A new procedure may offer relief for Cirrhosis-Related fluid buildup
NCT ID NCT07755059
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This study tests whether a procedure called proximal splenic artery embolization (PSAE) can reduce the need for repeated fluid drainage in adults with cirrhosis and ascites that no longer responds to water pills and diet. Participants will undergo a one-time procedure where small coils or plugs are placed in the artery supplying the spleen to slow its blood flow. The study will measure changes in the frequency and volume of fluid drainage, as well as liver pressure, symptoms, and quality of life over six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Proximal splenic artery embolization (PSAE), a one-time procedure using coils or plugs to slow blood flow in the splenic artery
- What this could lead to
- If PSAE works, it could offer a new way to reduce the frequency of fluid drainage procedures in people with cirrhosis-related ascites who cannot undergo the standard TIPS procedure.
- What could go wrong
- This is a small, early-stage study without a control group, so results may not be conclusive. The procedure carries risks such as bleeding, infection, or damage to the spleen, and it may not effectively reduce fluid buildup.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham & Women's Hospital
Boston, Massachusetts, 02115, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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