Hamilton Health Sciences Corporation

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests a drug called tideglusib in 120 people with a genetic heart condition that can cause dangerous heart rhythms. The drug aims to reduce abnormal heartbeats and improve heart function. Participants will take either tideglusib or a placebo daily for about a year to s…

This study compares a dye called ICG alone against the standard two-method approach (ICG plus a radioactive tracer) to find cancer in lymph nodes of women with early vulvar cancer. About 58 women will take part. If ICG alone works just as well, it could simplify surgery and reduc…

This study tests if using antiseptic washes and placing antibiotics directly into the wound during hip or knee replacement surgery can lower the chance of a serious infection that requires another operation. Over 21,000 adults getting a joint replacement will be randomly assigned…

This study tests whether injecting a numbing medication (bupivacaine) near a nerve cluster in the nose can reduce pain after minimally invasive pituitary tumor removal. About 108 adults will be randomly assigned to receive the nerve block, a placebo (saline), or no extra injectio…

This study looks at two different surgical methods for anterior cervical spine surgery. Both use the same skin cut but differ in how the surgeon reaches the spine. The goal is to see if one approach leads to fewer problems with swallowing and voice changes. About 100 adults havin…