New antibody combo takes on Hard-to-Treat cancers
NCT ID NCT05856981
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests an experimental drug called ADU-1805, alone or combined with the immunotherapy Keytruda, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 130 participants will take part across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ADU-1805 (an experimental antibody) and pembrolizumab (Keytruda)
- What this could lead to
- If successful, this could lead to a new treatment option for advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This is an early Phase 1 trial with a small number of participants, so safety and effectiveness are not yet known. The drug may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Gabrail Cancer & Research Center
RECRUITINGCanton, Ohio, 44718, United States
Contact
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Grand Hopital de Charleroi (GHdC) - Hopital Notre Dame
RECRUITINGCharleroi, Belgium
Contact
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Henry Ford Cancer Institute
RECRUITINGDetroit, Michigan, 48202, United States
Contact
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Hosp 12 de Octubre
RECRUITINGMadrid, Spain
Contact
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Hospital General Universitario Gergorio Maranon
RECRUITINGMadrid, Spain
Contact
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Virginia Cancer Specialists
RECRUITINGFairfax, Virginia, 22205, United States
Contact
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Washington University Medical Campus
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
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