New pill targets Hard-to-Treat cancers in early trial
NCT ID NCT06917079
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new drug called BBO-11818 in people with advanced cancers that have a KRAS mutation, including lung, pancreatic, and colorectal cancers. The main goals are to check safety and find the best dose, while also seeing if the drug can shrink tumors. About 665 adults will take part, and the drug may be given alone or with other cancer treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Huntsman Cancer Institute
RECRUITINGSalt Lake City, Utah, 84112, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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OSF Healthcare Cancer Institute
RECRUITINGPeoria, Illinois, 61637, United States
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Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, 3000, Australia
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Sarah Cannon Research Institute at Mary Crowley
RECRUITINGDallas, Texas, 75230, United States
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The Angeles Clinic and Research Institute - West Los Angeles Office
RECRUITINGLos Angeles, California, 90025, United States
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University of California Davis
RECRUITINGSacramento, California, 95817, United States
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University of California San Diego Moores Cancer Center
RECRUITINGSan Diego, California, 92037, United States
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University of California San Francisco Helen Diller Family Comprehensive Cancer Center
RECRUITINGSan Francisco, California, 94158, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06510, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can your own immune cells beat advanced cancer?
- Can a new immunotherapy combo outsmart advanced lung cancer?
- Double attack on mutant KRAS: can two targeted drugs outsmart resistant cancers?
- Can a pill keep lung cancer from returning after surgery?
- Seeing the fight: new imaging tracer may reveal how immune cells attack lung cancer
- Could a bronchial wash detect lung cancer mutations faster?