CANCER

This early-phase study tests a new drug called RP-001 in 66 adults with advanced solid tumors, including colorectal and pancreatic cancers. The main goal is to check safety and find the best dose. Researchers will also watch for any signs that the drug shrinks tumors.

This study tests whether daily online adaptive radiotherapy (ART) can safely deliver fewer, stronger radiation doses for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to either standard radiation or the new adaptive approach…

This early-phase study tests a new mRNA treatment (NCP-IL-22BP mRNA) in 9 people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors to help the body fight cancer. The main goal is to check safety, and researche…

This trial tests two approved drugs, dabrafenib and trametinib, in people with rare cancers that have a BRAF V600 mutation. The drugs are already used for melanoma and lung cancer. About 30 adults, children, and teens will take part. The goal is to see if the drugs shrink tumors …

This study tests a new drug called GFH276 in people with advanced cancers that have a specific gene change (RAS mutation). The cancers include pancreatic, lung, and colorectal cancer. The goal is to find a safe dose and see if the drug can shrink tumors. About 450 adults aged 18-…

This study tests whether lactulose, a type of sugar, can make immunotherapy more effective for people with advanced cancer. About 55 participants will take lactulose alongside their standard immunotherapy. Researchers will check if lactulose increases helpful gut bacteria and imp…

This early-stage study tests a new drug called IM-1617 in about 175 people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, finding the right dose, th…

This study tests a new treatment for people with advanced head and neck cancer that cannot be removed by surgery. The treatment combines two immunotherapy drugs (iparomlimab and tuvonralimab) with a special type of radiation and standard chemotherapy. The goal is to see if this a…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This early-phase study tests a targeted drug (trastuzumab deruxtecan) combined with precise radiation (stereotactic radiosurgery) in 20 people with HER2-positive breast cancer that has spread to the brain. The goal is to find the safest drug dose and see how well the combination …

This study tests whether using artificial intelligence to guide IV fluids during major cancer surgery can prevent dangerous drops in blood pressure. About 176 adults having long cancer surgeries will either get AI-guided fluid management or standard care. The goal is to see if th…

This early-phase trial tests a protein from snake venom (crotoxin) given through an IV to people with advanced solid tumors that no longer respond to standard treatments. The main goal is to see if slowly increasing the dose can reduce side effects and allow higher, potentially m…

This study tests a program called ONLOOP that sends reminders to adult survivors of childhood cancer in Ontario to get important screening tests. These tests can find late effects like heart disease or second cancers early. About 900 survivors will be randomly assigned to receive…

This study tests whether a 16-week supervised exercise program can help repair heart damage caused by breast cancer treatments like chemotherapy. Researchers will enroll 44 women who finished cardiotoxic therapy 6 to 12 months ago. Half will do twice-weekly strength and aerobic s…

This study looks at whether a pharmacist-led program can help adult cancer outpatients take their medications correctly and avoid errors. One hundred participants will either receive usual care or extra pharmacist counseling and follow-up. The goal is to improve medication adhere…

This study will test if a computer program can help emergency doctors find heart failure, lung disease, and cancer earlier by analyzing chest X-rays. About 25,000 adults visiting the ER will have their X-rays checked by the program, and researchers will compare how many new diagn…

This study will test a blood test called GRAIL Galleri that looks for signs of many different cancers. Researchers want to see how well it works in people who already have symptoms that might be cancer. About 100 adults will take the test, and the results will be compared to stan…

This study tests whether taking rosuvastatin (a statin) daily for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests if applying sesame oil, aloe vera gel, or nitroglycerin ointment to the skin can prevent phlebitis (vein inflammation) caused by chemotherapy. About 190 adults with breast or colon cancer receiving specific chemo drugs through a peripheral IV will be enrolled. Re…

This study tests whether glutamine, a natural supplement, can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants aged 6 to 18 will take glutamine for 14 days during treatment. Researchers will track who develo…

This study tests a support program called FamCASP, along with a digital screening tool, for family members of people with colorectal cancer. The goal is to see if the program reduces stress, improves coping, and meets families' needs better than standard care. About 800 adult fam…

This study looks at whether a structured exercise program can help women with stage IV (metastatic) breast cancer improve their physical function, fitness, and quality of life. About 78 women currently on treatment will take part. The program focuses on walking, strength, and bod…

This study looks at whether a 12-week resistance exercise program can improve quality of life, reduce frailty, and boost mental health in people with multiple myeloma. About 50 patients will be split into two groups: one doing supervised exercise and the other exercising at home.…

This study tests whether a tailored program can help teens and young adults (ages 15-24) with cancer take their oral medications more consistently. Participants will use an electronic pill bottle to track adherence and complete surveys about their quality of life. The goal is to …

This study looks at whether smelling cardamom oil or peppermint oil can help reduce nausea and vomiting caused by chemotherapy and improve how much patients eat. About 39 adults with cancer who are on certain chemo drugs will be randomly assigned to inhale one of the oils. Resear…

This study tests whether a smartphone app that guides patients through exercises, nutrition tracking, and mood check-ins before cancer surgery can improve their physical function and reduce anxiety. About 60 adults scheduled for elective cancer surgery will either use the app or …

This study tests a new chatbot tool designed to help cancer patients and their caregivers in rural areas get clear information about insurance, travel costs, and other financial aspects of cancer care. About 60 adults from rural parts of Utah, Idaho, Wyoming, Montana, and Nevada …

This study tests whether a smartphone app called the Cancer Exercise App (CEA) can help cancer survivors become more physically active. Researchers will enroll 750 adults who have finished cancer treatment and assign them to use the app or receive usual care for 12 weeks. The goa…

This study looks at whether sildenafil (the drug in Viagra) can reduce fatigue and improve thinking in women with breast cancer. About 30 women aged 30-50 with ER+/HER2- breast cancer will take sildenafil during their standard cancer treatments. Researchers will track changes in …

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have finished treatment for breast, prostate, or colorectal cancer. About 76 participants with mild to moderate depression will listen to short audio exercises each day for s…

This study tests whether personalized food and cooking advice can help slow muscle loss in adults with advanced cancer who are on chemotherapy. About 200 participants will either receive standard nutrition care or the same care plus tailored guidance based on their taste changes …

This study looks at whether adding electrotherapy and exercise video games to standard physical therapy helps children and teens who have finished cancer treatment. About 45 participants aged 3 to 16 will be split into groups to compare different therapy combinations. The goal is…

This study tests an online program called Finding My Way-UK for people who finished cancer treatment within the past year. The program includes six self-guided modules on managing side effects, emotions, and adjusting to life after cancer. Researchers want to see if it's helpful …

This study looks at whether having a detailed initial meeting with a psycho-oncology counselor soon after a cancer diagnosis can lower anxiety and depression and improve quality of life. About 148 newly diagnosed cancer patients will be randomly assigned to either receive this ex…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. About 108 adults with cancer and moderate to severe distress will use the manual and be compared before and after treatment. The goal is to see if it improve…

This study tests whether a virtual exercise program with a peer buddy helps older adults (60+) who have had cancer become more active and feel better. Participants are split into three groups: one gets a peer plus guidance from exercise pros, one gets peer support only, and one g…

This study tests a new drug called DS010 in 58 adults with cancer who are experiencing cachexia—a condition causing severe weight and muscle loss. The goal is to see if DS010 is safe and can help patients gain weight and improve muscle mass. The trial has two phases: first checki…

This study looks at whether listening to calming music during the first radiation session can help cancer patients feel less anxious, stressed, and in pain. About 72 adults starting radiation will be split into two groups: one gets standard care, the other also gets a 15-20 minut…

This study looks at whether virtual palliative care (video calls) works as well as in-person visits for adults with cancer. About 252 participants will be randomly assigned to one of two groups: virtual care or standard clinic care. The goal is to see if virtual care can improve …

This study tests whether trained community health workers can reduce stress and improve satisfaction for people caring for seriously ill older veterans in rural areas. About 480 care partners will be randomly assigned to receive extra support or usual care. The goal is to lighten…

This study tests a community-based program for people with cancer that helps them manage their energy and take part in meaningful activities. The program includes group workshops and hands-on activities to improve quality of life. Researchers will work with 30 adults to see if th…

This study looks at whether a respiratory rehabilitation (breathing exercise) program can improve quality of life for people with advanced non-small cell lung cancer who are on maintenance chemotherapy and immunotherapy. About 96 participants will either join the rehab program or…

This study tests a web-based program to help people with advanced cancer and their caregivers. The program aims to reduce symptoms like depression, pain, fatigue, and sleep problems in patients, and lower stress and depression in caregivers. About 40 patient-caregiver pairs will …

This study tests whether a small handheld device with bumps, called a Palm Stimulator, can help reduce pain, fear, and anxiety when cancer patients get an IV for chemotherapy. About 90 adults will be randomly assigned to either squeeze the device during the procedure or receive s…

This study tests a Traditional Chinese Medicine (TCM) regimen to help ovarian cancer patients with common symptoms like sleep trouble, fatigue, sadness, and distress. Researchers will compare the TCM treatment to a placebo in 316 women to see if it improves quality of life. The g…

This study looks at whether exercise and cognitive rehabilitation can improve memory and thinking in older cancer survivors (age 65+). 40 participants will be assigned to one of three programs or usual care. The goal is to see if these activities help with attention and mental cl…

This study tests whether virtual reality (VR) hypnosis can improve sleep in Chinese teens who survived childhood cancer. 186 participants aged 12-18 with poor sleep will be randomly assigned to VR hypnosis, cognitive behavioral therapy (CBT-I), or VR relaxation. The goal is to se…

This study tests a smart home system (smart speaker, lights, and Wi-Fi) that delivers AI-guided sleep therapy to young adult cancer survivors with chronic insomnia. The goal is to improve sleep quality and quality of life without needing in-person therapy. About 74 participants w…

This study tests a mobile health tool to help women on hormone therapy for breast cancer understand and manage side effects. Researchers will enroll 60 women to see if the app is easy to use and helps them stay on their medication. The goal is to improve quality of life and treat…

This study tests whether a digital platform called Beacon can help doctors better manage symptoms in people with advanced cancer. About 40 patients will wear a smartwatch and answer questions about how they feel. The platform combines this data to give doctors a clearer picture o…

This study tests whether eating only within an 8-hour window each day (time-restricted eating) can reduce side effects and improve well-being in 50 adults with solid tumors starting adjuvant therapy after surgery. Participants will follow either the time-restricted eating plan or…

This study looks at whether a structured exercise program can help women who have had breast or gynecological cancer and now have weak muscles (sarcopenia). The goal is to see if exercise can improve muscle strength, muscle mass, physical function, and quality of life. About 78 w…

This study tests whether a mobile app called Tools for Coping with Cancer can help people with a history of cancer feel less distressed. About 50 adults who have had cancer in the last two years will use the app at home for 8 weeks. Researchers will check if the app improves mood…

This study looks at how partnerships between universities and local health departments can help put cancer prevention programs into practice. Researchers will survey 364 health workers and academics across the U.S. to find out what works best. The goal is to learn how to make the…

This study tests whether using a Fitbit and weekly symptom surveys can help doctors remotely monitor cancer patients receiving immunotherapy. About 40 adults with advanced melanoma will participate. The goal is to see if this digital tool is easy to use and improves symptom manag…

This study looks at whether wearable sensors (like smartwatches) and electronic surveys are practical and acceptable for people taking part in early-phase cancer clinical trials. About 30 participants will wear a smartwatch and answer questions through a phone app for 4 weeks. Th…

This study tests if wearable health trackers (like a Fitbit) can be easily used in a cancer clinic to monitor patients getting chemotherapy and radiation. About 20 adults with cancer will wear a device during their treatment and for 4 weeks after. The goal is to see if patients a…

This study will collect blood samples from 100 adults with cancer who are starting immunotherapy. Researchers will analyze the samples to find patterns in immune cells and molecules that might predict how well the treatment works and whether it causes side effects. The goal is to…

This study will test a simple 3-step program (Assess-Advise-Refer) to help cancer survivors exercise more. About 1800 patients who finished cancer treatment in the last 5 years and have a BMI of 23 or higher will take part. The goal is to see if this program can become a standard…

This study looks at how platinum-based chemotherapy can cause permanent hearing loss in cancer patients, especially those from poorer backgrounds. Researchers will test hearing and thinking skills in 172 patients from North West England before and after treatment. The goal is to …

This study is building and testing an AI tool called ACTIVATE that looks at electronic health records to find which cancer patients might be eligible for clinical trials. The goal is to make it easier for doctors and patients to find and join relevant trials. No new treatments ar…

This study reviews past cases of lower lip reconstruction in 20 adults who had skin cancer removed. Researchers will ask patients to rate their satisfaction with how the lip looks and works one year after surgery, and compare that with surgeons' opinions. The goal is to learn wha…

This study will test a more thorough cancer screening program for 100 veterans aged 35 and older who were exposed to burn pits during deployment. The goal is to see if this program is practical and satisfying for participants, and to find any early signs of cancer. Researchers wi…

This study will observe how adults receiving chemotherapy use digital media and how skilled they are at finding and understanding health information online. Researchers will survey 80 patients to learn about their digital habits and eHealth literacy. The goal is to better underst…

This study looks at how safe current blood thinner management is for 700 cancer patients who need surgery or medical procedures. Researchers will track how often serious bleeding or blood clots happen within 30 days after the procedure. The goal is to use this information to impr…

This study looks at a new way to offer vaccines to adults with chronic illnesses or weakened immune systems while they are in the hospital. The goal is to see if offering vaccines during hospital visits helps more people get vaccinated. Researchers will track how many patients ar…

This study looks at whether starting palliative care early during an unplanned hospital stay helps people with advanced cancer avoid harsh treatments near the end of life. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers who are on palliative tre…

This study tests whether messages created by artificial intelligence can change how cancer survivors think about alcohol and cancer risk. About 850 adults who have had certain cancers and currently drink alcohol will receive either a gain-framed or loss-framed message. Researcher…

This study aims to collect information from 45 cancer patients who use cannabis. Participants will use a smartphone app to log how much and why they use cannabis, and report any helpful or unwanted effects. The goal is to help doctors better understand cannabis use in this group.

This study looks at why cancer patients and healthcare workers in Martinique decide to participate in clinical trials. Researchers will interview 30 patients and survey medical professionals to identify barriers and motivators. The goal is to improve trial participation and ensur…

This study will adapt a questionnaire called PROFFIT, originally developed in Italy, to measure the financial burden of cancer treatment for Turkish patients. Researchers will enroll 320 adults who have had cancer treatment in the last three months. The goal is to ensure the Turk…

This study talks to 120 adults in Texas who have breast, colorectal, lung, or prostate cancer. Researchers will use interviews and group discussions to learn what makes it easier or harder to get cancer treatment on time. The goal is to find ways to improve access to care for all…

This study looks at whether having type 2 diabetes makes quality of life worse for cancer patients receiving immunotherapy. About 920 adults with solid tumors will fill out surveys at the start, then at 3 and 6 months. The goal is to see if diabetes adds extra challenges during c…

This research programme aims to understand how lifestyle, environment, genetics, and social factors influence healthy aging and overall wellbeing. It will recruit 100,000 people aged 12 and older across the UK, who can participate from home using digital tools and at-home sample …

This study tests whether sending automated text messages to cancer patients after a hospital visit can help them use the right urgent care services instead of going to the emergency room. About 200 adults with active cancer will receive reminders about their oncology acute care o…

This study will follow one million adults aged 30-74 in Hubei, China, for up to 10 years. Researchers will collect health data and Traditional Chinese Medicine (TCM) body types to see how they relate to chronic diseases like heart disease, cancer, and diabetes. The goal is to cre…

This study will create a registry of 500 cancer patients receiving immunotherapy to better understand and manage immune-related side effects (irAEs). Researchers will collect data on patients' medical history, lab tests, and imaging both before and after side effects occur. The g…

This study will test an artificial intelligence (AI) tool designed to help doctors and physicists review radiation treatment plans for prostate cancer before treatment starts. The AI highlights differences in how doctors plan treatments and flags potential errors, aiming to reduc…

This study tests a one-stop Lung Health Check for people aged 55-74 who smoke or used to smoke. It uses a low-dose CT scan plus blood tests, an ECG, and a breathing test to find lung cancer early and also spot other conditions like COPD, heart disease, and weak bones. The goal is…

This study aims to discover rare genetic changes that make people more likely to develop cancer. Researchers will collect blood, saliva, and tumor samples from 100 participants who have had multiple cancers or have a strong family history of cancer. By analyzing the DNA, they hop…

This study aims to understand how well we can detect and analyze tumor markers in the blood of 620 adults with any type or stage of cancer. By collecting blood samples and sometimes tumor biopsies, researchers hope to improve diagnosis, predict treatment response, and monitor res…

This study checks if a short questionnaire called G8 can accurately identify frailty in people aged 70 and older with solid tumors. Researchers will compare the G8 results with a full geriatric assessment in 150 participants. The goal is to see if the G8 tool works well for Portu…