Custom-Made vaccine takes on liver cancer after surgery

NCT ID NCT04912765

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This phase 2 trial tests a personalized dendritic cell vaccine combined with the immunotherapy drug nivolumab in 60 people who had surgery for liver cancer or colorectal cancer that spread to the liver. The vaccine is made from each patient's unique tumor mutations and aims to train the immune system to recognize and destroy any remaining cancer cells. The goal is to see if this combination can improve relapse-free survival and trigger a strong immune response.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
personalized dendritic cell vaccine and nivolumab (Opdivo)
What this could lead to
If successful, this combination could help prevent liver cancer or colorectal liver metastases from coming back after surgery.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply to everyone. The vaccine is personalized, making it complex and costly to produce.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Cancer Center Singapore

    RECRUITING

    Singapore, 169690, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.