MYELODYSPLASTIC SYNDROMES

This early-phase study tested whether giving patients a special type of cell (interferon gamma-primed mesenchymal stromal cells) around the time of a bone marrow transplant could safely prevent graft-versus-host disease, a serious complication where donor cells attack the patient…

This study tested a new drug called BMS-986253 for people with myelodysplastic syndromes (MDS), a type of bone marrow cancer. It aimed to see if the drug is safe and works, either alone or with standard treatments. Only 2 people took part before the study was stopped early.

This study tested a drug called MBG453 in 10 people with a low-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to see if the drug could improve blood cell counts and reduce the need for blood transfusions. The trial was stopped early, but resear…

This study tested a new treatment called TCB008 for adults with acute myeloid leukemia (AML) that did not respond to standard therapy or came back after treatment. TCB008 uses specially grown immune cells from healthy donors to attack the cancer. The trial aimed to see if this th…

This study tested two oral drugs, eltanexor and Inqovi, for people with high-risk myelodysplastic syndromes (MDS) whose disease did not improve with standard treatment. Only 3 adults enrolled before the trial was stopped. The goal was to find a safe dose and see if the combinatio…

This study tested a new drug called SAR443579 in adults and children with hard-to-treat blood cancers like acute myeloid leukemia and acute lymphoblastic leukemia. The goal was to see if the drug was safe and could shrink or eliminate cancer. The trial was stopped early, so final…

This early-phase study tested a new drug called DSP107 combined with standard chemotherapy drugs (azacitidine with or without venetoclax) in people with relapsed or refractory acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or chronic myelomonocytic leukemia (CMML).…

This study tested whether adding the experimental drug MBG453 to standard chemotherapy (azacitidine) could help adults with high-risk myelodysplastic syndrome (MDS) or a related leukemia (CMML-2) live longer. About 530 participants were planned, but the trial was stopped early. T…

This early-stage study tested a new drug called CC-95251, alone or with other cancer drugs, in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that had come back or not responded to treatment. The main goals were to check safety and find the right dose…

This early-stage study tested a new drug called INKmune in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal was to see if it was safe and to find the best dose. Only 2 people took part before the study was stopped early.

This early-phase study aimed to find safe doses of drug combinations for adults with lower-risk myelodysplastic syndrome (MDS), a blood disorder. Researchers planned to enroll 33 participants to check side effects and how well the drugs were tolerated. The study was terminated ea…

This early-stage study tested a new drug, gentulizumab, in 58 adults with acute myeloid leukemia or myelodysplastic syndrome that returned or didn't respond to standard therapy. The drug works by blocking a protein called CD47 on cancer cells, helping the immune system attack the…

This study tested whether adding an experimental drug called MBG453 to standard chemotherapy (azacitidine or decitabine) could improve outcomes for people with high-risk myelodysplastic syndrome (MDS), a type of blood cancer. The trial included 127 adults who were not eligible fo…

This study tested an experimental drug called INCB000928 in 22 people with anemia caused by myelodysplastic syndromes (MDS) or multiple myeloma. The goal was to find a safe dose and see if it could improve red blood cell counts. The trial was stopped early, so results are limited…

This early-phase trial tested a new drug called SL-172154, given with standard chemotherapy drugs (azacitidine with or without venetoclax), in adults with higher-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The study aimed to find a safe dose and check for…

This study aimed to see if an oral (pill) form of the drug cladribine works similarly to the standard IV (intravenous) version in people with certain blood cancers like leukemia. Only 3 adults were enrolled before the study was stopped early. The main goal was to check safety and…