Which donor search strategy saves more lives?

NCT ID NCT03904134

Completed Knowledge-focused Sponsor: Center for International Blood and Marrow Transplant Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 1,753 patients needing a stem cell transplant for blood cancers or other serious blood disorders. Researchers compared two strategies: first searching for a matched unrelated donor, then trying an alternative donor if needed, versus going straight to an alternative donor. The goal was to see which approach leads to better survival within two years.

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Conditions

The condition(s) this trial relates to.

acquired aplastic anemia acute lymphoblastic leukemia acute myeloid leukemia Hodgkins lymphoma myelodysplastic syndrome Myelodysplastic Syndromes non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED APLASTIC ANEMIA ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA HODGKIN LYMPHOMA MYELODYSPLASTIC SYNDROMES NON-HODGKIN LYMPHOMA SICKLE CELL DISEASE

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Medical Center Dallas

Dallas, Texas, 75235, United States
Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
City of Hope

Duarte, California, 91010, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
H. Lee Moffitt Cancer Center

Tampa, Florida, 33612, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Loyola University

Maywood, Illinois, 60153, United States
M.D. Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Healthcare System

Pembroke Pines, Florida, 33028, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mount Sinai Medical Center

New York, New York, 10029, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Northside Hospital

Atlanta, Georgia, 30342, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Rosewell Park Cancer Institute

Buffalo, New York, 14263, United States
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Stanford Hospitals and Clinics

Stanford, California, 94305, United States
The Ohio State University

Columbus, Ohio, 43210, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California, San Diego Medical Center

La Jolla, California, 92093, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Maryland

Baltimore, Maryland, 21201, United States
University of Miami

Miami, Florida, 33136, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Minnesota

Minneapolis, Minnesota, 55414, United States
University of Mississippi

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center - Adults

Omaha, Nebraska, 68105, United States
University of Nebraska Medical Center - Pediatrics

Omaha, Nebraska, 68105, United States
University of North Carolina

Chapel Hill, North Carolina, 27599, United States
University of Oklahoma

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Utah

Salt Lake City, Utah, 84113, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

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