END STAGE LIVER DISEASE

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This study tests whether giving extra albumin (a protein in the blood) after a liver transplant can prevent acute kidney injury. About 400 adult liver transplant recipients will be split into two groups: one gets albumin to keep levels above 30 g/L for five days, the other only g…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This study tests whether a donor stem cell infusion can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. Twelve adults who had a liver transplant from a matched living donor at least one year ago will receive the infusion after a mild …

This phase 3 trial tests whether giving low-dose arginine vasopressin during liver transplant surgery can prevent acute kidney injury, a common complication. Researchers will compare vasopressin to the standard drug norepinephrine in 304 adults. The goal is to see if vasopressin …

This study tests if a drug called darbepoetin can lower the need for blood transfusions during liver transplant surgery. About 140 adults on the liver transplant waiting list with low hemoglobin will receive either the drug or a placebo. The goal is to see if the drug safely redu…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety cri…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during liver transplant surgery. The device measures blood clotting in real time. Researchers hope it will reduce bleeding and the amount of blood products needed. The…

This study tests if drinking a carbohydrate beverage before liver transplant surgery helps patients recover more quickly and spend fewer days in the hospital. About 434 adults receiving a liver transplant will be randomly assigned to drink either the carbohydrate drink or a place…

This study tests a home monitoring program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly check-ins to boost activity and manage symptoms. The goal is to see if this approach improves qual…

This study investigates whether measuring the thickness of the carotid artery (a major artery in the neck) before surgery can help predict blood pressure swings and complications during liver transplant operations. Researchers will measure carotid artery thickness using a simple,…

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This study follows 275 infants who received a liver transplant to see how they grow over time. Researchers want to understand growth patterns and find ways to improve care. The study is observational, meaning no new treatment is being tested.

This study from Mayo Clinic aims to understand the individual and social reasons why some patients with end-stage liver disease are not listed for or do not receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list, who receives a transpl…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This study looks at how frailty, muscle loss, nutrition, and mental health affect people waiting for a liver transplant. Researchers will test physical strength, walking ability, and daily living skills, and also check nutrition and psychological well-being. The goal is to see wh…

This study looks at how well people who have had a liver transplant can move and function. Researchers will use a 30-second test where patients lie down and sit up as many times as they can. The goal is to see how this test relates to muscle strength, exercise ability, and overal…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…