Ohsu Knight Cancer Institute

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with standard radiation for people with stage II or III rectal cancer that hasn't spread. The goal is to find the best dose that kills tumor cells while limiting side effects, before surgery to rem…

This early-phase trial tests a combination of two drugs—calaspargase pegol-mknl and cobimetinib—in about 15 people with advanced pancreatic cancer that has spread. The goal is to find the safest dose and see how well the drugs work together to starve cancer cells by cutting off a…

This study tests a combination of three drugs (apalutamide, abiraterone, and prednisone) given after chemotherapy to men with advanced prostate cancer that has spread and has not been treated before. The goal is to see if this hormone therapy can lower PSA levels more effectively…

This study aimed to see if adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. It was designed for adults with newly diagnosed, localized disease. However, the stud…

This study looks at whether a new electronic referral system, combined with extra training for clinic staff, can help more people who smoke get support to quit. Over 9,000 patients from community health centers in Oregon are taking part. The goal is to see if this approach increa…

This study tests a combination of three drugs (isatuximab, carfilzomib, and pomalidomide) in about 5 adults with multiple myeloma that has come back or stopped responding to prior treatments. The goal is to see if the combination can shrink or control the cancer. This is a diseas…

This early-stage trial tests a combination of two drugs—entrectinib and ASTX727—in adults with acute myeloid leukemia (AML) that has returned or not responded to treatment and has a specific genetic change (TP53 mutation). The goal is to find the safest dose and see if the combin…

This early-phase study tests a combination of drugs, including venetoclax, for adults with a specific type of leukemia (Ph+ ALL) that is either newly diagnosed or has returned. The goal is to find the safest dose and see how well the treatment works. About 20 participants will re…

This study tests whether adding the immunotherapy drug pembrolizumab can help men with advanced prostate cancer that has stopped responding to the hormone therapy enzalutamide. About 58 men whose cancer continued to grow despite enzalutamide will receive pembrolizumab. The main g…

This study tests a combination of two drugs—cabazitaxel (a chemotherapy) and enzalutamide (a hormone blocker)—in people with prostate cancer that has spread and stopped responding to standard hormone therapy. The goal is to find the safest dose and see if the combo can lower PSA …

This study tests whether switching from one chemotherapy combination to another before surgery can help people with pancreatic cancer that can be removed or has spread nearby. About 42 adults with specific stages of pancreatic cancer will receive either FOLFIRINOX or gemcitabine/…

This early-stage trial tests the safety and best dose of the chemotherapy drug eribulin given together with radiation before surgery for a rare cancer called retroperitoneal liposarcoma. About 15 adults with this tumor will receive the combination to see how well they tolerate it…

This study tests whether a new device called the OmnEcoil system can safely and effectively combine two separate procedures—MRI imaging and biopsy—into one session for diagnosing prostate cancer. The device uses a special coil placed in the rectum to take high-quality images and …

This study looks at whether a simple, swallowable device can help screen for Barrett's esophagus and esophageal cancer in rural areas, without needing a traditional endoscopy. About 110 people from rural Oregon with chronic heartburn and other risk factors will try this new metho…

This study looks at whether a special PET scan called Axumin can find prostate cancer that has returned after treatment, in cases where another common scan (PSMA PET) found nothing. About 50 adults with rising PSA levels and a negative PSMA scan will get an Axumin PET. The goal i…

This phase 2 trial tests whether atorvastatin, a widely used cholesterol medication, can prevent melanoma from returning or spreading in people who have had high-risk melanoma surgically removed. About 150 adults with stage IIA, IIB, or IIIA melanoma will receive either atorvasta…

This study looks at whether adding a simple picture guide to standard counseling can help lower anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 women will take part, and their stress levels will be tracked using qu…

This early-phase trial tests whether the drug glucarpidase can safely lower the toxic side effects of high-dose methotrexate in adults with osteosarcoma (a type of bone cancer). The study involves 12 participants and aims to see if the drug helps patients complete their planned c…

This study aims to find the genetic causes of blood and bone marrow cancers, such as leukemia. Researchers will look for specific cell abnormalities that drive cancer growth. Up to 5,000 people with these cancers will provide samples for analysis. The goal is to develop more effe…

This study aimed to see if a special MRI scan, using extra oxygen, could create maps of low-oxygen areas in brain tumors. Low oxygen makes tumors harder to treat. The study was withdrawn before enrolling anyone, so no results are available. It was designed for adults with known o…

This study tests a conversation aid designed to help people with lung cancer and their doctors make treatment decisions together. About 98 patients will use the tool to see if it reduces anxiety and regret while improving understanding. The goal is to make decision-making easier …

This study is testing a tool called MammoScreen that helps women and their doctors decide on breast cancer screening. About 1,100 women aged 40 to 74 will fill out a risk questionnaire through their online health portal. The goal is to see if the tool increases screening and iden…