MYELODYSPLASTIC SYNDROMES
Clinical trials for MYELODYSPLASTIC SYNDROMES explained in plain language.
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First patients test new pill aimed at slowing advanced cancers
Disease control CompletedThis was a first-in-human study to test the safety and find the right dose of a new oral drug, JNJ-64619178, for people with advanced cancers that have not responded to other treatments. It involved 114 adults with specific advanced solid tumors, non-Hodgkin lymphoma, or a type o…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Apr 01, 2026 18:41 UTC
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Experimental pill tested against seven rare blood diseases
Disease control CompletedThis study tested whether the drug dasatinib could help control several rare blood disorders including leukemia, myelofibrosis, and mastocytosis. Participants took dasatinib pills daily for as long as it helped control their disease. Researchers monitored blood counts and bone ma…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Scientists test new drug duo in fight against tough cancers
Disease control CompletedThis early-stage study tested the safety of combining two cancer drugs, bortezomib and clofarabine, in adults with advanced solid tumors, lymphomas, or blood disorders that had stopped responding to standard treatments. The main goal was to find the highest dose patients could to…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New hope for blood cancer patients: experimental combo aims to stop transplant complications
Disease control CompletedThis study tested a new three-drug combination (PTCy, sirolimus, and VIC-1911) to prevent two major problems after a stem cell transplant: graft-versus-host disease (GVHD) and cancer relapse. It involved 16 adults with blood cancers like leukemia and lymphoma who received a high-…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1, PHASE2 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Experimental cell therapy tested for Tough-to-Treat blood cancers
Disease control CompletedThis study tested the safety of a new type of donor immune cell infusion for patients with advanced myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) after their initial treatments stopped working. The goal was to see if these specially prepared cells from …
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1, PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New hope to tame dangerous side effect of Life-Saving transplants
Disease control CompletedThis study tested if a drug called palifermin, given before a stem cell transplant, could make the procedure safer and more effective. It involved 34 adults with blood cancers who received stem cells from an unrelated, matched donor. The main goals were to find a safe dose and se…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Oral drug trial aims to control blood disorder with fewer side effects
Disease control CompletedThis study tested different low-dose schedules of an oral drug called ASTX727 for adults with lower-risk myelodysplastic syndromes (MDS), a bone marrow disorder that affects blood cell production. The main goals were to find a dose and schedule that is safe and effective at impro…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1, PHASE2 • Sponsor: Taiho Oncology, Inc. • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New hope for older leukemia patients: gentler transplant tested
Disease control CompletedThis study tested the safety of a new, gentler transplant method for older adults or those who cannot have a standard bone marrow transplant for leukemia or related blood cancers. The approach uses a small, mismatched donor transplant but skips the strong drugs that suppress the …
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: Institut Paoli-Calmettes • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New pill aims to stop leukemia from coming back after transplant
Disease control CompletedThis early-stage study tested whether a weekly pill called ONC-201 could safely help prevent leukemia or MDS from returning after a stem cell transplant. It involved 20 patients who had recently received a transplant and took the pill for up to one year. The main goal was to chec…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: University of Nebraska • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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Race against time: study tests best way to find Life-Saving transplant donors
Disease control CompletedThis study aimed to find the best strategy for finding bone marrow transplant donors for patients with blood cancers and disorders. It compared whether patients should first search for a perfectly matched unrelated donor or go directly to alternative donors like family members or…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: NA • Sponsor: Center for International Blood and Marrow Transplant Research • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Scientists test new drug combo to make risky cancer transplants safer
Disease control CompletedThis study tested the safety of swapping out one drug (cyclophosphamide) for another (bendamustine) in the days following a bone marrow transplant. It involved 50 patients with various blood cancers who needed a transplant but lacked a perfectly matched donor. The goal was to see…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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New hope for blood cancer patients: gentler transplants from family donors
Disease control CompletedThis study tested a less intense bone marrow transplant procedure for adults with various blood cancers who needed a transplant but did not have a fully matched donor. It used stem cells from a half-matched family member (like a parent, child, or sibling) after a milder pre-trans…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE2 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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First human test of new leukemia pill seeks safe dose
Disease control CompletedThis was the first study in people to test the safety of a new oral drug called JNJ-74856665 for advanced blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The main goal was to find the highest dose patients could tolerate without severe side ef…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE1 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Feb 27, 2026 15:06 UTC
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Can a common antibiotic shield blood cancer patients from deadly infections?
Prevention CompletedThis study tested whether giving the antibiotic levofloxacin could prevent serious infections in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) who were receiving azacitidine treatment. Researchers compared 60 patients who either received the prevent…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: PHASE3 • Sponsor: Centre Henri Becquerel • Aim: Prevention
Last updated Mar 25, 2026 14:07 UTC
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Breaking the barrier: free blood transfusions offered to help dying patients access hospice sooner
Symptom relief CompletedThis study tested if paying for blood transfusions would help people with advanced blood cancers choose hospice care earlier. Patients often delay hospice because they need transfusions, which hospice usually doesn't cover. The research provided free transfusions to see if this h…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: NA • Sponsor: Adam Olszewski • Aim: Symptom relief
Last updated Mar 31, 2026 12:12 UTC
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Researchers look back at medical records to see how a blood disorder drug performs outside clinical trials
Knowledge-focused CompletedThis study looked back at the medical records of 418 adults in the US with a lower-risk type of myelodysplastic syndrome (MDS), a bone marrow disorder. The goal was to understand how patients fared in real life when treated with the drug luspatercept for anemia, compared to anoth…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Sponsor: Bristol-Myers Squibb • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Virtual visits aim to help seniors with cancer plan their future care
Knowledge-focused CompletedThis small pilot study tested whether a telehealth program could help older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) plan for their future medical care. Researchers wanted to see if the online program was easy to use and acceptable to patients,…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: NA • Sponsor: University of Rochester • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Scientists map genetic blueprint of blood disorder to predict patient outcomes
Knowledge-focused CompletedThis study aimed to understand how specific gene mutations affect the survival and disease progression of patients with myelodysplastic syndromes (MDS), a type of bone marrow disorder. Researchers followed 349 newly diagnosed patients for three years, using advanced genetic testi…
Matched conditions: MYELODYSPLASTIC SYNDROMES
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC