New pill targets KRAS cancers in early human trial
NCT ID NCT06835569
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests an oral drug called ALTA3263 in about 448 adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety, find the right dose, and see how the body processes the drug. Participants have already tried other treatments without success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ALTA3263 (oral tablet)
- What this could lead to
- If successful, this could point toward a new treatment option for people with advanced cancers that have KRAS mutations.
- What could go wrong
- This is an early Phase 1 trial focused on safety and dosing, not yet on effectiveness. Many drugs fail in early testing, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
RECRUITINGOrlando, Florida, 32827, United States
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Research Site
RECRUITINGBoston, Massachusetts, 02114, United States
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Research Site
RECRUITINGBoston, Massachusetts, 02115, United States
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Research Site
RECRUITINGSt Louis, Missouri, 63110, United States
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Research Site
RECRUITINGNew York, New York, 10016, United States
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Research Site
RECRUITINGNew York, New York, 10032, United States
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Research Site
RECRUITINGDurham, North Carolina, 27710, United States
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Research Site
RECRUITINGNashville, Tennessee, 37203, United States
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Research Site
RECRUITINGHouston, Texas, 77030, United States
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Research Site
RECRUITINGSan Antonio, Texas, 78229, United States
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Research Site
RECRUITINGFairfax, Virginia, 22031, United States
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Research Site #2
RECRUITINGSan Antonio, Texas, 78229, United States
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