New hope for liver cancer: pfizer tests experimental drug

NCT ID NCT07227012

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 6 times

Summary

This study tests a new drug called PF-08634404, given alone or with another drug (ipilimumab), in adults with advanced liver cancer that cannot be surgically removed. The goal is to check safety, side effects, and whether the drug shrinks tumors. About 138 participants will receive the treatment through IV infusions at clinical trial sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-08634404 (a biologic drug) and ipilimumab (also known as Yervoy)
What this could lead to: If successful, this could lead to a new treatment option for people with advanced liver cancer that cannot be removed by surgery.
What could go wrong: This is an early-phase trial (Phase 1b/2) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects are possible, and the combination with ipilimumab may increase risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver and intrahepatic bile duct neoplasm Liver Neoplasms pediatric hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED HEPATOCELLULAR CARCINOMA CARCINOMA, HEPATOCELLULAR HEPATOCELLULAR CANCER HEPATOCELLULAR CARCINOMA LIVER NEOPLASMS METASTATIC HEPATOCELLULAR CARCINOMA UNRESECTABLE HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Allina Health Cancer Institute - Abbott Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Allina Health Cancer Institute - Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Allina Health Cancer Institute - United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Duke Cancer Center
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Duke Cancer Center - Investigational Chemotherapy Service
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Duke Cancer Center Cary
NOT_YET_RECRUITING

Cary, North Carolina, 27518, United States
Duke Cancer Center Raleigh
NOT_YET_RECRUITING

Raleigh, North Carolina, 27609, United States
Duke University - Main Hospital and Clinics
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Keck Hospital of USC
RECRUITING

Los Angeles, California, 90033, United States
Keck Medical Center of USC Pasadena
RECRUITING

Pasadena, California, 91105, United States
Kindai University Hospital- Osaka Medical Campus
RECRUITING

Sakai, Osaka, 590-0197, Japan
Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States
Memorial Hospital
RECRUITING

Shiloh, Illinois, 62269, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Moffitt Cancer Center - International Plaza
RECRUITING

Tampa, Florida, 33607, United States
Moffitt Cancer Center - McKinley Campus
RECRUITING

Tampa, Florida, 33612, United States
Moffitt Cancer Center at SouthShore
RECRUITING

Ruskin, Florida, 33570, United States
Moffitt Cancer Center at Speros
RECRUITING

Land O' Lakes, Florida, 34638, United States
Moffitt Cancer Center at Wesley Chapel
RECRUITING

Wesley Chapel, Florida, 33544, United States
Moffitt McKinley Hospital
RECRUITING

Tampa, Florida, 33612, United States
National Cancer Center Hospital East
RECRUITING

Kashiwa, Chiba, 277-8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Kyushu Cancer Center
RECRUITING

Fukuoka, 811-1395, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Pan American Center for Oncology Trials, LLC
RECRUITING

San Juan, 00909, Puerto Rico
Pan American Center for Oncology Trials, LLC - Dorado Office
RECRUITING

Dorado, United States of America, 00646, Puerto Rico
Pan American Center for Oncology Trials, LLC - Mayaguez Office
RECRUITING

Mayagüez, United States of America, 00680, Puerto Rico
Pan American Center for Oncology Trials, LLC - Ponce Office
RECRUITING

Ponce, United States of America, 00730, Puerto Rico
Renown Health Medical Oncology
RECRUITING

Reno, Nevada, 89502, United States
Renown Office of Clinical Research
RECRUITING

Reno, Nevada, 89502, United States
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Saint Luke's Cancer Institute
NOT_YET_RECRUITING

Kansas City, Missouri, 64111, United States
Saint Luke's Hospital of Kansas City
NOT_YET_RECRUITING

Kansas City, Missouri, 64111, United States
Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63108, United States
Siteman Cancer Center - North County
RECRUITING

Florissant, Missouri, 63031, United States
Siteman Cancer Center - Shiloh
RECRUITING

Shiloh, Illinois, 62269, United States
Siteman Cancer Center - South County
RECRUITING

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St. Peters
RECRUITING

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County
RECRUITING

Creve Coeur, Missouri, 63141, United States
Taichung Veterans General Hospital
RECRUITING

Taichung, 407, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
USC/Norris Comprehensive Cancer Center / Investigational Drug Services
RECRUITING

Los Angeles, California, 90033, United States
University of Washington Medical Center- Montlake
RECRUITING

Seattle, Washington, 98195, United States
Virginia Mason Medical Center
NOT_YET_RECRUITING

Seattle, Washington, 98101, United States
Washington University School of Medicine - Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States

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