CANCER

This early-stage study is testing the safety of combining a targeted cancer drug (Trastuzumab Deruxtecan) with precise radiation therapy for people with HER2-positive breast cancer that has spread to the brain. The goal is to see if this combination can better control the cancer …

This study is testing if taking lactulose, a type of sugar, can change the gut bacteria in a way that makes immunotherapy more effective for people with advanced cancer. It will involve about 55 adults with specific cancers who are already scheduled to receive immunotherapy. Rese…

This study is testing whether a personalized support program can help teenagers and young adults with cancer take their oral medications as prescribed. Researchers will compare the personalized program to standard care in 160 participants aged 15-25. The goal is to see if the tai…

This study is testing if a supervised exercise program can help protect the heart in women who have survived breast cancer. Many life-saving cancer treatments can damage the heart over time. Researchers will compare a 16-week exercise program to standard health advice to see if e…

This study is testing a new program called ONLOOP that reminds adult survivors of childhood cancer in Ontario to get important health screenings. Many survivors are at higher risk for heart problems, breast cancer, or colon cancer due to their past cancer treatments, but often mi…

This study is testing a new system to help cancer survivors manage their weight through exercise. Doctors will use a simple 3-step plan (assess, advise, refer) to connect eligible patients with a weight management program. The goal is to see if this structured approach gets more …

This trial is testing if two already-approved cancer drugs, dabrafenib and trametinib, can help patients with rare cancers or common cancers that have a rare, specific genetic change called a BRAF V600 mutation. The drugs are already used for some cancers like melanoma, but resea…

This study is testing a new drug called GFH276 in adults with advanced cancers that have a specific genetic change called a RAS mutation. The main goals are to find a safe dose and see if the drug can shrink tumors in cancers like pancreatic, lung, and colorectal cancer. It is an…

This study is testing whether using an artificial intelligence (AI) system to guide how much fluid patients receive during major cancer surgery leads to more stable blood pressure and better recovery. Researchers will compare the AI-guided approach to standard fluid management in…

This study tests whether a new care coordination program helps cancer patients better manage chronic conditions like high blood pressure, diabetes, and high cholesterol during cancer treatment. Researchers will compare patients who receive the new program to those getting usual c…

This study tests a personalized care program for adults 65 and older who are receiving chemotherapy. Researchers will create individual support plans based on each person's health needs and check in weekly for 12 weeks. The goal is to help manage treatment side effects better and…

This study aims to see if a computer program using artificial intelligence (AI) can help emergency room doctors find early signs of lung cancer, COPD, and heart failure on chest X-rays. It will compare how many new cases are found when doctors use the AI tool versus when they don…

This study aims to test a new, more comprehensive health check for people at higher risk of lung cancer. It will offer 500 eligible adults in Glasgow a single clinic visit that includes a low-dose CT lung scan, a blood test, a heart trace, and a breathing test. The goal is to see…

This study is testing a new type of PET scanner to see if it can take better pictures of cancer inside the body. Researchers will compare images from the new scanner to those from a standard machine in 25 adult cancer patients. The goal is to see if the new technology can provide…

This study is testing a blood test called Galleri that looks for signs of many different cancers. It will enroll about 100 adults who have symptoms that could be cancer. The main goal is to see how well this test works compared to standard diagnostic methods for finding cancer in…

This study aims to create and test a practical system for hospitals to offer and give recommended vaccines to adults with chronic diseases or weakened immune systems. It will involve 1,500 patients, offering vaccines during their hospital visits or stays. The goal is to see if th…

This study is testing if a supplement called glutamine can prevent nerve damage (neuropathy) caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine powder twice daily for two weeks during their chemo…

This trial aims to see if a daily cholesterol-lowering pill (rosuvastatin) can safely prevent life-threatening blood clots in people with cancer. It will involve 4,000 patients who are at higher risk for clots but are not taking blood thinners. The study compares the statin to a …

This study is testing whether a specialized form of psychotherapy called the EMDR Toolbox Method can improve the psychological wellbeing of people diagnosed with cancer. It will compare this new method to standard EMDR therapy in 46 participants to see which is more feasible and …

This study aims to see if a 12-week physical exercise program can improve the quality of life, reduce frailty, and help with mental health for people being treated for multiple myeloma, a type of blood cancer. Researchers will compare a supervised exercise group with a home-based…

This study aims to see if a combination of physical therapy approaches helps children and teenagers recover after cancer treatment. Researchers will test whether adding video game exercises and muscle stimulation to standard physical therapy improves strength, fitness, pain, and …

This study aims to see if listening to calming music during a patient's first radiation therapy session can make the experience easier. Researchers will compare 72 cancer patients receiving standard care to those who also get a 15-20 minute music therapy session. They will measur…

This study is testing whether a supervised exercise program can help women with breast or gynecological cancer who have lost significant muscle mass and strength (a condition called sarcopenia). Researchers will compare the effects of exercise on muscle strength, body composition…

This study is testing whether a 10-week virtual exercise program with peer support can help older adults with cancer become more physically active and improve their well-being. Researchers will compare three groups: one gets a peer buddy plus a coach, one gets just a peer buddy, …

This study will test a support program and a digital screening tool designed to help family members of colorectal cancer patients. The goal is to see if this support reduces psychological distress, improves coping skills, and meets family needs better than usual care. Researchers…

This study aims to see if a self-guided mobile app can help people with a history of cancer manage emotional distress. Researchers will ask 50 participants to use the app for 8 weeks and track their mood, coping skills, and quality of life. The main goal is to find out if people …

This study is testing whether a remote monitoring system using a Fitbit and weekly symptom surveys can help patients better manage side effects during cancer immunotherapy. Researchers want to see if this digital tool is easy for patients to use and if it improves their quality o…

This study aims to see if inhaling the scents of cardamom or peppermint oil can help reduce the severe nausea and vomiting that often comes with chemotherapy for cancer. It will compare the two scents in 39 adults who are receiving specific chemo drugs. The goal is to find a simp…

This study is developing an online program called On-Trac to help adult cancer survivors learn skills to manage anxiety. The program uses techniques from established talk therapies and is delivered through group video sessions and individual coaching. Researchers will test if the…

This study aims to see if palliative care delivered through scheduled video calls is as helpful as traditional in-person visits for adults with cancer. Palliative care focuses on improving quality of life, managing symptoms, and providing support for patients and families. Resear…

This study is testing a new, brief mindfulness program delivered by daily text messages to help reduce symptoms of depression in people who have recently finished treatment for early-stage breast, prostate, or colorectal cancer. Researchers want to see if this short, daily format…

This study is testing a mobile phone app designed to help women taking hormone therapy for early-stage breast cancer. The app helps them track and manage treatment side effects, with the goal of helping them stay on their medication as recommended. Researchers will enroll 60 wome…

This study aims to find the best way to prevent a painful side effect of chemotherapy called phlebitis, which is inflammation of the veins. Researchers will compare three topical treatments—sesame oil, aloe vera gel, and nitroglycerin ointment—applied to the skin where the IV is …

This study examines whether involving palliative care specialists early during unplanned hospitalizations helps patients with advanced cancer. It focuses on reducing aggressive treatments near the end of life and improving quality of life. The research will compare outcomes for n…

This study will test if a guided self-help workbook based on Cognitive Behavioral Therapy (CBT) can help cancer patients manage anxiety and depression. About 108 adult cancer patients in Pakistan who can read Urdu and are experiencing psychological distress will participate. The …

This study is testing whether a simple handheld device can make it easier for cancer patients to get their IV chemotherapy. Patients will squeeze a palm-sized device with bumps during the needle insertion to see if it reduces pain and fear. The goal is to provide a drug-free, eas…

This study is testing whether personalized cooking and nutrition advice can help slow muscle loss in people with advanced cancer. About 200 adults on chemotherapy will receive either standard nutrition care or that care plus tailored food guidance based on their taste changes and…

This study aims to see if a Traditional Chinese Medicine (TCM) herbal formula can help ease a common cluster of symptoms in ovarian cancer patients, including fatigue, poor sleep, distress, and sadness. About 316 participants will be randomly assigned to receive either the TCM gr…

This study aims to help family and friends who care for seriously ill older veterans living in rural areas. It will test whether connecting these caregivers with a trained community health worker for six months can reduce their stress and improve their satisfaction with care. The…

This study is testing a new at-home system designed to help young adult cancer survivors who have trouble sleeping. The system uses a smart speaker, lights, and Wi-Fi router to deliver a proven sleep therapy program without needing a screen or an in-person therapist. Researchers …

This study is testing whether sildenafil, a medication commonly known as Viagra, can help prevent or reduce the 'brain fog' and severe fatigue that often come with cancer treatment. It will involve 30 women with a specific type of breast cancer who are receiving standard chemothe…

This study is testing three different programs to help older cancer survivors who have memory and thinking problems after treatment. Researchers will compare exercise training, brain training, and a combined program against usual care to see which works best. The goal is to find …

This study is testing if a supervised 30-minute bike ride, done right before a patient's chemotherapy or immunotherapy infusion, is a safe and practical way to help them maintain their fitness and energy levels during treatment. It will involve 80 adults with certain types of bre…

This study is testing whether adding a wearable device, like a smartwatch, to an existing remote symptom-tracking program helps cancer patients and their care teams. It aims to see if the device is easy for patients to use and if the data it collects relates to the symptoms patie…

This study is testing a new AI chatbot tool designed to help cancer patients and their caregivers, especially those living in rural areas, manage the high costs of care. About 60 participants will try one of two chatbot versions to get information on insurance, travel expenses, a…

This study is testing whether a virtual reality (VR) hypnosis program can improve sleep for young people who have survived childhood cancer. Researchers will compare the VR hypnosis to standard talk therapy (CBT-I) and a simple VR relaxation program in 186 participants. The goal …

This study is testing if a special breathing and exercise program can improve the day-to-day life of people with advanced lung cancer. It will compare 96 patients who receive this program alongside their regular cancer treatment to those who receive only standard care. The main g…

This study is testing a 4-week online self-help program designed to support the mental and emotional well-being of people who have recently finished curative cancer treatment. It will see if the program is easy to use and acceptable, and if it shows early signs of improving feeli…

This study is testing if a phone app can help people scheduled for cancer surgery get stronger and feel less anxious before their operation. About 60 adults will use the app for weekly walking tests and daily check-ins on exercise, nutrition, and mood. Researchers will compare th…

This study is testing a new AI tool designed to help match cancer patients with clinical trials they might be eligible for. The tool scans electronic health records to identify patients whose cancer is progressing and suggests relevant trials to their doctors. The goal is to see …

This study aims to understand if cancer patients are willing to share information about their social and economic backgrounds during clinical trials. Researchers will ask 1,000 participants about factors like income, education, housing, and experiences with discrimination. The go…

This study is testing a new computer tool that uses artificial intelligence (AI) to help doctors and medical physicists review radiation treatment plans for prostate cancer. The tool highlights potential errors and differences in how doctors plan treatments, aiming to catch mista…

This study is testing a digital app designed to help cancer patients understand their genetic test results. The goal is to see if using the app reduces patient distress and improves knowledge compared to receiving standard information from pamphlets or videos. The study will invo…

This study aims to find markers in the blood that can predict how well a cancer patient will respond to immunotherapy and what side effects they might experience. Researchers will collect blood samples from 100 adults with cancer who are starting immunotherapy treatment. The goal…

This study aims to develop a blood test to predict which cancer patients are most likely to develop dangerous blood clots during chemotherapy. Researchers will measure specific clotting markers in the blood of 380 patients with lung, ovarian, pancreatic, or stomach cancer at four…

This study is testing a program called 'My Care My Voice' designed to make it easier for patients with advanced cancer and their doctors to talk about palliative care. Palliative care focuses on managing symptoms and improving quality of life, and earlier conversations about it c…

This study aims to understand the real-world challenges and supports for getting timely cancer treatment in Texas. Researchers will conduct interviews and group discussions with 120 patients who have breast, colorectal, lung, or prostate cancer. The goal is to identify the main b…

This study aims to test if a simple electrical device can accurately measure fluid buildup (swelling) in the arms or legs of cancer patients. It will involve 46 patients in Denmark who have swelling after chemotherapy or radiation. Researchers will compare the device's readings a…

Healthspan Connect is a large UK research programme aiming to understand what helps people stay healthy as they age. It will follow 100,000 participants, aged 12 and up, to explore how lifestyle, environment, genetics, and social factors influence long-term health and wellbeing. …

This study aims to understand the quality of care for adolescents and young adults (ages 12-39) living with advanced or recurrent cancer. Researchers will survey and interview patients, caregivers, and clinicians to measure unmet needs in areas like emotional support, communicati…

This study aims to understand how having type 2 diabetes affects the quality of life of cancer patients receiving immunotherapy. Researchers will follow 920 patients for six months, comparing survey responses from those with and without diabetes. The goal is to see if diabetes ad…

This study aims to identify where young adults with cancer feel they lack information and support. Researchers will ask 300 participants, diagnosed between ages 15-39, to complete questionnaires about topics like fertility, finances, and emotional health. The goal is to gather in…

This study will follow one million adults in China for up to 10 years to learn how Traditional Chinese Medicine (TCM) concepts of body types relate to the development of modern chronic diseases like heart disease, cancer, and diabetes. It is an observational study, meaning resear…

This study aims to see if an intensive, yearly cancer screening program is practical and acceptable for veterans who were exposed to burn pits during military service. It will enroll 100 veterans to undergo multiple screening tests over three years. The research will also explore…

This study aims to understand how satisfied patients are with the look and function of their lower lip after reconstructive surgery, which is often needed after cancer removal. Researchers will look back at the experiences of 20 patients and also gather opinions from their surgeo…

This study aims to see if simple blood tests can detect cancer markers as effectively as invasive tissue biopsies. Researchers will enroll 620 patients with various cancers, focusing on lung cancer, to compare blood test results with traditional biopsy methods. The goal is to dev…

This study is testing a Turkish version of a survey designed to measure the financial burden and stress (often called 'financial toxicity') experienced by cancer patients. Researchers will ask 320 Turkish-speaking adult cancer patients who are currently receiving treatment to com…

This study aims to collect information about how cancer patients use cannabis products. Researchers will follow 45 patients who report using cannabis, asking them to track their usage in a smartphone app. The goal is to better understand why patients use cannabis, what types they…

This study is testing whether wearable health trackers (like smart watches) can be easily used to monitor patients during combined chemotherapy and radiation treatment for cancer. Researchers want to see if collecting daily health data (like heart rate and activity) helps doctors…

This study aims to learn more about the side effects that can occur when cancer patients receive immunotherapy drugs. It will follow 500 adult patients with various cancers to track when these side effects happen, how severe they are, and how they are managed. The goal is to gath…

This study aims to clarify whether eating nuts helps prevent major chronic diseases like diabetes, heart disease, cancer, and dementia. It will combine and analyze health data from over one million adults across the globe who have been tracked for at least five years. The goal is…

This study aims to test whether AI-generated messages can change how cancer survivors think about alcohol's link to cancer and influence their drinking plans. Researchers will show different message styles to 850 adult cancer survivors in the US who currently drink alcohol. The g…

This study aims to understand why cancer sometimes runs in families. Researchers will collect blood, saliva, and tumor samples from people with cancer and their relatives to look for inherited genetic changes. The goal is to find new genetic links to cancer risk that could help f…

This study aims to find the best ways to help university researchers and local public health departments work together more effectively. It will test different support strategies for these partnerships to see which helps them implement more proven cancer prevention and control pr…

This study aims to understand why cancer patients and healthcare professionals at a hospital in Martinique do or do not participate in clinical trials. Researchers will interview 30 patients and survey doctors and nurses to identify the main barriers and motivators. The goal is t…

This study aims to understand how safe current practices are for managing blood thinners in people with cancer who need surgery or medical procedures. Researchers will observe 700 patients to measure how often serious bleeding or dangerous blood clots happen after surgery. The go…