Ohsu Knight Cancer Institute

This study is testing whether removing a smaller border of healthy skin around an early-stage melanoma is as effective at preventing the cancer's return as the current standard of removing a wider border. It will enroll 1,000 adults with early-stage melanoma to see if the narrowe…

This early-stage trial is testing the safety and initial effectiveness of a new three-drug combination for people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The treatment combines two antibody drugs (tafasitamab and obinutuzu…

This study is testing whether combining three different cancer drugs is safe and effective for treating advanced solid tumors that have spread or returned after standard treatments. The three drugs work in different ways: one helps the immune system attack cancer, one blocks tumo…

This study is testing a new three-drug combination (glofitamab, ibrutinib, and obinutuzumab) for people with untreated mantle cell lymphoma (MCL), a type of blood cancer. It is for patients aged 65 and older, or younger adults with high-risk features. The main goals are to see if…

This trial is testing a refined bone marrow transplant method for people with cancers or other disorders who need a transplant but lack a perfectly matched donor. Doctors use a special machine to select only the most helpful stem cells from a partially matched donor's blood. The …

This early-stage study is testing the safety and best dose of a new combination of oral pills (venetoclax and dasatinib) for adults with a specific, aggressive type of blood cancer called Philadelphia chromosome positive acute lymphoblastic leukemia (ALL) or mixed phenotype acute…

This study tests whether injecting three medications directly into the spinal fluid can prevent severe brain-related side effects in patients receiving CAR-T cell therapy for blood cancers. CAR-T therapy can cause dangerous neurological complications in 20-70% of patients, rangin…

This early-stage study is testing if adding a new oral drug called pemigatinib after standard chemotherapy is safe and helpful for adults newly diagnosed with a higher-risk form of acute myeloid leukemia (AML). The goal is to see if blocking a specific growth signal in cancer cel…

This study is testing whether adding a targeted drug called venetoclax to a standard chemotherapy regimen works better than the current standard treatment for newly diagnosed acute myeloid leukemia (AML). It will involve about 102 adults and aims to see if the new combination lea…

This study is testing a new way to analyze MRI scans, called activity MRI (aMRI), to see if it can provide the same information about brain tumor activity as a standard PET scan. Researchers will compare the two scans in 20 adults with glioma to see if the new MRI method is a val…

This study is testing if using two different contrast agents (gadolinium and ferumoxytol) during a single MRI scan can improve the detection and diagnosis of brain abnormalities, including tumors and metastases. It will involve 150 participants who have neurological symptoms or k…

This study is testing if a heart medication called amiodarone can prevent a common and serious irregular heartbeat (atrial fibrillation) after a specific type of esophageal cancer surgery. About 90 patients will be randomly assigned to receive either the real medication or a plac…

This study is testing whether creative arts activities like drawing, painting, and making sculptures can help improve symptoms and quality of life for children with cancer. Researchers will compare children doing art activities with children watching videos to see which approach …

This study is testing whether olanzapine, a medication that affects brain chemicals, can help cancer patients who are losing too much weight and have poor appetite. The trial will involve 66 adults with advanced cancers of the stomach, liver, pancreas, colon, or lung who have los…

This study is testing whether a large-scale educational campaign across Oregon helps people learn the early signs of melanoma, a serious skin cancer. The program provides information to the public, high school students, and healthcare providers. Researchers will compare melanoma …

This study aims to understand how hormone therapy changes what doctors see on a special prostate cancer scan (PSMA PET). Researchers will track 80 men with prostate cancer, taking scans before treatment and again 8 and 28 days after starting hormone therapy. The goal is to learn …

This early study aims to understand how six different investigational drugs affect the biology of pancreatic cancer tumors. It will enroll about 90 adults with various stages of pancreatic cancer. Participants take one of the drugs for about 10 days before a scheduled biopsy or s…

This study aims to understand if men and women experience the side effects of cancer immunotherapy differently. It will also compare how patients report their symptoms versus how their doctors assess them. Researchers will observe 100 adults with various cancers who are starting …

This early research study aims to understand how an experimental drug called OMO-103 affects pancreatic cancer cells in patients. Twelve adults with advanced pancreatic cancer will receive two infusions of the drug and undergo tumor biopsies to see if it changes the tumor's biolo…

This study is testing whether a simple blood test can help doctors decide if rectal cancer patients need major surgery after initial treatment. Researchers will track cancer DNA in the blood of 50 patients with stage 2-3 rectal cancer before, during, and after standard treatment.…

This study is testing a new approach to finding people at high risk for inherited cancers. Researchers are offering free genetic testing to the general public to see if this broad screening catches more at-risk people than the current method, which only tests those with a known f…

This study aims to understand how taking a daily fiber supplement changes the community of bacteria and other microorganisms (the microbiome) in the colon. Researchers will enroll 120 adults with benign colon or anal conditions. Participants will take a fiber supplement daily for…

This study aims to understand if CAR-T therapy, a powerful cancer treatment, reduces the body's long-term protection from common vaccines like measles, mumps, and tetanus. Researchers will observe 45 adults with blood cancers, measuring their antibody levels before and after CAR-…