ACUTE KIDNEY INJURY

This study tests a drug called Auxora in 150 adults with acute kidney injury and breathing failure. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive and recover without needing a ventilator or kidney dialysis.

This study tests a device called the Selective Cytopheretic Device (SCD) in 10 ICU patients with acute kidney injury and hepatorenal syndrome, a serious complication of liver disease. The device filters certain white blood cells over 7 days to see if it can improve kidney functio…

This study compares a proactive fluid management plan to standard care in 150 critically ill adults with acute kidney injury who need dialysis. The goal is to achieve a neutral or negative daily fluid balance by preventing and treating fluid buildup. The trial focuses on feasibil…

This study tests whether a common blood pressure medication (angiotensin receptor blocker) can prevent serious heart problems and kidney decline in patients who had acute kidney injury while in the intensive care unit. About 508 adults aged 18–75 will receive either the drug or a…

This study compares a drug called Angiotensin II to the usual treatment for raising blood pressure in people with liver disease who have a dangerous drop in blood pressure (shock). The goal is to see if Angiotensin II helps the heart and blood vessels work together better. About …

This study is testing whether a drug called ambrisentan can help people with hepatorenal syndrome, a serious kidney complication that occurs in advanced liver cirrhosis and often leads to death. Researchers are comparing ambrisentan against the standard treatment, terlipressin, i…

This study tests a new urine test that measures a protein called L-FABP to see if it can predict acute kidney injury within 2 days after heart or blood vessel procedures that use contrast dye. About 450 adults with reduced kidney function or other risk factors will provide urine …

This study collects blood and urine from 800 adult ICU patients to see if a lab test called ProNephro AKI (NGAL) can help predict who will develop moderate to severe acute kidney injury within 48-72 hours. The goal is to find the right cutoff value for the test. Participants must…

This study tests whether a medicine called deferoxamine can prevent acute kidney injury in adults having heart surgery. The drug works by removing extra iron from the blood, which may protect the kidneys. About 320 participants will receive either the drug or a placebo before sur…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or too much fluid in their body and are treated with the Carpediem system. Doctors will use the machine as they normally would and collect information on survival and kidney recovery. The goal is…

This study follows 420 children in the pediatric intensive care unit (PICU) who are at risk for acute kidney injury. Researchers use a biomarker test (NGAL) and a kidney stress test to predict which children will become fluid overloaded and need dialysis. The goal is to improve h…

This study gathers information on a new dialysis machine (CARPEDIEM) designed specifically for critically ill infants with kidney failure. Researchers will track up to 1,000 babies across the U.S. to learn the best ways to use the machine, how well it works, and whether it helps …

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors better manage fluids and dialysis timing. However, the study was withdrawn before enrolling any participan…

This study re-examines data from 343 heart surgery patients to learn more about a blood purification device used during surgery. The device was linked to a 12% lower risk of acute kidney injury. Researchers now want to see how it affects antibiotics, blood thinners, and other dru…

This study looks at how to better assess fluid status in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be caused by dehydration, infection, or low blood pressure. Getting fluid levels right is critical—too little or too much can cause har…

This study tests whether metformin, a common diabetes medicine, is safe and practical to use for treating acute kidney injury caused by sepsis. Researchers will enroll 80 intensive care patients to monitor side effects and see if the treatment can be given successfully. This is a…

This study aimed to analyze medical records to see if preventing acute kidney injury during heart surgery is worth the cost in the UK. It planned to compare patients who had kidney injury after surgery with those who did not. However, the study was withdrawn before enrolling any …

This study planned to test if using ultrasound and oxygen sensors during heart surgery could help doctors predict kidney injury in children. The goal was to find a faster way to spot kidney problems right in the operating room. However, the study was withdrawn before any patients…

This study was designed to track the long-term health of hospitalized patients in China who experience acute kidney injury (AKI). Researchers planned to measure how often kidney function worsens, new heart problems occur, or death happens after AKI. However, the study was withdra…

This study looks at whether special monitors can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients. About 30 adults in the ICU with acute kidney injury or end-stage kidney failure will take part. The goal is to…

This study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) happens during a hospital stay. Researchers will also see how AKI affects patients' chances of recovery, readmission, and survival. The goal is to better understand…

This study planned to test two new methods for finding kidney damage early in adults having heart surgery. Researchers wanted to see if these methods could predict acute kidney injury better than current tests. However, the study was withdrawn before any patients were enrolled, s…

This study planned to test whether giving doctors machine learning predictions about patient risk could reduce serious complications after surgery, like unplanned ICU stays or death. It was designed for adults at high risk, but the study was withdrawn before any participants were…

This study looks back at medical records of about 4,000 newborns in intensive care to understand how common kidney injury is and what factors increase the risk. Researchers want to update old data and include more hospitals around the world. No new treatments or drugs are given; …