure how much drug enters the blood and brain, and how fast the body clears it. The study lasts up to 24 weeks and does not aim to treat any disease, but will help gu…

This study explores whether cancer patients can safely monitor their own blood counts at home during chemotherapy. About 265 participants from Denmark, Poland, and Germany will test a home monitoring device for several cycles. The goal is to reduce unnecessary hospital visits, lo…

This study looks at sleep quality in people who had cancer between ages 15 and 24. Researchers will ask 400 survivors to fill out a detailed online questionnaire about their sleep, pain, and daily life. The goal is to find out how many have moderate to severe insomnia and what fa…

This study looks at how adolescents and young adults (ages 15-29) with cancer prefer to be involved in decisions about their treatment. Researchers will use made-up scenarios to see if participants want an active, collaborative, or passive role. The goal is to better understand w…

This study looks at how the bacteria living in your gut (the microbiome) are linked to health and diseases like cancer and heart disease. Researchers will collect information from 16,000 adults over age 40 through questionnaires and samples. The goal is to build a large database …

This study is testing a virtual reality (VR) program called Life at 100.4 to help teens and young adults with cancer, along with their caregivers, learn about their diagnosis and treatment in an immersive way. About 45 participants will use the VR tool, and researchers will measu…

This study explores how a program that helps cancer patients with money problems (like paying for treatment or basic needs) affects their stress, quality of life, and emotional health. Researchers will look at data from about 40 patients and staff at a cancer clinic. The goal is …

This study enrolls 500 adults with cancer to collect blood and tissue samples over time. Researchers will analyze ctDNA (bits of tumor DNA in the blood) to see how it changes with standard treatment. The goal is to find biomarkers that could predict outcomes and guide future canc…

This study tests whether simple digital tools—like letters and text messages—can encourage adolescent and young adult survivors of childhood cancer to schedule and attend long-term follow-up appointments. About 530 participants who are overdue for care will receive different comb…

This study is creating a digital program to help East Asian immigrants with cancer build resilience and start conversations about advance care planning with their families. Researchers will interview religious leaders and test the tool with 84 patients to see if it is easy to use…

This study is enrolling 1,000 adults to track their lifestyle, family history, and health habits over time. Researchers will use questionnaires and body measurements to understand cancer risk factors. Participants found to be at high risk will be referred to a doctor for follow-u…

This study looks at why cancer patients who have needs like help with transportation, food, or housing choose not to accept support services. Researchers will survey 500 adults and interview a smaller group to understand their reasons. The goal is to improve how hospitals offer h…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study looks at how cancer patients in palliative care feel about stopping medications that are not for their cancer. About 120 participants will fill out questionnaires, watch an educational video, and receive a brochure. Researchers want to see if this information changes t…

This study looks for proteins and other markers in the blood of 2000 adults with or suspected of having cancer. The goal is to find markers that may help doctors confirm a cancer diagnosis, choose the right treatment, and predict how well a patient will respond or if the cancer w…

This study looks at the genes in cancer tumors to find mutations that might be important for how the cancer grows. Researchers will use leftover tissue from surgeries or biopsies, along with a blood or saliva sample, to compare cancer genes to normal genes. The goal is to underst…

This study looks at whether families of children with cancer are willing to join a program that provides financial support. About 40 families will be randomly assigned to either receive the PediRISE support program or standard care. The goal is to see if the program is feasible a…

This study looks at whether having a pharmacist review all medications (including those from other doctors) can improve safety for cancer patients receiving targeted radionuclide therapy. The study will include 600 adults with thyroid cancer, metastatic prostate cancer, or neuroe…

This study looks at whether a broad genetic test (microarray PGx) can find more drug-gene interactions than the standard single-gene test in 120 adults with cancer who are about to receive chemotherapy. The goal is to see if this extra information could help doctors adjust drug d…

This study compares two ways to diagnose cancer in people with fluid buildup around the lungs (pleural effusion). One method, thoracentesis, drains the fluid with a needle. The other, pleuroscopy, uses a tiny camera to look inside and take tissue samples. Researchers want to see …

This study is for adults about to start immune checkpoint inhibitor therapy for cancer. Researchers want to understand why some patients develop heart problems from this treatment. They will analyze blood samples and genetic factors from 1200 participants to find clues that could…

This study looks at how cancer survivors describe their fatigue, a common and often misunderstood symptom. Researchers will interview 80 survivors and their doctors to find common themes and language. The goal is to create a visual aid (like a Venn diagram) to help patients and p…

This study collects medical information and biological samples (blood, tissue, stool) from 1,000 cancer patients receiving immune checkpoint inhibitors. The goal is to understand why some patients develop immune-related side effects and find ways to predict and manage them. Parti…

This study looks at whether using video calls for geriatric checkups before cancer treatment can lower the number of unplanned hospital stays for patients aged 75 and older who live far from specialists. About 500 participants will be randomly assigned to either standard care or …

This study looks at whether adding an oncology research navigator (ORN) to standard cancer navigation helps patients with cancer. About 686 adults with new cancer appointments will take part. Some will get the usual navigation, while others also get an ORN who helps them find sup…

This study follows 50 cancer survivors who visit the MO.RE clinic to see how their physical activity levels change over time. The clinic offers personalized advice and support from a physiotherapist to help patients overcome barriers like fatigue or lack of motivation. The goal i…

This study is creating a large databank of blood, imaging, and tissue samples from 5,000 cancer patients. Researchers will track how patients respond to various treatments—including surgery, radiation, and chemotherapy—and look for biomarkers that predict tumor control, side effe…

This study is creating a large collection of blood and tissue samples from 100,000 adults with cancer. The samples and medical information will be stored and shared with researchers to develop better tests and treatments. The goal is to advance precision medicine and improve earl…

This study is testing a Spanish version of a questionnaire that helps identify emotional distress and unmet needs in adolescents and young adults (ages 15-25) with cancer. Researchers will enroll 100 participants to see if the tool accurately measures psychosocial challenges. If …

This study is gathering information from 500 cancer patients treated with proton therapy, a type of radiation that may cause fewer side effects than standard radiation. Researchers want to see how well it works in everyday practice and track any side effects. The goal is to build…

This study looks at whether cancer patients do better when they go to an emergency room at their own cancer hospital versus a regular hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital…

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if they get pregnant naturally, use stored eggs or tissue, or decide not to have children. The goal is to improve support and care for femal…

This study compares a self-guided online genetic testing program to standard in-person counseling for people at risk of hereditary cancer. About 1,000 adults who meet national guidelines for genetic testing will participate. The goal is to see if the online option works just as w…

This study follows 100 cancer patients aged 0-50 who used fertility preservation services to protect their ability to have children. Researchers will review medical records to see which methods led to successful pregnancies and what factors—like age or treatment type—influenced o…

This study aims to understand why some cancer patients develop autoimmune side effects when treated with immune checkpoint inhibitors. Researchers will analyze blood cells and genetics from 600 participants to identify features linked to these side effects. The goal is to improve…

This study uses brain scans (fMRI) to see if people with cancer, COPD, or heart failure have different brain activity patterns when they feel breathless. It also tests whether immersive virtual reality can help ease that breathlessness. Only 16 participants are being recruited to…

This study collects blood samples from up to 700 people, including stem-cell transplant patients and their donors, to understand how the immune system recovers after transplant. Researchers will analyze immune cells and T cell subsets to learn about immune reconstitution and graf…

This study follows people who have already received gene transfer therapy for cancer or other conditions. The goal is to monitor long-term safety and any side effects over up to 15 years. No new treatment is given; participants provide health updates and occasional blood samples.…

This pilot study tests whether a smartwatch and smartphone app can help track mood, stress, and sleep in adolescents and young adults recently diagnosed with cancer. Twenty-five participants will wear a device for 10 days and answer quick surveys. The goal is to see if this digit…

This study follows 5,000 cancer patients receiving chemotherapy or targeted drugs to watch for heart-related side effects. Researchers use regular heart tests and blood markers to detect problems early. The goal is to create a system that predicts and prevents serious heart event…

This study is gathering information from 15,000 cancer patients registered on the ROC platform across multiple centers. The goal is to track how quickly patients move through diagnosis, treatment decisions, and care, and to identify where delays or extra costs occur. No new treat…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This study looks at the gut bacteria of 16 people with advanced solid cancers who are receiving standard immunotherapy. Researchers will analyze stool samples and cognitive function to see if there is a link between the gut microbiome and how well the treatment works. The goal is…

This study tests a new care model for cancer survivors who experience late effects from treatment. About 30 doctors and their patients will use a questionnaire before visits to guide discussions and create personalized care plans. The goal is to see if this approach helps more pa…

This study tests a fertility preservation decision aid for young cancer survivors and their parents. The goal is to see if the tool helps them better understand fertility status and future parenthood options. About 358 participants will be randomly assigned to receive either the …

This study aims to find out if certain blood markers can predict how well cancer patients respond to immunotherapy. Researchers will collect blood samples from 1500 people with different types of cancer before and during treatment. Participants will be followed for up to 6 months…

This study looks at how gut bacteria might be linked to memory, thinking, and tiredness in people with cancer. Researchers will collect stool samples and do thinking tests at the start and after 6 months of standard cancer treatment. The goal is to find patterns that could help m…

This study aims to discover new genes that increase the risk of developing cancer, especially in people with a strong family history or unusual cancer patterns. Researchers will analyze genetic data from 1,500 adults and children who have or may develop inherited cancer. The goal…

This study tests a live online group class called GoPREPARE that teaches people how to get fitter, eat better, and manage stress before major cancer surgery. Researchers will recruit 24 patients awaiting surgery and randomly assign them to either the class or standard care. The g…

This study is looking at ways to freeze ovarian tissue so that people who might lose their fertility due to cancer treatment or ovary removal can still have a genetically related child later. Researchers are working on improving the freezing, thawing, and maturing of eggs from th…

This pilot study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss during treatment. 26 adults recently diagnosed with cancer will either receive usual care or meet with the navigator for six sessions over 12-18 …

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study is collecting information from 5,500 Canadian cancer patients whose tumors have rare genetic changes. Researchers want to see how well current targeted drugs work for these uncommon mutations. Participants are observed over time, and their treatment outcomes, side effe…

This study is testing a telehealth program to help young cancer patients (ages 0-50) get fertility care that matches their personal goals. The program includes needs screening, counseling, and fertility preservation services. Researchers want to see if this approach increases the…

This study is looking at tiny particles in the blood called microRNA and circulating tumor cells in 300 cancer patients who are about to start immunotherapy. By comparing blood samples taken before and after treatment, researchers hope to see how these markers change. The goal is…

This study aims to create a large collection of blood samples from 2,500 people with or at high risk for cancer. Researchers will use these samples to study liquid biopsies, which are blood tests that may help detect cancer, track treatment response, and spot recurrence. Particip…

This study looks at how the bacteria in your gut might influence diarrhea caused by cancer treatments. Researchers will follow 150 adults starting cancer therapy, collecting stool and blood samples to analyze gut microbiome changes. The goal is to better understand why some peopl…

This study aims to find genetic differences that make some cancer patients more likely to develop a rare but life-threatening heart inflammation (myocarditis) from immune checkpoint inhibitors. Researchers will compare the DNA of 100 patients who had this side effect with 400 who…

This study tracks 100 cancer survivors aged 18–74 to see how common muscle loss (sarcopenia) and cognitive problems ('chemo brain') are after treatment. Participants undergo physical and mental assessments. The goal is to better understand these long-term side effects and guide p…

This study is testing whether wearable devices (like smartwatches) can help catch infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to build a compute…

This registry study is collecting real-world data from 1,000 adults with cancer who use cannabis. Participants use an app to track symptoms, cannabis use, and changes in other medications. The goal is to help patients and doctors make informed decisions about using cannabis for s…

This study aims to see if new blood and urine tests can find cancer early in firefighters, who are at higher risk for certain cancers. About 2000 firefighters will provide samples to check how accurate these tests are. The goal is to improve early detection and save lives.

This study tests whether a smartphone app that sets daily exercise goals and helps you plan around barriers can change your automatic feelings about physical activity. Researchers will enroll 120 inactive adults who are overweight or obese. Participants wear a Fitbit and answer q…

This study follows 600 black and white adults with solid tumor cancer who use cannabis at least weekly or not at all. Participants report pain, symptoms, and cannabis use through a smartphone app and surveys for one year. The goal is to understand how cannabis affects pain and op…

This study is testing a web-based tool called ChangeGradients that uses machine learning to create personalized stories for teens who drink alcohol. The goal is to help them understand the risks and make healthier choices. Researchers are recruiting 200 adolescents aged 15-17 who…

This study follows 450 cancer patients receiving immunotherapy to see how cannabis use affects their symptoms like pain, sleep, anxiety, and quality of life. Participants complete surveys and daily assessments over a year. The goal is to understand the benefits and risks of canna…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study surveys 100 young adults (ages 18-39) receiving cancer treatment at a North Carolina hospital to compare their satisfaction in two different infusion spaces. Participants fill out surveys and may join interviews about their experience with the room design and mental he…

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 people with cancer will have their tumor genes analyzed, and the board will suggest …

This study is a large registry that collects information from adult cancer patients during their routine care. Researchers will track treatments, side effects, and outcomes to better understand how cancer is managed in real-world settings. Up to 20,000 participants will be enroll…

This study looks at how weight loss changes the way people with advanced cancer feel about their bodies. Researchers will survey 800 participants from different countries to understand differences related to gender and location. The goal is to create better, fairer nutrition advi…

This study tests a new way to help people get better cancer care and feel less distressed. It focuses on African American, Hispanic, and people living in underserved areas. Researchers will measure distress, depression, and social needs to see if the program helps.

This study looks at whether cancer survivors can use a smartwatch and a phone app to regularly report their symptoms and activity levels. Fifty adults who have finished cancer treatment and have stable disease will wear a smartwatch for about four months and fill out weekly quest…

This pilot study is collecting real-world information from 100 cancer patients to better understand how treatments affect their quality of life and survival. Participants will fill out regular questionnaires about their well-being and undergo standard scans or lab tests every few…

This pilot study follows 30 adults with incurable rare cancers or rare genetic changes who are already taking a Health Canada-approved targeted therapy that is not publicly funded. Researchers will track quality of life, survival, and tumor response over time to generate real-wor…

This study looks at genetic changes in metastatic pancreatic cancer to see if they can help guide treatment choices. Researchers will take tumor biopsies and blood samples from 190 patients starting chemotherapy. The main goal is to see if genetic test results can be returned wit…

This study is testing whether a more detailed genetic analysis of tumors (called 'complex' exome analysis) helps doctors choose better treatments for people with advanced solid tumors compared to a standard genetic analysis. About 8,000 participants will have their tumor and norm…

The ICARE registry is a research database for adults interested in studies on inherited cancer risk. Participants fill out a baseline questionnaire and follow-up surveys every two years. They may also be invited to join other studies. No treatment or medication is given—this is p…

This study tracks 125 cancer patients receiving standard chemotherapy and radiation to understand why they feel tired. Researchers will collect blood, stool, and survey data before, during, and after treatment. The goal is to find patterns that could help predict and manage fatig…

This study looks at whether a quick ultrasound of the thigh muscle can detect muscle loss (sarcopenia) in people who have finished cancer treatment. Researchers will compare the ultrasound results with a standard whole-body scan (DEXA) in 55 adults aged 18-74 with certain cancers…

This study surveys 200 adult cancer patients who have received CAR-T cell therapy to learn how it affects their fertility. The goal is to fill a gap in knowledge and help doctors improve fertility preservation advice. Participants complete a questionnaire about their fertility ex…

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study follows 540 adults with solid cancers to see how their anxiety and depression levels change over six months. Participants fill out questionnaires about their mood, coping, and quality of life at the start, 3 months, and 6 months. No drugs or treatments are given—the go…

This study looks at thymic epithelial tumors, a rare type of cancer in the chest. Researchers will collect tumor and blood samples from 50 patients during surgery to analyze the immune cells and genetic changes in the tumors. The goal is to better understand the disease and ident…

This study looks at how much protein cancer patients eat before, during, and after radiotherapy, and whether that affects their muscle mass and quality of life. Researchers will track 175 adults aged 45 and older undergoing radiation for various tumors. The goal is to understand …

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study is collecting DNA and medical history from 150 people in families where multiple members have had different types of cancer. Researchers will analyze the participants' exomes (the protein-coding parts of their DNA) to find new gene mutations that might explain why thes…

This study tracks 3,000 cancer patients taking oral anticancer drugs at home. Researchers want to see how well the drugs work in real life and what problems arise. The goal is to improve monitoring and coordination between hospitals and local doctors.