METASTATIC HEPATOCELLULAR CARCINOMA

This early-stage study is testing a new drug called ALN-BCAT, both by itself and combined with an existing immunotherapy (pembrolizumab), for people with advanced liver cancer that has spread. The main goals are to find safe doses and see how well the body handles the treatment. …

This early-phase study is testing the safety of a new personalized treatment for advanced cancers, primarily liver cancer. Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and infuse them back. The main goal is to see if this approach is sa…

This study is testing whether combining two drugs, sapanisertib and cabozantinib, works better than cabozantinib alone for people with advanced liver cancer that has a specific genetic mutation called β-catenin. The main goals are to find the safest dose of the combination and to…

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study is for people with advanced gastrointestinal cancers that have spread and have stopped responding to immunotherapy. Researchers want to see if giving a short, targeted course of radiation to one tumor can 'wake up' the body's immune system to attack all the cancer, inc…

This study is testing whether adding celecoxib, a common anti-inflammatory pain medication, can help two immunotherapy drugs work better against advanced liver cancer that has spread. The goal is to see if this combination can better control the cancer's growth and spread. Resear…

This study is testing a new method for giving the cancer drug atezolizumab. Researchers want to see if they can use lower doses, given less often, by carefully monitoring drug levels in a patient's blood. The goal is to see if this personalized approach can still control the canc…

This is the first study in people testing an experimental pill called TYRA-430. It aims to find a safe dose and see if it can help control advanced liver cancer and other solid tumors that have specific genetic changes in the FGF/FGFR pathway. The study will enroll about 100 adul…

This is a first-in-human study to test the safety and initial effectiveness of a new drug called BGB-B2033. It will be given alone or in combination with other cancer drugs to people with specific advanced or metastatic solid tumors, including certain liver, lung, stomach, and ge…

This study is testing a new drug called PF-08634404 to see if it is safe and effective for treating advanced liver cancer that cannot be removed by surgery. It will be given alone or combined with another drug (ipilimumab) to 138 adults who have not had other whole-body treatment…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This study is for people with advanced liver cancer that cannot be removed by surgery and has continued to grow despite their first treatment. Researchers want to see if continuing one of the original drugs (atezolizumab) alongside a new type of drug (cabozantinib or lenvatinib) …