Morning vs. afternoon: can timing boost cancer immunotherapy?

NCT ID NCT07405086

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at whether getting standard immunotherapy in the morning (before 11 am) or afternoon (after 12 pm) changes how well it fights advanced or metastatic solid tumors. Researchers think the body's internal clock (circadian rhythm) might affect immune activity. About 160 adults with several cancer types will be randomly assigned to morning or afternoon treatment, and the team will track how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
immune checkpoint inhibitor
What this could lead to
If timing matters, this could help doctors schedule immunotherapy to improve its effectiveness against several types of advanced cancer.
What could go wrong
This is an early-phase study on timing, not a new drug. The effect may be small or absent, and results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • OHSU Knight Cancer Institute

    RECRUITING

    Portland, Oregon, 97239, United States

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