New hope for hospital patients: drug may shield kidneys from harmful meds

NCT ID NCT06886464

Recruiting now Prevention Sponsor: Matthew James Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether cilastatin, a drug already used for other purposes, can prevent acute kidney injury in hospitalized patients who must take medications known to harm the kidneys. About 700 adults receiving certain antibiotics, chemotherapy, or contrast dyes will receive either cilastatin or a placebo every six hours. Researchers will monitor kidney function daily and follow up at 90 days to see if the drug reduces kidney damage.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2R3, Canada

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Calgary
RECRUITING

Calgary, Alberta, T2N 1N4, Canada