ACUTE KIDNEY INJURY

This study is testing whether metformin, a common diabetes medication, is safe and practical to use for treating sudden kidney failure caused by severe bloodstream infections (sepsis). Researchers will give metformin or a placebo to 80 adult patients in intensive care with sepsis…

This study is testing whether a blood pressure medication (an ARB called irbesartan) can help prevent future heart problems in people who survived a stay in the intensive care unit (ICU) and had acute kidney injury. About 508 participants will be randomly assigned to take either …

This study is testing if a drug called angiotensin 2, given during liver transplant surgery, can prevent kidney injury afterward. It will involve about 30 adults with severe liver disease who are receiving a transplant. Half will get the study drug along with standard medications…

This study is testing whether a drug called Auxora can help hospitalized patients who suddenly develop serious kidney damage while also having severe breathing problems. About 150 patients will receive either Auxora or a placebo through daily IV infusions for five days. Researche…

This study aimed to test whether giving doctors AI-powered risk alerts about patients after surgery could help prevent serious complications. The system would identify high-risk patients and notify their care teams, potentially allowing earlier intervention. The trial was withdra…

This study is testing a new, more active plan to manage fluid levels in critically ill patients whose kidneys have stopped working and require dialysis. It compares this planned approach to the usual care doctors provide. The goal is to see if carefully controlling fluid buildup …

This study is looking back at data from 343 patients who had long, non-emergency heart surgeries. It aims to better understand a special blood filter used during surgery. The main goal is to see if the filter safely helps protect the kidneys from injury after surgery and to check…

This small, early-stage study is testing a special blood-filtering device in 10 critically ill ICU patients whose kidneys are failing due to severe liver disease. The goal is to see if using the device for 7 days is safe and if it can help improve kidney and liver function. The s…

This study is testing a new, quick urine test that measures a protein called L-FABP. The goal is to see if this test can predict which patients are at high risk for kidney damage within two days after receiving contrast dye during heart or blood vessel procedures. Researchers wil…

This study aimed to test a new method for predicting which critically ill children and newborns in intensive care would develop severe kidney injury and fluid overload. Researchers planned to use a risk score and a urine test (NGAL) to identify high-risk patients early. The goal …

This study is testing a new blood and urine lab test to see if it can accurately identify which adult patients in the intensive care unit (ICU) are at high risk for developing serious kidney injury within 2-3 days. Researchers will collect samples from 800 critically ill patients…

This study aimed to test two new methods for detecting kidney injury much sooner after heart surgery. Researchers planned to use a special kidney ultrasound and a quick urine test within hours after surgery, comparing them to standard blood tests. The goal was to create a better …

This study is testing whether a drug called deferoxamine can prevent kidney injury in patients having heart surgery with a heart-lung bypass machine. The trial involves 320 adults at higher risk for this complication, who will receive either the drug or a placebo before and durin…

This study aims to collect information on how a specialized dialysis machine (CARPEDIEM) works for critically ill infants with severe kidney problems. Researchers will observe about 1000 infants across multiple hospitals who are already receiving this treatment as part of their s…

This study aims to create a better, standardized tool to assess fluid levels in hospitalized patients with sudden kidney injury (AKI). It will test different measurement methods, including a device called bioimpedance and patient symptoms, to see which are most useful. The goal i…

This study is collecting real-world information on how well the Carpediem system works for critically ill infants and small children with sudden kidney injury or severe fluid overload. Doctors at multiple U.S. hospitals will observe about 35 children (weighing 5.5 to 22 pounds) w…

This study aimed to see if two new monitoring tools could quickly predict kidney injury in children undergoing heart surgery. It planned to test special ultrasound and a light-based sensor during surgery to measure kidney blood flow and oxygen levels. The goal was to find a faste…

This study aimed to find out if a medical device called RenalGuard Therapy, which helps prevent kidney damage after heart surgery, is a good value for money for the UK's National Health Service. Researchers planned to analyze past medical records of heart surgery patients to comp…