LIVER METASTASES

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer or colorectal cancer that has spread to the liver from returning after surgery. About 60 adults with these cancers will receive t…

This study tests a new way to give radiation for liver cancer that uses real-time MRI to guide the beam and adjust the plan during a single treatment session. It aims to improve survival and reduce side effects compared to standard radiation. The trial is for adults with certain …

This study tests whether a single, high-dose session of MRI-guided radiation can stop liver tumors from growing in people with colorectal cancer that has spread. About 32 adults with up to 3 small liver lesions will receive the treatment. Researchers will monitor tumor control, s…

This study tests whether adding the drug bevacizumab to standard chemo-immunotherapy can help people with advanced small cell lung cancer that has spread to the liver. About 39 participants will receive the combination for four cycles, then continue on two maintenance drugs for u…

This study tests different combinations of immunotherapy drugs (with or without radiation) in people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these combinations change the immune environment in the liver tumors a…

This study tests whether a blood test that looks for cancer DNA (ctDNA) after liver surgery can help doctors decide who needs more chemotherapy. About 120 adults with colorectal cancer that spread to the liver will have their ctDNA levels checked after surgery. Those with detecta…

This study tests whether a single, extremely high dose of radiation delivered by a special MRI-guided machine (MR-Linac) can better control liver tumors that have spread from other cancers compared to the usual high dose. About 114 adults with up to three liver metastases from sp…

This study tests a new way to treat liver metastases by combining a drug called bevacizumab with a procedure called TACE, which delivers chemotherapy directly to the liver. The goal is to see if this combination helps patients live longer and shrinks tumors better than TACE alone…

This study tests whether adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. R…

This study tests whether adding low-dose radiation to the liver can help immunotherapy work better for people with melanoma or non-small cell lung cancer that has spread to the liver. About 21 participants will receive standard immunotherapy plus low-dose liver radiation. The goa…

This study tests whether adding two drugs (serplulimab and bevacizumab) to standard chemotherapy can improve outcomes for people with colorectal cancer that has spread to the liver and can be surgically removed. About 156 adults with a specific genetic type (RAS/BRAF wild-type, p…

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This study tests whether combining a liver-directed chemotherapy (HEPZATO KIT) with two immunotherapy drugs (nivolumab and relatlimab, together called Opdualag) is safe and effective for people with metastatic melanoma that has spread to the liver. About 15 participants who have …

This study involves 200 people with liver metastases who will have a tumor ablation procedure. After ablation, doctors will take a needle biopsy to check if any cancer cells remain alive. The goal is to see if this approach can guide next treatment steps, though biopsies carry so…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests a new approach using MRI-guided radiation to treat liver tumors that have spread from other cancers. The goal is to find the highest safe dose that can be given without causing severe side effects. About 32 adults with liver metastases will receive this treatment…

This study is collecting data from 1500 people with liver tumors who are getting a treatment called thermal ablation, which uses heat to destroy cancer. Researchers will use artificial intelligence to analyze this data to find the best ways to plan and evaluate the treatment. The…

This study looks at whether adding an MRI scan to the usual CT scan helps doctors choose the right treatment for people with pancreatic cancer. About 200 patients whose CT scans show no spread to the liver will be randomly assigned to get an MRI or not. The goal is to see if the …