Can a common gout pill shield hearts in kidney disease?

NCT ID NCT06203977

Completed Disease control Sponsor: Hamilton Health Sciences Corporation Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether colchicine, a drug used for gout, can safely reduce inflammation and potentially lower heart injury in people with advanced chronic kidney disease or on dialysis. Participants take colchicine daily for 16 weeks, starting at a low dose and then increasing it. The main goal is to see how well people tolerate the drug and whether they can stick with it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: colchicine
What this could lead to: If colchicine is well-tolerated, it could point toward a way to lower heart risk in people with kidney disease.
What could go wrong: This is a small, early-phase trial focused on tolerance, not on proving heart benefits. Colchicine can cause side effects like stomach upset, and the results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome kidney failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASES RENAL FAILURE

Contacts and locations

Locations

London Health Sciences Centre

London, Ontario, N6A 5A5, Canada
St. Joseph's Healthcare Hamilton

Hamilton, Ontario, L8N 4A6, Canada
University of Alberta Hospital

Edmonton, Alberta, T6G 2B7, Canada

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