Ohsu Knight Cancer Institute

This study tests whether adding the immunotherapy drug pembrolizumab can help men whose advanced prostate cancer has stopped responding to the standard drug enzalutamide. About 58 men with castration-resistant prostate cancer that has spread will receive pembrolizumab while conti…

This early-phase trial is testing whether adding the drug venetoclax to a standard treatment regimen can help adults with a specific type of leukemia (Philadelphia chromosome-positive ALL). The study involves 20 participants and aims to find the safest dose of venetoclax when com…

This early-phase trial tests a combination of two drugs—entrectinib and ASTX727—in people with a specific, hard-to-treat form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The study aims to find the safest dose and watch for side effects in 13 a…

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the …

This early-phase trial tests the safety and best dose of the chemotherapy drug eribulin when given with radiation therapy before surgery for retroperitoneal liposarcoma, a rare cancer that grows in the abdomen. About 15 patients will receive the combination to see how well they t…

This study tests a combination of two drugs—cabazitaxel (a chemotherapy) and enzalutamide (a hormone blocker)—in people with prostate cancer that has spread and stopped responding to standard hormone therapy. The goal is to find the safest dose and see if the combination can lowe…

This phase 2 trial tests whether adding apalutamide, abiraterone, and prednisone after chemotherapy can better control metastatic prostate cancer that still responds to hormone therapy. Seven men with high-risk, untreated disease are receiving this combination. The main goal is t…

This phase II trial tests whether switching from one chemotherapy regimen to another early on, before surgery, can help remove pancreatic cancer more completely. It includes patients with resectable, borderline resectable, or locally advanced unresectable pancreatic cancer. The s…

This study tests a combination of three drugs (isatuximab, carfilzomib, and pomalidomide) in adults with multiple myeloma that has come back or is not responding to prior treatments. The goal is to see if this mix can shrink or control the cancer. The trial enrolled 5 participant…

This early-phase trial tests two drugs together in 15 people with advanced pancreatic cancer. One drug, calaspargase pegol-mknl, lowers a nutrient that cancer cells need to grow. The other, cobimetinib, blocks a protein that helps cancer cells survive. The goal is to find a safe …

This study was designed to test whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard hormone therapy and radiation could improve outcomes for men with high-risk localized prostate cancer. The trial was withdrawn before enrolling any participants, so no resul…

This study looks at whether a special PET scan called Axumin can find prostate cancer that has returned after treatment, even when another common scan (PSMA PET) shows nothing. About 50 adults with rising PSA levels and a negative PSMA PET will get an Axumin scan. The goal is to …

This study tests whether a new device called OmnEcoil can safely and effectively combine two separate prostate cancer tests—MRI and biopsy—into a single procedure. About 45 men aged 45 and older with elevated PSA or abnormal exams will participate. The goal is to see if this appr…

This study looks at whether a simple, swallowable device can help screen for esophageal cancer in rural Oregon, where getting a traditional endoscopy is hard. About 110 adults with chronic heartburn and other risk factors will try the device at their local clinic. Researchers wan…

This study tests whether atorvastatin, a widely used cholesterol medication, can prevent melanoma from returning or spreading in people who have had high-risk melanoma surgically removed. About 150 adults with stage IIA, IIB, or IIIA melanoma will receive either atorvastatin or a…

This study tests whether adding a photo guide to standard counseling helps reduce anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 participants will either receive standard verbal counseling alone or with a pictoria…

This early-phase study tests whether glucarpidase can lower the toxic side effects of high-dose methotrexate in adults with osteosarcoma, a type of bone cancer. The goal is to help patients complete their planned chemotherapy doses and spend less time in the hospital. About 12 pa…

This study tests a conversation tool designed to help people with lung cancer understand their options and make decisions that match their values. About 98 patients will use the tool during their care. The goal is to see if it reduces anxiety, regret, and confusion, and improves …

This study tests whether a statewide educational campaign in Oregon helps people spot melanoma earlier. Over 75,000 participants, including patients and healthcare providers, receive training and digital materials. Researchers compare Oregon's results with neighboring states that…

This study is collecting blood, bone marrow, and tissue samples from 5,000 people with blood cancers like leukemia and lymphoma. Researchers will analyze the samples to find genetic abnormalities that cause cancer cells to grow. The goal is to understand why these cancers develop…

This study is testing a tool called MammoScreen, a simple questionnaire that helps identify women at average or increased risk for breast cancer. The goal is to see if using this tool in clinics leads to more appropriate screening referrals. About 1,141 women aged 40 to 74 who us…

This study looks at whether a new electronic referral system helps more people quit smoking by connecting them to free Quitline services. Over 9,000 patients from community health centers in Oregon took part. Researchers want to see if this approach is effective and cost-efficien…

This study was designed to see if a special MRI technique, using extra oxygen, could create maps of low-oxygen areas in brain tumors. Low oxygen can make tumors grow and resist treatment. The goal was to help doctors plan more personalized therapies. However, the study was withdr…