MRI brain scan could prevent unnecessary stroke surgeries
NCT ID NCT07556887
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which patients with a recent stroke or TIA should have surgery or stenting. About 613 participants will be randomly assigned to either the IMPROVE-based approach or usual care, and followed for several years to compare stroke rates and costs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- IMPROVE risk model (a decision tool using MRI scans to assess stroke risk)
- What this could lead to
- If it works, this could help doctors decide more accurately who needs surgery to prevent a stroke, reducing strokes and unnecessary procedures.
- What could go wrong
- This is a mid-stage trial with 613 participants, so results may not apply to everyone. The new method might not be as effective as the standard approach, and MRI scans can be costly or unavailable.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Albert Schweitzer Ziekenhuis
NOT_YET_RECRUITINGDordrecht, South Holland, 3300 AK, Netherlands
Contact Email: •••••@•••••
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Amsterdam UMC
NOT_YET_RECRUITINGAmsterdam, North Holland, 1105 AZ, Netherlands
Contact Email: •••••@•••••
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Erasmus MC
NOT_YET_RECRUITINGRotterdam, South Holland, 3000 CA, Netherlands
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Haaglanden MC
NOT_YET_RECRUITINGThe Hague, South Holland, 2501 CK, Netherlands
Contact Email: •••••@•••••
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Isala
NOT_YET_RECRUITINGZwolle, Overijssel, 8025 AB, Netherlands
Contact Email: •••••@•••••
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Maastricht University
RECRUITINGMaastricht, Limburg, 6229 ER, Netherlands
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud UMC
NOT_YET_RECRUITINGNijmegen, Gelderland, 6525 GA, Netherlands
Contact Email: •••••@•••••
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Rijnstate
NOT_YET_RECRUITINGArnhem, Gelderland, 6800 TA, Netherlands
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Utrecht UMC
NOT_YET_RECRUITINGUtrecht, Utrecht, 3584 CX, Netherlands
Contact Email: •••••@•••••
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Zuyderland
NOT_YET_RECRUITINGHeerlen, Limburg, 6419 PC, Netherlands
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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