National Cancer Centre, Singapore

This study tests a three-drug chemotherapy regimen given at lower, continuous doses for people with metastatic pancreatic cancer. The drugs—capecitabine, oxaliplatin, and irinotecan—are dosed based on a patient's genetic profile to reduce side effects. The goal is to see if this …

This phase 2 trial is testing whether a year-long combination of tislelizumab (an immunotherapy) and low-dose capecitabine (a chemotherapy pill) can prevent cancer relapse in 53 patients with high-risk nasopharyngeal carcinoma. Participants have already received standard chemothe…

This phase II study is testing a combination of three drugs—lenvatinib, pembrolizumab, and letrozole—in people with advanced hormone receptor-positive, HER2-negative breast cancer that has stopped responding to standard hormone therapy. The goal is to see if this combination can …

This study tests histotripsy, a non-invasive treatment that uses focused ultrasound to destroy liver tumors without needles or surgery. It involves 40 adults with liver cancer who cannot have surgery or other standard treatments. The goal is to see if it is safe and effective at …

This phase 2 trial is testing whether adding two drugs (atezolizumab and bevacizumab) after a targeted radiation treatment (SIRT-Y90) can help shrink tumors in people with advanced liver cancer that hasn't spread. About 100 participants will be randomly assigned to receive either…

This phase 2 trial tests a personalized dendritic cell vaccine combined with the immunotherapy drug nivolumab in 60 people who had surgery for liver cancer or colorectal cancer that spread to the liver. The vaccine is made from each patient's unique tumor mutations and aims to tr…

This phase 2 trial tests whether combining pembrolizumab (an immunotherapy) with olaparib (a targeted drug) can shrink tumors in people with peripheral T-cell lymphoma that has come back or not responded to treatment. About 24 adults in Singapore will receive the drugs intravenou…

This study tests whether a 24-week exercise program combining brisk walking and strength training can improve survival in women with early-stage breast cancer. Over 2,000 participants will be enrolled within 8 weeks of finishing surgery or chemotherapy. The program starts with in…

This study is testing whether combining low-dose CT scans with blood-based biomarker tests can improve lung cancer screening in high-risk people. It will enroll 1,000 participants in Singapore, including both smokers and non-smokers. The goal is to see if this approach is practic…

This pilot study in Singapore tests whether exercise therapy and cognitive behavioral therapy (CBT) can reduce fatigue and improve treatment adherence in female breast cancer patients. 100 women who have completed surgery and chemotherapy will be enrolled. The study focuses on wh…

This study tests whether inhaling scents from Asian plants can reduce distress and anxiety in breast cancer patients about to start radiotherapy. 300 adults with breast cancer will use aromatherapy and have their stress levels, anxiety, and stress hormones measured. The goal is t…

This study tests a program called ENABLE-SG, which provides phone-based coaching sessions to people recently diagnosed with advanced cancer and their caregivers. The goal is to help them manage stress, symptoms, and planning early on, rather than waiting for a crisis. Researchers…

This pilot study tests a smartphone app called iCareBreast+ designed to help women with breast cancer manage the challenges of chemotherapy. The app provides self-care tools and information to boost confidence and reduce anxiety. The study will enroll 40 women and assess whether …

This study investigates why some liver cancers respond to immunotherapy (atezolizumab plus bevacizumab) after surgery while others do not. Researchers will collect detailed molecular data from tumors and blood samples of 30 patients to find biomarkers that predict response, resis…

This study analyzes the DNA of solid tumors from 5,500 cancer patients to find genetic changes that could be targeted by specific treatments. The goal is to use this molecular profile to match patients with appropriate clinical trials. Participants must have a confirmed solid tum…

This study is for people with advanced solid tumors who have run out of standard treatment options. Researchers will track how well off-label or non-standard therapies work when chosen based on the tumor's genetic profile. The goal is to create a standard way to measure responses…

This study compares genetic counselling done by video (telegenetics) with traditional in-person sessions for people at risk of hereditary breast, ovarian, or colorectal cancer. Researchers will measure how well patients understand their options, their emotional responses, and the…