CRC (COLORECTAL CANCER)

This study tests whether adding the drug SHR-1701 to standard chemoradiotherapy can completely eliminate tumors in people with locally advanced rectal cancer before surgery. About 48 adults with severe rectal cancer will receive the drug combination, then undergo surgery to remov…

This study tests whether adding the experimental drug INCA33890 to standard chemotherapy and bevacizumab can help people with metastatic colorectal cancer that is microsatellite stable. About 700 adults with stage IV cancer who have not had prior treatment for their advanced dise…

This early-stage trial tests a new method called PIPAC that sprays chemotherapy directly into the abdomen for people with colorectal cancer that has spread there. The study aims to find the safest dose and check for side effects. About 42 adults aged 18-75 with no other cancer sp…

This early-phase study tests a new drug called KQB365 in adults with advanced solid tumors (like colorectal cancer) that have specific KRAS mutations (G12C or G12S). The main goals are to find a safe dose and see if the drug can shrink tumors when given alone or with other cancer…

This early-phase study tests a new drug called TGI-5, either alone or combined with the immunotherapy nivolumab, in people with advanced solid tumors (colorectal, melanoma, liver, or lung cancer) that cannot be removed by surgery. The main goals are to check safety and find the r…

This early-phase study tests a new drug called ALX2004 in people with advanced or metastatic solid tumors (lung, head and neck, colorectal, esophageal) that have not responded to standard treatments. ALX2004 is an antibody drug conjugate designed to deliver chemotherapy directly …

This early-phase study tests a new drug called ADU-1805, alone or with another cancer drug (pembrolizumab), in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and how the drug moves through the body. About 130 p…

This early-phase study tests a new drug called ALTA3263 in adults with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS gene mutation. The main goals are to check safety and find the right dose. About 188 people who have tried other tr…

This study tests a new drug (GFH375) combined with either cetuximab or chemotherapy in people with advanced solid tumors that have a specific KRAS G12D mutation. The goal is to see if the combination is safe and can shrink tumors. About 126 adults who have not responded to standa…

This early-phase study tests a new drug called BBO-11818 in adults with advanced lung, pancreatic, or colorectal cancers that have a KRAS mutation. The main goals are to check safety and find the best dose, while also seeing if the drug can shrink tumors. About 387 participants w…

This study tests a new way to create detailed 3D images of lung and colorectal cancer tissue. Researchers will use special processing and staining methods on tumor samples from 1,000 patients. The goal is to see cancer features more clearly than with standard 2D slides, which may…

This study tests a real-time AI system that helps doctors measure the size of polyps found during colonoscopy. Accurate sizing is important because polyps larger than 10 mm have a higher risk of becoming cancer. About 278 adults getting a colonoscopy will join, and the AI's measu…

This study tests an experimental drug called NGM120 in 136 people with colorectal cancer who are experiencing cancer-related weight loss (cachexia). The goal is to see if the drug helps patients maintain or gain weight over 12 weeks compared to a placebo. The study is currently r…

This study looks at whether a video featuring a virtual tribal community health educator can encourage more American Indians in Oklahoma to get screened for colorectal cancer. About 150 people aged 45 to 75 will watch either a real-life testimonial video or interact with a virtua…

This study is looking for 600 people with metastatic colorectal cancer to help develop a blood test that could predict whether standard chemotherapy (FOLFOX or FOLFIRI) will be effective. Researchers will analyze DNA markers in the blood to tell apart patients who respond well fr…

This study is looking for 500 people with advanced colorectal cancer who are about to start targeted therapy. Researchers want to see if a blood test that looks at DNA changes can tell who will benefit from the treatment. The goal is to develop a tool to help doctors choose the r…

This study aims to find new blood markers that could help doctors predict and diagnose colorectal cancer earlier. Researchers will compare blood samples from 60 people: those with colorectal cancer, those with precancerous growths, and those with healthy colons. The goal is to cr…