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Talking about the end: could guided conversations reduce futile cancer treatments?

NCT ID NCT05444348

Recruiting now Symptom relief Sponsor: Christoffer Johansen Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests a program called ACT, which trains doctors and nurses to have compassionate, structured conversations with blood cancer patients and their families about end-of-life care. The goal is to help patients understand their prognosis and make informed decisions, potentially reducing the use of chemotherapy in the last month of life and easing anxiety for both patients and caregivers. The study involves about 920 participants across multiple hospitals, with some clinicians using the ACT approach and others providing usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
A structured communication intervention called Advance Consultations Concerning Your Life and Treatment (ACT), involving clinician training, patient preparation, and guided conversations about end-of-life care.
What this could lead to
If effective, this approach could help blood cancer patients and their families make more informed decisions, reduce unnecessary treatments near the end of life, and improve the quality of their final days.
What could go wrong
The trial is relatively small and relies on clinician training and adherence, which may vary. It is uncertain whether the intervention will change outcomes, and it may not be feasible in all clinical settings.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia lymphoma myelodysplastic syndrome Myelodysplastic Syndromes myelodysplastic/myeloproliferative neoplasm plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA LYMPHOMA MULTIPLE MYELOMA MYELODYSPLASTIC SYNDROMES

Contacts and locations

Locations

  • Aalborg Universitetshospital

    RECRUITING

    Aalborg, 9100, Denmark

  • Aarhus Universitetshospital

    RECRUITING

    Aarhus, 8200, Denmark

  • Lillebælt syge - Vejle Sygehus

    RECRUITING

    Vejle, 7100, Denmark

  • Odense Universitetshospital

    RECRUITING

    Odense, 5000, Denmark

  • Regionshospitalet Gødstrup

    RECRUITING

    Herning, 7400, Denmark

  • Sjællands universitetshospital Roskilde

    RECRUITING

    Roskilde, 4000, Denmark

  • Sydvestjysk sygehus - Esbjerg

    RECRUITING

    Esbjerg, 6700, Denmark

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