New combo therapy targets breast cancer brain metastases
NCT ID NCT07454668
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether combining the targeted drug trastuzumab deruxtecan (T-DXd) with precise radiation (SRS) is safe for people with HER2-positive breast cancer that has spread to the brain. Up to 20 participants will receive the drug by IV every three weeks along with a single session of focused radiation. The main goal is to find the best dose and check for severe side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Trastuzumab deruxtecan (T-DXd) and stereotactic radiosurgery (SRS)
- What this could lead to
- If this combination proves safe, it could lead to a new way to control brain metastases in HER2-positive breast cancer, potentially improving outcomes for patients.
- What could go wrong
- This is a very early Phase 1 trial with only 20 people, focused on safety and dosing. It may not show enough benefit to move forward, and side effects from the drug or radiation could be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRAIN METASTASES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Miami Cancer Institute at Baptist Health, Inc.
Miami, Florida, 33176, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a radioactive tracer pinpoint Cancer's first stop?
- A good Night's sleep: could a simple program ease Cancer's toll on rest?
- Can a personalized exercise program boost recovery in cancer survivors?
- Smartwatch could spot nerve damage before it starts
- Could sitting up make radiation therapy more comfortable?
- Could ionized gas help fight breast cancer after surgery?