Which citrate solution minimizes metabolic chaos in kidney therapy?
NCT ID NCT07751861
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests two different concentrations of citrate solution used to prevent blood clotting during continuous kidney replacement therapy in critically ill patients with acute kidney injury. The goal is to see which concentration leads to fewer metabolic complications, such as the need for extra electrolytes like magnesium, phosphate, or potassium. By comparing the low and high concentration solutions, the study aims to identify a safer approach for managing these patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low concentrated citrate solution (18 mmol/L) or high concentrated citrate solution (136 mmol/L)
- What this could lead to
- If one citrate solution proves safer, it could become the standard choice for kidney replacement therapy in intensive care, reducing metabolic complications and improving patient outcomes.
- What could go wrong
- The trial is relatively small and focuses on a specific ICU population, so results may not apply broadly. Both solutions carry risks of electrolyte imbalances or acid-base disturbances.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Antwerp University Hospital
Edegem, Antwerp, 2650, Belgium
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