MYELODYSPLASTIC SYNDROMES

This study is testing a new drug called CTX-712 for adults whose acute myeloid leukemia or myelodysplastic syndromes have returned or not responded to prior treatments. The main goals are to find a safe and effective dose and to see if the drug can help put the cancer into remiss…

This study is testing a new, lower-dose weekly schedule of two approved drugs (decitabine and venetoclax) for people with certain blood cancers like AML and MDS. The goal is to see if this gentler approach can control the cancer while causing fewer severe side effects and treatme…

This early-stage study is testing a new cell therapy for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who still have detectable cancer cells after initial treatment. Doctors collect a patient's own immune cells, modify them in a lab to better target …

This early-stage trial is testing the safety of a modified donor stem cell transplant, called Orca-Q, for people with certain blood cancers like leukemia. The goal is to see if this engineered transplant can help patients recover their blood counts while reducing serious complica…

This study is testing an investigational oral drug called AND017 for people with lower-risk myelodysplastic syndromes (MDS) who have anemia. The main goal is to see if the drug can safely increase hemoglobin levels (a measure of red blood cells) and reduce the need for blood tran…

This study is comparing two treatment approaches for adults with higher-risk myelodysplastic syndrome (MDS), a serious bone marrow disorder. Researchers want to know if going straight to a stem cell transplant from a donor works as well as first trying other treatments to control…

This study is testing if adding a drug called venetoclax to the standard pre-transplant chemotherapy improves outcomes for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 patients aged 12-60 will be randomly assigned to receive eit…

This early-stage study is testing a new type of stem cell transplant for adults with aggressive or hard-to-treat forms of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if adding special donor immune cells can help the transplant fight the can…

This study is testing if a combination of home-based exercise training and a dietary supplement can help young people who have survived a bone marrow transplant. The goal is to rebuild lost muscle mass and improve their overall fitness and heart health. Researchers will compare t…

This early-stage study is testing the safety of a new cell therapy called Orca-T for adults with advanced blood cancers like leukemia. The goal is to see if combining Orca-T with two standard medications can reduce serious complications after a stem cell transplant from a partial…

This early-stage study is testing a new therapy that uses specially trained immune cells from a donor to try to prevent blood cancers from coming back after a stem cell transplant. The goal is to see if these 'memory-like' natural killer (NK) cells, given with a supporting drug, …

This study is testing whether changing when a key drug is given can better prevent a serious complication called graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. It will enroll about 29 adults with leukemia or related disorders who are receiving a …

This is the first study in people testing a new drug called MGD024 for several types of blood cancers that have come back or stopped responding to standard treatments. The main goal is to find a safe dose and understand how the drug works in the body. Researchers will also look f…

This study is observing how well umbilical cord blood stem cells from unrelated donors work for patients with serious blood cancers and disorders. Researchers will track how quickly patients' blood counts recover, how often the transplant fails, and the rates of disease relapse a…

This study is testing a new cell therapy called Orca-T for adults with acute myeloid leukemia or myelodysplastic syndrome who need a stem cell transplant but are too frail for the strongest chemotherapy. The therapy uses specially prepared donor cells to help rebuild the patient'…

This early-stage study is testing a new oral drug called EP0042, both alone and combined with other cancer treatments, in adults with advanced blood cancers like acute myeloid leukemia (AML). The main goal is to find a safe and tolerable dose. The study is for patients whose canc…

This early-stage study is testing the safety of a new cell therapy called MNV-201 for adults with low-risk myelodysplastic syndrome (MDS), a bone marrow disorder that causes low blood counts. The therapy involves taking a patient's own blood stem cells, boosting them with mitocho…

This study is testing a new treatment for adults and teens whose blood cancers like leukemia have come back after a stem cell transplant. The treatment involves giving patients special immune cells, called CIML NK cells, from their original transplant donor, along with a drug cal…

This early-stage study aims to find a safe and effective dose of an experimental drug called SX-682 for patients with myelodysplastic syndrome (MDS), a type of blood cancer. Researchers will test SX-682 alone and combined with another drug, decitabine, in up to 151 adults whose p…

This study is testing an oral drug called pacritinib for people aged 12 and older with myelodysplastic syndromes (MDS), a group of serious blood and bone marrow disorders. The first part aims to find a safe dose for teenagers, and the second part will see how well the drug works …

This study is testing whether combining four different cancer drugs can help control aggressive forms of blood and bone marrow disorders. It's for adults with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia, including those whose disease has returned afte…

This study is testing whether the drug luspatercept can help patients with a lower-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder. The main goal is to see if the drug can safely reduce or eliminate the need for regular blood transfusions in these patients. R…

This is the first time researchers are giving a new oral drug called BH-30236 to people. The study aims to find a safe dose and see if the drug can help control two aggressive blood cancers—acute myeloid leukemia or myelodysplastic syndrome—that have come back or haven't responde…

This study is testing whether adding an infusion of donor immune cells to a standard drug regimen is safe and effective for treating intermediate- to high-risk myelodysplastic syndromes (MDS), a type of bone marrow cancer. It is for patients who cannot receive a standard stem cel…

This early-stage study is testing a new cell therapy for adults with certain blood cancers who have received a bone marrow transplant from a partially matched family donor. Researchers take a special type of the patient's own immune cells, grow and activate them in a lab, and the…

This early-stage study is testing the safety and best dose of a drug called venetoclax when added to standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML) or advanced myelodysplastic syndrome (MDS). The goal is to see if this combination can better co…

This study is testing a new method to help patients recover their immune systems faster after a stem cell transplant for leukemia. It involves giving patients a special, filtered portion of their donor's immune cells, aiming to reduce the risk of life-threatening viral and fungal…

This is the first study in people to test a new oral medication called GLB-001. It aims to find a safe and effective dose for adults with advanced forms of acute myeloid leukemia or myelodysplastic syndromes that have returned or not responded to other treatments. The main goals …

This early-stage study is testing a new drug called BGB-11417, both by itself and combined with an existing drug (azacitidine), for people with certain blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goals are to find a safe and effec…

This study is testing a new approach for patients with myelodysplastic syndromes (MDS, a type of blood cancer) who have had a stem cell transplant. Researchers will use a sensitive blood test one month after transplant to check for tiny traces of leftover cancer. If found, patien…

This study is testing whether adding high-dose vitamin C given through an IV can make the standard drug azacitidine work better for adults with higher-risk myelodysplastic syndrome (MDS), a type of blood and bone marrow disorder. The main goals are to see if the combination is sa…

This study is testing a new oral drug called enzomenib for people with advanced blood cancers like acute leukemia that have come back or not responded to other treatments. The main goals are to find a safe and effective dose and to see if the drug, given alone or with standard ch…

This study is testing an experimental drug called DISC-0974 in people with myelofibrosis or myelodysplastic syndrome who have anemia. The main goals are to see if the drug is safe and if it can help improve red blood cell counts, potentially reducing or eliminating the need for b…

This study is testing a modified stem cell transplant procedure for people with inherited bone marrow failure disorders like Fanconi anemia. The goal is to see if removing specific immune cells from the donor cells before transplant can reduce the risk of a serious complication c…

This study is testing a new oral pill called ASTX030 for people with certain blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goal is to see if the pill works as well as or better than the standard injected medication. It will also tes…

This study is testing whether the drug luspatercept can help adults with anemia from certain lower-risk bone marrow disorders become less dependent on regular blood transfusions. Researchers will enroll about 70 participants who currently need frequent transfusions and see if add…

This study is testing whether combining two drugs, luspatercept and ESA, works better than luspatercept alone for patients with a lower-risk type of bone marrow disorder called MDS. It is for adults whose disease has not improved or has returned after a common first treatment. Th…

This study is testing a two-part treatment for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) has come back after a stem cell transplant. The treatment combines an immune-boosting drug (interferon-gamma) with an infusion of cells from the original tra…

This study is testing whether a two-drug treatment given after a bone marrow transplant can help prevent leukemia and related blood cancers from coming back. It involves children and young adults up to age 39 who have had a transplant for conditions like acute myeloid leukemia (A…

This early-stage study aims to find the safest dose of a new two-drug combination for people with high-risk myelodysplastic syndromes (MDS) and certain types of leukemia. The trial combines an approved tablet with an experimental drug to try to better control these serious blood …

This study is testing whether a pill called olutasidenib can help control certain early-stage blood disorders that have a specific genetic change (IDH1 mutation). It will involve about 15 adults with conditions like clonal cytopenia of undetermined significance (CCUS), lower-risk…

This early-stage trial is testing a new approach to stem cell transplants for adults with advanced blood cancers like leukemia. Researchers are modifying the donor cells by adding specific immune cells (regulatory T-cells) alongside the standard transplant. The goal is to help th…

This study is testing an investigational drug called elritercept to see if it can help adults with a lower-risk type of myelodysplastic syndrome (MDS) become less dependent on regular red blood cell transfusions. About 225 participants will receive either the drug or a placebo vi…

This early-stage study is testing the safety and initial effectiveness of a new drug called Danvatirsen, first by itself and then combined with an existing drug, Venetoclax. It is for adults with advanced forms of blood cancer (MDS or AML) that have returned or not responded to a…

This study is testing a new transplant method for adults with high-risk leukemia or myelodysplastic syndromes (MDS) who do not have a perfectly matched donor. It combines cells from a partially matched family donor with cells from umbilical cord blood. The goal is to see if this …

This early-stage study is testing whether giving specially grown immune cells from a stem cell donor can help prevent cancer from coming back after a transplant for acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal is to see if this approach is safe a…

This early-stage trial is testing if adding two anti-cancer drugs, decitabine and venetoclax, to a standard stem cell transplant procedure is safe for adults with high-risk blood cancers like acute myeloid leukemia (AML). The main goal is to find the safest dose and see if this c…

This study is testing an investigational drug called KER-050 (elritercept) to see if it can safely help the body make more healthy red blood cells in adults with lower-risk myelodysplastic syndromes (MDS) who have anemia. The main goals are to check the drug's safety and see if i…

This study aims to see if a newer drug called luspatercept works better and is safer than the standard drug epoetin alfa for treating anemia in adults with lower-risk myelodysplastic syndromes (MDS). It will enroll 360 participants who have not yet taken similar anemia drugs and …

This study is testing whether a telehealth program helps older patients with serious blood cancers have better conversations with their doctors about future care wishes. It aims to see if these structured video calls reduce patient anxiety and distress, and help more people compl…

This study is testing a new hospice care program that provides blood transfusions at home for patients with advanced blood cancers. The goal is to see if this program improves patients' quality of life and mood, and helps more people choose hospice care, compared to the usual sta…

This study is testing if a widely available, inexpensive drug called tranexamic acid can safely reduce bleeding episodes in outpatients with serious blood cancers (MDS or AML). About 75 adult patients with low platelet counts will be randomly assigned to receive either the drug o…

This study is testing whether cancer patients with low blood counts can safely receive blood transfusions at home instead of at the hospital. Researchers will enroll 30 patients who regularly need blood transfusions and give them 1-5 transfusions at home. The main goal is to see …

This study is testing a new laboratory method to see if it can better predict which patients with a blood cancer called myelodysplastic syndrome (MDS) might relapse after receiving a stem cell transplant. Researchers will track 163 patients after their transplant to see if the ne…

This early-stage study aims to understand how a cancer drug is processed by the body in patients with moderate to severe liver problems. It will enroll about 27 adults with certain blood cancers or solid tumors to measure drug levels and check for side effects. The main goal is t…

This study aims to learn more about myelodysplastic syndromes (MDS), a group of rare blood disorders, by observing how the disease naturally progresses over a very long time. Researchers will enroll about 1,100 people, including those with MDS and healthy donors, to collect blood…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This early-stage study aims to understand how a combination cancer pill is processed by the body in patients with severe kidney problems compared to those with normal kidney function. It will enroll about 18 adults with certain blood cancers or solid tumors who could benefit from…

This study aims to collect blood, bone marrow, skin, saliva, and stool samples from 1,000 healthy adults. Researchers will use these samples as a 'healthy comparison' to better understand myelodysplastic syndromes (MDS), a type of blood cancer. The goal is to build a database tha…

This study aims to understand how the services from the nonprofit Blood Cancer United affect people with blood cancers. Researchers will follow 400 patients for six months to see if the organization's help improves their access to medical care, quality of life, and financial stre…

This study aims to understand why some early, non-symptomatic blood conditions turn into cancer. Researchers will observe 10,000 adults who have these early conditions or a history of cancer. They will analyze genetic material from routine blood and tissue samples to identify cha…

This study is collecting and storing blood and tissue samples from patients with blood cancers like leukemia and lymphoma. The goal is to build a library of samples for researchers to study, which may help them better understand these diseases and develop new treatments in the fu…

This study is testing a new, detailed genetic test called ChromoSeq for patients with blood cancers AML or MDS. Researchers want to see if this test, which looks at a person's entire genetic code, finds more cancer-related changes than current standard tests. They will enroll 325…

This study aims to collect blood, saliva, and health information from people with blood diseases and their family members to build a research library. The goal is to discover unknown genetic causes and understand why disease severity varies between people. This is a research stud…

This study collects health information from patients receiving stem cell transplants for various blood cancers and immune disorders. Researchers will track 2,000 patients over time to gather data on survival rates and treatment complications. The goal is to build a comprehensive …

This study aims to understand how inherited changes in certain genes, especially the DDX41 gene, increase a person's risk of developing blood cancers like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Researchers will follow over 500 participants, including peo…

This study is testing a new, more detailed genetic test called ChromoSeq to see if it works as well as the standard genetic tests used for patients with myelodysplastic syndromes (MDS), a type of blood and bone marrow disorder. Researchers will enroll 60 adults with MDS to compar…