National Cancer Centre, Singapore

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer or colorectal cancer that has spread to the liver from returning after surgery. About 60 adults with these cancers will receive t…

This study tests whether combining two drugs, pembrolizumab and olaparib, can shrink tumors or slow the growth of peripheral T-cell lymphoma (PTCL) that has returned or not responded to prior therapy. About 24 adults will receive the drugs in 3-week cycles for up to 2 years. The …

This study tests a year-long maintenance treatment with two drugs (tislelizumab and low-dose capecitabine) in 53 adults with high-risk nasopharyngeal cancer who still have detectable virus levels after initial chemotherapy. The goal is to see if this combination can improve the c…

This study tests a new way to destroy liver tumors using sound waves (histotripsy) without needles or surgery. It includes 40 adults with liver cancer who cannot have standard treatments. The goal is to see if it is safe and works well for Asian patients, who have high rates of l…

This study tests a combination of three drugs—lenvatinib, pembrolizumab, and letrozole—in people with advanced hormone receptor-positive, HER2-negative breast cancer that has stopped responding to standard hormone therapy. The goal is to see if this mix can shrink tumors or slow …

This study tests whether a 24-week exercise program (aerobic and strength training, 3 times a week) can help prevent breast cancer from returning in people with early-stage breast cancer. About 2,156 participants who have completed surgery and any chemotherapy or radiation will t…

This study tests whether a two-step treatment—internal radiation therapy followed by an immunotherapy drug combination—can shrink tumors better than radiation alone in people with advanced liver cancer that hasn't spread outside the liver. About 100 participants will be randomly …

This study tests a proactive telehealth coaching program called ENABLE-SG for people recently diagnosed with advanced cancer and their caregivers. The program provides early support to help them cope better and avoid medical crises. Researchers will measure whether it improves qu…

This study is testing a smartphone app called iCareBreast+ designed to help women with breast cancer manage their care during chemotherapy. The app provides information and support to improve self-confidence and knowledge about treatment. About 40 women will use the app, and rese…

This study looks at whether exercise therapy and cognitive behavioral therapy (a type of talk therapy) can help reduce fatigue in women with breast cancer. About 100 female patients in Singapore will take part. The goal is to see if these treatments are acceptable, culturally sen…

This study looks at the genetic makeup of solid tumors in 5,500 cancer patients to help doctors choose the most suitable treatments and clinical trials. Participants provide a tumor sample for molecular profiling. The goal is to learn how genetic changes relate to treatment outco…

This study compares genetic counseling done by video (telegenetics) with in-person visits for people at risk of hereditary breast, ovarian, or colorectal cancer. Researchers will measure how well each method helps patients make informed choices and feel empowered, as well as the …

This study is testing whether low-dose CT scans and blood tests can help find lung cancer early in people at risk, including smokers and non-smokers. About 1,000 adults aged 50-80 in Singapore will take part. The goal is to see if this screening approach is practical and accurate…

This study looks at 50 adults with advanced solid tumors that no longer respond to standard treatments. Researchers will use genetic tests to match patients with experimental or off-label therapies, then track how well the tumors shrink and how patients feel. The goal is to creat…