Viagra tested as surprising new treatment for cancer fatigue and brain fog

NCT ID NCT06800092

Not yet recruiting Symptom relief Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily 50mg dose of sildenafil (Viagra) can prevent or reduce the fatigue and cognitive problems (brain fog) that often come with cancer treatment. The trial will enroll 30 women with ER+/HER2- breast cancer, aged 30-50, and track their symptoms using questionnaires and gut microbiome analysis. It is a combined Phase 2/3 study, meaning it is still in early-to-mid stages.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sildenafil (Viagra)
What this could lead to: If it works, this could point toward a simple, daily pill to ease cancer-related fatigue and thinking problems.
What could go wrong: This is a small, early-stage trial with only 30 people. The drug is already approved for other uses, but it may not help with these symptoms, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer estrogen-receptor positive breast cancer Fatigue Mental Fatigue neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER

Contacts and locations

Locations

The University of Texas Medical Branch

Galveston, Texas, 77555, United States

More trials for these conditions

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