Experimental drug targets leukemia and lymphoma in early trial

NCT ID NCT00081874

First seen Jun 19, 2026 · Last updated Jun 19, 2026

Summary

This study tested a drug called RAD001 (everolimus) in 29 people with blood cancers like leukemia, lymphoma, or myelofibrosis that had come back or not responded to treatment. The goal was to find the safest dose and see if it could shrink or control the cancer. The trial combined early safety testing (Phase I) with a first look at effectiveness (Phase II).

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LEUKEMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • M.D. Anderson Cancer Center

    Houston, Texas, 77030, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

RAD001 (everolimus, Afinitor)

What this could lead to

If it works, this could point toward a treatment option for certain blood cancers that have not responded to standard therapy.

What could go wrong

This is an early-phase trial with only 29 participants, so results may not apply broadly. The drug may cause side effects or fail to control the disease.

Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia B-cell chronic lymphocytic leukemia blast phase chronic myelogenous leukemia, BCR-ABL1 positive chronic myelomonocytic leukemia leukemia mantle cell lymphoma myelodysplastic syndrome myelofibrosis Precursor Cell Lymphoblastic Leukemia-Lymphoma primary myelofibrosis Recurrence T-cell leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.