STROKE, ISCHEMIC

This study tests whether dulaglutide, a diabetes drug, can improve blood flow in the brain for people with severely narrowed arteries that raise stroke risk. About 130 adults who recently had a mini-stroke or mild stroke will receive either standard care or standard care plus wee…

This study tests whether repeatedly inflating a blood pressure cuff on the arm (remote ischemic preconditioning) can help grow new blood vessels around blocked arteries in the brain. About 300 stroke survivors with narrowed or blocked neck arteries will receive either the cuff tr…

This study is testing whether two drugs, colchicine (an anti-inflammatory) and ticagrelor (a blood thinner), can reduce the risk of another stroke, heart attack, or related death in people who have already had an ischemic stroke. About 2,800 high-risk participants will take these…

This study tests whether a newer clot-busting drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will be …

This study tests whether a catheter-based procedure to close a small pouch in the heart (the left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4,000 participants with a high risk of stroke wil…

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by advanced imaging, helps people recover better than standard medical care alone. It includes 568 adults who had a stroke within the last 24 hours. The goal is to see if this appr…

This study tests whether the drug tenecteplase can help people who have had a stroke caused by a blockage in a medium-sized brain artery. Participants must be treated within 4.5 to 24 hours of symptoms starting. The goal is to see if the drug improves recovery and reduces disabil…

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is better than waiting 4 to 15 days. About 456 adults with a blocked neck artery and recent symptoms will be randomly assigned to one of two timing groups. The goal is to s…

This study tests whether giving a drug called tirofiban before a standard clot-removal procedure can help people recover better after a severe stroke caused by a blocked large artery. About 870 adults with anterior circulation strokes will receive either tirofiban or a placebo be…

This study looks at whether a procedure called endovascular therapy (EVT) can help people who had a mild stroke but then got worse because of a large blood vessel blockage. It involves 272 adults whose symptoms worsened within 7 days and who are treated more than 24 hours after t…

This study tests whether performing skull surgery early, before dangerous brain swelling occurs, can improve outcomes for people who have had a severe stroke. About 380 adults aged 18-75 with large strokes and high risk of brain swelling will be randomly assigned to either early …

This study looks at whether high-intensity interval training (HIIT) or moderate continuous exercise is better at rebuilding muscle and improving function in people who have had a stroke and suffer from muscle loss (sarcopenia). About 32 adults who had a stroke 1-6 months ago will…

This study looks at whether a procedure called endovascular thrombectomy (EVT) helps people who already have a moderate-to-severe disability and then have a major stroke. About 1,060 adults will be randomly assigned to get EVT or standard medical care. The goal is to see if EVT i…

This study looks at whether high-dose statins can reduce or stabilize fatty plaques in brain arteries that cause strokes. About 100 recent stroke patients will get intensive statin therapy and have their plaques checked with a special MRI. The goal is to see if the plaques shrink…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It includes 95 adults whose arm function stopped improving after 1-5 years of rehab. The goal is to see if the surgery can improve arm movement and control.

This study checks if a smartwatch can spot an irregular heartbeat (atrial fibrillation) in 500 older adults who had a stroke with an unknown cause. Participants wear a study smartwatch and a standard heart monitor for 30 days. Researchers compare the smartwatch data to the standa…

This study tests a new device (NobleStitch EL) that uses stitches to close a small hole in the heart, compared to an approved device (Amplatzer) that uses a plug. The goal is to see which works better to prevent another stroke in 640 adults aged 18-60 who had a stroke from an unk…

This study looks at whether Vojta therapy, a type of physical therapy that uses gentle pressure on specific body areas to trigger natural movement patterns, can help people who had a stroke improve their posture and trunk control. Researchers will compare standard physical therap…

This study tests whether mild electrical stimulation to the front of the brain can reduce fatigue and improve language and attention in people who have had a stroke. About 60 adults who are at least 6 months post-stroke will receive either real or fake stimulation during speech t…

This study tests a home-based rehabilitation program called TASSRET for stroke survivors who have limited access to physical therapy. Fifty participants will use either a video or a manual guide to practice specific tasks aimed at improving arm and leg function, balance, and walk…

This study tests a brain implant called the CorTec Brain Interchange system in 4 people who had an ischemic stroke at least 6 months ago. The implant delivers electrical stimulation to encourage the brain to rewire itself and improve arm movement. Participants will undergo weekly…

This study tests whether a safe, non-invasive brain stimulation method called theta burst stimulation (TBS) can improve language recovery in people who have trouble speaking after a stroke. 45 adults with non-fluent aphasia will receive either real TBS (targeting the left or righ…

This study tests whether early brain-training feedback (EEG neurofeedback) can help people recover arm movement after a stroke. About 40 adults who had a stroke within the past 3 weeks will receive either real or fake (sham) neurofeedback along with standard rehabilitation. The g…

This study tests whether combining special prismatic glasses with mild brain stimulation (tDCS) can help people who have trouble paying attention to one side of space after a stroke. The researchers will compare this combo to glasses plus a fake stimulation in 30 adults who had a…

This study tests whether amantadine, a drug used for other conditions, can help people recover after a stroke. Sixty adults who had an ischemic or hemorrhagic stroke will receive either amantadine or a placebo for one month. Researchers will track side effects and measure recover…

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use brain scans to see if visual training can help the remaining healthy parts of the brain improve sight. The goal is to better understand vision recovery, not to test a new treatm…

This study is tracking 350 adults with severe stroke caused by a blocked large artery in the brain. Researchers want to see how well a procedure called endovascular thrombectomy (which removes the clot) works in real-world hospitals across Asia-Pacific, not just in controlled cli…

This study examines tiny RNA molecules in the blood of 300 adults who had a stroke and received a procedure to remove the clot. Researchers want to see if certain RNA patterns can help predict how well patients recover. The goal is to find new markers that could guide future stro…

This study is a large registry that will follow 4000 people with brain aneurysms or ischemic stroke who receive Medtronic devices. The goal is to see how well the devices work in everyday medical practice, measuring success rates and patient independence. Participants must be at …

This study looks at 1,000 people who had a minor stroke to see if early information can predict their quality of life more than 4 years later. Participants fill out questionnaires and may give a saliva sample or have an MRI. The goal is to build a model that helps doctors underst…

This study is testing whether brain scans and a technique called transcranial magnetic stimulation can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to …

This study is looking at 200 people with narrowed neck arteries who have had a mini-stroke or stroke in the past year. Researchers will use special PET/MR scans to measure blood flow and sugar use in the brain. The goal is to find better ways to diagnose and treat these patients,…

This study looks at how people with vision loss from a stroke steer and navigate in a virtual driving environment. Researchers will compare 40 participants with and without vision problems to understand how they adapt. The goal is to learn more about these behaviors, not to test …

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…

This study is testing a new MRI technique that measures blood flow pressure in narrowed brain arteries to see if it can better predict stroke risk. Researchers will follow 400 adults with intracranial atherosclerotic stenosis (ICAS) for one year. The goal is to improve how doctor…

This study looks at whether a simple CT scan can be used instead of more advanced scans to decide if stroke patients should have a procedure to remove a blood clot. About 1,846 adults who had a stroke within the last 24 hours will take part. The goal is to see if the simple scan …

This study checks if a tool called TriAGE+ can accurately predict stroke risk in people who come to the emergency room with dizziness. About 841 adults with dizziness will be enrolled. The goal is to see if the score helps doctors identify strokes that are often missed, especiall…

This study is following 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk. Researchers will collect medical records and survey data over time to identify what factors lead to brain diseases. The goal is to find ways to keep br…

This study aims to understand how a protein called BD-tau, which is released into the blood when the brain is injured, changes over time in people having a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults with acute ischemic stroke. The goal is …

This study tests a virtual program that combines cognitive strategy training with health coaching for people who have had a stroke and their family members. The goal is to see if the program can help lower the risk of another stroke and slow down cognitive decline. The study will…

This study is creating a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults—including stroke patients, their families, and healthy volunteers. Researchers will use these samples to study the genetics of stroke and related blood vessel diseases, hoping to f…