New device aims to stop strokes in High-Risk heart patients

NCT ID NCT05963698

Recruiting now Disease control Sponsor: Hamilton Health Sciences Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled. The goal is to see if adding this procedure to standard medication offers extra protection.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation ischemic stroke prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION STROKE, ISCHEMIC SYSTEMIC EMBOLISM

Contacts and locations

Locations

ASBL CHU Helora - Hôpital de La Louvière - site Jolimont
RECRUITING

La Louvière, Hainaut, 7100, Belgium
AZ Delta VZW
RECRUITING

Roeselare, West-Vlaanderen, 8800, Belgium
AZ Glorieux
RECRUITING

Ronse, Oost-Vlaanderen, 9600, Belgium
AZ Sint Jan Brugge AV
RECRUITING

Bruges, West-Vlaanderen, 8000, Belgium
AZORG vzw and Hartcentrum Aalst
RECRUITING

Aalst, East-Flanders, 9300, Belgium
Aarhus University Hospital (AUH)
RECRUITING

Aarhus, Region Midt, 8200, Denmark
Affinity Hospital dba Grandview Medical Center
WITHDRAWN

Birmingham, Alabama, 35243, United States
American Heart of Poland SA
RECRUITING

Ustroń, 43-450, Poland
Arrhythmia Research Group
RECRUITING

Jonesboro, Arkansas, 72401, United States
Asklepios Kliniken Hamburg GmbH
RECRUITING

Hamburg, 20099, Germany
Asklepios Kliniken Hamburg GmbH
RECRUITING

Hamburg, 20099, Germany
Aultman Hospital
RECRUITING

Canton, Ohio, 44710, United States
Azienda Ospedaliero Universitaria Sassari
RECRUITING

Sassari, Sassari, 07100, Italy
Babtist Health Lexington
RECRUITING

Lexington, Kentucky, 40503, United States
Baylor Research Institute
RECRUITING

Dallas, Texas, 75204, United States
CHR Metz-Thionville / Hôpital de MERCY
RECRUITING

Ars-Laquenexy, Moselle, France
CHR de la Citadelle
RECRUITING

Liège, Liège, 4000, Belgium
CHRISTUS Northeast Texas Health System
RECRUITING

Tyler, Texas, 75701-2263, United States
CHU Saint Etienne
RECRUITING

Saint-Etienne, Auvergne-Rhône-Alpes, 42055, France
CVC Rhein-Main GmbH
RECRUITING

Frankfurt am Main, Hesse, 60389, Germany
Cambridge Cardiac Care Inc.
RECRUITING

Cambridge, Ontario, N1R 6V6, Canada
Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island
RECRUITING

Rock Island, Illinois, 61201, United States
Centre Cardiologique due Nord
RECRUITING

Saint-Denis, Île-de-France Region, 93200, France
Centre Hospitalier Régional Universitaire de Tours
RECRUITING

Tours, Centre-Val de Loire, 37044, France
Centre Hospitalier Universitaire de Toulouse
RECRUITING

Toulouse, Occitanie, 31059, France
Centre hospitalier de l'Université de Montréal
RECRUITING

Montreal, Quebec, H2X OC1, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)
RECRUITING

Sherbrooke, Quebec, J1J 3H5, Canada
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 12203, Germany
Charité Universitätsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Circulate Cardiac & Vascular Centre (CCVC)
RECRUITING

Burlington, Ontario, L7M 1K9, Canada
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinique Pasteur
RECRUITING

Toulouse, Occitanie, 31076, France
CommonSpirit Health Research Institute
RECRUITING

Tacoma, Washington, 98405, United States
Community Health Network Inc.
RECRUITING

Indianapolis, Indiana, 46256, United States
Complejo Asistencial Universitario de León
RECRUITING

León, 24071, Spain
Cornell University for and on behalf of its Joan & Sanford I. Weill Medical College and The New York Presbyterian Hospital
RECRUITING

New York, New York, 10065, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Esbjerg & Grindsted Hospital - University Hospital of Southern Denmark
RECRUITING

Esbjerg, Region Syddanmark, 6700, Denmark
European Georges Pompidou Hospital
RECRUITING

Paris, 75908, France
Fondazione Poliambulanza Istituto Ospedaliero
RECRUITING

Brescia, 25124, Italy
Glanecare, Inc. d/b/a HCA Florida Brandon Hospital
RECRUITING

Brentwood, Tennessee, 37027, United States
HCA Florida Ocala Hospital
RECRUITING

Ocala, Florida, 34471, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hamilton Health Sciences Corp
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Heart Rhythm Associates
WITHDRAWN

The Woodlands, Texas, 77380, United States
Heinrich-Braun-Klinikum gemeinnützige GmbH
RECRUITING

Zwickau, Saxony, 08060, Germany
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Herzzentrum Leipzig GmbH
RECRUITING

Leipzig, Saxony, 04289, Germany
Hospital Clínico Universitario de Valladolid
RECRUITING

Valladolid, 47003, Spain
Hospital Prive Jacques Cartier
RECRUITING

Massy, Île-de-France Region, 91300, France
Hospital Álvaro Cunqueiro
RECRUITING

Vigo, Pontevedra, 36312, Spain
Hôpital Bichat
RECRUITING

Paris, 75018, France
Hôpital Pitie Salpétrière
RECRUITING

Paris, 75013, France
Imeldaziekenhuis
RECRUITING

Bonheiden, Antwerpen, 2820, Belgium
Infirmerie Protestante de Lyon
RECRUITING

Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300, France
Institut Médico-chirurgical Montsouris
RECRUITING

Paris, 75014, France
Institut de Cardiologie de Montreal (ICM)
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
RECRUITING

Québec, Quebec, G1V 4G5, Canada
JFK Medical Center Limited Partnership d/b/a HCA Florida JFK Hospital
RECRUITING

Atlantis, Florida, 33462, United States
Johann Wolfgang Goethe Universität Franfurt - Universitätsklinikum Franfurt
RECRUITING

Frankfurt am Main, Hesse, 60590, Germany
Kardiovaskulaeres Zentrum Darmstadt
RECRUITING

Darmstadt, Hesse, 64287, Germany
Katholisches Krankenhaus "St. Johann Nepomuk"
RECRUITING

Erfurt, Thuringia, 99097, Germany
Kootenai Health Inc.
RECRUITING

Coeur d'Alene, Idaho, 83814, United States
Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH
RECRUITING

Bad Oeynhausen, North Rhine-Westphalia, 32545, Germany
L'Assistance Publique-Hôpitaux de Marseille
RECRUITING

Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France
Lahey Clinic Inc.
RECRUITING

Burlington, Massachusetts, 01805, United States
Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical Center
RECRUITING

Largo, Florida, 33770, United States
Lawrence Park Cardiology
RECRUITING

Toronto, Ontario, M4N 3N1, Canada
Lawson Health Research Institute
RECRUITING

London, Ontario, N6A 2R5, Canada
Liverpool Heart and Chest Hospital NHS Foundation Trust
RECRUITING

Liverpool, L14 3PE, United Kingdom
Loma Linda University Health
RECRUITING

Loma Linda, California, 92354, United States
MVZ CCB Frankfurt und Main-Taunus GbR
RECRUITING

Frankfurt am Main, Hesse, 60431, Germany
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Health Services
RECRUITING

Fountain Valley, California, 92708, United States
MercyOne Iowa Heart Center
RECRUITING

West Des Moines, Iowa, 50266, United States
Mission Hospital HCA
RECRUITING

Asheville, North Carolina, 28801, United States
NYU Grossman School of Medicine
WITHDRAWN

New York, New York, 10065, United States
Narodowy Instytut Kardiologii Stefana kardynała Wyszyńskiego
RECRUITING

Warsaw, Masovian Voivodeship, 04-628, Poland
Niagara Health System - Niagara Falls
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
Niagara Health Systems - St. Catharines
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
North Denmark Regional Hospital
RECRUITING

Hjørring, 9800, Denmark
Northwestern University
RECRUITING

Evanston, Illinois, 60208, United States
Nottingham University Hospital NHS Trust
RECRUITING

Nottingham, Nottinghamshire, NG5 1PB, United Kingdom
Ochsner Clinic Foundation
RECRUITING

New Orleans, Louisiana, 70121, United States
Odense Universitets Hospital
RECRUITING

Odense C, 4500, Denmark
Ottawa Heart Institute Research Corp
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Partners in Advanced Cardiac Evaluation (PACE)
RECRUITING

Newmarket, Ontario, L3Y 2P6, Canada
Prairie Valscular Research Inc. (PVRI)
RECRUITING

Regina, Saskatchewan, S4P 0W5, Canada
Presbyterian Healthcare Services d.b.a. Presbyterian Heart Group
RECRUITING

Albuquerque, New Mexico, 87106, United States
Region Hospital Viborg
RECRUITING

Viborg, Central Jutland, 8800, Denmark
Research St. Joseph's - Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Rigshospitalet (RH)
RECRUITING

Copenhagen, 2100, Denmark
SCP des Médecins Cardiologues
RECRUITING

Toulouse, Occitanie, 31076, France
Saint Francis Hospital
RECRUITING

Tulsa, Oklahoma, 74136, United States
Saskatchewan Health Authority
RECRUITING

Saskatoon, Saskatchewan, S7K 0M7, Canada
Southern California Permanente Medical Group
RECRUITING

Pasadena, California, 91101, United States
Southlake Regional Health Centre
RECRUITING

Newmarket, Ontario, L2Y 2P9, Canada
St Luke's Regional Medical Center, Ltd
RECRUITING

Boise, Idaho, 83712, United States
St. Boniface Hospital Inc.
RECRUITING

Winnipeg, Manitoba, R2H 2A6, Canada
St. Vincent's Health System
RECRUITING

Jacksonville, Florida, 32204, United States
Stichting Catharina Ziekenhuis
RECRUITING

Eindhoven, North Brabant, 5623EJ, Netherlands
Städtisches Klinikum Karsruhe gGmbH
RECRUITING

Karlsruhe, Baden-Wurttemberg, 76133, Germany
Sunnybrook Health Sciences Center
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sutter Valley Hospitals dba Sutter Institute for Medical Research
RECRUITING

Sacramento, California, 95816, United States
Texas Cardiac Arrhythmia Research Foundation
WITHDRAWN

Austin, Texas, 78705, United States
The Feinstein Institutes for Medical Research
RECRUITING

Manhasset, New York, 11030, United States
The Fondation de l'AP-HP
RECRUITING

Paris, Paris, 75012, France
The Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
The Pennsylvania State University and The Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
The Rector and Visitors of the University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
The Trustees of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
The University of South Florida
RECRUITING

Tampa, Florida, 33620, United States
The University of Tennessee
RECRUITING

Memphis, Tennessee, 38163, United States
TriHealth Inc.
RECRUITING

Cincinnati, Ohio, 45202, United States
Unity Health Toronto
RECRUITING

Toronto, Ontario, M5B 1W8, Canada
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, 1090, Belgium
Universitario La Luz - Grupo Quirónsalud
RECRUITING

Madrid, 28003, Spain
University General Hospital Dr. Balmis
RECRUITING

Alicante, 03010, Spain
University Health Network
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
University Hospitals Coventry and Warwickshire
RECRUITING

Coventry, West Midlands, CV2 2DX, United Kingdom
University Hospitals Sussex NHS Trust
RECRUITING

Worthing, West Sussex, BN11 2DH, United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, Leicestershire, LE1 5WW, United Kingdom
University of Calgary
RECRUITING

Calgary, Alberta, T2N 1N4, Canada
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45221, United States
University of Kansas Medical Center Research Institute, Inc.
RECRUITING

Kansas City, Kansas, 66160, United States
University of Maryland Baltimore
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh Medical Center (UPMC) Presbyterian Heart and Vascular Institute
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Universitätsklinikum Hamburg-Eppendorf (UKE)
RECRUITING

Hamburg, 20246, Germany
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitätsklinikum Schleswig - Holstein
RECRUITING

Lübeck, Schleswig-Holstein, 23538, Germany
Universitätsmedizin Rostock
RECRUITING

Rostock, Mecklenburg-Vorpommern, D-18057, Germany
Universitätsspital Basel
RECRUITING

Basel, Canton of Basel-City, 4031, Switzerland
Vancouver Coastal Health Authority
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Waterloo Wellington Cardiovascular Research Institute (WWCRI)
RECRUITING

Kitchener, Ontario, N2M 5N6, Canada
Westpfalz-Klinikum GmbH
RECRUITING

Kaiserslautern, Rhineland-Palatinate, 67665, Germany

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