ACUTE KIDNEY INJURY

This study tests if cilastatin is as good as thiosulfate at preventing kidney damage in women with ovarian cancer who undergo surgery with heated chemotherapy. About 90 women aged 18-75 will receive one of the two drugs during their procedure. The main goal is to see how many dev…

This study tests a blood filter called HA380 in 40 very ill adults (ages 18–65) who are on dialysis or a heart-lung machine (ECMO) due to severe infection, injury, or major surgery. The filter aims to remove inflammatory substances from the blood, potentially reducing time on lif…

This study monitors children (ages 10 to 22, weighing at least 22 pounds) who receive a device called QUELIMMUNE for acute kidney injury caused by sepsis. The device filters blood during dialysis to calm the immune system. The main goal is to see if it causes fewer new bloodstrea…

This study tests a device called the Selective Cytopheretic Device (SCD) in intensive care unit (ICU) patients with sudden, severe kidney injury who are already on a kidney replacement machine. The goal is to see if adding up to ten 24-hour SCD treatments to standard care helps m…

This study tests whether giving a protein called albumin after a liver transplant can lower the chance of acute kidney injury. About 400 adults receiving a new liver will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only gets it …

This study tests a device called JuxtaFlow that helps protect the kidneys during heart surgery. It is for people with kidney problems who are having heart surgery with a heart-lung machine. The device gently reduces pressure in the kidneys to help them work better. The goal is to…

This study tests whether using very low amounts of contrast dye during heart X-rays is safe for people who already have acute kidney injury. About 32 hospitalized adults will be randomly assigned to get the heart imaging right away or wait until their kidneys stabilize. The goal …

This study tests whether giving a stomach acid drug (pantoprazole) early after severe bleeding from injury can reduce kidney damage. About 100 adults with hemorrhagic shock will be randomly assigned to get the drug early or at the usual time. The goal is to see if early treatment…

This study tests whether adding an SGLT2 inhibitor (a type of diabetes medicine) to standard hospital care helps people with heart failure who also develop acute kidney injury. Researchers will compare outcomes like survival, need for dialysis, and symptom improvement between tho…

This study tests whether a special follow-up program helps adults who had a serious kidney injury spend fewer days in the hospital over 3 months. About 2,145 participants will either get the program or usual care. The program includes extra monitoring and support to prevent furth…

This study looks at whether a simple test using a water pill (furosemide) can help doctors decide when to safely stop continuous kidney replacement therapy in critically ill patients. The test measures how well the kidneys respond, aiming to avoid unnecessary time on the machine …

This study tests if briefly inflating a blood pressure cuff on the arm before a heart procedure can protect the kidneys and heart in people with heart failure. About 240 adults with heart failure who need a heart catheterization will be randomly assigned to receive either the cuf…

This study tests whether a virtual home hospital program, using digital tools and remote monitoring, can help adults with acute kidney injury recover at home instead of staying in the hospital. The goal is to reduce hospital readmissions and improve long-term outcomes. About 354 …

This study looks at whether giving a lower dose of continuous dialysis (CRRT) to critically ill patients with sudden kidney failure is safe and works as well as the standard dose. About 100 adults in the ICU who need dialysis will be randomly assigned to receive either the standa…

This study tests a personalized care plan for people leaving the hospital after acute kidney injury (AKI). About 6,000 adults in Alberta hospitals will be randomly assigned to either receive a tailored care plan based on their risk or usual care. The plan uses digital tools in th…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 people in intensive care will receive either the drug or a placebo daily through an IV. The main goal is to see if the drug helps the kidneys work better compared…

This study tests a drug called Niyad in 70 adults with acute kidney injury who need continuous dialysis but cannot take the standard blood thinner, heparin, because of bleeding risk. The drug is added to the dialysis machine to prevent clots from forming in the filter. The goal i…

This study tests whether SGLT2 inhibitors, drugs already used for diabetes and chronic kidney disease, can help people with acute kidney disease (AKD) recover and avoid progressing to chronic kidney disease. About 264 adults with AKD, with or without diabetes, will receive either…

This study tests whether giving two medicines, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with kidney problems. About 100 adults with chronic kidney disease or acute kidney injury who need noncardiac surgery will take part. The goal is to see…

This study tests whether removing excess fluid more quickly (2 mL/kg/h) in ICU patients with acute kidney injury on dialysis improves recovery and reduces the need for breathing machines, blood pressure drugs, and dialysis. About 250 adults will be randomly assigned to either a f…

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The goal is to see if adding this device to standard care helps improve blood gas levels and reduce lung injury. About 99 adults with …

This study looks at whether SGLT2 inhibitors (a type of diabetes drug) can prevent acute kidney injury caused by contrast dye used during heart procedures like angiography or stenting. Researchers will analyze data from 4,000 patients to compare kidney function before and after t…

This study tests whether using a patient's own modified white blood cells can help the kidneys recover faster after acute injury from heart surgery. About 98 adults who develop kidney problems within 48 hours after surgery will receive either the cell therapy or a placebo. The go…

This study tests whether giving extra fluids through an IV before and after a new type of heart procedure (pulsed field ablation) can prevent kidney injury in people with atrial fibrillation. About 290 adults will be randomly assigned to receive either standard care or extra flui…

This study looks at whether using a lower sodium concentration in dialysis fluid can reduce dangerous fluid buildup in ICU patients with acute kidney injury. About 158 adults on a specific type of slow daily dialysis will be randomly assigned to receive either standard high-sodiu…

This study tests whether stem cells from donated fat tissue can prevent kidney injury from getting worse in people who have been badly hurt or burned. About 70 adults in intensive care will receive the cells and be watched for side effects and kidney recovery. The goal is to see …

This study looks at whether plasma exchange or newer drugs like daratumumab can help the kidneys recover in people with multiple myeloma who have a type of kidney damage called light chain cast nephropathy. About 450 adults with this condition will be followed for 90 days to see …

This study compares starting kidney dialysis early versus at the usual time for people in severe heart shock who are on a heart-lung machine (ECMO) and have kidney injury. The goal is to see if early dialysis reduces death or the need for long-term dialysis. About 408 adults will…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to find which approach is safer and works better. About 50 hospitali…

This study tests a new treatment called Amimestrocel, made from stem cells, for people with acute kidney injury (sudden kidney damage). Researchers want to see if it can safely improve kidney function and reduce the need for dialysis. About 50 adults aged 18 to 75 will take part.…

This study looks at whether a bedside ultrasound test, called renal resistive index, can detect acute kidney injury early in high-risk patients in the surgical intensive care unit. About 100 adults with conditions like severe pre-eclampsia, trauma, or sepsis will be enrolled. The…

This study is testing a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsy samples. The goal is to see if this method can quickly and accurately identify signs of acute kidney injury or chronic kidney disease, compared to t…

This study looks at whether a blood test called cystatin C can find kidney injury earlier than the usual test in people with chronic kidney disease who get contrast dye for CT scans or heart procedures. About 100 adults will be followed for up to 10 days after their scan. If cyst…

This study explores a new ultrasound technique called Shear Wave Elastography to detect acute kidney injury early after vascular surgery. Researchers will compare results from 50 healthy volunteers and surgery patients to see if the test can identify kidney damage sooner than sta…

This study tests an investigational drug called LSALT peptide to see if it can prevent or reduce acute kidney injury (AKI) in people having heart surgery with a heart-lung machine. About 240 adults scheduled for non-emergency heart surgery will receive either the drug or a placeb…

This study tests whether the drug cilastatin can prevent acute kidney injury in hospitalized patients who must take medications known to harm the kidneys. About 700 adults receiving certain antibiotics, chemotherapy, or contrast dyes will receive either cilastatin or a placebo ev…

This study tests whether melatonin, a natural sleep hormone, can prevent kidney injury caused by the antibiotic vancomycin. Researchers will give melatonin to 300 hospitalized adults aged 18-75 who are starting vancomycin therapy. The goal is to see if melatonin reduces the risk …

This study tests whether a special salt solution (hypertonic saline) given right after a heart transplant can prevent or lessen kidney damage. About 74 adults who have just received a heart transplant will take part. The goal is to see if this simple treatment can keep creatinine…

This study tests whether giving theophylline, a drug used for asthma, can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. About 30 infants will receive the drug soon after birth. The goal is to see if this app…

This study looks at a modified dialysis method for adults in the ICU with acute kidney injury. The goal is to see if a specific blood-filtering technique using citrate helps keep electrolyte levels stable and reduces the need for extra supplements. About 43 participants will be f…

This study tests whether using a special ultrasound technique (VExUS) to guide fluid levels during lung surgery can lower the risk of lung and kidney problems after the operation. About 230 adults having video-assisted lung surgery will be split into two groups: one gets standard…

This study is looking at 5,000 adults with or at risk for kidney disease, including transplant recipients, to find molecular clues that predict disease progression or complications. Researchers will analyze blood and urine samples using advanced techniques to identify genes, prot…

This study looks at whether starting kidney dialysis earlier or later helps critically ill patients with sudden kidney failure live longer. Researchers will review records from over 50,000 ICU patients in Sweden. The goal is to find the best timing for dialysis to improve surviva…

This study looks at a new way to monitor kidney transplant health by measuring kidney-specific DNA in the blood. Researchers will test 30 adults with end-stage kidney failure before and after their transplant surgery. The goal is to tell the difference between DNA from the patien…

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 participants with CF, both during routine visits and during hospital stays for lung flare-ups, and compare them to samples fr…

This study aims to see if adding blood and urine tests to an AI-based risk score can better predict which hospitalized patients will develop severe acute kidney injury (AKI). Researchers will enroll 800 adults at high risk and collect samples over three days. The goal is to impro…

This study looks at whether taking creatine for a week can reduce kidney injury risk and help thinking stay sharp after hard exercise in hot conditions. Twenty healthy, active adults will take either creatine or a placebo, then cycle in a hot room. Researchers will measure urine …

This study is testing whether a special type of MRI scan, called manganese-enhanced MRI (MEMRI), can help predict heart and kidney complications in people with kidney disease. Researchers will scan 120 adults with conditions like acute kidney injury, chronic kidney disease, or ki…

This study watches how hospitals in Latin America treat sudden kidney failure that needs dialysis. Researchers will track 1,000 ICU patients to see what care they get and how they recover. The goal is to find ways to improve treatment and outcomes across different countries.

This study tests a teaching program for families of children with acute kidney injury (AKI). About 25 children aged 1 to 18 who are in the hospital with AKI will take part. The goal is to see if the program helps families better understand AKI and improve care.

This study looks at whether new biological markers can predict acute kidney injury and long-term kidney disease in 60 adults who have a kidney removed due to cancer. Current tests are slow and not always accurate. Researchers will measure these markers in blood and urine before, …

This study is observing 2,000 children (0-16 years old) from hospitals around the world to see how often kidney injury happens after non-heart surgery. Researchers will track kidney function with blood and urine tests to find early warning signs. The goal is to better understand …

This study looks at 158 adults on a heart-lung machine (ECMO) who also need kidney dialysis. Doctors want to see if connecting the dialysis directly into the ECMO circuit works as well as using a separate tube. The main goal is to measure how long the dialysis filter lasts before…

This study investigates why many ICU patients develop acute kidney injury, especially after sepsis or major surgery. Researchers will measure inflammatory markers in urine, blood, and sputum from 100 participants to see if these markers are linked to kidney damage. The goal is to…

This study is for adults who need emergency non-cardiac surgery. It will track their hemoglobin (a protein in red blood cells) before surgery and see if low levels are linked to acute kidney injury afterward. The goal is to understand the connection better, not to test a new trea…

This study is testing an artificial intelligence (AI) tool that helps emergency room doctors detect and manage acute kidney injury (AKI) earlier. Researchers will roll out the tool at three hospitals and track whether it improves care, such as catching kidney issues sooner and av…

This study looks at whether a common blood-saving technique used during heart surgery might increase the risk of kidney injury. Researchers will compare 100 adults having bypass surgery—some who get the technique and some who don't—by measuring kidney injury markers in their urin…

This study tracks 230 adults having planned heart surgery to see if drops in blood pressure during the operation lead to serious problems like confusion, kidney damage, stroke, or death within 30 days. Researchers will monitor blood pressure and use of medicines to raise it, then…

This study looks at how to improve follow-up care for people who have had acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin) to see which better measures kidney function after AKI. They will also interview patients about their experience…

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam versus vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury using more sensitive markers than standard…

This study is testing whether a non-invasive light sensor (NIRS) placed on the skin can detect low oxygen levels in the kidneys during lung transplant surgery. The goal is to see if these readings can predict which patients will develop acute kidney failure shortly after the oper…

This study looks at whether a campaign called Choosing Wisely can safely reduce unnecessary medical tests in intensive care units (ICUs). About 10,000 adult patients in Swedish ICUs will take part. The goal is to see if using fewer tests affects survival rates and recovery.

This study tests whether a computer algorithm can accurately predict acute kidney injury (AKI) in children admitted to the intensive care unit (ICU). Researchers will enroll 800 children aged 1 month to 18 years and compare the tool's predictions to actual kidney function changes…