CRC (COLORECTAL CANCER)

This study tests whether adding the experimental drug INCA33890 to standard chemotherapy and bevacizumab helps people with metastatic colorectal cancer that is microsatellite stable (a type that doesn't respond well to immunotherapy). About 700 adults who have not had prior treat…

This early-phase trial tests an oral drug called ALTA3263 in about 448 adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a KRAS mutation. The main goals are to check safety, find the right dose, and see how the body processes the drug. Part…

This early-phase study tests a new drug called BBO-11818 in people with advanced cancers that have a KRAS mutation, including lung, pancreatic, and colorectal cancers. The main goals are to check safety and find the best dose, while also seeing if the drug can shrink tumors. Abou…

This early-stage study is testing a new drug called ALX2004 in people with advanced lung, head and neck, esophageal, or colorectal cancers that have not responded to standard treatments. ALX2004 is an antibody-drug conjugate designed to deliver a cancer-killing payload directly t…

This early-phase study tests an experimental drug called KQB365 in adults with advanced solid tumors that have KRAS G12S or G12C mutations and haven't responded to standard treatments. The main goals are to find a safe dose and see if KQB365 alone or combined with other drugs can…

This study tests whether adding the drug SHR-1701 to standard chemoradiotherapy can completely eliminate tumors in people with advanced rectal cancer before they have surgery. About 48 adults aged 18-75 with a specific type of rectal cancer will receive the treatment over several…

This early-phase trial is testing a new drug called TGI-5, given alone or with the immunotherapy nivolumab, in people with advanced solid tumors such as colorectal, liver, lung, and skin cancers. The study aims to find safe doses and check for side effects in about 194 participan…

This early-stage trial tests a new way to deliver chemotherapy for colorectal cancer that has spread to the lining of the abdomen. Doctors use a spray (PIPAC) to send the drugs mitomycin or raltitrexed directly into the belly during a keyhole surgery. The main goal is to find a s…

This early-stage trial tests an experimental drug called ADU-1805, alone or combined with the immunotherapy Keytruda, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 130 pa…

This study tests a new drug (GFH375) combined with either cetuximab or chemotherapy in people with advanced solid tumors that have a specific KRAS G12D mutation. The goal is to see if the combination is safe and can shrink tumors. About 126 adults who have not responded to standa…

This study tests an AI tool called EndoAIM that helps doctors measure the size of polyps found during a colonoscopy. Accurate size measurement is important because larger polyps (over 10 mm) have a higher risk of becoming cancer. The study will enroll 278 adults undergoing colono…

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use a special preprocessing system and 3D imaging to get a clearer picture of tumors. The goal is to improve how doctors diagnose and plan treatment for these cancers. T…

This study aims to develop a blood test that uses epigenetic markers (chemical changes on DNA) to predict whether a patient with metastatic colorectal cancer will respond to targeted therapies like cetuximab or bevacizumab. Researchers will analyze blood samples from 500 patients…

This study tests a drug called NGM120 in people with colorectal cancer who are losing weight due to cancer cachexia. The goal is to see if NGM120 can help patients gain or maintain weight and improve their quality of life. About 136 participants will receive either NGM120 or a pl…

This study tests two ways to encourage colorectal cancer screening among American Indians in Oklahoma. Participants will either watch a video of a real community health educator or interact with a virtual health educator. The goal is to see which method reaches more people and he…

This observational study is looking for new substances in the blood that could signal colorectal cancer (CRC) or pre-cancerous growths. Researchers will compare blood samples from 60 people: those with CRC, those with a pre-cancerous polyp, and healthy individuals. The goal is to…

This study is looking for a way to predict which patients with advanced colorectal cancer will benefit from standard chemotherapy. Researchers will analyze blood samples from 600 patients to find specific markers that separate responders from non-responders. The goal is to help d…