Kidney shield? drug may protect young cancer patients from chemo harm

NCT ID NCT06196853

Not yet recruiting Disease control Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug aminophylline can protect the kidneys of children receiving cisplatin chemotherapy. Twenty-four children will be randomly assigned to receive either aminophylline or a placebo alongside their standard chemo hydration. Researchers will measure kidney function and damage markers over five days to see if aminophylline helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: aminophylline
What this could lead to: If it works, this could point toward a way to reduce kidney damage in children undergoing cisplatin chemotherapy.
What could go wrong: This is a very small, early-phase trial with only 24 children, so results may not be conclusive. Aminophylline can cause side effects like nausea, vomiting, and heart rhythm changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE KIDNEY INJURY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cancer childhood malignant neoplasm renal tubule disorder acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY RENAL TUBULOPATHY

Contacts and locations

Locations

Siriraj hospital, Mahidol university

Bangkok, 10700, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.