Better crystal ball for liver crisis: new scores put to the test

NCT ID NCT07734896

Not yet recruiting Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

Acute-on-chronic liver failure (ACLF) is a sudden, life-threatening worsening of long-term liver disease that often leads to multiple organ failure. Standard scoring systems may miss key signs of inflammation and organ damage. This study compares two newer scoring models—the CLIF-C ACLF-D and MELD-complication scores—against traditional ones to see which best predicts death within 28 days. Researchers will follow 100 adults admitted to the ICU with ACLF, tracking their survival and comparing the accuracy of each scoring system.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If the new scores prove more accurate, doctors could better identify which ACLF patients need urgent interventions, potentially improving survival rates.
What could go wrong: This is a small, single-center observational study, so results may not apply to all hospitals. The new scores may not outperform existing ones in real-world settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure chronic liver failure cirrhosis of liver End Stage Liver Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE-ON-CHRONIC LIVER FAILURE (ACLF) END STAGE LIVER DISEASE LIVER CIRRHOSIS

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