MYELODYSPLASTIC SYNDROMES

This study tested whether adding a drug called VIC-1911 to standard medications can prevent graft-versus-host disease (GVHD) and cancer relapse after a stem cell transplant. Sixteen adults with blood cancers like leukemia or lymphoma took part. The goal was to find the best dose …

This study looked at whether giving the antibiotic levofloxacin can prevent serious infections in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are being treated with azacitidine. Infections are a major risk for these patients. The study enrolled…

This study tested a new treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) whose first therapy stopped working. The treatment uses specially selected immune cells from a donor to fight the cancer without causing long-term side effec…

This study tested a stem cell transplant from half-matched (haploidentical) family donors for people with various blood cancers. The treatment used a reduced-intensity chemotherapy and radiation regimen to prepare the body for the transplant. The goal was to see how many patients…

This study tested the drug dasatinib in 68 adults with several blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control these diseases and to check its safety. Results focused on how many pa…

This study tested a new type of transplant for 25 people with acute myeloid leukemia or myelodysplastic syndromes who could not have a standard bone marrow transplant. Instead of using strong immune-suppressing drugs, doctors gave a small number of blood stem cells from a partial…

This early-stage study tested a new drug called JNJ-74856665 in 153 people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The main goal was to find safe doses and check for side effects. The drug works by blocking a protein that cancer cells need to grow.

This early-phase study tested the safety of combining two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. Participants received the drugs in 21-day cycle…

This early-stage study tested an oral drug called NTX-301 in 22 adults with certain blood cancers (MDS, AML, or CMML) that had not responded to prior treatment. The main goal was to see if the drug is safe and tolerable, while also checking for any signs that it might help contro…

This study tested different low doses and schedules of the drug ASTX727 in 160 adults with lower-risk myelodysplastic syndromes (MDS), a type of blood cancer. The goal was to find a dose that improves blood cell counts and reduces the need for blood transfusions while being safe.…

This early-phase study tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. The goal was to see if taking ONC-201 weekly for a year could help prevent the cancer f…

This study tested a drug called palifermin in 34 adults with blood cancers who received stem cell transplants from unrelated donors. The goal was to see if palifermin could reduce severe chronic graft-versus-host disease (GVHD), a serious complication where donor cells attack the…

This early-stage study tested a new drug called JNJ-64619178 in 114 adults with advanced cancers (like lymphoma, solid tumors, or myelodysplastic syndromes) that had not responded to other treatments. The main goal was to find the safest dose and check for side effects. The drug …

This study tested whether replacing a standard transplant drug (cyclophosphamide) with a different drug (bendamustine) could make half-matched bone marrow transplants safer for people with blood cancers like leukemia and lymphoma. About 50 patients took part. The goal was to redu…

This study looked at whether covering the cost of blood transfusions would encourage people with blood cancers to enroll in hospice earlier. Many patients delay hospice because they need regular transfusions for symptom relief, which hospices often can't afford. The study offered…

This study tested whether a telehealth program could help older adults (60+) with acute myeloid leukemia or myelodysplastic syndrome plan their future medical care. Researchers worked with 36 patients, their caregivers, and doctors to see if the program was easy to use and practi…

This study aimed to understand how certain gene mutations impact survival in people with myelodysplastic syndromes (MDS), a group of bone marrow disorders. Researchers enrolled 349 patients and used advanced DNA sequencing to track mutations. The goal was to improve predictions a…

This study looked at 1,753 patients needing a bone marrow transplant for blood cancers or other serious blood disorders. It compared two approaches: first searching for a matched unrelated donor, or going straight to an alternative donor (like a half-matched family member). The g…

This study looked back at medical records of 418 adults with lower-risk myelodysplastic syndromes (MDS) who had not received prior treatment with ESAs. Researchers wanted to see how doctors actually use luspatercept and what happens to patients, including blood transfusion needs,…