Can immune cell infusions help fight solid tumors?
NCT ID NCT06524024
First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time
Summary
This trial tests a cell therapy called DC-CTL, made from a patient's own immune cells, combined with standard anti-tumor treatment. The goal is to see if this approach is safe and may help control solid tumors such as colorectal, esophageal, lung, liver, and breast cancer. About 20 adults with these cancers will receive multiple cycles of cell infusions. Researchers will track how long patients live without their disease worsening and overall survival.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Tumor polypeptide pool induced DC-CTL cell injection
- What this could lead to
- If it works, this could point toward a new way to boost the immune system's attack on solid tumors, potentially improving how long patients live without their cancer progressing.
- What could go wrong
- This is a small, early exploratory study with only 20 participants, so results may not apply broadly. The treatment involves multiple cell infusions and carries risks like immune reactions or side effects from the added conventional therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years old, gender is not limited; 2. Patients clinically diagnosed with solid tumors such as colorectal cancer, esophageal cancer, lung cancer, liver cancer, breast cancer, etc., who need routine anti-tumor therapy; 3. KPS score ≥80 (Appendix 1), expected survival ≥3 months; 4. If imaging is available, the target lesion can be measured by conventional CT or MRI≥10 mm, and the short diameter of lymph node ≥15mm; 5. Liver function: TBIL≤3ULN, AST, ALT ≤2.5ULN; Renal function: Cr≤1.25ULN; Blood routine: WBC ≥ 4.0×109/L, Hb ≥90 g/L, PLT ≥ 80×109/L; 6. Good cardiac function (LVEF≥ 50%); 7. The peripheral superficial veins of the study participants were smooth, which could meet the needs of intravenous infusion; 8. No history of other malignant tumors, except for cured carcinoma in situ and papillary thyroid carcinoma; 9. Study participants agree to use a reliable contraceptive method for contraception from the time of signing the informed consent to the entire clinical study; 10. Study participants agree to participate in the clinical study and sign the Informed Consent form. Exclusion Criteria: 1. Pregnant or lactating women (women of childbearing age need to do pregnancy tests); 2. Had a serious, uncontrolled infectious disease (bacterial, viral, or fungal infection) within 4 weeks prior to enrollment; 3. have chronic active hepatitis, AIDS or syphilis; 4. have a serious autoimmune disease or immunodeficiency disease (such as systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis); 5. Severe allergy; 6. serious mental disorders; 7. suffering from serious heart, liver, kidney dysfunction, serious uncontrollable diabetes and other diseases; 8. Patients who had systematically used large amounts of glucocorticoids in the 4 weeks prior to enrollment (except those who used inhaled hormones); 9. Those who have previously been treated with other gene products; 10. Other investigators consider it inappropriate to participate in the study, or other circumstances that affect the analysis of the results of this clinical study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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