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Double transplant: kidney and bladder together for the first time

NCT ID NCT04626167

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial at Mayo Clinic is testing whether it is possible to transplant a bladder along with a kidney in people who have kidney failure due to bladder problems. Up to 30 participants will receive both organs from a deceased donor. The goal is to see if the bladder works well and safely over time, avoiding the need for bowel tissue to rebuild the bladder.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bladder and kidney transplant surgery
What this could lead to
If successful, this could offer a new option for people needing both a kidney and a working bladder, potentially avoiding the need for bowel segments in bladder reconstruction.
What could go wrong
This is a very early phase 1 trial with only 30 participants, so it is not yet proven safe or effective. There are risks from major surgery, organ rejection, and lifelong immunosuppression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bladder exstrophy bladder neck obstruction chronic kidney disease chronic renal failure syndrome kidney failure lower urinary tract obstruction, congenital posterior urethral valve transplant rejection urinary bladder disorder Urinary Bladder, Neurogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER ABSENCE BLADDER DYSFUNCTION BLADDER EXSTROPHY BLADDER OUTLET OBSTRUCTION CHRONIC KIDNEY DISEASES FAILURE, KIDNEY NEUROGENIC BLADDER POSTERIOR URETHRAL VALVE TRANSPLANT

Contacts and locations

Locations

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55901, United States

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

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