ACUTE KIDNEY INJURY

This study tests whether repeatedly inflating and deflating a blood pressure cuff on the arm before heart procedures can protect patients' kidneys from damage. Researchers are enrolling 240 people with heart failure who need coronary angiography or stents. The goal is to see if t…

This study is testing whether an experimental drug called AZD4144 can help improve kidney function in hospitalized adults whose kidneys have been injured by a severe bloodstream infection (sepsis). About 124 participants will be randomly assigned to receive either the drug or a p…

This study investigates whether giving a common heartburn medication (pantoprazole) very early can help prevent kidney damage in trauma patients who have gone into shock from severe bleeding. Researchers will compare early treatment against usual care in 100 adult patients. They …

This study is testing whether stem cells from umbilical cords can help treat sudden kidney failure, known as acute kidney injury. Researchers will give the cells to 50 patients to see if they improve kidney function and reduce the need for dialysis. The main goal is to check if t…

This study is testing whether adding a special medical device to standard dialysis treatment can help patients with sudden, severe kidney failure in the intensive care unit. The device, called the Selective Cytopheretic Device (SCD), is used alongside dialysis and aims to improve…

This pilot study aims to find out if a lower dose of continuous dialysis is as safe and effective as the current standard dose for critically ill patients with sudden kidney failure. It will involve 100 patients in intensive care units. The goal is to see if the lower dose works …

This study is testing whether a class of drugs called SGLT2 inhibitors can help people with acute kidney disease. Researchers want to see if these medications, already used for chronic kidney problems, can safely reduce protein in urine and protect kidney function during this cri…

This study is tracking the safety of an FDA-approved medical device called QUELIMMUNE for children with severe kidney injury caused by sepsis. It will follow 300 children and teens who receive the device, comparing their rates of new bloodstream infections to similar children who…

This study is testing a new follow-up program for adults who have just recovered from a serious episode of sudden kidney injury (AKI). The program provides extra support from a care team after leaving the hospital. Researchers want to see if this extra help keeps people healthier…

This study is testing which speed of fluid removal is better for ICU patients with sudden kidney failure who need dialysis. Researchers want to know if removing fluid more aggressively or more slowly helps patients get off life support machines faster and recover better. They are…

This study aims to find the best way to connect kidney dialysis to a life support machine called ECMO, which helps patients with severe heart failure. Researchers will compare connecting the dialysis machine directly into the ECMO circuit versus using a separate connection. The g…

This study aims to see if two common, low-cost drugs can safely reduce dangerous bleeding during surgery for people with advanced kidney disease. It will enroll 100 patients with severe kidney problems who are having non-heart surgery. The trial is a pilot to prepare for a larger…

This study aims to find out if starting a kidney support machine earlier than usual is better for patients with severe heart failure who are also on a heart-lung life support machine. It will compare the safety and effectiveness of early treatment versus the standard timing in ab…

This study is testing if a special blood filter called the HA380 can help critically ill patients who need machines to support their kidneys or lungs. The filter aims to remove harmful inflammation from the blood, which might help patients get off life support faster and spend le…

This study aims to find the best treatment to help patients with multiple myeloma recover from severe kidney damage caused by the disease. It will compare three approaches: a blood-filtering procedure called plasma exchange, newer drug regimens based on daratumumab, and older dru…

This study is testing a new, personalized guidance system for giving IV fluids to patients with advanced liver disease who develop sudden kidney injury. Researchers will compare this new system against the standard albumin treatment to see which is safer, more effective, and easi…

This study is testing a new medical device designed to protect kidney function in patients with existing kidney problems who need heart surgery. The device, called JuxtaFlow, works by gently supporting the kidneys' natural filtering process during the stressful period of surgery.…

This study is testing if using a special ultrasound scan, called VExUS, to guide how much fluid a patient receives during lung surgery can help prevent serious complications. Researchers will compare this scan-guided approach to the standard fluid plan in 230 patients. The main g…

This study is testing if adding a pill called an SGLT2 inhibitor (a type of diabetes drug) to standard hospital care is safe and helps patients who are hospitalized with both worsening heart failure and sudden kidney injury. Researchers will enroll 130 adults and randomly give th…

This study is testing a new digital care plan to help people recover after a sudden kidney injury during a hospital stay. It uses a patient's electronic health record to calculate their personal risk of future kidney or heart problems and creates a tailored plan for their care af…

This study is testing a new, short-acting blood thinner called Niyad for patients with sudden kidney failure who need continuous dialysis but cannot use standard blood thinners due to a high risk of bleeding. The goal is to see if Niyad can safely prevent the dialysis filter from…

This study is testing whether stem cells from donor fat tissue can help prevent kidney damage from getting worse in adults who have suffered a major trauma or burn. Researchers will give three infusions over three days to 70 patients who have already developed early signs of kidn…

This study aims to see if it's safe to perform a crucial heart imaging test immediately, using an ultra-low amount of dye, in hospitalized patients who have a sudden drop in kidney function. Researchers will compare patients who get the test right away to those who wait until the…

This study is testing which level of sodium in dialysis fluid works best for ICU patients with sudden kidney failure. Researchers are comparing a standard higher sodium level against a slightly lower one to see if the lower level can control dangerous fluid buildup just as well w…

This study is testing whether giving patients extra albumin, a protein made by the liver, for five days after a liver transplant can help prevent kidney injury. It will compare a group that gets enough albumin to keep their blood levels high with a group that gets less. The goal …

This study aims to see if one drug (cilastatin) works as well as another (thiosulfate) at protecting the kidneys during a specific, intensive surgery for ovarian cancer. The surgery involves removing visible tumors and then bathing the abdomen with heated chemotherapy. Researcher…

This study is testing a medical device called PrismaLung+ that helps remove excess carbon dioxide from the blood of critically ill patients who are on breathing machines. The research will compare patients using the device along with standard ventilator care against those using o…

This study aims to improve the early detection of serious kidney injury in hospitalized adults. Researchers will test whether adding simple blood and urine tests to a computer's risk prediction score makes it more accurate. They plan to enroll 800 patients at high risk for kidney…

This study is testing whether a special type of ultrasound can detect kidney injury earlier in patients who have had vascular surgery. Researchers will compare scans from 50 healthy people to scans from patients who develop kidney problems after their operation. The goal is to se…

This study is testing a new imaging technology called dynamic full-field optical coherence tomography to see if it can help doctors analyze kidney biopsies faster and more accurately. Researchers will compare this new method to standard biopsy analysis in 50 adult patients with s…

This study is testing if a blood test for a protein called cystatin C can detect kidney injury caused by imaging dye earlier than the standard creatinine test. It will enroll 100 adult inpatients with chronic kidney disease who are having a CT scan or heart angiogram. The goal is…

This study is testing a new blood test to monitor kidney transplants. Researchers want to see if they can detect early signs of transplant problems by measuring tiny bits of kidney DNA in the blood. If successful, this could help doctors catch issues sooner and reduce the need fo…

This study is testing if a quick, non-invasive ultrasound scan can detect early signs of kidney injury in high-risk patients in the surgical intensive care unit. Researchers will compare this scan to standard blood and urine tests to see if it provides an earlier warning. The goa…

This study looks at whether a common class of diabetes drugs, called SGLT2 inhibitors (flozins), can help prevent kidney injury caused by the contrast dye used during heart imaging and procedures. Researchers are reviewing the medical records of 4,000 patients who had these heart…

This study is testing if an existing drug called cilastatin can prevent sudden kidney injury in hospitalized adults. About 700 patients receiving medications known to sometimes harm the kidneys will receive either cilastatin or a placebo. The goal is to see if the drug can safely…

This study is testing whether melatonin, a common over-the-counter supplement, can prevent kidney damage in hospitalized patients who need strong antibiotics. It will involve 300 adults who are prescribed a specific combination of antibiotics. Participants will receive either mel…

This study is testing if a drug called theophylline can prevent kidney injury in newborns who experience a lack of oxygen to the brain at birth. It will enroll 30 infants who are already receiving standard cooling therapy. The main goal is to see if it's feasible to run a larger …

This study is testing whether an experimental drug called LSALT peptide can prevent or lessen kidney injury in patients having major heart surgery using a heart-lung machine. About 240 adult patients at higher risk for kidney problems will receive either the drug or a placebo (sa…

This large global study is testing whether a daily pill called dapagliflozin can prevent severe kidney injury in 3000 critically ill patients admitted to intensive care. Patients are randomly assigned to receive either the active drug or a placebo pill for up to 30 days while in …

This study is testing whether an investigational drug called GDC-8264 can prevent serious kidney injury in people undergoing major heart surgery. It will involve about 404 adults who are at moderate to high risk for kidney problems after their operation. Participants will receive…

This study aims to find better early warning signs for kidney injury after kidney removal surgery. Researchers will test new markers in the urine and blood of 60 patients undergoing this operation. The goal is to see if these markers can predict both immediate and long-term kidne…

This study aims to understand why some critically ill patients develop sudden kidney damage, especially after severe infections or major surgery. Researchers will measure inflammation markers in blood, urine, and sputum from 100 ICU patients with sepsis, recent surgery, or chemic…

This study is testing a non-invasive sensor that measures oxygen levels in the kidneys during lung transplant surgery. Researchers want to see if low oxygen readings during the operation can predict which patients will develop kidney failure in the days after surgery. The goal is…

This study aims to understand how severe kidney injury is treated and what happens to patients across different Latin American countries. Researchers will observe 1,000 critically ill adults who need dialysis for sudden kidney failure. The goal is to collect data on current care …

This study aims to understand why kidney disease happens, gets worse, or leads to complications like infections or heart problems. Researchers will follow 5,000 adult patients with or at risk for kidney disease for 10 years, collecting blood and urine samples. They will analyze t…

This study is looking to see if taking creatine supplements for one week changes markers of kidney injury, inflammation, and thinking ability in healthy, active young adults after they exercise in hot conditions. Researchers will compare people taking creatine to those taking a p…

This international study aims to understand how often children develop sudden kidney problems after non-heart surgery and why it happens. Researchers will observe 2,000 children aged 0-16 after their operations, checking their blood and urine for signs of kidney stress. The main …

This study is testing a special type of MRI scan to see if it can help doctors predict which patients with kidney disease are most likely to develop serious heart problems. Researchers will scan the hearts and kidneys of 120 people with different kidney conditions, including rece…

This study aims to understand if a patient's hemoglobin level (a measure of red blood cells that carry oxygen) before emergency surgery is linked to their risk of developing sudden kidney injury afterward. Researchers will observe 420 patients undergoing emergency surgery, record…

This study aims to find out if safely reducing unnecessary blood tests and x-rays in intensive care units (ICUs) affects patient survival. It will involve 10,000 adult patients across Sweden's ICUs. Researchers will compare standard care to a new approach that questions the need …

This study aims to understand why some hospitalized adults develop sudden kidney injury (AKI) and what happens to them afterward. Researchers will follow 1,000 patients, collecting health data and samples to identify risk factors and long-term outcomes like heart disease or chron…

This study aims to understand how drops in blood pressure during heart surgery affect patients' recovery. Researchers will follow 230 adults having planned heart surgery to see if low blood pressure during the operation leads to serious complications like kidney problems, confusi…

This study aims to find out if two standard antibiotic combinations used to treat serious infections in the hospital carry different risks of kidney injury. Researchers will enroll 750 adult patients and compare kidney health using newer, more sensitive tests over the first five …

This study aims to improve care for children who develop sudden kidney injury during a hospital stay. Researchers will interview families and healthcare providers to understand challenges and create better educational tools. The goal is to develop resources that help families man…

This study aims to find out if starting continuous kidney dialysis (CRRT) earlier is better than starting it later for critically ill patients with sudden kidney failure. Researchers will analyze the medical records of 50,000 ICU patients from three Swedish hospitals to compare s…