Ohsu Knight Cancer Institute

This early-stage study is testing a new combination of two drugs, calaspargase pegol and cobimetinib, for people with advanced pancreatic cancer that has spread. The main goal is to find the safest and most effective dose. Researchers hope the two drugs will work together to cut …

This early-stage study aims to find the safest dose of the chemotherapy drug TAS-102 when given alongside radiation therapy to patients with stage II or III rectal cancer. The goal is to shrink the tumor before the patient undergoes standard surgery and follow-up chemotherapy. Re…

This study is testing whether making it easier for doctors to electronically refer patients to state Quitline services helps more people get support to stop using tobacco. It involves over 9,000 patients across 20 community health centers in Oregon. Researchers are comparing two …

This early-stage study is testing whether two drugs—entrectinib and ASTX727—can be safely combined to treat acute myeloid leukemia (AML) that has returned or resisted treatment and has a specific genetic change (TP53 mutation). The trial involves about 13 adults and aims to find …

This study is testing a combination of three drugs (apalutamide, abiraterone acetate, and prednisone) for men with advanced prostate cancer that has spread and is still sensitive to hormone-blocking therapy. The goal is to see if this combination, given after standard chemotherap…

This study is testing a flexible approach to chemotherapy before surgery for pancreatic cancer. If the first chemotherapy regimen isn't working well or causes too many side effects, doctors can switch patients to a different combination. The goal is to better control the cancer a…

This study aimed to see if adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could better eliminate cancer in men with high-risk prostate cancer that hasn't spread. The main goal was to check if a follow-up biopsy showed no cancer after treatme…

This early-stage study is testing the safety and best dose of a chemotherapy drug called eribulin when given with radiation therapy before surgery. It involves 15 patients with a rare abdominal cancer called retroperitoneal liposarcoma. The goal is to see if this combined approac…

This small, early-stage study is testing whether a drug called glucarpidase can help adults with osteosarcoma (a type of bone cancer) better tolerate their chemotherapy. The goal is to see if giving glucarpidase after high-dose methotrexate treatment reduces side effects and lead…

This study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…

This study is testing if adding the immunotherapy drug pembrolizumab can help control advanced prostate cancer that has started growing again despite treatment with the standard drug enzalutamide. It involves about 58 men whose cancer has spread and is no longer responding to hor…

This study is testing the safety and effectiveness of combining two drugs, enzalutamide and cabazitaxel, for men with advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. The goal is to see if using these drugs together can better c…

This study is testing a combination of three drugs—isatuximab, carfilzomib, and pomalidomide—for adults with multiple myeloma that has come back (relapsed) or stopped responding to treatment (refractory). The goal is to see if this combination can control the cancer and for how l…

This study is testing a new, swallowable capsule that collects cells from the esophagus to screen for cancer and pre-cancerous conditions. It aims to see if this simple, non-invasive tool is practical and acceptable for use in rural primary care clinics, where access to tradition…

This study is testing if a different type of imaging scan (Fluciclovine PET) can find recurring prostate cancer in men whose standard PSMA PET scan was negative. It involves 50 men whose blood tests suggest the cancer has returned. The main goal is to see if this second scan can …

This study is testing whether photos taken with smartphone apps and special imaging devices can be as good as a visit to a dermatologist for finding melanoma early. Researchers are comparing three portable imaging systems to see how accurately they can identify suspicious moles t…

This study is testing whether a new device called the OmnEcoil system can safely combine two prostate cancer detection steps into one procedure. Currently, men with suspicious prostate findings typically get an MRI scan first, then return later for a separate biopsy. This device …

This study is testing whether atorvastatin, a drug commonly used to lower cholesterol, can prevent melanoma skin cancer from spreading (metastasizing) in people who have had it surgically removed but are at high risk of it returning. About 150 participants who have had surgery fo…

This study is testing a digital questionnaire called MammoScreen that helps identify women at average or increased risk for breast cancer. It aims to see if integrating this tool into electronic health records helps more women get appropriate screening and genetic counseling refe…

This study is testing a simple, easy-to-understand conversation tool designed to help people with non-small cell lung cancer. The tool aims to improve how patients and doctors talk about treatment options, making the decision-making process clearer and less stressful. Researchers…

This study aims to discover what causes blood and bone marrow cancers like leukemia. Researchers will analyze cancer cells from up to 5,000 participants to find the specific abnormalities that make the cells grow. The goal is to use this knowledge to develop more effective and le…

This study aimed to test if a special type of MRI scan, done while a patient breathes extra oxygen, could create a map showing which parts of a brain tumor have low oxygen. Low oxygen in tumors can make standard treatments like radiation less effective. The goal was to see if thi…