Chronic kidney disease

This early-stage trial tests a vaccine called OSU-2131, designed to help the immune system fight Epstein-Barr virus (EBV). EBV can cause cancers in people who have weakened immune systems, such as those awaiting organ transplants. The study includes healthy volunteers and transpl…

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study tests if a new drug called siplizumab can safely prevent kidney transplant rejection better than the current standard treatment. About 120 adults receiving a kidney transplant will be split into three groups: two groups get different doses of siplizumab, and one gets t…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This phase 1 trial tests whether giving a bone marrow infusion along with a deceased donor kidney transplant can help the body accept the new kidney without needing lifelong anti-rejection drugs. The study enrolls adults with end-stage kidney disease who are already listed for a …

This study tests whether a special treatment before a kidney transplant can help the body accept the new organ without needing lifelong anti-rejection drugs. Participants receive radiation and immune-suppressing drugs, followed by an infusion of donor stem cells and the patient's…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works…

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This study tests whether giving people access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor can help Black and Hispanic adults with high blood pressure (and often diabetes) get their numbers down. About 100 participants will be randomly assi…

This trial investigates whether using icodextrin, a special dialysis solution, can help people on peritoneal dialysis (a type of home dialysis for kidney failure) stay on a lower-dose regimen for longer. Participants are randomly assigned to receive either icodextrin or a standar…

This study tests a virtual weight management program for 60 adults with obesity and advanced kidney disease who want to lose weight to become eligible for a kidney transplant. Participants either join the program (which includes coaching and a weight-loss medication called semagl…

This early-stage trial tests a new drug called MTX-439, an antibody that blocks a protein linked to kidney scarring. It will be given to healthy volunteers and people with diabetic kidney disease to check for safety and how the body processes it. The study is small (88 participan…

This study tests a new drug called AP306 in 168 adults on maintenance hemodialysis who have high phosphate levels (hyperphosphatemia). Participants take one of several fixed doses of AP306 or a placebo daily for 8 weeks. The main goal is to see if AP306 safely lowers blood phosph…

This study tests whether a new drug called R3R01 can reduce the amount of protein leaking into the urine in adults with type 2 diabetes and kidney disease. About 60 participants will take either R3R01 or a placebo for 3 months. Researchers will measure urine protein, kidney funct…

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better protect the kidneys and heart in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone. The stu…

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medica…

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs …

This study tests whether taking creatine supplements and doing light exercise during dialysis sessions can help people with advanced kidney disease maintain muscle strength and body health. About 48 adults on dialysis will take either creatine or a placebo daily for 8 weeks, whil…

This study tests whether empagliflozin, a medicine already used for diabetes, can help children aged 2 to 17 with chronic kidney disease. About 120 kids will take either the drug or a placebo for 6 months, then everyone gets the drug for a year. Researchers will check kidney func…

This study tests a device called the Amplifi Vein Dilation System, which is a temporary blood pump used before creating a dialysis access point (fistula) in the arm. The goal is to see if it helps widen small veins so the fistula works better for dialysis. About 160 adults with e…

This study tests a special cartridge (pHA130) added to regular dialysis to remove toxins that standard dialysis misses. One hundred adults with kidney failure on maintenance dialysis will be split into two groups: one gets the new cartridge once a week plus standard dialysis twic…

This early-stage trial tests whether BHV-1400 is safe and tolerable for people with IgA nephropathy, a kidney disease. About 20 participants with confirmed IgA nephropathy will receive the drug subcutaneously. The main goal is to check for side effects and lab abnormalities.

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether adding BI 690517 (Vicadrostat) to empagliflozin can slow kidney disease and prevent heart failure hospitalizations or cardiovascular death in people with chronic kidney disease. About 11,000 adults with or without type 2 diabetes will take either BI 69051…

This study tests a device that uses radiofrequency energy to disrupt nerve signals in the kidney and liver arteries, aiming to lower blood pressure in people with uncontrolled hypertension. About 175 adults aged 18-80 with high blood pressure despite medication will be enrolled. …

This study tests whether adding finerenone to standard blood pressure medicines can reduce protein in the urine of children with chronic kidney disease. About 219 children aged 6 months to under 18 years will take either finerenone or a placebo for 6 months. The main goal is to s…

This phase 3 trial tests roxadustat, an oral medication, for treating anemia in children and teenagers with chronic kidney disease. About 100 participants will take the drug three times a week for up to a year. The goal is to see if it can safely raise hemoglobin levels and offer…

This study tests a drug called veverimer in 150 adults with moderate-to-severe chronic kidney disease (CKD) and a condition called metabolic acidosis, where acid builds up in the blood. The goal is to see if the drug can raise blood bicarbonate levels and improve physical functio…

This phase 3 trial tests whether ravulizumab, given intravenously, can reduce the severity of delayed graft function (DGF) in adults at high risk after kidney transplant. DGF is when the new kidney is slow to start working, often requiring dialysis. The study will compare ravuliz…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study tests whether adding terlipressin to standard care helps maintain stable blood pressure during kidney transplant surgery. Researchers will compare two groups of 150 adults: one receiving terlipressin plus dobutamine, the other dobutamine alone. The main goal is to see …

This study tests a new treatment called AdiaVita, made from umbilical cord stem cells, for adults with chronic kidney disease. About 100 people aged 18 to 80 with moderate kidney problems will receive monthly infusions and a daily skin spray for three months. The goal is to see i…

This trial tests whether a drug called coated aldehyde oxystarch (Xiqing) can reduce protein-bound uremic toxins in adults with end-stage renal disease who are on dialysis. Participants take the drug three times daily for three months. Researchers measure toxin levels in the bloo…

This study tests a new device that creates a connection between an artery and a vein using a small needle puncture instead of open surgery. The goal is to provide a reliable access point for dialysis in people with kidney failure. About 126 adults will be enrolled and followed fo…

This study compares two cholesterol-lowering strategies in about 1,950 adults with chronic kidney disease and heart or blood vessel disease. One group gets a moderate-dose statin plus ezetimibe, the other gets a high-dose statin alone. The goal is to see if the combo is just as g…

This study is testing an education program for people with type 2 diabetes who also have chronic kidney disease. The program provides patients with information about their kidney health and suggests medications that could slow kidney damage. Researchers will see if this approach …

This pilot study tests a 3-month program that combines online education, music-paced brisk walking, group discussions, and phone follow-ups for 40 adults with both metabolic syndrome and chronic kidney disease. The goal is to see if the program can reduce waist circumference and …

This Phase 2 trial tests whether the drug LSALT peptide can prevent or reduce acute kidney injury in 240 adults undergoing on-pump cardiac surgery. Participants receive either the drug or a placebo before surgery, and doctors monitor kidney function for a week. The goal is to see…

This study tests a new drug called TS-172 in 30 adults on peritoneal dialysis who have high phosphorus levels. Participants take the drug daily for several weeks to see if it can safely bring their phosphorus down to a target range. The goal is to find a better way to manage this…

This study tests a new drug called AZD7760 in healthy volunteers and people with end-stage kidney disease who are on dialysis. The goal is to see if the drug is safe and how the body processes it. If it works, it could help prevent serious staph infections that often occur in dia…

This study tests whether a specially designed health behavior program can help people with metabolic syndrome and chronic kidney disease reduce their waist size and improve kidney function. Researchers will compare the program to usual care in 160 adults, measuring changes in wai…

This early-phase trial tests a combined kidney and bone marrow transplant from the same donor to help the body accept the new kidney without needing lifelong anti-rejection drugs. Up to 12 adults with kidney failure will receive the treatment. The goal is to see if this approach …

This early-stage study tests an experimental oral drug called ONO-3310 in healthy Japanese men and in people with type 2 diabetes who also have chronic kidney disease. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure its eff…

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This study looks at kidney transplant patients who take immunosuppressants to prevent organ rejection. It compares the effects of belatacept, a newer drug, against standard anticalcineurins on blood vessel function. The goal is to see if belatacept improves vascular health and re…

This study tests an experimental drug called praliciguat in 60 adults with a rare kidney disease called FSGS. The goal is to see if it can reduce protein in the urine, a sign of kidney damage. Participants will first receive either the drug or a placebo for 24 weeks, then everyon…

This early-phase trial tests whether a powerful immune reset using a patient's own stem cells can clear the antibodies that block them from receiving a kidney transplant. Ten highly sensitized adults with end-stage kidney disease will undergo intense conditioning to wipe out thei…

This study tests a kidney health coaching program for Black patients with advanced chronic kidney disease. The goal is to help delay the need for dialysis or prevent early death. Researchers will also use a clinical decision support tool to improve screening and care. About 600 p…

This study tests whether a 12-week course of a multi-species synbiotic supplement can lower harmful gut toxins and reduce inflammation in adults on hemodialysis. About 30 participants will take the supplement and have their blood and urine levels of toxins and inflammatory marker…

This study is testing whether a 12-week course of a multi-species synbiotic (a mix of probiotics and prebiotics) can improve gut health and reduce harmful toxins in the blood of people on hemodialysis. The trial will enroll 30 adults who have been on dialysis for at least 3 month…

This study looks at the long-term safety of a drug called zigakibart for adults with IgA nephropathy, a kidney disease. It is for people who have already finished a previous zigakibart study. Researchers will monitor side effects and check kidney function over 96 weeks.

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can reduce kidney damage in people with type 1 diabetes and diabetic kidney disease. About 60 adults will receive either semaglutide or a placebo for 26 weeks. Researchers will measure changes in …

This study tests whether taking equol, a compound from soy, for 12 weeks can improve blood vessel function in postmenopausal women with moderate chronic kidney disease (stages 3-4). The goal is to lower their high risk of heart disease. Researchers will measure changes in artery …

This study compares two different drugs, vicadrostat and spironolactone, both taken with empagliflozin, to see how they affect kidney function and protein levels in blood and urine. The trial involves 100 adults with chronic kidney disease and heart disease or heart failure. Part…

This study is testing whether a kidney from a genetically modified pig can safely work in people with end-stage renal disease who cannot get a human kidney. Up to 50 participants will receive the pig kidney and be followed for at least 24 weeks to check survival, kidney function,…

This study tests whether a new type of immunotherapy called CAR T cells can safely lower the immune system's reactivity in people waiting for a kidney transplant. Participants have a very high chance of rejecting most donor kidneys (cPRA of 99.5% or higher). The treatment involve…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This early-stage trial is testing a drug called orellanine, derived from a mushroom, in 75 people with advanced kidney cancer who are also on dialysis. The drug is given intravenously to see if it is safe and can shrink tumors. All participants have end-stage kidney disease and h…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether a natural substance called red propolis can lower inflammation and oxidative stress in people with chronic kidney disease (stages 3-5) who are not yet on dialysis. Researchers will measure changes in inflammatory markers like IL-6 and TNF-α. The goal is t…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in the urine (a sign of kidney damage) better than baxdrostat alone. About 218 adults with chronic kidney disease and high blood pressure will take either the combo or baxdrostat plus a placebo. The goal …

This study tests a new drug called tegoprubart along with other medicines to help people with type 1 diabetes and chronic kidney disease receive pancreatic islet cell transplants. The goal is to see if this approach is safe and can improve blood sugar control without needing life…

This study tests whether taking royal jelly supplements can reduce inflammation and slow cell aging in people with chronic kidney disease who are on hemodialysis. Thirty participants will take either royal jelly or a placebo daily for two months. Researchers will measure changes …

This large trial in New Taipei City will test whether a mobile digital health platform with interactive modules helps people better control high blood pressure, high blood sugar, and high cholesterol. It will also compare taking blood pressure medication at night versus in the mo…

This study is testing whether taking green propolis extract and royal jelly together can reduce inflammation and oxidative stress in people with high blood pressure or chronic kidney disease. Over two months, 153 participants will take capsules of the supplements or a placebo. Re…

This pilot study tests whether time-restricted eating (eating all meals within an 8-hour window each day) can reduce protein in the urine and slow kidney function decline in people with moderate chronic kidney disease. Fifty adults with stage 2-3 CKD and elevated albuminuria will…

This study compares starting dialysis twice a week versus the standard three times a week in elderly patients (60+) with end-stage kidney disease who still produce some urine. The goal is to see if fewer sessions reduce hospitalizations, falls, and other complications while maint…

This study tests a special monitor that predicts low blood pressure during dialysis in ICU patients. The goal is to prevent dangerous drops by alerting doctors early. About 46 adults with kidney injury or failure will take part. If successful, this approach could make dialysis sa…

This study tests whether giving a kidney transplant recipient blood stem cells from their sibling donor can train the body to accept the new kidney without lifelong anti-rejection drugs. Fifteen adults receiving a kidney from an identical sibling will get a conditioning regimen o…

This study tests whether a short course of the blood thinner apixaban can help new dialysis access points (arteriovenous fistulas) mature properly in people with end-stage kidney disease. About 190 adults will receive either apixaban or a placebo around the time of fistula creati…

This early-stage trial tests a new drug called OJR520 in healthy volunteers and people with chronic kidney disease. The main goal is to check if the drug is safe and how the body processes it. About 112 participants will receive either OJR520 or a placebo. This is the first time …

This study looks at different ways to give iron to people with kidney failure who are on peritoneal dialysis. Participants will get either high-dose or low-dose intravenous iron, or oral iron tablets. The main goal is to see if a larger trial is possible by checking how many peop…

This study tests whether taking sodium bicarbonate (baking soda) daily can improve muscle energy and physical endurance in people with chronic kidney disease and metabolic acidosis. About 80 adults with moderate-to-severe kidney disease will receive either sodium bicarbonate or a…

This pilot study is testing whether providing free produce boxes and nutrition education can improve health outcomes for Veterans with kidney disease and food insecurity. The study will enroll 20 participants and measure changes in blood pressure and kidney function. Researchers …

This study tests whether dapagliflozin, a drug used for diabetes and kidney protection, can improve kidney structure and blood flow in people who received a kidney transplant one year ago. About 48 participants will be randomly assigned to take dapagliflozin or standard care alon…

This study tests whether a community health worker program can help people with advanced kidney disease start treatment more smoothly. The program provides support, education, and help with social challenges. Researchers will compare this to standard care in 448 adults with chron…

This study tests whether a smartphone app can help people with chronic kidney disease (CKD) follow the latest KDIGO treatment guidelines. Researchers will enroll 80 adults aged 16-30 with CKD who own a smartphone. The app provides reminders, education, and care recommendations to…

This study tests whether a daily 25 mg dose of empagliflozin (a diabetes drug) is safe and helps preserve remaining kidney function in 20 adults on peritoneal dialysis. Participants must still produce at least 250 mL of urine daily. The trial measures changes in kidney filtration…

This study tests a program called CommunityRx-Kidney Health for people with early-stage chronic kidney disease living in rural North Carolina. The program connects patients with medical care, social services, and self-care resources to help manage their condition. Researchers wil…

This study tests an oral testosterone pill called JATENZO in 20 men who have both low testosterone and chronic kidney disease. The goal is to see if the pill can raise testosterone levels and improve red blood cell counts, muscle strength, lean body mass, and sexual function. Par…

This early-stage trial tests a new cell therapy called Eight Treg in 9 people receiving a kidney from a living donor. The therapy uses the patient's own immune cells, grown in a lab, to help the body accept the new kidney without strong anti-rejection drugs. The main goal is to c…

This study tests whether dapagliflozin, a drug already used in adults to protect kidneys, can reduce protein leakage in the urine of teenagers with mild chronic kidney disease. Two hundred adolescents aged 14 to 18 will receive either the drug or a placebo for six months. The goa…

This phase 2 trial tests whether a single infusion of a patient's own regulatory T cells (TRK-001) can prevent the immune system from attacking a new kidney. 34 living-donor kidney transplant recipients will either receive standard anti-rejection drugs alone or those drugs plus t…

This study tests a new type of artificial blood vessel (STARgraft) for people with end-stage kidney disease who need dialysis. The graft is placed in the arm to help connect the patient to the dialysis machine. The goal is to see if it works better than standard grafts at keeping…

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This early-phase trial at Mayo Clinic is testing whether it is possible to transplant a bladder along with a kidney in people who have kidney failure due to bladder problems. Up to 30 participants will receive both organs from a deceased donor. The goal is to see if the bladder w…

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests whether a special egg white protein pudding can help people with kidney failure who are on dialysis. Participants will eat one pudding after each dialysis session, three times a week for 12 weeks. The researchers want to see if this is practical and if it improve…

This study is testing whether a diet rich in plant-based foods is feasible and safe for people with stage 3 or 4 chronic kidney disease (CKD) in Singapore. Forty adults will either follow a plant-based diet or a standard kidney-friendly diet, with regular dietitian support. The m…

This study tests whether a drug called ferric citrate can lower a harmful protein (FGF23) in children aged 6–18 with moderate chronic kidney disease. About 160 kids will take either the drug or a placebo for 12 months. The goal is to see if the drug is safe and helps control kidn…

This study tests a drug called ferumoxytol, a type of intravenous iron, to treat iron deficiency anemia in children aged 2 to 17 with chronic kidney disease. The trial compares ferumoxytol to another iron drug, iron sucrose, to see which is safer and works better. About 129 child…

This Phase 2 study tests whether a combination of two drugs, zibotentan and dapagliflozin, works better than dapagliflozin alone at reducing protein leakage in urine for adults with chronic kidney disease. About 224 participants will receive either the combo or the single drug. T…

This study tests whether an experimental drug called AV-001 can protect the brain from injury caused by hemodialysis. The drug is designed to strengthen blood vessels in the brain and reduce inflammation. Researchers will enroll 60 adults who have been on dialysis for at least th…

This early-phase trial tests a single dose of AZD0120, a CAR-T cell therapy that targets two immune proteins (CD19 and BCMA), in 12 highly sensitized adults with end-stage kidney disease awaiting a transplant. The goal is to safely reduce the antibodies that make finding a compat…

This study looks at whether adding a community health worker to a kidney care team helps more patients with advanced kidney disease choose or start home dialysis. About 106 adults with severe chronic kidney disease will be split into two groups: one gets standard team care, the o…

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces protein in the urine, a key s…

This study tests whether adding sodium thiosulfate (STS) to the fluid that keeps donated kidneys cold during transport can help them work sooner after transplant. About 120 adults with kidney failure who receive a kidney from a deceased donor will take part. Half of the kidneys w…

This study tests a device called EchoMark/EchoSure that is implanted during fistula surgery for dialysis patients. The device uses automated ultrasound to monitor healing every two weeks. The goal is to see if it helps the fistula mature faster and reduces the need for additional…

This study tests whether a 16-week exercise program can help older adults with chronic kidney disease regain muscle and strength after being in the hospital. Researchers will use ultrasound and strength tests to measure changes. The goal is to find better ways to help patients re…

This study tests whether storing donated kidneys at 10°C (instead of the usual 4°C on ice) helps them work better after transplant. About 30 adults waiting for a kidney transplant will take part. Researchers will measure kidney function and check for early injury using urine test…

This study tests an experimental drug called WAL0921 in 96 adults with kidney diseases that cause protein in the urine, including diabetic nephropathy and several rare conditions. Participants receive either the drug or a placebo as an IV infusion every two weeks for 14 weeks, th…

This study tests whether a daily ergothioneine supplement can replenish low levels of this nutrient in people with kidney failure who are on dialysis. Dialysis removes waste but also strips away beneficial chemicals like ergothioneine. Researchers will give 28 participants either…

This study is for adults with chronic kidney disease (CKD) who are already receiving standard care. It tests different treatments, alone or in combination, to see which best slows kidney decline and prevents kidney failure. About 1,000 participants will be followed for over two y…

This study tests whether two infusions of AION-301 are safe and can reduce symptoms or slow the worsening of Stage 3 chronic kidney disease. About 36 adults will receive either AION-301 or a placebo, along with oral vitamins, and be followed for up to 24 months. The main goal is …

This early study tests a new medicine called SC101, given as a single injection around the kidneys, for people with resistant high blood pressure and moderate to severe chronic kidney disease. The main goal is to check safety, with only 3 participants. Researchers will also monit…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The device is designed to remove waste and extra fluid from the blood during in-center dialysis sessions. Researchers will check how safe it is and how well it works in 46…

This Phase 3 trial tests an oral drug called AND017 for anemia in people on dialysis due to end-stage kidney disease. About 300 participants will receive either AND017 capsules or a standard injected ESA. The goal is to see if AND017 can maintain healthy hemoglobin levels as well…

This Phase 3 trial tests whether HRS-1780 tablets can slow the decline of kidney function in nearly 2,000 adults with chronic kidney disease. Participants take the drug or a placebo alongside standard treatment. The study will track kidney health over 32 months to see if the drug…

This study tests a stem cell treatment called Amimestrocel in 120 people with diabetic kidney disease. The cells are given through an IV multiple times over 6 months. Researchers will check if it lowers protein in urine and improves kidney function. The goal is to see if this app…

This study tests a genetically modified pig kidney (called the 10 GE Xenokidney) in 50 adults with end-stage kidney disease who cannot get a human kidney transplant or face a long wait. The goal is to see if the pig kidney works safely and well, improving survival and quality of …

This study is testing a device called the WavelinQ EndoAVF System that creates a connection between an artery and a vein (AV fistula) in people who need dialysis. The goal is to make it easier to start and continue dialysis with fewer complications. About 280 adults with end-stag…

This phase 3 trial tests XyloCore, a dialysis solution with less glucose and added xylitol and L-carnitine, in 170 adults with end-stage kidney disease on continuous ambulatory peritoneal dialysis. The goal is to see if it can maintain dialysis effectiveness while improving metab…

This study tests whether dapagliflozin, a drug usually used for diabetes, can help people with end-stage kidney disease who are on peritoneal dialysis. Over six months, 38 participants will take the drug daily to see if it improves fluid removal, dialysis adequacy, and urine outp…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This study compares a once-daily anti-rejection drug (Envarsus XR) to the standard twice-daily drug in 78 adults receiving a kidney transplant. The goal is to see if the once-daily option reduces hidden rejection and improves immune system markers. Participants will be followed f…

This study tests whether a daily pill called sotagliflozin can slow kidney function loss in people with type 1 diabetes who already have moderate to severe kidney disease. About 150 participants will take either the drug or a placebo for 3 years, while following a special plan to…

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This phase 3 trial tests the drug etelcalcetide (Parsabiv) in 24 children aged 2 to 17 with secondary hyperparathyroidism due to chronic kidney disease who are on hemodialysis. The goal is to see if the drug can safely lower parathyroid hormone levels and improve mineral balance.…

This study tests a smartphone app called StenoFood that gives dietary advice and self-monitoring tools to people with type 2 diabetes and early kidney disease. The goal is to see if the app helps them follow low-sodium and moderate-protein diet guidelines. About 104 participants …

This study tests whether specially trained community pharmacists can help people with type 2 diabetes and early kidney disease start and stick with medications that protect the kidneys and heart. The trial will include 120 adults in Nova Scotia who don't have a family doctor. Par…

This study tests a special scale that measures heart signals and fluid levels in people on peritoneal dialysis for kidney failure. The goal is to see if the scale can warn patients and doctors early when fluid overload is about to happen, so they can take action before an emergen…

This early study tests a new treatment called REGEND003, made from human kidney progenitor cells, in 15 people with type 2 diabetes and chronic kidney disease. The main goal is to check if the treatment is safe and tolerable. Participants will receive either the cell therapy or a…

This trial tests a new drug-coated stent called Solaris DE for dialysis patients whose veins become narrowed or blocked. About 120 participants will either receive the stent plus balloon angioplasty or angioplasty alone. The goal is to see if the stent keeps the vein open longer …

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study looks at whether a plant-focused diet can help malnourished adults on peritoneal dialysis (a type of kidney treatment) improve their nutrition and overall health. About 100 participants will be randomly assigned to either a plant-focused diet or a standard kidney diet …

This study tests whether canagliflozin, a diabetes drug, can improve fluid removal and reduce scarring in people on peritoneal dialysis for kidney failure. Thirty adults will receive either the drug or a placebo for 26 weeks, then switch. The goal is to see if the drug helps the …

This study tests whether a 6-week aerobic exercise program can reduce cardiovascular risk in people with chronic kidney disease or rheumatoid arthritis. About 90 participants will be assigned to either an exercise program, educational phone calls, or no intervention. Researchers …

This study tests a new medicine called NNC0519-0130, given as a weekly injection, in 465 people with chronic kidney disease, with or without type 2 diabetes, who are also overweight or have obesity. The goal is to see if it can improve kidney function and how safe it is compared …

This study compares drinking water to receiving IV fluids for preventing kidney injury caused by contrast dye used in CT scans. Researchers will enroll 198 emergency department patients with mild-to-moderate kidney disease. Participants will either drink water or get IV fluids be…

This Phase 3 trial compares two treatments for people with high blood pressure and chronic kidney disease: finerenone versus a fixed-dose combination of torsemide and spironolactone. The study will enroll 30 adults to see which approach better lowers blood pressure, reduces prote…

This study tests a home monitoring system called VIEWER for people with advanced chronic kidney disease (stage 5) or end-stage renal disease. The system includes a tablet, blood pressure cuff, scale, oxygen monitor, and motion tracker. Researchers want to see if using this platfo…

This study tests whether a potassium-lowering drug called sodium zirconium cyclosilicate (Lokelma) can help elderly patients with heart failure and chronic kidney disease safely take higher doses of RAASi medications, which are often limited by high potassium levels. The trial wi…

This early-stage study tests whether stem cells from human amniotic fluid can help heal painful skin wounds (calciphylaxis) in people with chronic kidney disease. Nine participants will receive the stem cell treatment, and researchers will measure wound healing and pain levels. T…

This study looks at whether a program of aerobic and strength exercises can improve physical performance and quality of life in adults with chronic kidney disease, including those on dialysis. About 50 participants will be randomly assigned to either an exercise group or a contro…

This study tests whether a single injection of Berinert, a protein that reduces inflammation, into a donor kidney just before transplant can improve kidney function in the first year. Researchers will compare this to a placebo in 180 high-risk patients receiving deceased-donor ki…

This phase 3 trial tests etelcalcetide (Parsabiv) in 56 children aged 28 days to under 18 years who have secondary hyperparathyroidism and chronic kidney disease and are on hemodialysis. The drug aims to lower parathyroid hormone levels and improve mineral balance. Participants r…

This pilot study tests whether the drug eplerenone is safe and feasible for people with both heart failure (reduced pumping ability) and severe chronic kidney disease. Previous studies excluded such patients due to risks like high potassium. The trial will enroll 40 participants …

This phase 3 trial tests whether the drug dapagliflozin (Farxiga) can reduce deaths and heart or kidney problems in people leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support will take either the drug or a placebo daily…

This study tests a program to help Black adults with chronic kidney disease (CKD) reduce their daily sitting time. Half of the 40 participants will receive support to sit less, while the other half will get general CKD education. The goal is to see if cutting down on sitting can …

This early-phase trial aims to see if it's possible to run a study of empagliflozin, a drug already used in adults for kidney disease, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers …

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study looks at whether a type of dialysis done more often but with a slower flow can help kidney patients who have been in the hospital regain muscle strength and function. About 50 adults with end-stage kidney disease will take part. They will do a rehab program with exerci…

This study tests whether adding urea to the dialysis fluid can prevent dialysis disequilibrium syndrome — a set of neurological symptoms like headache, confusion, and seizures — in people with kidney failure who need urgent dialysis for severe electrolyte problems. Researchers wi…

This study tests whether a fully automated insulin delivery system (CamAPS HX) can improve kidney oxygen levels in people with type 2 diabetes and chronic kidney disease. About 76 adults will use either the automated system or standard insulin therapy with a glucose monitor for 2…

This study tests a program that uses an AI chatbot, health coach, and home monitoring devices to help 300 adults with heart disease, diabetes, or kidney disease manage their conditions. The goal is to see if this approach reduces hospital visits, complications, and deaths over 6 …

This study tests a blood filtering procedure called rheopheresis to treat calciphylaxis, a rare condition causing painful skin wounds in people on dialysis. About 138 participants will receive either rheopheresis or a sham procedure to see if it helps wounds heal completely withi…

This study tests a one-time injection of stem cells from donated umbilical cords into the kidneys of 10 adults with diabetic kidney disease. The goal is to see if the treatment is safe and whether it can improve kidney function and reduce inflammation over 12 months. All particip…

This study looks at whether taking TARPEYO (budesonide) for a longer period helps adults with IgA nephropathy, a kidney disease. Participants have already taken the drug for 9 months and will now take it for another 15 months. The main goal is to see if protein levels in urine st…

This study tests whether formoterol, a drug already used for asthma, can help control diabetic kidney disease. About 120 adults with type 2 diabetes and kidney problems will be randomly assigned to add formoterol to their usual care or continue usual care alone. The main goal is …

This study tests an experimental drug called IG3018 for people with high uric acid, some of whom also have chronic kidney disease. About 60 adults will receive either the drug or a placebo for 4 weeks. Researchers will check safety, side effects, and how well the drug lowers uric…

This study tests whether stem cells from donated bone marrow are safe for people with chronic kidney disease, including those who have had a kidney transplant. Up to 75 participants will receive the cells through an IV or directly into the kidney arteries, with repeat doses allow…

This phase 3 trial tests whether AP301, a drug taken with meals, can safely lower high blood phosphate in people on kidney dialysis. About 264 participants will receive either AP301 or a low-dose version for 8 weeks, then all get AP301 for 24 weeks. The goal is to see if AP301 he…

This study tests whether a ketoanalogue supplement (Ketosteril) can prevent muscle loss in 100 adults with stage 4 or 5 chronic kidney disease who are on a moderately low-protein diet. Participants take the supplement daily for a period, and researchers measure changes in muscle …

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study tests whether gentle shockwaves applied to the kidneys can lower blood pressure in people with chronic kidney disease. Thirty adults with high blood pressure and moderate-to-severe kidney disease will receive either real or fake (sham) treatments over three weeks. The …

This study compares taking two blood thinners (aspirin plus clopidogrel or prasugrel) for less than 3 months versus at least 6 months after a heart stent procedure in people with advanced chronic kidney disease. Researchers want to see if a shorter course reduces bleeding without…

This study tracks 150 adults with end-stage kidney disease who use the EndoForce System to connect a dialysis graft to a vein. The device is already FDA-approved, so this is not an experiment—it's a check on long-term safety and how well it works over time. Researchers will monit…

This study tests whether people with chronic kidney disease can safely eat potassium-rich fruits and vegetables instead of following the usual low-potassium diet. Thirty participants will receive home-delivered groceries with either high- or low-potassium produce in a random orde…

This study tests whether taking activated bamboo charcoal and probiotics can reduce inflammation and slow kidney disease in people with diabetes. About 300 participants with different stages of chronic kidney disease will receive one or both treatments for 6 months. Researchers w…

This study looks at 140 heart failure patients to see if taking a medicine called ARNI before coming to the hospital leads to better short-term health. Researchers will compare those who were already on ARNI with those who were not, tracking heart and kidney events during the hos…

This study tests three different approaches given during donor anesthesia to help the new kidney work better right after transplant. The goal is to see which method—mannitol, dopamine, or extra fluids—best improves kidney function. The study involves 60 adults with end-stage kidn…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This phase 3 trial compares two common beta blockers—metoprolol and carvedilol—in about 2,540 hemodialysis patients. The goal is to see if metoprolol, which is removed by dialysis, leads to fewer major heart events like heart attacks, strokes, or heart failure hospitalizations. P…

This study looks at whether lowering high parathyroid hormone levels can help protect bone density in people with advanced chronic kidney disease. About 70 adults aged 50 and older with kidney failure not on dialysis will be assigned to different treatment targets for their hormo…

This study looks at whether a program that combines digital health coaching for patients and support for clinics can help low-income people with diabetes better manage their condition. Researchers will enroll 600 adults with uncontrolled diabetes or high blood pressure. The goal …

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study looks at whether adding CoQ10 (a supplement that supports cell energy) to high-intensity interval training can help people with end-stage kidney disease build muscle and improve physical function. 156 adults on dialysis will be assigned to exercise alone or exercise pl…

This study looks at whether GLP-1 drugs, used for diabetes and weight loss, can improve kidney health in people with chronic kidney disease. Researchers will measure changes in fat around the kidneys and heart, as well as kidney function. The goal is to see if these drugs reduce …

This study tests whether a manuka honey mouthwash can improve gum health in people with kidney failure who are on dialysis and also have gum disease. About 150 adults will rinse with a diluted honey solution three times daily. Researchers will measure gum attachment, bleeding, pl…

This phase 2 study tests a drug called nedosiran (DCR-PHXC) in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney impairment, with or without dialysis. The goal is to see if the drug safely lowers plasma oxalate levels, which can cause kidney stones and dama…

This study tests whether a personalized sodium (salt) management feature on dialysis machines can help people with end-stage kidney disease. It compares the new approach to standard dialysis in 130 adults. The goal is to see if it reduces weight gain between sessions, improves fl…

This study tests a new device called the InnAVasc graft, which is surgically placed in the arm to provide a reliable access point for hemodialysis in people with end-stage kidney disease. About 133 participants will receive the graft and be followed for two years to see how well …

This early-phase trial tests whether a stomach acid drug called vonoprazan fumarate can reduce delayed graft function, a common complication where a new kidney doesn't work right away. About 47 first-time kidney transplant recipients will take the drug for seven days after surger…

This study tests whether giving a donor kidney a 4-6 hour warm bath on a machine (normothermic machine perfusion) right before transplant helps it work better a year later. The trial includes 240 adults receiving a kidney from a donor aged 50 or older. Half get the standard cold …

This study tests whether patiromer, a drug that lowers potassium, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and lower …

This trial tests whether a smartphone app (Yueya mini-program and WeChat) can help people with end-stage renal disease who are on maintenance hemodialysis. The app provides personalized guidance on diet, exercise, medications, and health monitoring. Researchers will compare outco…

This study looks at whether dietary nitrate, given as beetroot juice, can help people with high blood pressure and early-stage kidney damage. About 14 to 20 adults will receive either nitrate or a placebo for two weeks, then switch after a break. Researchers will measure changes …

This phase 3 study tests a new drug called TS-172 in 300 adults on hemodialysis who have high phosphate levels. Participants take the pill daily for up to a year to see if it safely and effectively controls phosphate. The goal is to offer a better treatment option for a common co…

This study tests whether using a low-sodium, potassium-enriched salt substitute instead of regular salt can help protect kidney function in people who have had surgery for a kidney tumor. Two hundred adults who had a partial or full kidney removal will either use the salt substit…

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study tests whether special filters (sorption technologies) can lower inflammation in people on long-term hemodialysis for kidney failure. About 60 adults with high inflammation levels will receive the filter during their regular dialysis sessions. The main goal is to see if…

This phase 4 trial tests whether taking ramipril once daily or split into two smaller doses works better for protecting kidney function in 80 adults with chronic kidney disease and heart failure. Over 30 days, researchers will measure changes in blood markers of kidney function, …

This study tests whether thiazide diuretics (water pills) can lower blood pressure in people on peritoneal dialysis who have high blood pressure. About 40 adults with end-stage kidney disease will take the drug and have their blood pressure, weight, and body fluid levels measured…

This study tests whether exercising during dialysis, with or without a blood flow restriction cuff, can reduce heart strain and improve heart function in kidney patients. About 108 adults on dialysis will be randomly assigned to standard care, exercise alone, or exercise with blo…

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure in people with advanced kidney disease (stage 4 or 5) or on dialysis. About 92 participants will receive either the drug or a placebo for 12 months, with heart changes measured by MRI. T…

This study tests whether empagliflozin, a diabetes medicine, is safe and helps control body fluid levels in 60 adults who are starting hemodialysis for end-stage kidney disease. Participants will take either empagliflozin or a placebo for 12 weeks. The goal is to see if the drug …

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and t…

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive a conditioning treatm…

This study tests a weekly injection called UBT251 in 180 overweight or obese adults with chronic kidney disease. The goal is to see if it can reduce protein in the urine (a sign of kidney damage) and help with weight control. Participants will receive either the drug or a placebo…

This study tests whether using specific biomarkers to choose and combine three kidney-protecting drugs (dapagliflozin, semaglutide, and finerenone) can slow kidney function decline better than standard care. About 125 adults with chronic kidney disease and albuminuria will be ran…

This study compares two special dialysis membranes (HYDROLINK and HeprAN) to see if they can safely reduce or eliminate the need for heparin, a blood thinner that raises bleeding risk. About 302 adults on long-term hemodialysis will take part. The goal is to complete dialysis ses…

This study is testing whether taking aspirin can safely lower the risk of major heart problems, like heart attacks and strokes, in people with kidney failure who are on dialysis. About 9,000 adult dialysis patients will be randomly assigned to take aspirin or not, and researchers…

This study is testing a new dialysis machine called Moda-flx for people with end-stage kidney disease who are already on stable dialysis. The goal is to see if the machine is safe and works well both in a clinic and at home when used by trained patients or care partners. About 50…

This study tests a device called VasQ that is placed around a blood vessel connection (fistula) used for dialysis in people with kidney failure. The goal is to see if VasQ helps the fistula work well enough for dialysis sooner and for longer compared to standard fistula creation.…

This study tests whether people with chronic kidney disease can safely adjust their own blood pressure medications at home, guided by a pharmacist. 160 veterans with uncontrolled high blood pressure and stage 2-4 kidney disease will either self-manage their meds or just monitor t…

This study tests a device that helps people on dialysis get needles into their fistula more easily. It is for patients whose fistula is too deep for standard needle sticks. The study will check if the device works well and is safe over 6 to 12 months. About 100 adults will take p…

This study tests whether mindfulness meditation and a mild nerve stimulation device can improve nerve function and blood pressure in people with chronic kidney disease. About 150 participants with moderate kidney disease will take part. The goal is to see if these approaches can …

This study tests a treatment called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function better than standard care. Participants will be randomly assigned to receive…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests a program that helps people with high blood pressure, diabetes, or kidney disease manage their health at home. Participants use a blood pressure monitor that sends readings to their care team, and they get support from community health workers and pharmacists. Th…

This trial tests whether a team of doctors and pharmacists can safely reduce the number of unnecessary medications taken by people with chronic kidney disease in Qatar. 424 patients will be randomly assigned to receive the deprescribing program or usual care. The goal is to see i…

This Phase 3 trial tests a new drug called MT1013 against an existing drug, cinacalcet, in 424 adults on dialysis who have secondary hyperparathyroidism (overactive parathyroid glands). The study aims to see if MT1013 better controls parathyroid hormone levels and improves bone h…

This study looks at whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive recipients. Researchers will follow 30 adults with HIV and end-stage kidney disease who receive a kidney from an HIV-positive donor. The goal is to learn more about pat…

This study tests whether a single dose of equol, a compound made from soy, can improve blood vessel function in postmenopausal women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taking equol. The goal is t…

This early-stage trial tests a drug called KN060 in 12 adults with end-stage kidney disease who are on regular hemodialysis. The goal is to see if KN060 is safe and can prevent blood clots from forming in the dialysis machine or the patient's blood vessels. Participants will rece…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant recipients who have mild or no symptoms. About 15 adults will receive the drug starting just before their transplant. The goal is to see if this approach all…

This study tests a procedure called renal denervation, which uses ultrasound to calm overactive kidney nerves, in 12 dialysis patients with hard-to-treat high blood pressure. The goal is to see if it safely lowers blood pressure over 3 to 6 months. It is a small, early-stage tria…

This study tests a liquid medication called ACE Reno, taken under the tongue four times daily for 12 weeks, in 300 adults with chronic kidney disease from diabetes, high blood pressure, autoimmune disorders, or other causes. The goal is to see if it safely reduces protein in the …

This study tests whether colchicine, an anti-inflammatory drug, can improve heart function in people with chronic kidney disease. Researchers will measure changes in heart strain using ultrasound. The trial aims to enroll 20 adults aged 21-80 with moderate to severe kidney diseas…

This study tests whether a drug called Xiqing, which absorbs waste in the gut, works better when combined with probiotics in people with chronic kidney disease (CKD). The trial will enroll 120 adults with moderate to advanced CKD who are not on dialysis. Researchers will track ki…

This study tests whether a device that measures brain waves (called BIS) can detect dialysis disequilibrium syndrome, a complication that can occur during first-time dialysis. Twenty new dialysis patients will be monitored during their first three sessions. The goal is to see if …

This study tests a new imaging technique called dynamic full-field optical coherence tomography (OCT) to analyze kidney biopsies. The goal is to see if this method can identify signs of acute kidney injury or chronic kidney disease as well as or better than standard microscope an…

This study is testing an artificial intelligence model that reads kidney biopsy images to diagnose chronic kidney disease. Researchers will compare the AI's results to the standard diagnosis made by pathologists. About 2,900 patients with chronic glomerulonephritis will participa…

This study looks at whether a special ultrasound inside the vein (IVUS) can find blockages better than the usual X-ray method in people on dialysis. About 50 adults with kidney failure who have trouble with their dialysis access will take part. The goal is to see if IVUS gives cl…

This study is testing a new smart sensor that listens to chest sounds to help doctors screen for pneumonia in people who have had a stroke or are on dialysis for kidney failure. About 50 adults will take part, and the sensor's findings will be checked against chest X-rays. The go…

This study tests whether shear wave elastography, a special ultrasound that measures tissue stiffness, can help doctors quickly tell the difference between acute and chronic kidney disease. Researchers will scan 800 adults in the emergency room and compare the results with standa…

This study tests a smartphone app that uses ECG readings to detect dangerously high potassium levels in people with chronic kidney disease. About 50 adults will use the app during clinic visits or at home for up to four weeks. The goal is to see how accurate, easy-to-use, and rel…

This study looks at whether a blood test for cystatin C can detect acute kidney injury earlier than the standard test in people with chronic kidney disease who receive contrast dye for CT scans or heart procedures. Researchers will compare how often kidney injury is found using e…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether using a lung water monitor to tailor fluid intake can prevent acute kidney injury in elderly patients with kidney disease who are undergoing coronary angiography. 320 participants will receive hydration rates adjusted based on their lung water levels. The…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study tests whether having patients with advanced chronic kidney disease (stages 4 and 5) report their symptoms monthly through an electronic questionnaire, with results shared with their kidney doctors, can improve symptom management and quality of life. The trial will enro…

This study compares two types of ultrasound-guided nerve blocks for pain control after open kidney removal surgery. Ninety adults will receive either a rhomboid intercostal sub-serratus plane block or an external oblique intercostal block. Researchers will measure how long it tak…

This study tests a medicine called difelikefalin in teenagers aged 12 to 17 who are on hemodialysis and have moderate to severe itching. The goal is to see if the drug is safe and how much gets into the blood. About 18 teens will receive the medicine up to 4 times a week for 12 w…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests the safety of a new drug called IGT-303 in healthy volunteers and people with chronic kidney disease (CKD). About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. Researchers will monitor for side effects t…

This study tests whether drinking beetroot juice before exercise can reduce inflammation and improve physical function in people with chronic kidney disease. Researchers will give 25 patients either beetroot juice or a placebo, then have them exercise. The goal is to see if this …

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and cope better with stress. About 60 adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in…

This study is testing whether a new type of dialyzer, called Theranova, can help reduce common symptoms like pain, fatigue, and poor sleep in people with end-stage renal disease who are on dialysis. About 100 participants will use their usual dialyzer for the first 4 weeks and th…

This study tests whether a 12-week home-based exercise program is safe and practical for adults aged 60 and older who are waiting for a kidney transplant. Participants will either receive usual care plus a physical activity tracker, or usual care plus the tracker and online exerc…

This study tests whether a 15-20 minute session in a specially designed sensory modulation room before kidney transplant surgery can reduce pain, anxiety, and sleep problems afterward. The room has dim lights, nature videos, calming music, and tactile objects like stress balls. R…

This study tests whether a nerve block called transversalis fascia plane block can reduce pain after kidney transplant surgery. Fifty adults will receive either the nerve block plus standard painkillers or standard painkillers alone. The goal is to see if the block lowers pain sc…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This study looks at whether adding a blood-filtering step called hemoadsorption to regular dialysis can help people with kidney failure who still have bothersome symptoms like itching, tiredness, and trouble sleeping. Researchers will follow 120 adults for 6 months, tracking how …

This study tests whether a drug called icatibant can prevent sudden drops in blood pressure during dialysis, a common and serious problem. About 26 adults with kidney failure who often experience these drops will receive either the drug or a placebo in random order. The goal is t…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

This study tests whether progressive muscle relaxation exercises can reduce depression and fatigue in people receiving hemodialysis. Sixty patients will practice these relaxation techniques, and researchers will measure changes in their mood and energy levels. The goal is to see …

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end-stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes, three times a week, for four weeks. Researchers will com…

This study tests whether watching exercise videos designed for chronic kidney disease (CKD) patients can improve their physical fitness and activity levels. Sixty adults with early-stage CKD will be randomly assigned to either a 12-week multimedia education program or standard ed…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests whether a combination of flywheel resistance and aerobic exercise can reduce fatigue and improve muscle function in veterans with chronic kidney disease who are not yet on dialysis. Researchers will measure changes in leg muscle endurance, perceived exhaustion, a…

This study tests whether a 12-week supervised exercise program done during dialysis can improve muscle mass, strength, sleep, and quality of life in adults over 40 with chronic kidney disease. Participants are randomly assigned to either exercise during the first 90 minutes of di…

This study tests whether having dialysis patients report their symptoms every month – and automatically alerting their care team when symptoms are severe – can improve their quality of life. About 2,293 adults with end-stage kidney disease on dialysis will take part across French…

This study is testing a program called TĀCcare 2.0, which combines medication and talk therapy to help people on hemodialysis manage pain, fatigue, and depression. About 424 adults who have been on dialysis for at least 3 months will take part. The goal is to see if this team-bas…

This study looks at a new way to do dialysis using just one needle in the arm instead of two, which may cause less damage to the blood vessel used for treatment. About 100 adults on long-term dialysis will try this method, and researchers will check if it keeps dialysis working w…

This study tests whether doing physical therapy during dialysis or just before it works better for people with end-stage kidney disease. 72 adults on hemodialysis will be split into two groups and exercise twice a week for 12 weeks. Researchers will measure walking ability, stren…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 adults on …

This pilot study tests whether a device that gently stimulates a nerve in the ear (taVNS) is safe and tolerable for people with chronic kidney disease stages 3-5 who have autonomic nervous system dysfunction. Thirty participants will use the device daily for two weeks. The main g…

This pilot study tests whether a 12-week high-velocity resistance training program is safe and doable for older adults with advanced chronic kidney disease. Thirty participants will either do the exercise program or join weekly healthy lifestyle sessions. The goal is to see if th…

This study tests whether personalized support from an exercise teacher and a nurse can help people on hemodialysis become more physically active at home. The study will include 70 adults who have been on dialysis for less than a year. The goal is to see if this support leads to l…

This study tests whether combining a hands-on nerve treatment (intraneural facilitation) with a balance exercise program can reduce pain, improve balance, and enhance quality of life in people with diabetic peripheral neuropathy. About 65 adults aged 50-75 with type 2 diabetes an…

This study tests whether a symptom-monitoring system called SMaRRT-HD helps dialysis patients feel better. About 2,400 adults on hemodialysis at up to 36 U.S. clinics will either use the system or receive usual care. The system lets patients report symptoms on a tablet and alerts…

This study tests whether a 6-week aerobic exercise program (done on non-dialysis days) can lower serum uric acid levels, improve walking ability, and boost quality of life in 32 adults aged 40-60 who are on hemodialysis. Half will exercise 3 times a week; the other half will rece…

This phase 2 trial tests whether taking sodium bicarbonate pills and doing regular stationary bike exercise can improve exercise capacity in people with chronic kidney disease (CKD). Researchers will enroll 156 adults with CKD, kidney transplant recipients, or healthy controls. P…

This study tests whether a 12-week physical activity program can help teens aged 13–18 with chronic kidney disease (stages II–V) become more active. Participants will wear a Fitbit to track their moderate-to-vigorous exercise. The goal is to see if the program increases daily act…

This study tests whether a program that combines gentle walking with progressive muscle relaxation can help reduce the extreme tiredness (fatigue) that many people with end-stage kidney disease feel while on dialysis. Researchers will enroll 40 adults who are on hemodialysis and …

This observational study will follow 3,000 Chinese adults with chronic kidney disease (CKD) to see how they are treated in real-world clinics and what happens to their health over time. Researchers will track medications, kidney function, heart risks, and hospital visits. The goa…

This study follows up to 2000 people with immune-related kidney diseases, such as nephrotic syndrome and lupus nephritis. Researchers will collect medical history, lab tests, and blood or urine samples to better understand these conditions. The goal is to learn more about causes …

This study compares two anesthesia methods—general anesthesia with sevoflurane and combined spinal-epidural anesthesia—in adults receiving a kidney transplant. Researchers will measure blood markers related to cell damage and protection to see if one method better shields the new…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. …

This study investigates how changes in kidney cell metabolism relate to the rate of kidney function decline in people with ANCA vasculitis and other kidney diseases. Researchers will analyze kidney biopsy samples and blood/urine tests from 146 participants over one year. The goal…

This study will follow 500 adults with chronic kidney disease and type 2 diabetes who are taking finerenone, a drug that helps protect the kidneys and heart. Researchers want to see if a tool called the Klinrisk score, which estimates the risk of kidney disease getting worse, imp…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This observational study will compare blood fat (lipid) levels in 200 adults with chronic kidney disease—half with diabetes and half without. Researchers want to find out if having diabetes leads to worse fat problems in these patients. Participants will fast for 10 hours before …

This study looks at how well the immune system works in people with end-stage kidney disease. Researchers will take blood samples from 100 patients and healthy donors to study T-cells, a key part of the immune system. They also plan to test a lab technique to restore T-cell funct…

This study is a long-term follow-up for 20 people with chronic kidney disease who received an experimental drug called vonsetamig and then had a kidney transplant in an earlier study. No new treatment is given here. Researchers will track how the drug affects the body and monitor…

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study looks at how a 12-week lifestyle change affects inflammation and stress markers in 60 overweight adults with type 2 diabetes and moderate chronic kidney disease. Participants will follow a modified diet and exercise plan. The goal is to see if these changes can reduce …

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This observational study will follow 50,000 people in Asia and the United States who have chronic kidney disease and type 2 diabetes and are already taking finerenone as part of their regular care. Researchers will collect data from electronic health records and insurance claims …

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study looks at whether sending home test kits or ordering standard lab tests can help more people with type 2 diabetes get screened for chronic kidney disease (CKD). About 750 adults who are missing key kidney function tests will be enrolled. The goal is to see if these appr…

This early-stage study looks at how safe a new drug called INCB123667 is for people with severe kidney disease or kidney failure. Researchers will measure how the drug moves through the body and check for side effects. The study involves 16 adults aged 18 to 85.

This study watches 500 adults in South Korea who have chronic kidney disease and type 2 diabetes and are taking finerenone as part of their normal care. Researchers will collect information from medical records and doctor visits over up to 12 months to see why doctors prescribe i…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study measures hip muscle strength in 50 adults on hemodialysis using a handheld device. The goal is to create reference values for lower-limb strength in this group. Researchers will also check how strength relates to handgrip, walking speed, and quality of life.

This pilot study looks at whether giving dialysis on the same day as surgery is better than not giving it for people with end-stage kidney disease. About 30 participants will be randomly assigned to one of two schedules. Researchers will track safety issues like electrolyte probl…

This early-stage trial tests a new drug called CTX001 in 72 healthy adults. The goal is to check for side effects and see how the drug affects iron levels in the blood, with or without iron supplements and food. It is a first step toward possibly treating anemia and iron deficien…

This study is testing whether a blood test that looks at tiny genetic molecules called microRNAs can accurately detect bone problems in people with chronic kidney disease. Currently, doctors rely on a bone biopsy, which is invasive and not practical for most patients. The researc…

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This study looks at whether short-term use of NSAID pain relievers (like ibuprofen) after surgery increases the risk of acute kidney injury in children with mild-to-moderate chronic kidney disease. About 164 children over 18 months old with CKD stages 2-3a who are having urologic…

This study looks at whether replacing red meat with plant-based protein can lower levels of certain gut toxins in people with stage 3 chronic kidney disease. Fifteen participants will try both a vegetarian diet and a diet with red meat, with a break in between. Researchers will m…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study looks at whether giving more protein (over 1.2 grams per kilogram per day) to critically ill patients with acute kidney injury helps their kidneys recover faster or causes harm. Researchers will review medical records from 344 adults in five Argentine ICUs, comparing t…

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study follows 100 adults with end-stage kidney disease who need long-term dialysis but have no working access sites left. Researchers are watching how well the HeRO and Super HeRO grafts perform over two years, checking for infections, blockages, and overall safety. The goal…

This study watches what happens to the lungs when doctors use a balloon to clear a clot in a dialysis patient's arm graft. Using a special belt that takes pictures of lung activity, researchers will check if tiny clot pieces briefly affect how air and blood flow in the lungs. Twe…

This study follows 60 kidney transplant recipients in Denmark to find out how often blood vessel problems cause poor kidney function or hard-to-treat high blood pressure. Participants will get special imaging tests, and if a narrowed artery is found, they may receive balloon trea…

This study looks at whether making changes at hospitals and dialysis centers can help more people with kidney failure start the process to get a transplant. About 14,000 patients at five large transplant centers will be included. The goal is to see if these changes lead to more p…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is looking at 1,000 liver transplant recipients to see if testing their blood, urine, and tissue samples can detect early signs of chronic kidney disease, acute rejection, or hepatitis C. The goal is to find simple biomarkers that could lead to earlier treatment and fe…

This study follows 500 American Indian adults with early kidney disease to learn how their condition progresses and what factors affect heart health. Researchers will measure kidney function and track heart events like heart attacks and strokes. The goal is to fill knowledge gaps…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study will compare kidney function in 3,000 adults with Crohn's disease or ulcerative colitis to 3,000 adults without these conditions. Participants will provide blood and urine samples and have a kidney ultrasound. The goal is to learn how common kidney problems are in IBD …

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and acid levels in 110 veterans with and without CKD. The goal is to understand the body's response,…

This study uses a quick, painless eye scan (OCT) to see if blood vessels in the eye look different in people with high blood pressure or chronic kidney disease compared to healthy people. Researchers want to learn if these differences improve with treatment. About 150 adults aged…

This study looks at whether getting a flu shot in the morning or evening makes a difference for people with chronic kidney disease. Researchers will measure antibody levels four weeks after vaccination to see which time works better. The study involves 735 adults with advanced ki…

This study at Yale University is testing whether the body can store sodium without holding onto extra water, a concept called 'water-free sodium storage.' Ten adults on peritoneal dialysis with heart failure will receive either a special dextrose solution or standard dialysis flu…

Many people with chronic kidney disease also have heart disease, but heart procedures like angiograms and surgery can raise the risk of kidney complications. This study tests an online decision aid called 'My Heart and CKD' that helps patients and doctors weigh the benefits and r…

This study looks at how semaglutide, a drug used for diabetes and weight loss, changes fat tissue around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers will compare patients taking semaglutide to those not taking it. The goal …

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study looks at how quickly people on dialysis gain weight from drinking fluids between sessions. It aims to understand if thirst right after dialysis leads to more fluid intake. The results could help improve care for kidney patients.

This study looks at better ways to check kidney function after acute kidney injury (AKI). Researchers will compare two blood tests (creatinine and cystatin C) to see which is more reliable. They will also interview patients about their recovery experiences and hold workshops to d…

This study looks at how long a person has been on dialysis and how much urine they still make affects bladder size and flexibility. Researchers will measure bladder function in 87 adults with kidney failure who are waiting for a transplant. The goal is to find bladder problems ea…

This study tests two programs to help people aged 75 and older with advanced kidney disease decide on their treatment. One program provides standard information and support, while the other adds a video decision aid and coaching from a specialist. Researchers will compare which a…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study aims to understand how social needs like food or housing insecurity affect self-care in African American adults with diabetic kidney disease. Researchers will interview patients and community stakeholders, then survey 300 participants to measure blood pressure, blood s…

This study looks at whether a new type of dialysis filter (medium cut-off dialyzer) helps kidney patients live longer and have fewer complications compared to standard filters. Researchers will review medical records from 1,000 adults on maintenance dialysis. The study is observa…

This study collects small tissue samples from the abdomen of children and adults undergoing peritoneal dialysis (a type of kidney treatment). The goal is to learn how the lining of the belly changes over time with dialysis. Researchers will also take samples from healthy people h…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study looks at how genes influence the risk of kidney disease. Anyone 18 or older living in the US can join, even without kidney disease. Participation is online: you fill out health surveys and mail in a saliva sample. You may get free genetic ancestry information in return…

This study is creating a large database of 8,000 adults with heart, kidney, or metabolic diseases to track their health over up to 5 years. Researchers will collect medical records, imaging, and lab data to understand how these conditions interact and affect long-term outcomes. T…

This early-stage study tests a single dose of Zovaglutide (ZT002), an experimental drug for overweight and obesity, in 40 adults with varying levels of kidney function. Researchers will measure how the drug moves through the body and check for side effects. The goal is to underst…

This study follows children with chronic kidney disease to track how their condition changes over time and what factors affect their health. Researchers will monitor kidney function, heart health, and other outcomes in about 1,300 participants. The goal is to better understand th…

This study asks 500 adults with advanced kidney disease to complete a questionnaire that presents different dialysis options. Patients choose between home dialysis (with a financial allowance) and in-center dialysis (without the allowance) 13 times, each with varying features lik…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1000 volunteers. Researchers will use advanced technology to identify different disease types and find new targets for therapies. The goal is to pave the way for pe…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This study explores whether advanced MRI scans can noninvasively diagnose and track diabetic kidney disease (DKD). Researchers will scan 150 people—including DKD patients and healthy volunteers—using multiple MRI techniques. The goal is to see if these scans can predict kidney fu…

This study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…

This study looks at a rare but serious condition called calciphylaxis, where small blood vessels in the skin harden, often leading to death. Researchers will compare 860 adults with chronic kidney disease—some who have calciphylaxis and some who don't—to find clues about what cau…

This study looks at why people with chronic kidney disease (CKD) often lose muscle mass and strength, a condition called sarcopenia. Researchers will follow 1,000 adults with CKD to find risk factors for sarcopenia and see how it affects their health over time. The goal is to bet…

This study tests a single dose of hydroxynidone capsules in 56 people with different levels of kidney function and healthy volunteers. The goal is to see how the drug moves through the body and if it is safe in people with kidney problems. Participants will have blood and urine t…

This study looks at whether kidney failure changes how well the flu vaccine works in people on dialysis. Researchers will compare the immune response of 146 dialysis patients and healthy volunteers after they get the flu shot. Participants will give blood samples over several mon…

This study is for older adults, including those in the hospital or with low priority care needs. Researchers want to see if newer methods, like body scans and blood tests, can better detect malnutrition and kidney problems than current standard tests. The goal is to make diagnosi…

This study tests easier methods to measure how well the kidneys can handle extra work (kidney reserve). It involves 44 adults with sickle cell kidney disease or who have donated a kidney. Participants take a protein drink, and researchers check changes in a blood test called eGFR…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This study compares three ways to help people with advanced chronic kidney disease prepare for hemodialysis vascular access. 360 participants will either get a video and brochure, the same materials plus coaching sessions, or usual care. The goal is to see which approach helps mo…

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This study follows 300 preterm and full-term infants from birth to age 10 to see how their kidneys grow and function. Researchers use ultrasound and blood/urine tests to find early markers of kidney injury and high blood pressure. The goal is to identify at-risk children before t…

This study looks at how the drug eloralintide enters the bloodstream and leaves the body in people with severe kidney disease or kidney failure, compared to healthy volunteers. About 28 participants will receive a single shot under the skin. The study lasts about 14 weeks and doe…

This study tracks 15 people getting a simultaneous liver-kidney transplant to see how much their own kidneys recover. Researchers use a special nuclear scan and blood tests to measure kidney function before and after transplant. The goal is to create a way to predict who might no…

This study tests whether a nurse-led foot care education program, based on the Health Belief Model, can improve foot care knowledge and behavior in diabetic patients undergoing hemodialysis. Fifty participants will be randomly assigned to receive the training or standard care. Th…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study looks at how common stomach symptoms like pain and nausea are in people with Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed. Researchers will use a simple breath test done at home to check how well the stomach empt…

This study aims to understand how a thin layer inside blood vessels, called glycocalyx, and oxidative stress affect blood flow in people with chronic kidney disease. Researchers will compare 105 participants, including kidney disease patients, people with high blood pressure, and…

This observational study examines kidney tissue from adults with diabetic kidney disease who are already having a kidney biopsy or surgery as part of their regular care. Researchers want to see if people taking SGLT2 inhibitors (a type of diabetes medicine) show different biologi…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study compares three ways to check for fluid overload (too much fluid in the body) in people doing dialysis at home. Researchers will ask about symptoms, do a physical exam, and use a safe ultrasound of the lungs. The goal is to find which method works best to help prevent h…

This study tests whether a simple neck ultrasound can accurately measure fluid status in people receiving chronic haemodialysis. Researchers will compare ultrasound results with standard methods in 100 participants. The goal is to find a safer, non-invasive way to guide fluid rem…

This study is collecting kidney tissue, blood, urine, and genetic samples from 400 adults with diabetes who are already scheduled for a kidney biopsy. Researchers will compare people whose kidney function declines quickly versus slowly to find molecular clues. The goal is to bett…

This study compares two muscle relaxant drugs (rocuronium and cisatracurium) used during general anesthesia in people with chronic kidney disease. Researchers want to see which drug leads to fewer lung problems after surgery. About 490 adults with kidney disease will take part.

This study follows 200 adults with advanced chronic kidney disease as they start dialysis, comparing those who choose home dialysis with those who go to a center. Researchers will track quality of life, frailty, fatigue, mood, and thinking skills every 3 to 6 months for a year. T…

This study is testing whether a special CT scan of the heart (CTCA) can better predict heart attacks and other heart problems in people waiting for a kidney transplant. About 332 patients on the transplant list will get a single CTCA scan before their surgery. Researchers will th…

This study is tracking 200 kidney transplant patients in Scotland to see if certain biomarkers can help predict transplant rejection. Researchers will compare biomarker levels with standard biopsy results. The goal is to find a simpler, less invasive way to monitor transplant hea…

This study is testing whether a special MRI technique called MR elastography can detect kidney scarring (fibrosis) in people with early chronic kidney disease. Researchers will scan 200 adults—some with kidney disease and some healthy—and track their kidney function for two years…

This observational study will use special PET scans to measure how much oxygen the heart and kidneys use in people with type 1 diabetes. Researchers want to see if a more intensive treatment plan (multifactorial intervention) lowers oxygen demand compared to standard care. Forty …

This study surveys 100 adults on chronic dialysis to understand how the treatment impacts their sexual quality of life. Participants fill out a questionnaire during a dialysis session, covering sexual function and body image. The goal is to gather up-to-date information to help h…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This study looks at how the eyes, brain, and kidneys affect each other in people with chronic kidney disease (CKD). Researchers will use MRI scans and eye imaging to see if changes in the brain and retina are linked to thinking problems and kidney function. About 1,500 adults wit…

This study is testing how different levels of dietary phosphorus affect people with moderate chronic kidney disease (stages 3-4) compared to healthy volunteers. Participants will follow three different phosphorus diets over 21 days, and researchers will measure blood markers to f…

This study tests different coaching sessions to help people with stage 4 chronic kidney disease and their caregivers work together on health decisions. 128 patient-caregiver pairs will try one or more training components, like extra coaching or communication practice. The goal is…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study surveys healthcare professionals in European dialysis centers to understand how they measure intraperitoneal pressure (belly pressure) in children with kidney failure who are on peritoneal dialysis. The goal is to learn about current practices and improve how dialysis …

This observational study will follow 90,000 people in China, including those with chronic kidney disease (CKD) and those at risk, to track how the disease develops and worsens over time. Researchers will collect real-world data to better understand CKD and improve prevention stra…

This study looks at how frailty affects people getting a kidney transplant. Researchers will use a simple physical test called the Short Physical Performance Battery (SPPB) to measure frailty before and after transplant. They hope to learn if frailty scores can help predict recov…

This study tests a mobile app called MiDialisis, designed to help people with chronic kidney disease on peritoneal dialysis share their health data with doctors. About 55 adults who have been on dialysis for at least 3 months and own a smartphone will use the app for a period. Re…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This pilot study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for people with chronic kidney disease (CKD). Twenty adults with moderate to advanced CKD will use the device for 15 minutes. Researchers will measure heart rate changes a…

This study aims to understand the link between calcium and phosphorus from food and the stage of kidney disease in patients with advanced chronic kidney disease (stage 4-5). Researchers will compare two methods of tracking diet: taking photos of meals and weighing food. The goal …

This study tests a website called 'My Voice' that helps kidney failure patients on dialysis plan their future medical care. The website teaches patients about their illness, helps them decide what kind of care they want, and coaches them on how to talk to doctors and family. Abou…

This study is looking at 300 people with type 2 diabetes who have high levels of protein in their urine, a sign of kidney trouble. Researchers will take small samples of kidney tissue (biopsies) and analyze blood, urine, and stool to find patterns that could improve diagnosis and…

This study is testing a new food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney problems. Researchers will compare the questionnaire results with a 24-hour urine test, which is the gold standard for…

This study looks at whether a special exercise program, which combines regular training with a technique that limits blood flow to the muscles, can help people with chronic kidney disease improve their ability to exercise. The researchers will measure changes in breathing muscle …

This study reviews medical records of 10 adult transplant patients who have a hard-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. No new treatments or procedures are given; the …

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study looks at how different forms of vitamin D work in the body. Researchers will measure free vitamin D (the active form) in healthy adults, pregnant women, and people with hormone or kidney problems. The goal is to see if free vitamin D gives a more accurate picture of vi…

This study tests whether a 12-week virtual exercise and education program is practical for people with end-stage kidney disease who are waiting for a transplant. About 30 participants will either do the program or receive usual care. The main goal is to see if enough people join,…

This study is for adults who have had a liver transplant and now have kidney issues. Researchers want to learn how often kidney function gets worse and what factors might cause that decline. They will look at results from kidney biopsies already done in the past 3 months. The goa…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to find biological markers that predict disease progression and help create personalized prevention and treatment plans. Particip…

This study looks at whether using a lower amount of bicarbonate in the dialysis fluid is better for the heart than the usual higher amount. About 141 hospitalized adults on long-term dialysis will be randomly assigned to receive either lower or higher bicarbonate during their dia…

This study follows 544 adults with advanced kidney disease who need an arteriovenous fistula for dialysis. Researchers want to find out why some people develop hand ischemia (reduced blood flow) after surgery. They will track symptoms like cold hands, pain, or sores to identify r…

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will examine blood and kidney tissue samples taken before and after the transplant to find the cause. The g…

This study looks at how common sleep apnea is in people with chronic kidney disease and whether it makes kidney function worse over time. Researchers will follow 356 adults with moderate kidney disease for several years, tracking their health and sleep patterns. The goal is to fi…

This observational study follows 200 adults with chronic kidney disease and a type of heart failure (HFpEF), some taking SGLT2 inhibitors (flozins) and some not. Researchers will measure arterial stiffness, heart function, and kidney decline over time to see if flozins are linked…

This pilot study tests whether adjusting magnesium levels in dialysis fluid can reduce harmful blood cell activation during treatment. Fifteen adults with kidney failure will try three different dialysis fluid recipes over six weeks. Researchers will measure blood cell counts and…

This study tests a 12-week program that provides education, navigation, and self-management support to African American adults hospitalized with advanced chronic kidney disease. The goal is to see if the program improves patients' understanding of kidney disease, blood pressure, …

This study is testing a smartphone app designed to help older adults (55+) with conditions like heart failure, diabetes, and kidney disease manage their health after leaving the hospital. The app provides fall prevention tips, a personalized care plan, and a way to track symptoms…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure it…

This study will follow 80 people with advanced chronic kidney disease who are waiting for a kidney transplant. Researchers will use PET scans and echocardiograms to measure blood flow and heart function before and after transplant. The goal is to see if improving kidney function …

This study looks at how the sedative remimazolam behaves in the body of 30 adults receiving a kidney transplant. Researchers will measure drug levels in the blood and monitor sedation depth to ensure safe and predictable anesthesia. The goal is to gather information for better se…

This study is testing a new blood test that looks for kidney-specific DNA to detect injury or rejection after a kidney transplant. Researchers will measure these DNA markers before and after surgery in 30 patients with end-stage kidney disease. The goal is to see if the test can …

This study is testing a new device called PatenSee that can check the health of dialysis access points without touching the patient. About 90 adults with kidney failure who need regular dialysis will take part. The device uses light and sound to see and hear the access point, and…

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…