ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Clinical trials for ACUTE-ON-CHRONIC LIVER FAILURE (ACLF) explained in plain language.
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Liver dialysis breakthrough? new device could save lives in severe liver failure
Disease control Not yet recruitingThis study tests a device called DIALIVE 2.0, which acts like a dialysis machine for the liver, in people with acute-on-chronic liver failure (ACLF) grades 2-4. About 72 adults aged 18-70 with liver cirrhosis and recent worsening will either receive standard care or standard care…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: PHASE3 • Sponsor: Yaqrit Ltd • Aim: Disease control
Last updated May 17, 2026 08:03 UTC
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Pig liver trial offers hope for liver failure patients
Disease control Not yet recruitingThis early-stage study tests a genetically-modified pig liver (EGEN-5784) used outside the body with a special device to temporarily support liver function in 20 adults with acute-on-chronic liver failure. Participants are not eligible for a transplant. The goal is to check safet…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: PHASE1 • Sponsor: eGenesis, INC • Aim: Disease control
Last updated May 17, 2026 08:01 UTC
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Can vitamin c save kidneys in liver failure patients?
Disease control Not yet recruitingThis study tests whether adding vitamin C to standard treatment can help patients with severe liver disease (ACLF) who have a serious infection (septic shock) and kidney injury. Vitamin C is a safe, cheap antioxidant that may reduce inflammation and protect the kidneys. The study…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: NA • Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated May 17, 2026 07:58 UTC
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New blood filter could save lives in sudden liver failure
Disease control Not yet recruitingThis study tests a blood-filtering therapy called DPMAS for people with acute-on-chronic liver failure, a life-threatening condition where the liver suddenly stops working. About 56 adults will be randomly assigned to receive either standard care alone or standard care plus DPMAS…
Matched conditions: ACUTE-ON-CHRONIC LIVER FAILURE (ACLF)
Phase: NA • Sponsor: Institute of Liver and Biliary Sciences, India • Aim: Disease control
Last updated May 17, 2026 07:57 UTC