Maastricht University Medical Center

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study tests a new, gentler steroid eye drop plan after corneal transplant surgery. The goal is to prevent rejection while reducing side effects like high eye pressure. About 342 adults getting a DMEK transplant will be followed for two years to see if a milder steroid works …

This study is for adults with solid tumors that have certain genetic features (HRD/FAD) or are growing despite immunotherapy. The experimental drug CP-506 is designed to activate only in low-oxygen areas of tumors, potentially killing cancer cells while sparing healthy tissue. Th…

This study is testing whether a blood test can find tumor DNA in people with cancer. If successful, it could lead to a less invasive way to diagnose cancer compared to current methods like tissue biopsies. The study will enroll 40 adults with newly diagnosed breast, colorectal, l…

This study is testing a new blood test (the HMEC test) to see if it can better identify which patients with thrombotic microangiopathy (TMA) have a specific immune system problem driving their disease. TMA is a severe condition that damages kidneys and the brain. The researchers …

This study compares two PET scan tracers—standard 18F-FDG and newer 68Ga-FAPI-46—in 20 women with ER-positive breast cancer. The goal is to see if the new tracer finds more cancer lesions, especially where the standard one may miss them. Better detection could lead to more accura…

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This study is testing whether eating a soft chew containing plant stanols every day can reduce asthma symptoms in people with allergic asthma. Plant stanols are known to lower cholesterol, but they may also shift the immune system away from the type of response that triggers asth…

This study tests a surgery called lymphaticovenous anastomosis (LVA) to see if it reduces chronic swelling (lymphedema) in cancer survivors. About 110 people with swelling in one arm or leg after cancer treatment will be randomly assigned to receive either LVA or a sham surgery. …

This study looks at whether adding febuxostat (a gout medicine) to the standard lung cancer drug osimertinib can increase the amount of osimertinib that reaches the brain. It involves 7 adults with a specific type of advanced lung cancer who are already taking osimertinib. Resear…

This study aims to understand why some people have unexplained bleeding that standard tests cannot diagnose. Researchers will study blood samples and ask participants about their symptoms and quality of life. The goal is to find the causes of this bleeding disorder and improve ca…

This study looks at how healthy young adults process protein from whole foods like beef patties. Twenty people aged 18-35 will eat different amounts of protein (1, 2, or 4 patties) in a random order. Researchers measure how much protein the body uses over 24 hours. The goal is to…

This study tests whether taking a ketogenic nutritional supplement every evening for 4 weeks can change how the body burns energy overnight and affect muscle health. Researchers will study 14 healthy but overweight adults aged 60-80 who are not very active. Participants will eith…

This study looks at how a week of either eating less or exercising daily affects prostate tumor growth and muscle health in 45 men with prostate cancer. Participants will be assigned to a reduced-calorie diet, daily exercise with mild diet changes, or their usual routine. After 7…

This study looks at whether taking short walking breaks during long periods of sitting can help thinking and blood sugar levels. Researchers will have 33 young, sedentary adults try four different break patterns over four separate lab visits. The goal is to see which break freque…

This study tests a precise method called doubly labeled water to measure how much energy critically ill patients use. By collecting urine samples, researchers hope to better tailor nutrition to each patient's needs. The goal is to improve recovery and reduce complications like in…

This study tests whether giving critically ill patients more protein in their tube feed (1.3 grams per kg of body weight per day, instead of the standard 0.8 grams) can help their muscles build protein and reduce wasting. Twenty-six adults on ventilators in the ICU will be random…

This study is building a biobank of genetic samples and medical information from 3600 patients visiting the Clinical Genetics department in Maastricht. Researchers will use the stored data to compare genes and discover unknown functions. The goal is to better understand how genet…

This study reviews medical records of 600 adults with liver cirrhosis to see how often they visit doctors, get scans, or undergo procedures. Researchers want to understand what factors, like mental health, affect healthcare use. The goal is to find ways to improve care for people…

This study looks at how a ketone supplement affects the way the body uses carbohydrates during exercise. Twenty trained cyclists will drink a sports beverage with or without ketones while riding for three hours. Researchers will measure how much carbohydrate the body burns to see…

This study is testing whether eating wild blueberry powder every day for 16 weeks can improve blood flow and insulin sensitivity in the brains of older adults. Researchers will use MRI scans to measure changes in 36 overweight volunteers aged 60-75. The goal is to understand how …