ACUTE KIDNEY INJURY

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This study tests an experimental drug called Auxora in 150 adults with acute kidney injury and breathing failure. Patients receive either Auxora or a placebo daily for five days. The goal is to see if Auxora helps patients survive, breathe without a machine, and avoid kidney dial…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study tests whether ambrisentan, a drug approved for lung blood pressure, can help patients with hepatorenal syndrome—a serious kidney problem that can occur in advanced liver cirrhosis. About 54 hospitalized adults will receive either ambrisentan or the standard drug terlip…

This study tests a device called the Selective Cytopheretic Device (SCD) in ICU patients with acute kidney injury and hepatorenal syndrome, a serious complication of liver disease. The device filters white blood cells from the blood for 7 days to see if it improves kidney functio…

This study tests whether irbesartan, a blood pressure medication, can reduce the risk of major heart problems and kidney disease in people who had acute kidney injury while in the intensive care unit (ICU). About 500 adults aged 18-75 will take either irbesartan or a placebo for …

This study looks at whether a substance called UDP-glucose in urine can help doctors find kidney injury earlier in children after heart surgery. Current tests often miss early signs, delaying treatment. About 305 children under 8 years old having heart surgery will provide urine …

This study involves 800 adults in intensive care who provide urine samples to test a new lab test called ProNephro AKI (NGAL). The goal is to find the right cutoff value that best identifies patients at risk for moderate to severe acute kidney injury within 48-72 hours. The test …

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care or …

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which is thought to damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo …

This study tests a non-invasive ear stimulation technique (taVNS) to prevent acute kidney injury in 152 adults having heart surgery with a heart-lung machine. Half receive real stimulation before and after surgery; the other half get a sham. The main goal is to see if fewer peopl…

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study follows thousands of critically ill adults in intensive care units across China to better understand acute kidney injury (AKI), a common and dangerous complication. Researchers will collect medical data, images, and biological samples to build a large database. The goa…

This study planned to test whether giving doctors machine-learning alerts about patient risks after surgery could reduce serious complications like kidney injury or unplanned ICU stays. It was designed for high-risk patients, but the study was withdrawn before enrolling anyone, s…

This study was designed to track the long-term health of hospitalized patients in China who develop acute kidney injury (AKI). Researchers planned to monitor kidney function decline, new heart problems, and death rates over time. However, the study was withdrawn before any partic…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study follows about 36 children weighing 2.5-10 kg who have acute kidney injury or fluid overload and are treated with the Carpediem continuous renal replacement therapy system. Researchers will track survival, kidney recovery, and hospital stay lengths to see how well the d…

This observational study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) develops during a hospital stay. Researchers will also compare death rates and readmission rates between patients who develop AKI and those who do not…

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study looks at whether a biomarker test (NGAL) can help doctors better manage fluids and dialysis in children with acute kidney injury in the pediatric ICU. Researchers will follow 420 children at risk for kidney problems to see if the test helps make faster, safer treatment…

This study compares a proactive, prescription-based fluid management plan to usual care in 150 critically ill patients who need kidney replacement therapy (dialysis). The goal is to see if a standardized daily prescription can help achieve a neutral or negative fluid balance, pre…

This study aimed to compare costs and health outcomes for heart surgery patients who developed acute kidney injury versus those who did not. Researchers planned to review medical records from UK hospitals over a 10-year period. The study was withdrawn before enrolling any partici…

This study re-analyzes data from a previous trial of 343 heart surgery patients who received a blood purification device (oXiris) connected to the heart-lung machine. The original trial found a 12% reduction in acute kidney injury within 7 days. Now researchers will examine how t…

This study was designed to see if doctors could predict kidney damage in children after heart surgery by using an ultrasound probe in the esophagus and a light-based oxygen sensor on the skin. The goal was to catch kidney problems early. However, the study was withdrawn before an…

This study looks at better ways to check fluid levels in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different assessment methods, including physical exams and bioi…

This study planned to test two new methods for spotting acute kidney injury early in adults after heart surgery. Researchers wanted to see if these methods could predict kidney damage better than current tools. However, the study was withdrawn before enrolling any participants, s…