New drug cocktail takes on Hard-to-Treat leukemia
NCT ID NCT05396859
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a combination of two drugs—entrectinib and ASTX727—in people with a specific, hard-to-treat form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The study aims to find the safest dose and watch for side effects in 13 adults whose leukemia has a TP53 gene mutation. The hope is that the two drugs together can kill more cancer cells than either alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- entrectinib and ASTX727 (decitabine and cedazuridine)
- What this could lead to
- If it works, this could point toward a new treatment option for people with a hard-to-treat form of AML that has come back or not responded to therapy.
- What could go wrong
- This is a very early, small Phase I trial with only 13 participants, focused on safety and dosing. It is too soon to know if the combination will be effective, and there may be significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
OHSU Knight Cancer Institute
Portland, Oregon, 97239, United States
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