HEPATOCELLULAR CANCER

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer or colorectal cancer that has spread to the liver from returning after surgery. About 60 adults with these cancers will receive t…

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This early-phase study tests an experimental drug called ABBV-324 in about 232 adults with liver cancer (hepatocellular carcinoma) or a type of lung cancer (squamous non-small cell lung cancer). The main goals are to check safety, side effects, and whether the drug shrinks tumors…

This early-phase study tests a new treatment where a patient's own immune cells are modified in a lab to better recognize and attack cancer cells that carry a specific marker called GPC3. The treatment is given after a short course of chemotherapy. The main goal is to see if this…

This study tests whether giving a combination of radiation beads (SIRT) and two immunotherapy drugs (tremelimumab and durvalumab) before surgery is safe and effective for people with liver cancer that can be removed. About 20 participants will receive the treatment and then have …

This study tests a new medicine called PF-08634404, given alone or with another drug (ipilimumab), for adults with advanced liver cancer that cannot be removed by surgery. The goal is to check safety and see if the treatment shrinks tumors. About 138 participants will receive the…

This study collects samples from 320 people, including those with solid cancers and those undergoing lung cancer screening, to detect tumor cells and DNA in blood, urine, and bone marrow. The goal is to learn more about how cancer spreads and to improve early detection and person…