ACUTE KIDNEY INJURY

This study tests whether a personalized care plan at hospital discharge helps people who survived acute kidney injury recover better. Depending on their risk level, patients get education, a primary care visit, or specialist monitoring. The goal is to see if this approach increas…

This study tests an experimental drug called AZD4144 in 124 adults with sepsis who have also developed acute kidney injury. Participants receive either the drug or a placebo daily by IV while in the hospital. The main goal is to see if the drug helps maintain kidney function bett…

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This study tests whether a personalized digital care plan, given at hospital discharge, can reduce serious health problems after acute kidney injury (AKI). About 6,000 adults who had AKI in hospital will be randomly assigned to receive either the tailored plan or usual care. The …

This Phase 2 trial tests whether the drug LSALT peptide can prevent or reduce acute kidney injury in 240 adults undergoing on-pump cardiac surgery. Participants receive either the drug or a placebo before surgery, and doctors monitor kidney function for a week. The goal is to see…

This study looks at people with a sudden kidney blockage from a stone in their only working kidney. Doctors will randomly use either a tube placed through the bladder or one through the back to drain urine. The goal is to see which method helps kidney function recover better and …

This early-stage study tests whether adding an iron-binding drug (MEX-CD1) to dialysis fluid can safely remove extra iron from the blood of adults in the ICU with sepsis and acute kidney injury. Each participant will receive two 24-hour dialysis sessions—one with standard fluid a…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests whether using very little contrast dye (less than 20cc) during coronary angiography is safer for patients who already have acute kidney injury. Researchers will compare immediate angiography with delayed angiography to see if ultra-low contrast reduces the risk o…

This study compares two types of continuous dialysis used in the ICU for patients with sudden kidney failure. One method uses a citrate-based blood thinner, the other uses heparin. The goal is to see if the citrate method is just as effective at removing waste from the blood. 80 …

This study monitors the safety of QUELIMMUNE, a device already approved for emergency use in critically ill children with acute kidney injury caused by sepsis. Researchers will track 50 patients to see how many develop new bloodstream infections within 28 days. The goal is to ens…

This study tests whether a virtual home hospital program with remote monitoring can help people recover from acute kidney injury without needing to stay in the hospital. Researchers will enroll 354 adults who are at high risk of readmission. Participants will receive digital tool…

This study tests whether a patient's own modified white blood cells can help kidneys recover faster after acute injury from heart surgery. About 98 adults will receive either the cell therapy or a placebo. The goal is to see if the treatment shortens recovery time and is safe.

This study tests a special monitor that predicts low blood pressure during dialysis in ICU patients. The goal is to prevent dangerous drops by alerting doctors early. About 46 adults with kidney injury or failure will take part. If successful, this approach could make dialysis sa…

This study looks at whether a lower dose of continuous dialysis (CRRT) is safe and works as well as the standard dose for critically ill patients with acute kidney failure in the ICU. About 100 adults who need dialysis will be randomly assigned to receive either the standard dose…

This study tests a device called the Selective Cytopheretic Device (SCD) in 339 ICU patients with severe acute kidney injury who are already on continuous kidney replacement therapy. The device filters blood to reduce inflammation, and researchers want to see if it improves survi…

This study looks at whether a special blood filter called oXiris helps people with septic shock and kidney failure survive. Researchers will review medical records of 360 adults in the ICU who needed continuous blood filtering. They will compare those who got the oXiris filter wi…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This trial tests a device called JuxtaFlow that applies mild suction to the kidneys during heart surgery. The goal is to see if it can protect kidney function in people with pre-existing kidney problems. 124 adults undergoing heart surgery with a heart-lung machine will be random…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom relief between those wh…

This study tests a volume assessment guidance algorithm (VAGA) to help doctors decide how much and what type of IV fluid to give cirrhosis patients with acute kidney injury. Fifty hospitalized adults with cirrhosis and kidney injury will be randomly assigned to receive either VAG…

This study tests whether stem cells from donated fat tissue can prevent kidney injury from getting worse in people who have been severely hurt in accidents or burns. About 70 ICU patients will receive either stem cells or a placebo. The goal is to see if the treatment is safe and…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study looks at whether giving the acid-reducing drug pantoprazole (Protonix) early after a traumatic injury with severe bleeding can lower the risk of acute kidney injury. Researchers will compare early dosing (within 2 hours of arrival) to usual timing (in the ICU) in 100 a…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the d…

This study compares two approaches to removing excess fluid in intensive care patients with acute kidney injury who are on dialysis. One group will have fluid removed at a moderate rate to actively reduce fluid buildup, while the other group will have fluid removed slowly to just…

This study is for adults with severe cardiogenic shock who need a heart-lung machine (ECMO) and have developed acute kidney injury. Researchers want to see if starting dialysis (continuous renal replacement therapy) earlier improves survival and reduces long-term kidney dependenc…

This study tests whether SGLT2 inhibitors, drugs already used for diabetes and chronic kidney disease, can help people with acute kidney disease (AKD). AKD occurs between 7 and 90 days after a kidney injury and can lead to chronic kidney disease. The trial will give either the dr…

This study tests whether briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with congestive heart failure. About 240 participants will be randomly assigned to receive either the real cuff inflations or a sham ve…

This study looks at whether SGLT2 inhibitors (drugs like empagliflozin and dapagliflozin, typically used for diabetes) can prevent acute kidney injury caused by contrast dye used in heart X-rays and stent procedures. Researchers will review records of 4,000 patients who had these…

This study looks at two treatments—plasma exchange (a blood-filtering procedure) and the drug daratumumab—to see if they help patients with multiple myeloma recover from acute kidney injury caused by light chain cast nephropathy. Researchers will track 450 adults to see who survi…

This study compares two drugs, cilastatin and thiosulfate, for protecting the kidneys in women with ovarian cancer who undergo surgery with heated chemotherapy. About 90 patients will be randomly assigned to receive one of the drugs during the procedure. The main goal is to see w…

This study tests a drug called Niyad as a blood thinner for people with acute kidney injury who need continuous dialysis but cannot use the standard drug heparin or are at high risk for bleeding. About 70 participants will receive either Niyad or a placebo to see if it safely pre…

This study compares two sodium levels (140 vs 145 mmol/l) in the dialysis fluid given to ICU patients with acute kidney injury. The goal is to see if the lower sodium level reduces dangerous fluid buildup while still keeping blood pressure stable during treatment. About 158 adult…

This study tests whether Amimestrocel, a stem cell therapy from umbilical cords, can help people with acute kidney injury. Fifty adults aged 18 to 75 will receive the cells through an IV on four days. Researchers will check kidney function and safety over time.

This study tests whether a special follow-up program led by nurses and kidney specialists helps people recover better after a serious kidney injury. About 2,145 adults who had moderate to severe kidney injury in the hospital will be randomly assigned to either the program or usua…

This study investigates whether a urine test called Nephrocheck can predict which patients with septic shock will develop severe acute kidney injury. The test measures two markers of kidney damage (TIMP2 and IGFBP7). Researchers will analyze data from previous studies involving a…

This study tests a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsies. The goal is to see if this method can identify signs of acute kidney injury or chronic kidney disease as well as or better than standard microscope an…

This study tests whether a bedside ultrasound technique called renal resistive index can detect acute kidney injury earlier than standard methods in high-risk ICU patients. Researchers will enroll 100 adults with conditions like severe pre-eclampsia, trauma, or sepsis. They will …

This study looks at whether a blood test for cystatin C can detect acute kidney injury earlier than the standard test in people with chronic kidney disease who receive contrast dye for CT scans or heart procedures. Researchers will compare how often kidney injury is found using e…

This study is testing a new ultrasound technique called Shear Wave Elastography to see if it can detect acute kidney injury early after vascular surgery. Researchers will compare results from 50 healthy volunteers and surgery patients. The goal is to find a quick, non-invasive wa…

This study tests whether the drug R2R01 can prevent acute kidney injury in people at high risk who are having heart surgery with a heart-lung machine. Participants receive either R2R01 or a placebo before and after surgery. The goal is to see if the drug reduces kidney damage and…

This study tests whether giving a concentrated saltwater solution (hypertonic saline) right after a heart transplant can prevent or lessen acute kidney injury. About 74 adults who are hospitalized for a heart transplant will take part. The goal is to see if this simple approach c…

This study tests whether melatonin, a common sleep aid, can prevent kidney damage in hospitalized patients who need a strong antibiotic called vancomycin. About 300 adults aged 18 to 75 will receive either melatonin or a placebo alongside their antibiotic. The goal is to see if m…

This study tests whether cilastatin, a drug already used for other purposes, can prevent acute kidney injury in hospitalized patients who must take medications known to harm the kidneys. About 700 adults receiving certain antibiotics, chemotherapy, or contrast dyes will receive e…

This study tests whether putting a drug called aminophylline into the bladder before placing a ureteral stent helps doctors get the stent past a blocking stone more easily. The trial involves 72 adults with sudden kidney failure from stones in a single working kidney. Half get th…

This study watches how blood flows to the kidneys in 51 adults having elective minimally invasive abdominal surgery. Researchers use two non-invasive tools—ultrasound and light sensors—to measure kidney function at key times during and after surgery. The goal is to see if these t…

This study looks at whether giving more protein (over 1.2 grams per kilogram per day) to critically ill patients with acute kidney injury helps their kidneys recover faster or causes harm. Researchers will review medical records from 344 adults in five Argentine ICUs, comparing t…

This study observes 2000 children aged 0-16 who have noncardiac surgery to see how often kidney injury occurs. Researchers will also test urine markers for early detection. The goal is to find risk factors and improve prevention strategies.

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study looks at better ways to check kidney function after acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin C) to see which is more reliable. They will also interview patients about their recovery experiences and hold workshops to d…

This study looks at whether giving less fluid during heart surgery, a technique to reduce blood loss, increases the risk of kidney injury. Researchers will measure kidney injury markers in 100 adults having elective bypass surgery. The goal is to understand if this common practic…

This study is testing an artificial intelligence tool designed to help emergency room doctors detect and manage acute kidney injury (AKI) sooner. Researchers will roll out the AI system at three hospitals and track whether it improves care, reduces kidney damage, and fits into do…

This study looks at how a blood-filtering cartridge (HA 380) used with continuous kidney dialysis removes antibiotics in ICU patients with septic shock and kidney failure. Researchers will take blood samples before and after the filter at several time points to measure changes in…

This study is testing whether a computer algorithm can accurately predict acute kidney injury in children admitted to the intensive care unit. Researchers will enroll 800 children and use the algorithm to assess risk, but the results will not be shared with doctors during the stu…

This study tests a modified blood-thinning protocol using citrate during continuous kidney replacement therapy in 43 ICU patients with acute kidney injury. The goal is to see if the new method reduces loss of important minerals like potassium and magnesium, cutting down on the ne…

This study looks at whether a furosemide stress test can help doctors decide when to stop continuous kidney replacement therapy in critically ill patients with acute kidney injury. The test measures how well the kidneys respond to a diuretic. The goal is to reduce complications f…

This study looks at whether a person's hemoglobin (a part of red blood cells) before emergency surgery is linked to developing acute kidney injury afterward. Researchers will follow 420 adults having non-cardiac emergency surgery. The goal is to better understand this connection,…

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study looks at whether taking creatine for a week can reduce kidney injury and keep thinking sharp during exercise in the heat. Twenty healthy, active adults will cycle in a hot room after taking creatine or a placebo. Researchers will measure urine markers of kidney stress …

This study is observing 1,000 critically ill adults in Latin American ICUs who need dialysis for severe acute kidney injury. Researchers will track treatments, outcomes, and country differences to understand what works best. The goal is to gather data that can improve care and gu…

This study tests whether a non-invasive light sensor placed on the lower back can detect low oxygen levels in the kidneys during lung transplant surgery. The goal is to see if these readings can predict which patients will develop acute kidney failure shortly after the operation.…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at two methods for providing kidney dialysis to patients on ECMO (a heart-lung machine). One method uses a separate line for dialysis, while the other connects the dialysis machine directly into the ECMO circuit. The goal is to see if the direct connection works …

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…

This study tracks 230 adults having planned heart surgery to see if unstable blood pressure during the operation raises the risk of serious problems like confusion, kidney injury, stroke, or death within 30 days. Researchers will monitor blood pressure dips and use of pressure-ra…

This study is looking at 100 intensive care patients to see if certain inflammatory markers in urine, blood, and sputum can help predict acute kidney injury. The researchers are comparing patients with sepsis, those recovering from major surgery, and non-inflamed individuals. The…

This study tests an interactive iPad educational tool to help families of children with acute kidney injury (AKI) learn more about the condition. Researchers will measure AKI knowledge before and one month after using the tool. The goal is to improve patient-centered care and red…

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary tests and treatments in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if this approach lowers costs and improves care without …

This study is testing whether a special ultrasound technique called VExUS can help doctors manage fluids better during chest surgery. The goal is to see if it lowers the chance of lung and kidney problems after surgery. About 230 adults having video-assisted lung surgery will tak…

This study is testing a new blood test that looks for kidney-specific DNA to detect injury or rejection after a kidney transplant. Researchers will measure these DNA markers before and after surgery in 30 patients with end-stage kidney disease. The goal is to see if the test can …

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…

This study is testing whether adding blood and urine biomarkers to a computer risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). Researchers will enroll 800 adults at high risk (top 10% by the risk score) and track them for th…

This study is testing whether certain substances in urine and blood can predict acute kidney injury and chronic kidney disease after radical nephrectomy (complete kidney removal). Researchers will monitor 60 adults undergoing this surgery, collecting samples at several time point…

This study reviews medical records from over 50,000 critically ill patients to see if starting dialysis earlier helps them live longer. Researchers will compare patients who started dialysis early versus late, looking at survival up to 90 days and beyond. The goal is to find the …