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Can your own kidneys bounce back after a Liver-Kidney transplant?

NCT ID NCT05717842

Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might not need a donated kidney at all.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nuclear medicine scan (MAG3)
What this could lead to
If successful, this could help doctors predict which patients' own kidneys will recover after a combined liver-kidney transplant, possibly avoiding unnecessary kidney transplants.
What could go wrong
This is a small, early observational study with only 15 participants, so results may not apply to everyone. The nuclear scan involves low-dose radiation, but the main risk is that the findings may not lead to a clear prediction tool.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals who have end stage liver disease (ESLD) and kidney dysfunction, who are not on dialysis and have eGFR \>=25 and \<=40 ml/min for a duration of at least 6 weeks.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. \> 18 years old 2. Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis at time of transplant surgery) 3. Candidates with two native kidneys. 4. Willing to participate and sign informed consent form. Exclusion Criteria: 1. Unstable patients (e.g. in the ICU or those who are on Continuous Renal Replacement Therapy (CRRT) who cannot complete the nuclear medicine scan or those with AKI on Hemodialysis 2. Prior history of any solid organ transplant. 3. Those who are currently pregnant or breast feeding. 4. Patients who have Autosomal Dominant polycystic kidney disease

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic liver failure transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Transplant

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IU Health University Hospital

    RECRUITING

    Indianapolis, Indiana, 46202, United States

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