Could a lung drug save kidneys in liver patients?

NCT ID NCT06256432

Ongoing Disease control Sponsor: Noorik Biopharmaceuticals AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether ambrisentan, a drug approved for lung blood pressure, can help patients with hepatorenal syndrome—a serious kidney problem that can occur in advanced liver cirrhosis. About 54 hospitalized adults will receive either ambrisentan or the standard drug terlipressin. The goal is to see if ambrisentan improves kidney function and reduces death risk, with treatment continuing at home for up to 60 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ambrisentan
What this could lead to: If it works, this could offer a new treatment option for hepatorenal syndrome, potentially improving kidney function and survival in patients with advanced liver disease.
What could go wrong: This is an early Phase 2 trial with only 54 participants, so results may not apply to everyone. Ambrisentan may not work better than the current standard treatment, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE KIDNEY INJURY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute kidney injury cirrhosis of liver hepatorenal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY ASCITES HEPATIC HEPATORENAL SYNDROME LIVER CIRRHOSIS

Contacts and locations

Locations

All India Institute of Medical Sciences

New Delhi, National Capital Territory of Delhi, 110029, India
Asian Institute of Gastroenterology (AIG)

Hyderabad, Telangana, 500082, India
Aster CMI Hospital

Bangalore, Karnataka, 560092, India
Ganesh Shankar Vidyarthi Memorial (GSVM) Medical College

Kanpur, Uttar Pradesh, 208002, India
Medanta Multi Super Specialty Hospital

Lucknow, Uttar Pradesh, 226030, India
Sir HN Reliance Hospital Foundation

Mumbai, Maharashtra, 400004, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.