LIVER METASTASES

This study tests whether combining a precise form of radiation (SBRT) with an immunotherapy drug (PD-1 monoclonal antibody) can help people whose colorectal cancer has spread to the liver and cannot be removed surgically. The trial enrolls adults aged 18 to 75 with a specific typ…

This study tests whether combining a liver-directed chemotherapy (HEPZATO KIT) with an immunotherapy drug (Opdualag) is safe and effective for people with metastatic melanoma that has spread to the liver. About 15 participants who have not received prior systemic treatment will r…

This study is testing a new type of radiation therapy called DaRT for people with liver tumors that have spread from colorectal cancer. The treatment involves placing tiny radioactive seeds directly into the tumors during surgery. The goal is to see if this approach is safe and f…

This early-phase trial is testing whether MRI-guided radiation therapy (SBRT) can be given at higher doses safely to people with cancer that has spread to the liver. Up to 32 participants will receive 5 radiation sessions over 1.5 to 2 weeks. The main goal is to find the highest …

This study tests a precise type of radiation called proton beam therapy for people with liver tumors that have spread from other cancers and cannot be removed by surgery. The treatment delivers high-dose radiation in three sessions over two weeks. The goal is to see if it is safe…

This study tests different combinations of immunotherapy drugs (with or without radiation) in 24 people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these treatments change the immune environment inside the liver tum…

This study tests whether adding two drugs (serplulimab and bevacizumab) to standard chemotherapy improves outcomes for people with colorectal cancer that has spread to the liver and can be surgically removed. The trial involves 156 adults aged 18-75 with specific genetic types (R…

This study tests whether adding a non-invasive sound wave treatment (histotripsy) to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. The go…

This study tests whether a single, extremely high dose of radiation, guided by advanced MRI technology, can control liver tumors that have spread from other cancers better than the usual high dose. About 114 adults with up to 3 liver metastases will be randomly assigned to receiv…

This study tests whether adding low-dose radiation to the liver before standard immunotherapy can help people with melanoma or non-small cell lung cancer that has spread to the liver. About 21 participants will receive radiation before their first three immunotherapy cycles. The …

This study tests whether a single, high-dose session of MRI-guided radiation can control colorectal cancer that has spread to the liver. Researchers will treat up to 32 adults with up to 3 small liver tumors. They will track tumor growth, side effects, and look for MRI features t…

This study is testing a new way to deliver radiation therapy for liver cancer. Instead of multiple sessions over weeks, patients receive a single, high-dose treatment guided by real-time MRI scans. The approach aims to be more precise and convenient. The trial will enroll 62 adul…

This study tests whether a blood test that detects tiny bits of tumor DNA (ctDNA) after liver surgery can help doctors decide who needs more chemotherapy. About 120 adults with colorectal cancer that spread to the liver will have their ctDNA levels checked after surgery. Those wi…

This early-phase trial is testing a new approach for people with liver metastases (cancer that has spread to the liver from elsewhere). Doctors are using a procedure called TACE to deliver the drug bevacizumab directly into the liver's blood vessels, aiming to concentrate the tre…

This study tests whether adding the drug bevacizumab to standard chemo-immunotherapy can help people with extensive-stage small cell lung cancer that has spread to the liver. About 39 participants will receive the combination for up to a year. The goal is to see if it delays canc…

This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung…

This phase 2 trial tests a personalized dendritic cell vaccine combined with the immunotherapy drug nivolumab in 60 people who had surgery for liver cancer or colorectal cancer that spread to the liver. The vaccine is made from each patient's unique tumor mutations and aims to tr…

This study is testing whether adding an MRI scan to the usual CT scan helps doctors make better decisions about surgery for pancreatic cancer. About 200 patients who are initially thought to be candidates for surgery will be randomly assigned to get either a standard CT alone or …

This study is testing whether a blood test that looks for cancer DNA (called ctDNA) can find leftover cancer cells after surgery in people with colorectal cancer that has spread to the liver. The goal is to see which test works best at predicting if the cancer will come back. Thi…

This study looks at genetic changes in patients with colorectal cancer that has spread only to the liver and cannot be removed by surgery. Researchers will perform liver transplants and then analyze tumor genetics and blood samples to better understand why the cancer spreads and …

This study is creating a large database of 2000 people whose cancer has spread to the liver. Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and improve future care. No new treatments are being tested; the goal is…

This study is testing whether taking a needle biopsy right after a tumor ablation procedure for liver metastases can detect cancer cells that survived the treatment. The results could help doctors decide if more treatment is needed right away. The study also looks at imaging and …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study will collect data from 1,500 people with liver tumors who are getting a procedure called thermal ablation, which uses heat to destroy tumors. Researchers will use artificial intelligence to analyze the data and find better ways to select patients, plan treatments, and …