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Could a two-vein embolization trick turn inoperable liver tumors into operable ones?

NCT ID NCT07717437

Knowledge-focused Sponsor: Maastricht University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This international registry collects medical images and health data from people with liver cancer or liver metastases who received a procedure called combined portal and hepatic vein embolization (PVE/HVE). The procedure blocks two sets of veins in the liver to encourage the healthy part to grow larger, potentially making surgery possible for tumors that were previously too risky to remove. Researchers aim to identify which patients benefit most and how safe the technique is.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
combined portal and hepatic vein embolization (PVE/HVE)
What this could lead to
If the data show that PVE/HVE reliably makes more liver tumors removable, this technique could become a standard step before surgery for people with initially unresectable liver cancer.
What could go wrong
This is an observational registry, not a controlled trial, so it can only suggest associations, not prove the technique works. Results depend on the quality and completeness of data from many hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 350 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2021

Expected to finish

Nov 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with primarily unresectable / potentially resectable liver cancer or liver metastases, who are treated with combined embolization of both portal and hepatic veins (PVE/HVE) in order to increase future liver remnant before resection.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who have undergone PVE/HVE or technical variations on this procedure * 18 Years and older * Men and women

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma hepatocellular carcinoma hilar cholangiocarcinoma liver cancer Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver cancer Liver metastases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    31 sites in 13 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aintree University Hospital

    RECRUITING

    Liverpool, Merseyside, L9 7AL, United Kingdom

  • Amsterdam UMC

    RECRUITING

    Amsterdam, North Holland, 1105 AZ, Netherlands

  • Auckland City Hospital

    RECRUITING

    Grafton, Auckland, 1023, New Zealand

  • CHU de Liège

    RECRUITING

    Liège, Liège, 4000, Belgium

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

  • Erasmus Hospital

    RECRUITING

    Anderlecht, Brussels Capital, 1070, Belgium

  • Erasmus MC

    NOT_YET_RECRUITING

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Hospital Universitari Germans Trias i Pujol

    RECRUITING

    Badalona, Barcelona, 08916, Spain

  • Juravinski Hospital and Cancer Centre

    RECRUITING

    Hamilton, Ontario, L8V 5C2, Canada

  • Karolinska University Hospital

    RECRUITING

    Stockholm, Stockholm County, 17176, Sweden

  • Klinik Hirslanden

    RECRUITING

    Zurich, Canton of Zurich, 8032, Switzerland

  • Klinikum Saarbrücken

    RECRUITING

    Saarbrücken, Saarland, 66119, Germany

    Contact Email: •••••@•••••

  • Leids Universitair Medisch Centrum

    RECRUITING

    Leiden, South Holland, 2333, Netherlands

  • MUMC+

    RECRUITING

    Maastricht, Limburg, 6229HX, Netherlands

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • McGill University Health Centre

    RECRUITING

    Montreal, Quebec, H3G 1A4, Canada

  • MedUni Wien

    RECRUITING

    Vienna, State of Vienna, 1090, Austria

  • Monash Medical Centre

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Newcastle upon Tyne Hospitals

    RECRUITING

    Newcastle upon Tyne, North East England, NE7 7DN, United Kingdom

  • Oslo University Hospital

    RECRUITING

    Oslo, Oslo, 0424, Norway

  • Queen Elizabeth Hospital

    RECRUITING

    Birmingham, West Midlands, B15 2GW, United Kingdom

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Social Center South (Klinik Favoriten)

    RECRUITING

    Vienna, State of Vienna, 1100, Austria

  • The Ottawa Hospital

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • UZ Antwerpen

    RECRUITING

    Edegem, Antwerpen, 2650, Belgium

  • UZ Gent

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Universitair Medisch Centrum Groningen

    RECRUITING

    Groningen, Provincie Groningen, 9713 GZ, Netherlands

  • University Hospital Aachen (Uniklinik RWTH Aachen)

    RECRUITING

    Aachen, North Rhine-Westphalia, 52074, Germany

    Contact Email: •••••@•••••

  • University Hospital Linköping

    RECRUITING

    Linköping, Östergötland County, 581 85, Sweden

  • Universitätsklinikum Halle

    RECRUITING

    Halle, Saxony-Anhalt, 06120, Germany

  • Vall d'Hebron University Hospital

    RECRUITING

    Barcelona, Barcelona, 08035, Spain

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