Could a vaccine before liver transplant cut antiviral use?
NCT ID NCT06075745
First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vaccine doses or a placebo before transplant, and researchers track antiviral use and side effects for 100 days after transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CMV-MVA Triplex vaccine
- What this could lead to
- If successful, this vaccine could reduce the need for strong antiviral drugs after a liver transplant, lowering side effects and improving recovery.
- What could go wrong
- This is a phase 2 trial, so it's still early. The vaccine may not work as hoped, and side effects like injection site pain or fever are possible. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University School of Medicine
RECRUITINGDurham, North Carolina, 27710-1000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University Hospital
RECRUITINGAtlanta, Georgia, 30322-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Johns Hopkins University School of Medicine
RECRUITINGBaltimore, Maryland, 21205-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic, Rochester - College of Medicine and Science
RECRUITINGRochester, Minnesota, 55905-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern University, Feinberg School of Medicine
RECRUITINGChicago, Illinois, 60611-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oregon Health & Sciences University
RECRUITINGPortland, Oregon, 97239-3098, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford University
RECRUITINGRedwood City, California, 94063-3126, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Alabama at Birmingham, School of Medicine
WITHDRAWNBirmingham, Alabama, 35233, United States
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University of California, San Diego School of Medicine
RECRUITINGLa Jolla, California, 92093, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Miami, Jackson Memorial Hospital
RECRUITINGMiami, Florida, 33136-1003, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan Medical Center
RECRUITINGAnn Arbor, Michigan, 48109-1274, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198-7835, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania School of Medicine
RECRUITINGPhiladelphia, Pennsylvania, 19104-5127, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390-0000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington Medical Center: Transplantation
RECRUITINGSeattle, Washington, 98195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University School of Medicine
RECRUITINGNashville, Tennessee, 37232-0011, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A machine that keeps donor livers alive outside the body — could it transform transplantation?
- Blood-Clotting showdown: which device best guides bleeding care in High-Risk patients?
- Could a daily pill shield transplant patients from a common virus?
- Which liver biopsy needle delivers the best tissue? a Head-to-Head comparison
- Frailty test could predict who survives liver transplant waiting list
- Could a single infusion of 'Trainer' cells free liver transplant patients from lifelong drugs?